A new study has uncovered a previously unknown genetic process that could inform the development of novel treatment options for glioblastoma (GBM), a virtually incurable brain tumor. The epidermal growth factor receptor (EGFR) signaling pathway and long non-coding RNA molecules, such as lncEPAT, play critical roles in GBM tumorigenesis.
A study by Hokkaido University researchers found that low concentrations of cetylpyridinium chloride in mouthwash can inhibit SARS-CoV-2 infectivity and viral load, regardless of variant. This antiviral effect is thought to be due to disruption of the lipid membrane surrounding the virus.
Researchers created a new approach to predict genomic information in plant breeding, allowing for more diverse crop varieties. The strategy led to plants that outyielded current wheat varieties in multiple field trials, offering potential solutions to crop disease evolution and climate change.
Researchers found that petting real dogs activates the prefrontal cortex more than stuffed animals, with increased brain activity each time interaction occurs. This effect persists after the dog is gone, suggesting a long-lasting impact of social bonding.
Researchers found that B-type procyanidins induce hormesis in hemodynamic and metabolic responses, with optimal doses triggering improved cognitive functions and stress resistance. The study suggests a link between B-type procyanidin intake and CNS neurotransmitter receptor activation.
In some sub-Saharan African countries, up to 88% of adolescents express vaccine hesitancy due to safety and efficacy concerns. The study identifies determinants of this phenomenon, shedding light on strategies to improve vaccination rates in the region.
A new clinical trial found that the bionic pancreas device was more effective at maintaining blood glucose levels within normal range than standard-of-care management among people with type 1 diabetes. The device requires minimal user input and provides more automation, resulting in improved glycemic control.
Researchers at Aarhus University use RNA origami sponges and CRISPR technology to regulate protein production levels and gene expression in bacteria and yeast. This approach generates stable, interactive molecules for synthetic biology-based regulation, enabling unique applications in industrial, diagnostic, and therapeutic fields.
Researchers used directional hydrophones to track blue whale movements, revealing they respond to changes in the wind. The whales seek out cooler water plumes where krill are abundant, finding a crucial source of food.
Researchers at McGill University developed a cost-effective way to produce nanocrystals from cellulose and chitin using high-humidity shaker aging. The new technique reduces water usage, eliminates toxic solvents, and increases yields.
A recent analysis published in Contemporary Economic Policy found that 6-week paid family leave in California saved 339 infant lives from 2004-2008. The study also revealed a significant reduction in post-neonatal mortality rates for infants with married mothers and boys.
The CMU Array, a new microelectrode array, offers customized treatments for neurological disorders by allowing for three-dimensional sampling and ultra-high-density configurations. This technology has the potential to transform how doctors treat conditions like epilepsy and limb function loss.
Scientists at the University of Pittsburgh create microcapsules that exhibit life-like autonomy through self-generated motion and chemical signals. The system mimics protocell behavior, showcasing the potential for simple mechanisms to produce complex biological functions.
A Nagoya University research team found that soil nitrate in the riparian zone is the primary source of increased stream nitrate during rainstorms. The researchers' study may help reduce nitrogen pollution and improve water quality in downstream bodies of water.
A new epigenetics drug, tazemetostat, has been found to stop bladder cancer growth by activating the immune system, not just inhibiting tumors. The drug targets the EZH2 gene and is being tested in clinical trials for late-stage bladder cancer.
Researchers at UNC Lineberger Comprehensive Cancer Center have found a way to overcome barriers limiting cancer immunotherapies. They discovered that activating the STING protein can increase regulatory B cells, which suppress anti-cancer immunity.
Scientists have discovered that mitochondrial DNA can insert itself into human nuclear DNA in every 4,000 births, leading to the development of rare diseases and some cancers. The new inserts can cause cancer and trigger its development in some cases.
A team of scientists and high school students collaborated to study Hong Kong's soil biodiversity, collecting 3,588 individual samples and identifying 150 species. The project also raised public awareness about the importance of citizen science in understanding local biodiversity.
A new study reveals that coaches displaying authentic leadership qualities can decrease athlete aggression and increase trust, enjoyment and commitment. Researchers found athletes training with authentic coaches are less likely to act aggressively towards competitors.
Researchers found that machine learning models outperformed traditional risk prediction models in predicting suicide-related outcomes. These models can identify patterns associated with suicide risk and have been shown to correctly predict 66% of people who would experience a suicide outcome.
