Researchers found that IGF1 gene therapy increases kisspeptin expression and GnRH release, and alters microglial cell numbers, suggesting a potential protective effect against reproductive decline. This could lead to new strategies for optimizing lifespan and combating age-related health problems in women.
A new study by Cedars-Sinai investigators has identified risk factors for developing diabetes in people with chronic pancreatitis, including smoking and being overweight. The findings suggest that models can be built to predict diabetes risk, allowing clinicians to connect patients with weight loss or smoking cessation programs.
A new injectable hydrogel has been developed with enhanced shear-thinning properties, improved cellular biocompatibility, and significantly reduced clotting times. The biomaterial was created by adding sodium phytate to a gelatin-based compound, promoting even greater cohesion and triggering the initiation of blood coagulation.
Female putty-nosed monkeys deliberately use alarm calls to recruit males to defend the group, a first observed intentional vocalization in animal kingdom. Researchers found females react directly to male actions, adjusting their behavior when goal achieved.
Researchers found that adding water increases selectivity of 2,3-butanediol generation by 57%. Hydrogen bonding stabilizes radical intermediates, avoiding oxidation and promoting selective coupling. The study reveals non-chemical bonding interactions can steer reaction paths for selective photocatalysis.
Researchers at the Technion-Israel Institute of Technology have developed a novel printing and growing technique for tissue, which suppresses the typical shrinkage of printed tissues prior to transplantation. The print-and-grow method uses an innovative microgel support material, preserving the size and shape of the tissue.
A comprehensive genomic analysis of over 200 patients with metastatic urothelial carcinomas identified potential treatment options for nearly 70% of patients. The study found that integrating clinical and molecular features could predict response to immunotherapies, offering hope for personalized treatment approaches.
A new MIT study found that children from lower socioeconomic backgrounds have distinct brain patterns linked to reading difficulties, differing from those of higher-SES students. The research suggests that tailored interventions may be necessary for different groups of children.
The Princess Máxima Center has been awarded a Marie Sklodowska-Curie COFUND grant to train 28 PhD students from around the world in pediatric oncology research. The program aims to advance the field and promote international collaboration.
A team of researchers from Japan Advanced Institute of Science and Technology has discovered thermodynamically stable phases in Y–Ce–H and La–Ce–H systems that exhibit high-temperature superconductivity. Calculations predicted Tc values of up to 173 K, paving the way for the development of more energy-efficient and sustainable societies.
Scientists have created a new type of 3D mesostructure that can change shape and actuate at high frequencies, enabling new applications in robotics, MEMS, sensing, and wireless communication. The structure uses magnetism to control its deformation and has been successfully integrated into various devices.
Researchers at Washington University School of Medicine studied 350 people to understand how Alzheimer's disease affects the brain. The study found that gene APOE is active in the areas most damaged by the disease, leading to symptoms like language and vision problems.
A new University of Colorado Boulder study shows that people tend to prioritize others' health and wellbeing when taking a moment to reflect on their behavior. When instructed to practice 'structured reflection,' participants were more likely to cancel gatherings and minimize public health risks, valuing others' health and wellbeing.
Researchers studied how shrimp legs minimize drag while swimming and how fruit flies use flapping wings to 'sniff out' smells for navigation. They also explored how honeybees fly in windy conditions, finding that windy conditions don't affect flight performance but increase evasive maneuvers.
A new study by CHOP researchers found that antibiotic-resistant Enterococcus enhances C. difficile virulence by modulating the gut environment, increasing toxin production and nutrient supply. This interaction supports increased colonization and persistence of C. difficile in the gut.
A new study from the University of Washington found that the number of US adult handgun owners carrying a loaded handgun on their person doubled from 2015 to 2019. In 2019, approximately 16 million adult handgun owners had carried a loaded handgun in the past month, with 6 million carrying every day.
Two new specimens, Mieridduryn bonniae, have been discovered in a Welsh fossil deposit, providing insights into the evolution of arthropods. The fossils feature striking similarities to Opabinia, suggesting that they may be related to modern arthropod larvae.
An international study found that flu vaccines significantly reduce pneumonia, hospitalization, and cardiovascular deaths in people with heart failure. The study, led by McMaster University researchers, showed a 40% reduction in pneumonia and 15% reduction in hospitalization.
A pooled data analysis estimates that 24% of teens and young people engage in unsafe listening practices from personal listening devices and 48% attend loud music venues. This translates to a potential risk of hearing loss for 0.67-1.35 billion young people worldwide.
Researchers found that higher levels of polybrominated diphenyl ethers (PBDEs) in pregnant women were associated with increased anxiety scores in their children at age 12. The study suggests that exposure to flame retardants during early brain development may be a risk factor for developing anxiety symptoms in early adolescence.
