Researchers at John Innes Centre discovered a mechanism of flowering plant sperm compaction using histone protein H2B.8. This mechanism allows for moderate nuclear condensation without compromising gene activity, essential for immotile sperm and pollen tube travel.
A new study by the University of California School of Global Policy and Strategy found that credible trade agreements help U.S. firms invest in new export markets during economic downturns. The research suggests that trade agreements can mitigate the impact of a global recession, particularly for industries dependent on exports.
A study found that young adults who drink moderate to heavy amounts of alcohol have a higher risk of stroke than those who drink low amounts or no alcohol. The risk increases with the number of years of drinking.
Researchers developed a 3D organoid model that mimics human heart development, revealing how low levels of cadmium can block cardiomyocyte formation and induce heart abnormalities. The study supports decades of toxicology research on environmental exposures contributing to human diseases.
A literature review of existing research identified key areas for future research on race and racism in emergency medicine. The study's findings inform a research agenda aimed at developing evidence-informed interventions to address racial health inequities, including access, treatment, and provider experience.
Dual-energy CT (DECT) metrics provide insight into physiologic changes after lung cancer surgery, beyond PFTs and conventional CT. Lung perfusion ratio increases were greater after lobectomy than limited resection.
Researchers developed a single-cell Raman-based tool to efficiently mine live functional microbes from nature, eliminating the need for traditional culturing methods. This technique, called scRACS-Culture, allows for the direct screening and cultivation of cells with specific metabolic functions.
A researcher developed a system to determine the pose of cooperative spacecraft using ToF cameras and reflector markers. The system consists of three steps: reflector detection, matching, and pose calculation, and was tested in experiments with high accuracy.
Researchers developed a novel method to create deep nanochannels in hard and brittle materials like silica, diamond, and sapphire. By employing femtosecond laser direct writing technology, they achieved sub-100-nm feature sizes and ultrahigh aspect ratios.
Amanda Woerman's research aims to disrupt tau misfolding, a common thread in fatal neurodegenerative disorders PSP and CBD. The grant-funded study seeks to test a proof-of-concept gene therapy for these conditions, potentially leading to personalized medicine breakthroughs.
A new study published in the New England Journal of Medicine found that semaglutide, an approved obesity drug for adults, also helps adolescents with obesity lose weight and have healthier hearts. After 68 weeks, 72.5% of participants who received semaglutide had achieved at least 5% weight loss compared to just 17% on placebo.
Researchers demonstrate that protein CGL160 recruits ATP synthases to assemble efficient photosynthetic machinery. This discovery sheds light on chloroplast development and adaptation to varying light conditions.
A team of researchers is developing a new method to evaluate the viability of donor kidneys using optical coherence tomography (OCT) scanning technology. OCT scans provide a more complete view of the organ's overall functional capacity, allowing for better matching with transplant patients. The goal is to increase kidney availability a...
A new analysis finds that intensified meat production can bring short-term rewards, such as decreased deforestation, but long-term risks, including the spread of zoonotic diseases like avian influenza. The study suggests that shifting to plant-rich options and supporting forest protections may be necessary to mitigate these risks.
Deep learning models can become less accurate in recognizing specific categories of images, sounds, or text after network pruning. Researchers demonstrate a technique to address this challenge, improving the fairness of deep learning models.
A multidisciplinary team of researchers has uncovered the mechanism that modifies the connective tissue of the lung in severe COVID-19, revealing a mosaic-like pattern to the damage. The study, published in The Lancet – eBioMedicine, identifies specific blood markers and vascular changes that can predict post-COVID pulmonary fibrosis.
The new guidelines aim to improve the cat's emotional experience during veterinary visits. They provide practical tips on creating a more reassuring environment, such as minimizing visual stimulation and using synthetic feline pheromones. The guidance also emphasizes the importance of remaining 'cat-focused' during interactions.
Researchers have discovered that mutations in mitochondrial-related genes can trigger hyperinflammation, leading to diseases such as Crohn's disease and tuberculosis. The study found that these mutations lead to a new type of cell death called necroptosis, which causes an aggressive inflammatory immune response.
The Congo peatlands, the world's largest tropical peatland complex, are fragile and vulnerable to drought. If modern-day global heating produces droughts in the region, they could release up to 30 billion tonnes of carbon, accelerating climate change.
A researcher swam 1,600 miles along the Danube River to raise awareness about water pollution and its effects on wildlife and human health. He highlighted microplastics, toxic algal blooms, and changes in river chemistry due to climate change.
