Tel Aviv University researchers discovered that skin cancer cells interact with astrocytes in the brain, promoting metastasis. By inhibiting this interaction using existing treatments, they delayed the spread of melanoma to the brain by 60-80%. This breakthrough has implications for treating advanced-stage melanoma.
Research reveals that tumor cells form temporary structures to avoid destruction by the immune system. The findings suggest that timed inhibition of relevant signaling pathways is necessary alongside immunotherapy to prevent tumor resistance.
A recent study published in Advances in Atmospheric Sciences identifies compensating errors in widely used climate model protocols, known as CMIP6. The researchers analyzed five CMIP6 models and found large uncertainties in cloud microphysical properties, including cloud fraction, liquid water path, and droplet effective radius.
A team of scientists has developed a novel fabrication method for aspheric micro-lens arrays, enabling large-area and high-precision creation. The single beam exposure DLWL technology satisfies the high optical performance requirements.
Researchers have developed an injectable shear-thinning hydrogel that exhibits enhanced cohesive strength, resisting fragmentation even under pulsating liquid flows. The gel, similar to toothpaste, retains its structure when force is removed, making it a potential breakthrough in treating critical vascular conditions.
A pioneering behavioural diagnostic tool, SPUR, has been developed to improve medication adherence in type 2 diabetes patients. The study found that the tool can reliably identify patients struggling with their medicines and the reasons why.
Sooby's research aims to develop an AI algorithm to rapidly provide high-quality data during alloy fabrication, reducing time and cost. Her lab collaborates with Computer Science professor Amanda Fernandez to leverage deep learning approaches for image labeling, increasing efficiency by 99%.
A joint study by the Israel Antiquities Authority, Tel Aviv University, and the Weizmann Institute of Science has revealed the world's earliest known evidence of opium use in the Late Bronze Age. Eight ceramic vessels containing opium residue were found in Canaanite graves at Tel Yehud.
A new study found that COVID-19 infection increases the risk of potentially life-threatening blood clots for at least 49 weeks. The excess risk to individuals reduces over time, but preventive strategies such as medication can help reduce cases of serious clots.
Research at Karolinska Institutet shows that people with diabetes have lower levels of psoriasin, a key peptide that weakens the bladder's protective barrier function. This increases the risk of urinary tract infections. Oestrogen therapy may help regulate the immune response to UTIs in patients with diabetes.
Helen Hansma proposes that primitive life emerged from precursors corralled between layers of mica, offering a stable environment for molecules to grow and processes to develop. The presence of potassium ions in micaceous clay supports this hypothesis, as cells have high intracellular concentrations of potassium.
Researchers found that stress granules are abundant in obesity-related pancreatic cancer and blocking their formation stops cancer growth in animals. The study reveals a potential new direction for developing cancer therapy by targeting stress granule formation.
The University of Texas at Dallas is receiving a $5 million NSF grant to advance quantum research and education. The grant aims to train the workforce needed for neutral-atom-based quantum information processing, which has immense potential to speed up computation.
Researchers from the University of Copenhagen have identified a new mechanism in ARVC that could lead to a potential treatment strategy. They found that activating sirtuin-3 can slow down disease progression, and honokiol, a natural product extracted from the tulip tree, has been shown to work similarly.
The SETI Institute and Unistellar are launching a new exoplanet detection program that engages citizen scientists worldwide. Citizen astronomers will help confirm exoplanet candidates identified by NASA's TESS using Unistellar's eVscope or other telescopes.
The Hastings Center introduces five ethical criteria to improve human subject protections in phase I healthy volunteer trials and research biopsies. These guidelines focus on translational science value, fair opportunity and burden sharing, fair compensation for service, experiential welfare, and enhanced voice and recourse.
A team of researchers led by Gunnar Schotta found that DNA methylation is a decisive factor in silencing endogenous retroviruses in certain cell types. The presence of histone modifications, however, is not sufficient for complete silencing.
A new study predicts that the disruption of crop production in Ukraine due to the Russian invasion will lead to increased global carbon emissions and food prices. However, other countries are stepping up their production to compensate for the loss, which may alleviate food insecurity but with significant environmental impacts.
A Hebrew University study reveals that desert isopods, when predators like scorpions are nearby, prefer larger females but settle for smaller ones instead. Males also adjust their behavior, with smaller males opting for second-best females closer to the predator.
The Montefiore Einstein Cancer Center has received a $10 million grant from the National Cancer Institute to study lung metastasis in breast cancer. The research aims to understand the mechanisms of tumor cells seeding tumors in the lungs, a key site for triple-negative breast cancer metastasis.
