Researchers have developed a Principal Odor Map (POM) that models the connections between an odorant's chemical structure and its perceptual property. The map performs as well as trained human sniffers in describing odor quality, enabling the prediction of odor intensity and similarity.
Autophagy helps protect cardiomyocytes from damage caused by anthracycline drugs like Doxorubicin. The study found that a protein regulator called ER-phagy alleviates Dox-induced cardiomyopathy, promoting cell survival.
A randomized clinical trial of psilocybin treatment found a clinically significant sustained reduction in depressive symptoms and functional disability. The study's findings support the potential of psilocybin as a novel intervention for major depressive disorder when administered with psychological support.
Researchers at the University of Illinois are exploring how gut microbe communities impact broccoli's health benefits. They plan to identify which microbes maximize the benefits and develop custom probiotics to help people with lower-efficiency microbial communities.
A genomic model by Wangjie Hu and colleagues reveals a severe population bottleneck in human ancestors between 800,000 and 900,000 years ago, with only 1280 breeding individuals surviving. The decline coincided with climate changes, droughts, and glaciations, resulting in the loss of 98.7% of the ancestral population.
Researchers at the University of Miami Miller School of Medicine identified distinct genomic events responsible for resistance to anti-BCMA and anti-GPRC5D immunotherapies in multiple myeloma. Mutations in the extracellular domain of BCMA impede T-cell binding without affecting protein expression or downstream signaling.
Researchers at Shanghai Jiao Tong University have developed a new scattering matrix method that can sculpt light output with minimal optimization time. The method offers unparalleled nonlinear scattered light control, enabling high-resolution scanning microscopy and particle trapping through dense, scattering media.
Researchers at Michigan State University have found that over half of Campylobacter jejuni infections in Michigan are caused by antibiotic-resistant strains, which can lead to severe complications and death. The study's findings highlight the importance of food hygiene and safety, particularly in rural areas where exposure to animals a...
By controlling the arrangement of multiple layers within crystals, researchers can tune the materials' optoelectronic properties and emit light of specific energies. This technique has significant implications for applications such as LEDs, solar cells, and lasers.
Liver fibrosis development is driven by various factors, including metabolic syndrome and insulin resistance. CD8+ T cells play a significant role in activating hepatic stellate cells, which produce scar tissue.
Patients with cancer had disparate COVID-19 mortality rates during the winter Omicron wave compared to the general US population. The study suggests that immune-evasive SARS-CoV-2 variants pose a significant threat, requiring prioritized efforts to prevent transmission.
A new study from the University of Washington and Polar Bears International reveals a direct link between cumulative greenhouse gas emissions and polar bear demographic changes. The study shows that reducing greenhouse gas emissions can help protect polar bears, with implications beyond just this species.
Research based on the Trøndelag Health Study found that people in good physical shape fill fewer prescriptions for anxiety and depression medications. The study suggests that improving physical fitness can help prevent anxiety and depression, with men experiencing greater benefits from exercise than women.
Conservation gardening can help address declining plant biodiversity in Germany by planting vulnerable species, with 988 out of 2,350 Red List species suitable. This approach could be expanded globally to boost biodiversity.
A new study found that nearly half of dog owners in the US hold negative views about vaccinating their pets, citing safety and efficacy concerns. This hesitancy is linked to public mistrust in human vaccines during the pandemic, posing serious public health implications for both animals and humans.
A new study by University of Missouri biochemist Steven Van Doren reveals the fusion peptide's crucial role in virus attachment and cell penetration. This research could inform the development of more effective vaccines capable of fighting all types of coronavirus infections.
A Rutgers-led study found that marine heat waves have minimal lasting effects on fish communities. Fish populations can find safe havens by moving to areas with cooler water during heat waves, but the impacts vary and are unpredictable.
A new field campaign, CoURAGE, will investigate the influence of surface-atmosphere interactions around Baltimore, Maryland, on its climate. The campaign aims to provide sound evidence for climate change mitigation options, such as urban greening, and partner with neighborhoods that have been historically neglected.
A study published in Frontiers in Neuroscience found that the activity of zygomaticus major, heart rate variability, and EEG indicators can predict film scores. The researchers used a machine learning model to analyze physiological data from 21 participants who watched short films and rated them on a scale from 1 to 10.
A Michigan Medicine study found that pulmonary embolism death rates remained unchanged over the past decade, with higher mortality rates among men, Black patients, and those from rural areas. The study analyzed over 100,000 deaths related to pulmonary embolism between 2006 and 2019.
Research presented at the EASD Annual Meeting found that low-dose aspirin among older adults aged 65 and older is associated with a 15% lower risk of developing type 2 diabetes. The study also showed a slower rate of increase in fasting plasma glucose levels among those taking aspirin.
A new study suggests that emphasizing the need for energy independence and environmental stewardship could change people's minds about climate change. The research found that those who deny climate change often focus on personal experiences and local issues, but may not be aware of the scale of the problem.
Researchers at Affilogic developed nanofitins that inhibit SARS-CoV-2 by binding to its spike proteins, demonstrating quick reach and clearance of the lungs. The technology has potential for treating other infectious respiratory diseases with lower costs and higher accessibility.