A systematic review found significant effects on anxiety, depression, fatigue, physical activity, quality of life, and social impairment in cancer patients who combined behavioural graded activity with psychological therapies. The effects remained significant after a period of one to three months.
Researchers used native top-down mass spectroscopy to study the interplay between glycans and oligomerization in various therapeutic hormones and cytokines. They found that glycans significantly stabilize some proteins, such as tumor necrosis factor-α, while others, like interferon-β, are independent of glycosylation status.
Researchers from the University of Ottawa found an association between marijuana smoking and chronic damage to airways, including higher rates of paraseptal emphysema and airway inflammatory changes. The study suggests that marijuana smoking may lead to additional lung damage beyond what is seen in tobacco smokers.
A new analysis proposes a four-step framework to overcome barriers and enhance the success of early warning systems for climate-related disease outbreaks. Engaging crucial decision makers immediately is key, as well as training local health providers in environmental science.
Scientists at King's College London and the University of Bath have made a groundbreaking discovery about a molecule that plays a crucial role in nerve cell development. The study found that this molecule, known as SNRNP70, is not only present in the nucleus but also in the cytoplasm of nerve cells, where it shapes messenger RNA strand...
A new study co-authored by Bayes Business School found that larger public companies suffer from loss of innovation and lower share price value when managers are permitted to take decisions in their own self-interest. The study examined the effects of waiving fiduciary duties on R&D investment, finding a significant decline.
Scientists used single-cell integrative secretion profiling technology to map the interaction between neurons and immune cells, revealing heterogeneity in secreted factors and their roles in regulating neuronal function. The study found that infiltrating macrophages inhibit neuronal secretion of exosomes, while microglia promote neuros...
A new report by the European Groundshot Commission highlights current and future challenges in cancer research across Europe. The authors estimate that approximately one million cancer diagnoses were missed during the COVID-19 pandemic, and the war in Ukraine poses a significant threat to clinical trials and workforce gaps.
Researchers at NC State University have developed a ring-shaped soft robot capable of crawling across surfaces when exposed to elevated temperatures or infrared light. The 'ringbots' are made of liquid crystal elastomers in the shape of looped ribbon, resembling a bracelet, and can pull a small payload across various environments.
Researchers predict a decrease in coronary heart disease and stroke deaths in most prefectures of Japan between 2020 and 2040. This drop is attributed to the aging population and changes in health trends, which will lead to increased healthcare spending for dementia and frailty.
Researchers at KAUST have developed a spintronics-based logic lock to defend chip security, which can be integrated into electronic chips to fend off malicious attacks. The design uses magnetic tunnel junctions to scramble the circuit's operation unless the correct key combination signal is supplied.
A three-year study in Mozambique shows that parasite density and detectability in primigravid women decline as disease transmission decreases, despite stable antibody levels. This suggests non-immunological factors control infections in pregnant women.
A team of scientists at Boston Children's Hospital created a new tool to analyze vaccine responses, enabling better understanding of immune system reactions. The Immune Signatures Data Resource contains data from 53 studies covering 24 different vaccines.
A large Nordic study found that children born to mothers with preeclampsia have higher risk of ischemic heart disease and stroke. The association holds even after accounting for other birth complications such as preterm birth and low birth weight.
A study by CHOP researchers found that financial stress during the pandemic contributed to depressive symptoms in adolescents across all income groups. The effect was most pronounced in low-income adolescents, but also affected those with lower pre-pandemic household income.
A new calculator will assess an individual's risk and benefit of taking bisphosphonates for osteoporosis, considering factors such as fracture history and comorbid conditions. The calculator aims to provide personalized guidance on whether a drug holiday is beneficial or not.
A new study published in the Journal of Clinical Endocrinology & Metabolism reveals that pancreas transplantation can provide up to 90% of recipients with diabetes freedom from insulin therapy and glucose monitoring. Despite high success rates, transplant numbers have declined due to lack of consensus criteria, education, and resource ...
Researchers have identified potential new lead compounds for treating depression and anxiety disorders, which display reduced risk of drug abuse and adverse effects. These substances, derived from synthetic cathinone compounds, are known to release serotonin without significantly increasing dopamine levels in the brain.
Researchers used a terahertz scanning probe microscope to investigate Methylammonium Lead Iodide perovskite, a potential alternative to silicon in solar cells. The team found significant variation in light scattering along grain boundaries, shedding light on the material's degradation issue.
A bike box setup can help cyclists stay safe at urban, signalized intersections by providing a visible space to navigate through the intersection. The study found that among three treatments, bike boxes were the most versatile, offering a balance of safety and requiring riders to perceive potential danger.