Researchers at FAU's Schmidt College of Medicine are developing a pilot program to tackle health disparities by leveraging electronic health records, artificial intelligence, and machine learning. The project aims to improve AI/ML delivery and research operations in community health centers and federally qualified health centers.
Researchers at University of Toronto Engineering use supercritical carbon dioxide to recover lithium, cobalt, nickel and manganese from end-of-life lithium-ion batteries. The process matches conventional extraction efficiency while using fewer chemicals and generating less secondary waste.
A large Kaiser Permanente study found that most patients with a thoracic aortic aneurysm less than 5.5 cm are not at high risk of experiencing dissection or requiring surgery. The study's findings support the current consensus guidelines recommending surgery for patients with larger aneurysms.
A new study from Flinders University has shown that reboxetine, previously used to treat depression, can reduce obstructive sleep apnoea (OSA) severity. The study found that reboxetine alone reduces the number of sleep apnoea events per hour and improves oxygen levels.
Researchers identified TDRD7 as a key regulator against influenza A virus and found that inhibiting its function increases virus replication. The study's findings could inform the development of novel therapeutic interventions against influenza virus infection in humans.
The Earth System Grid Federation is upgrading its climate projection data system to improve access and curation, with the goal of enabling scientists to make the best guess about the future trajectory of our climate. The new system will provide faster download speeds and enable previously infeasible data analyses.
Cyanophycin synthetases, previously thought to require primers, have a hidden reaction centre that cleaves bonds between amino acids. This discovery reveals a 'Swiss army knife enzyme' capable of slow polymerization in the absence of primers.
A retrospective cohort study of hospitalised patients with COVID-19 found significant reductions in all-cause mortality and disease progression among those receiving oral antivirals like molnupiravir and nirmatrelvir–ritonavir. The study supports the use of these antivirals in this population.
A Swedish cohort study found that direct oral anticoagulants (DOACs) were associated with a lower risk of kidney function decline or kidney failure compared to vitamin K antagonists (VKA). DOACs also showed a lower risk of acute kidney injury.
Assistant Professor SUZUKI Hiroo and colleagues have developed a method to grow highly crystalline TMDCs, such as MoS2 and WS2, using chemical vapor deposition in a stacked substrate configuration. The technique produces samples with large domains and optimal photoluminescence characteristics.
Research reveals forest elephants disperse seeds over long distances, aiding timber species regeneration. Logging can be part of conservation efforts when planned and legally conducted.
Researchers developed a durable perovskite solar cell capable of generating electricity for over 1,000 continuous hours with an efficiency of more than 20%. The team improved durability by creating a water-repellent interface between the electron and hole transport layers.
A new category of shape-memory materials made of ceramic, rather than metal, has been discovered by MIT researchers. The ceramic material can actuate without accumulating damage and withstand much higher temperatures than existing metals, making it suitable for applications such as actuators in jet engines.
Researchers found that placing layers of white hollow glass microspheres onto Arctic sea ice would darken its surface, accelerate the loss of sea ice, and further warm the climate. The study challenges a previous claim that spreading hollow glass microspheres on young Arctic sea ice could increase reflectivity and protect it from the sun.
New research by Cornell University ILR School tracks the rise of militant leadership in California Nurses Association, adopting fixed-duration strikes to build a more militant membership and resist concessions. The fixed-duration strike proved highly effective in protecting worker interests, imposing financial costs on employers.
A new genetic test called PancreaSeq accurately classifies pancreatic cysts as potentially cancerous or benign, improving the accuracy of diagnoses compared to current guidelines. The test distinguishes between different types of cysts with higher accuracy than traditional forms of surveillance and current pancreatic cyst guidelines.
Researchers identified a rare hybrid bird between a rose-breasted grosbeak and a scarlet tanager, blending divergent species lines. The study, published in Ecology and Evolution, utilized genomic sequencing and song analysis to confirm the hybrid's ancestry.
Researchers from Osaka University found that serum albumin can prevent the formation of amyloid fibrils in dialysis patients by interfering with β2m protein clumping. Monitoring serum albumin levels may help predict and delay the onset of dialysis-related amyloidosis, a condition also linked to Alzheimer's disease.
Researchers found a 'zero-price effect' in Japan's child healthcare system, where zero cost increases demand for health services. However, this can lead to poor allocation of resources and overuse of antibiotics.
Researchers found that administering nitric oxide to preterm mice after birth can reverse symptoms of congenital hypogonadotropic hypogonadism, including sensory and cognitive disorders. A clinical trial is now underway to test this treatment in human preterm infants.