The study reveals that abnormal distribution of phospholipid PIP2 inhibits FAK activation, leading to brain dysfunction. Researchers found reduced activity of focal adhesion kinase proteins in brain tissues of HD patients and mouse models.
A new study by the University of Maryland found that white-tailed deer in suburban environments often bed down and spend the night within 50 meters of residential properties. This revelation has significant implications for tick management and reducing the risk of human exposure to diseases like Lyme disease and anaplasmosis.
The aviation industry faces radical solutions to address its growing impact on climate change, with cleaner fuels and carbon offsetting deemed inadequate. The industry needs to invest in new technologies, such as hydrogen and electricity-powered planes, to reduce emissions and mitigate contrails' warming effects.
Research shows that COVID-19 pandemic, murder of George Floyd, and contentious presidential election may have hindered young adults' social development. Studies found decreased intimacy and relationship satisfaction among those affected.
Researchers Konstanze Zwintz and Thomas Steindl develop new model to study pre-main sequence stars, shedding light on their early formation and its effects on stellar evolution. The model improves understanding of the chaotic phase of star birth and its impact on oscillation behavior.
Researchers analyzed over 6,700 patients treated for blood clots and irregular heart rhythms. Stopping aspirin significantly reduced bleeding complications by 32.3% and prevented one major bleeding event per every 1,000 patients who stopped taking aspirin.
Researchers at the University of Illinois have developed a new method to capture and predict the fatigue strength of metallic materials using automated high-resolution electron imaging. This approach allows for rapid prediction of metal failure and breakage, leading to design of safer and more resilient materials for various applications.
Researchers found that certain survey question sets can minimize stigma and increase disclosure among women. The study suggests redesigning surveys to improve data quality and support maternal, child, and reproductive health. The findings have the potential to influence national surveys and provide guidance to the field.
Researchers found that infants differentiate sounds based on neighboring sounds and vowel durations. Their study suggests that babies can learn the speech contrasts of their language through naturalistic speech data.
Researchers found evidence of declining dinosaur diversity in central China, with only three species of eggs and low number of dinosaurs for the last 2 million years. This decline may have been caused by global climate fluctuations and massive volcanic eruptions.
Geologists mapped how historical coking and smelting led to toxic metal pollutants in Pittsburgh's soil, particularly in the eastern half of the city. The team found that concentrations of soil metals were higher in valleys influenced by rivers, with cadmium posing a lesser-known risk.
A study of global dietary patterns found that diets globally are not much healthier today than they were thirty years ago. Despite modest gains, there is a significant variation in dietary quality among countries, with some nations like Vietnam and Iran showing improved healthy eating habits.
A global risk assessment reveals that 56-65% of urban tree species are already at risk due to increasing temperatures and decreasing precipitation. By 2050, this figure could rise to 68-76%, with France expecting a 71% risk for common ash species.
A team of researchers has successfully transplanted the RNA editing machinery from a moss into human cells, including kidney and cancer cells. The corrected mechanism was found to work on over 900 targets in nuclear transcripts, offering a potential basis for inducing specific changes in human cells and treating hereditary diseases.
Researchers develop TiO2-δNδ nanowire arrays to enhance N2 reduction to ammonia, achieving high yields and efficiency. The study demonstrates synergistic effects of oxygen vacancies and titanium ions in improving electrocatalytic performance.
A new study has found that a medication typically used to treat heart problems and high blood pressure may also reduce alcohol consumption in humans. The study's findings support further research into spironolactone as a potential treatment for alcohol use disorder, which affects millions of people in the US.
Researchers found mutations in leukocyte and T-cell proliferation regulation processes that contribute to ICI treatment response and resistance. The study provides a framework to develop predictors for melanoma, potentially enhancing responses and increasing patient numbers.
Researchers found that using race-free creatinine formula helps equalize access for Black and white patients. The study showed that among 350 Black patients, kidney failure was reached at an average 23 months, versus an average 22 months for 122 white patients.
The study found that nearly 9% of Americans aged 12 or older experienced a past-year major depressive episode. Depression was particularly common among adolescents (16.9%) and young adults (17%), with increased prevalence among various demographic groups, yet low help-seeking rates remained consistently low.
A University of Illinois study shows rumen-protected lysine can improve uterine health in dairy cows during the transition period. The supplement reduced genes involved in inflammatory proteins and increased genes keeping the uterus clean, leading to less inflammation and improved reproductive outcomes.