A new study shows that a simple nutrition care program can improve nutritional status, physical functionality, cognitive function, and psychological well-being in older adults. The program reduced hospitalizations by 40% and associated costs.
Researchers at Rice University have engineered bacteria to quickly sense and report on the presence of various contaminants. The living bioelectronic sensors can be programmed to identify chemical invaders and report within minutes by releasing a detectable electrical current.
Researchers at the University of Bonn have identified a new signaling pathway that triggers inflammatory responses in the skin after UV damage. This pathway involves the activation of p38 molecularly modifying NLRP1, a critical switch for inflammation, and initiates the assembly of inflammasomes.
Researchers found that cancer cells can migrate faster in higher viscosity environments due to the formation of denser actin networks and cooperative signaling pathways. This discovery provides a new framework for understanding metastasis and may lead to the identification of potential targets to combat cancer spread.
Researchers from Ulsan National Institute of Science and Technology (UNIST) demonstrate a feasible waste plastic pyrolysis model, increasing profitability and reducing CO2 emissions compared to centralized processes. The study also found significant decreases in transportation costs and related emissions.
A clinical trial of elite Swedish ice hockey teams found that early head-and-neck cooling resulted in a significantly shorter recovery time after concussion. The median time to return-to-play was 9 days in the intervention group, compared to 13 days in the control group.
Researchers developed a contrastive learning model that can detect compromised lung function in long-COVID patients from 2D chest X-ray images. The model successfully identified small airways disease and separated it from more advanced respiratory issues, offering an affordable diagnosis option for clinics without CT scanning equipment.
Researchers analyzed the survival mechanisms of snail species during the end-Triassic mass extinction event. Over half of other gastropod species were affected, with some species exhibiting adaptations that allowed them to thrive.
A multicenter clinical trial showed that combining brentuximab vedotin with standard chemotherapy reduced event-free survival by 10%, decreasing relapse risk. This targeted therapy approach may set the stage for FDA approval and improve cure rates without adding significant long-term toxicity.
A multicentre clinical trial found that a single dose of COMP360 psilocybin significantly reduced depression symptoms in participants with treatment-resistant depression. The study, involving 233 participants, showed improved outcomes for those receiving the 25mg dose compared to the control group.
A new troponin test has been developed to help diagnose heart attacks more accurately. By detecting only large troponin molecules, the test can distinguish between heart attacks and other conditions such as renal insufficiency.
Dr. Michael Yartsev was selected as the 2022 Peter Gruss Young Investigator Award winner for his groundbreaking research on naturalistic behavior in bats. His work has made a significant impact on the scientific community, inspiring young scientists and promoting cooperation.
A new study found that afternoon or evening physical activity is associated with reduced liver fat content and improved insulin sensitivity. Performing MVPA in the afternoon or evening was linked to reduced insulin resistance by 18% and 25% respectively.
Dr. Bruce Ovbiagele has made significant contributions to understanding stroke prevention and improving post-stroke outcomes, especially in Africa. His research has identified genetic variables associated with increased stroke risk and explored the effectiveness of mobile health-based technology in reducing regional disparities.
A comparison of two cancer drugs reveals that life cycle management strategy is crucial for a drug's commercial success. The research found that product sales are closely linked to the number of approved indications and inter-organizational alliances.
Researchers measured rhino horns from photographs taken between 1886 and 2018, finding a significant decrease in length across all five species. The decline is believed to be caused by intensive hunting, which has also led to a shift in human perceptions of rhinos from hunting to conservation.
Researchers at Hefei Institutes of Physical Science found that a novel mutant, low grain weight (lgw), affects grain size by regulating GW7 expression and cell elongation. The discovery sheds light on the molecular mechanisms controlling grain size in rice.
Researchers from North Carolina State University have developed a new method for identifying genes relevant to the aging process in the C. elegans roundworm model. By exposing thousands of worms to random genetic mutations, they can pinpoint which genes are associated with protein aggregation and reduced lifespan.
The SwRI experiment helped predict the effects of NASA's DART impact on asteroid Dimorphos. The study assessed ejecta momentum enhancement created by the space probe's collision, measuring a 3.4-fold increase in momentum transfer.
Researchers found that first-degree relatives of patients with advanced fibrosis are at a 15% risk of developing nonalcoholic fatty liver disease. Early screening for advanced fibrosis among siblings and offspring of patients can help prevent the progression to cirrhosis or liver failure.