The November issue of CHEST journal features new guidelines for perioperative management, studies on COVID-19 treatment and COPD treatment, as well as research on sleep apnea and long COVID. These findings have significant implications for patient care and healthcare resource use.
Researchers have developed a novel proposal for designing flip-flop dynamic crystals with temperature-regulated apertures to separate water isotopologues. The new material exhibits excellent separation factor and high selectivity, overcoming the century-old challenge in separation science.
A new model predicts individual breast cancer risk based on ten known risk factors, allowing for tailored screening strategies. The study found that the risk of developing breast cancer ranges from 0.22% to 7.43%, with some factors, such as exercise, having a greater impact than previously thought.
A new microscopy system using optical tapered fibers has successfully acquired images of photoacoustic signals without contrast agents. The resolution is sufficient for cellular imaging, including red blood cells, with a resolution of 1.0 ± 0.3 micrometers.
New research from King's College London found increasing CBD content in cannabis does not significantly change the effects of THC on cognitive performance or psychotic symptoms. The study suggests that choosing cannabis with higher CBD:THC ratios may be safer due to lower THC levels, but CBD has no impact on intoxication quality.
Researchers have successfully segregated oppositely helical supramolecular polymers in a solution using audible sound, inducing surface vibrations and advection currents. This approach allows for the spatiotemporal control of chiral supramolecular systems, enabling the segregation of multiple aggregates.
Researchers discovered that genetic duplication of genes is crucial for the formation of symbiotic structures between nitrogen-fixing bacteria and legumes. This discovery has potential to engineer other plant species to fix nitrogen directly, reducing dependence on manure and synthetic fertilizer.
A large-scale study found that high plant diversity in meadows and pastures supports numerous ecosystem services, including pollination, soil quality and cultural experiences. Various stakeholder groups, from local residents to the tourism industry, can benefit from increased biodiversity.
Researchers have discovered a new critical period for sex determination in sea turtle embryos, influenced by temperature fluctuations. The study reveals two peaks in temperature's impact on sex ratio during the thermosensitive period of development.
Researchers have found that genetic differences within individual sperm cells can affect their swimming behavior, which has implications for fertility and birth defects. The study identified greater variability in velocity among mutated samples compared to normal ones.
Researchers at University of Cambridge found that a thin shell of water surrounding proteins can determine aggregation, with slower movement leading to more clumping. The discovery has significant implications for treating protein misfolding diseases like Parkinson's and Alzheimer's.
A study published in Current Biology found that children exhibit rapid boosts of GABA during visual training, stabilizing new learning and making it more efficient. This discovery suggests that children may acquire new knowledge and skills faster than adults, with implications for teaching and learning strategies.
A study published in Radiology found that marijuana smokers have a higher incidence of emphysema and airway inflammation compared to non-smokers and tobacco-only smokers. The researchers suggest that the unfiltered nature of marijuana smoke and longer breath-hold puffs may contribute to these findings.
A recent meta-analysis published in Human Reproduction Update reveals a significant worldwide decline in sperm counts of over 50% in the past 46 years. The study also shows an accelerated post-2000 decline in sperm counts globally.
A new web-based tool called Taxonium is helping scientists track the evolution of SARS-CoV-2 and other viruses by analyzing massive genetic datasets. The analysis reveals that COVID-19 variants worldwide are repeatedly evolving the same mutations, suggesting a convergent evolutionary process.
Researchers at the University of Michigan and NASA discovered a major vulnerability in time-triggered ethernet networks, which could lead to unpredictable and potentially catastrophic behavior. The PCspooF attack exploits a trusted network technology to introduce disruptive messages, causing systems to operate unpredictably.
Studies investigate the impact of temperature, speed, and materials on chocolate fountain flow, as well as oil and vinegar separation in vinaigrettes. A framework also describes the fluid dynamics involved in squeezing sauces out of bottles.
The USPSTF recommends against routine screening for obstructive sleep apnea (OSA) in asymptomatic adults and those with unrecognized symptoms. OSA is linked to various adverse health outcomes, including cardiovascular disease and cognitive impairment.
Scientists have developed a new technology that captures the key features of human bone marrow, allowing for the screening of multiple anti-cancer drugs and testing personalized treatments. The 'bone marrows in a dish' can support the survival of cells from patients with blood malignancies
Scientists have identified a potential therapy to reduce the side effects of cisplatin chemotherapy, which can cause kidney toxicity and neuropathic pain. Istradefylline, an approved Parkinson's disease drug, has been found to mitigate these harmful effects while preserving cisplatin's anti-tumor properties.