Researchers discovered titanium's record-high superconductivity above 26K at high pressures, exceeding the previous record by 4K. The high-temperature superconductivity is attributed to electron correlations and phonon coupling, making it suitable for applications in diverse environments.
A Brazilian study analyzed risk factors for heart attacks and found that high blood sugar had the most significant impact on mortality. Reducing smoking prevented most deaths from cardiovascular disease, while lowering diabetes incidence could have saved up to 5,000 lives over a decade.
Researchers have developed a new method for detecting ultrafast electronic processes using entangled photons, enabling high-resolution Raman spectroscopy. The technique overcomes the diffraction limit and allows for sensitive detection of molecular excitations on the femtosecond scale.
A new universal system called SeqCode formally registers and names single-celled microorganisms known as prokaryotes. The system uses genome sequence data for both cultivated and uncultivated prokaryotes, aiming to improve resource sharing and communication among researchers.
The project aims to improve climate change predictions for cities, including strategies for adapting to and mitigating changes. Penn State brings expertise in measurement and modeling of the urban atmospheric boundary layer and the interplay among buildings, climate, and human health.
New research highlights the importance of non-biting flies in transmitting diseases. These synanthropic flies ingest pathogens while feeding on human and animal waste, which they then store in their crop. When they regurgitate this content, it can spread illnesses to humans through food contact.
Research from North Carolina State University and the International Research Laboratory Takuvik found that wildfire smoke in Siberia amplified a phytoplankton bloom in the Arctic Ocean. The bloom was larger than normal, requiring a substantial influx of new nitrogen supply to occur.
Researchers discovered that autophagy facilitates the elimination of cancer cells via cell competition, highlighting its potential as a target for cancer prevention and treatment. The study sheds light on the role of autophagy in maintaining tissue homeostasis and opening avenues for novel anti-cancer therapeutics.
A randomized clinical trial found that rituximab significantly improved disease control in patients with new-onset myasthenia gravis, reducing the need for cortisone treatments and hospitalizations. The study's results offer hope for a more effective treatment strategy, but larger studies are needed to assess long-term effects.
A genetically modified yeast strain can alter fermentation to create beers with intense tropical flavors and aromas. The strains increase the amounts of free thiols, which provide aromatic compounds found in hops.
A study published in the American Journal of Obstetrics & Gynecology found that COVID-19 damages the placenta's immune response, leading to increased rates of preterm birth. The study, led by UW Medicine researchers, suggests that babies born to mothers infected with COVID-19 may need to be monitored for potential long-term effects.
Researchers have confirmed the existence of Pekeris waves, a type of atmospheric wave theorized in 1937 but never proven to occur naturally. The waves were detected following the 2022 Tonga volcanic eruption using state-of-the-art observational data and computer simulations.
A new study finds that using race-free equations for estimating kidney function can minimize racial differences in accrued preemptive waiting time. The research suggests that a specific equation, creatinine-based, reduces racial disparities more effectively than another equation, cystatin C-based.
A better detection system for emerging and re-emerging respiratory pathogens is crucial in Canada, suggests a new analysis published in CMAJ. Waste-water testing, population-based testing, and genomic sequencing are key components of the proposed system.
Researchers at Aalto University suggest using crop residues and by-products in livestock and aquaculture production to free up human-usable material. This could increase the global food supply by up to 13% without increasing resource use or requiring major dietary changes.
Researchers identified ways to decrease political division by highlighting similarities, correcting misconceptions and building dialogue skills. Targeted approaches can help partisans gain more accurate perceptions of each other.
A new record of past Indian monsoon drought history has been developed using oxygen isotopes in stalagmites, correlating with historical accounts of severe droughts and societal changes. Protracted droughts tend to occur in clusters within decades-long intervals of weaker monsoon rainfall.
Researchers discovered that the TERRA molecule, present at higher levels in ALT cancer cells, sets a damage threshold for these cells. Increasing TERRA levels causes DNA damage that is unsustainable for cancer cells, leading to their death.
A study by the University of Geneva team shows that disrupted circadian clocks lead to a rigidity in the membrane of pancreatic endocrine cells, affecting their function. The researchers also found that lipid profiles oscillate more during the day than previously thought, particularly in phospholipids and sphingolipids.
Researchers create mammalian cells that synthesize a noncanonical amino acid, which can be used to make therapeutic proteins. The discovery could lead to the development of new treatments for various diseases.