Researchers at MIT have developed a machine-learning model that captures how sounds propagate through spaces, allowing for accurate visual renderings of rooms. This technique has potential applications in virtual and augmented reality, as well as improving AI agents' understanding of their environment.
Physicists at Ural Federal University have developed a theory regulating the solidification of iron-nickel alloys to control characteristics and improve uniformity. This technology will affect high-precision instruments like clocks, seismic sensors, and engines.
A new study published in Journal of the American College of Cardiology found that drug-coated balloons outperformed bare metal stents in treating femoropopliteal lesions. The research showed improved 12-month patency and freedom from clinically driven reintervention and major adverse events with drug-coated balloons.
Two new discoveries led by Cedars-Sinai Cancer investigators improve understanding of ovarian cancer's development and suggest personalized therapeutic approaches. They identified four new genetic regions linked to increased ovarian cancer risk and found that some tumors may develop resistance to chemotherapy from an early stage.
Mount Sinai researchers catalogued thousands of sites in the brain where RNA is modified throughout the human lifespan, increasing with age. This study provides a model depicting how A-to-I editing evolves over a lifetime, shedding light on its role in health and disease.
Researchers from Shibaura Institute of Technology created a novel method to produce self-folding origami honeycomb structures using paper sheets, which can provide excellent protection against shocks and compression. The developed technique has potential applications in packaging, agriculture, and other fields.
A new study found that COVID-19 infection directly interferes with the healthy balance of microbes in the gut, further endangering patients. The research revealed that antibiotic-resistant species can escape into the bloodstream, putting patients at greater risk for life-threatening secondary infections.
Researchers have developed a new model that combines nuclear physics and string theory to describe the transition to dense and hot quark matter in neutron star collisions. The model allows for the calculation of gravitational-wave signals, showing that both hot and cold quark matter can be produced.
Researchers at UIC have developed a new method to study ribosome function by attaching peptides to tRNAs, providing high-resolution structures of the ribosome and its interactions with nascent chains. This breakthrough sheds light on protein synthesis and antibiotic resistance.
Higher-quality violins produce more detectable objective combination tones, which are linked to air resonance and structural material. The study aims to analyze a greater number of violins to identify the origin of combination tones.
A team of researchers from Japan and the USA have proposed an optimized design strategy for additive manufacturing using laser powder bed fusion. They simultaneously optimized laser hatching orientation and lattice density distribution to minimize residual stress in metal parts, reducing warpage by up to 39%.
A new Concordia University study reveals that extreme weather events, such as hurricanes and heatwaves, have failed to drive government climate action. Despite the devastating economic and human costs of these disasters, governments have remained slow to enact meaningful reforms.
Scientists have uncovered the mechanics of the blood-tumour barrier in medulloblastoma, a malignant paediatric brain tumour. By silencing a specific ion channel, researchers found that chemotherapy medication etoposide was better able to cross the barrier and treat the tumour cells.
Adults with hypertension experienced a small rise in blood pressure levels during the first eight months of the COVID-19 pandemic, while the number of measured readings decreased significantly. The study found that telemedicine and home monitoring may have contributed to better blood pressure control.
A study found that patient-reported outcome measures (PROMs) were infrequently accessed by clinicians, even when integrated into electronic health records. The data collection rate was high, but the use of PROMs among surgeons and care teams was nearly non-existent.
The Sleep Research Society advocates for the elimination of daylight saving time and adoption of permanent standard time due to its association with acute sleep loss and chronic circadian misalignment. This can lead to stress, altered metabolism, and inflammation, ultimately resulting in adverse health consequences.
Researchers at Texas A&M University used functional near-infrared spectroscopy to monitor participant responses during human-robot collaborations. They found that faulty robot actions decreased operator trust and associated it with increased brain activity in the frontal, motor, and visual cortices.
Two new studies reveal a link between fault surface morphology and earthquake nucleation potential, as well as significant Neogene transpressional exhumation in central California. Additionally, researchers explain the low Au endowment of continental intraplate alkaline magmas by identifying an early Au-rich sulfide liquid saturation
Researchers developed a nanopore-based method to detect microbes in immunocompromised cancer patients with high sensitivity, identifying bacterial infections, fastidious pathogens, and co-infections. The method reduces turnaround time to approximately 17.5 hours, enabling prompt diagnosis and timely treatment.
A new study reveals that global warming can lead to an exponential increase in heat injury accumulation for ectothermic organisms, with temperatures exceeding their tolerance level resulting in severe injuries. The rate of heat injury doubles for each degree the temperature rises.