A new study identifies Scleromochlus taylori as an early relative of pterosaurs, shedding light on the evolution of flying reptiles. The discovery uses CT scans to provide detailed reconstructions of the fossil, confirming its link to lagerpetids and supporting the hypothesis that flying reptiles evolved from small, bipedal ancestors.
Researchers at Stanford University have developed a new RNA vaccine tool called RADAR, which can selectively target specific cells and induce protein production. This technology could offer precise treatment options for various diseases, including cancer.
A workshop on flood risk governance in Brazil and the UK identified research gaps, including local data, integration systems, and visualization tools. Innovative initiatives are being developed using tools such as an app that empowers citizens to input data and improve disaster prevention.
A secondary analysis of a randomized clinical trial found that positive patient beliefs about antibiotic effectiveness for appendicitis are linked to lower risk of surgery and faster symptom resolution. This association remains unclear, with further research needed to understand its underlying mechanisms.
Researchers have developed a strong seaweed-based separator to prevent dendrite growth in sodium-metal batteries, increasing storage capacity and efficiency. The breakthrough paves the way for greener and more efficient energy storage systems, reducing reliance on scarce materials like lithium.
New research reveals that shark fishing can cause rapid temperature spikes in caught and released sharks, with one blue shark experiencing a 2.7°C increase in just minutes. The study found that it took up to 40 minutes for the sharks to cool down after release.
Nonadherence with buprenorphine treatment was associated with increased opioid overdose risk and higher healthcare expenditures in a study of 34,000 Medicare patients. The study found that treatment gaps led to more frequent overdoses and increased healthcare costs.
The study found a significant need for stable and durable diagnostics to differentiate infected animals from vaccinated ones. The researchers propose five priorities: vaccinology, antimicrobial resistance, climate mitigation, digital health, and epidemic preparedness.
Astronomers have discovered a stellar binary with an extremely short orbit of just 51 minutes, confirming a decades-old prediction. The system is believed to be a cataclysmic variable, in which a white dwarf is accreting material from its companion star.
Researchers found that hepatocyte adenosine kinase promotes excessive fat deposition and liver inflammation, suggesting a key role in the pathogenesis of nonalcoholic fatty liver disease. Dietary changes may help prevent or reduce NAFLD severity by inhibiting ADK activity.
Researchers developed algorithms that can predict volleyball players' actions with over 80% accuracy, combining visual data with hidden variables. The algorithms also showed promise in predicting multiple actions across sequences of up to 44 frames.
Researchers at Penn State developed a method to erase memories in disordered solids, allowing for new opportunities in diagnostics and programming of materials. The study provides insight into how memories form in these materials and demonstrates a way to 'read' and erase them.
A new study demonstrates that standardizing ultrasound-guided PIV insertions using an innovative sterile barrier dressing, UltraDrape, improves outcomes and reduces costs. The results show a 73% reduction in supply costs and a 50% decrease in staff time for insertions.
A new study reveals that exercise training has opposite effects on muscle and fat tissues compared to high-fat diet-induced obesity. Exercise is found to down-regulate extracellular matrix-related pathways, while obesity up-regulates them. Conversely, exercise up-regulates circadian rhythm pathways, which are reversed by obesity. This ...
A Rutgers study found that over 40% of store visits in New Jersey resulted in underage buyers successfully purchasing cigarettes and other tobacco products. The strongest predictor of an underage sale was failing to card, with independent stores and gas kiosks showing lower rates of age verification.
The use of Frictionless Data enhances both machine readability and human engagement with scientific outputs, turning articles into dynamic entities. Interactive figures enable readers to directly interact with data points, making the publication process more efficient and reproducible.
SpineX's proprietary SCiP TM device demonstrates unparalleled functional improvements in children with cerebral palsy, treating underlying neurological dysfunction and improving connectivity between the brain and spinal cord.
A study published in the Review of Development Economics found that investments in high-quality education for rural farm people are crucial to breaking the cycle of low soil health and human capital development. Annual returns to schooling in Malawi were 3-4% after correcting for various factors.
A study of over 420,000 households found that gender inequality is a significant predictor of child physical abuse. High levels of inequality are associated with higher rates of abuse, particularly in situations where women face economic insecurity.
A study published in Nature has identified 61 additional genetic loci associated with stroke and six genes that are potential targets for drug therapy. The research also found a significant overlap between stroke and dementia, suggesting common biology between the two conditions.