A Swedish study of 150,000 patients found female surgeons achieved better outcomes and operated more slowly than their male counterparts. The results may shed light on gender differences in the surgical specialty.
A study published in JAMA Pediatrics found that children who spent more than four hours a day on screens at age one were more likely to experience developmental delays by age four. The research suggests that different domains of development, such as communication and problem-solving skills, may be affected differently by screen time.
A new study suggests that policymakers should emphasize the benefits of climate action beyond economic growth to motivate countries to protect the climate. The researchers analyzed 761 statements from UN member states and found that countries are influenced by how their allies frame issues.
Researchers found that bat's place neurons encoded information about the presence and identity of other bats in their social space. The study reveals how the same hippocampus structure that navigates through space also helps bats navigate complex social behaviors.
Researchers at Duke University Medical Center developed a new monoclonal antibody that successfully prevented organ rejection in primates undergoing kidney and islet transplantations. The findings suggest a safer alternative to existing immunosuppressive drugs, reducing side effects and improving graft survival rates.
A new method can detect drivers' attention levels from their eye movements, enabling the development of more effective takeover signals. The study found that drivers who are engrossed in on-screen activities take longer to respond to warnings, highlighting a potential safety concern.
Researchers have discovered a blood cancer drug that can kill 'silent' HIV cells and delay reinfections. This breakthrough could lead to a future cure for the disease, which affects an estimated 39 million people worldwide.
The American Heart Association introduces principles for data sharing to advance patient outcomes, highlighting transparency and privacy concerns. The new policy statement aims to protect patients' sensitive information while facilitating valuable research discoveries.
Skateboarders possess a unique sensory knowledge of cities, which can help mediate conflicts between those who enjoy and those who dislike the sport's sounds. By paying attention to sound, individuals can gain 'sonic' agency over spaces in the city.
Scientists at Mainz University and TU Darmstadt developed a method to write in water by utilizing microbeads that exchange ions for protons, altering local pH values. This allows ink particles to accumulate in specific areas, creating fine lines and patterns.
Scientists have discovered that tissue-resident memory T cells can be enhanced to fight off infections and tumors by redirecting their cholesterol-making process. A drug and statins were found to boost coenzyme Q production in these cells, improving their effectiveness.
The study found that despite invasive strains, all yeast lineages belonged to the ethanol fermentation environment, keeping the industrial process stable. The researchers plan to investigate yeast population dynamics in more detail, including the impact of external agents like bacteria.
Researchers at Kyoto University have discovered the mechanism by which breast cancer forms in mammalian epithelial cells. The team found that approximately 20 mutations accumulate annually in each cell until menopause, after which the rate decreases significantly.
The University of Kansas has established a virtual institute to train leaders in cybersecurity and electromagnetic spectrum research, partnering with Ohio State and Purdue universities. The VICEROY Virtual Institute will offer courses, scholarships, and hands-on training to combat growing cyber threats.
Researchers studied 1,500 middle-aged women and found that those with four or more adverse childhood experiences were nearly twice as likely to be sexually inactive. The study also showed that these women were two times more likely to experience sexual dysfunction in midlife. Healthcare providers are encouraged to screen for childhood ...
A $2 million grant from the National Science Foundation will support research on developing tools to help landowners plan controlled burns more effectively. The project aims to create a cloud-based platform that simulates burn plans, using satellite and weather data to predict fire spread and duration.
A large private laboratory is still processing finger prick tests for oestrogen levels despite warnings of unreliability. Experts raise concerns about the validation and regulation of online tests and laboratories, citing a lack of robust assessment and oversight.
The editorial discusses epigenetic mechanisms leading to oocyte quality loss, a significant factor in age-related fertility decline. Researchers highlight the importance of understanding this process to address the growing issue of advanced maternal age and its impact on reproduction.
The EPFL study found that having neighbors with solar panels plays a significant role in deciding whether someone installs them, alongside factors like socioeconomic category. The results also show a correlation between solar-panel installation and urbanization, highlighting the importance of flexible policies to promote renewable energy.
A study of medical and genetic data reveals that carrying a particular gene version reduces the risk of Alzheimer's and Parkinson's by over 10% on average. The protective allele, DR4, also correlates with a later onset of symptoms in both diseases.
Researchers found that gig workers' lack of traditional workplace interaction leads to less trust, but this may not negatively impact their performance. Instead, gig workers tend to rebound more quickly from issues with managers.
Researchers propose using gravitational wave searches to detect dark matter through neutron star effects. The study forecasts constraints on heavy dark matter particles within the next decade, offering a potential tool for testing dark matter theories.
Researchers found four main barriers to healthy diets in young female cancer survivors with fertility challenges, including lack of trust in healthcare providers and motivation. To overcome these barriers, nutrition programs should use evidence-based strategies and tools like motivational interviewing and social support.
Researchers have developed a new way to engineer bacterial enzymes, creating unique versions that are hyper-sensitive to existing antibiotics. This breakthrough could lead to the creation of more potent treatments for bacterial infections and improve our understanding of antibiotic resistance.
Researchers found that individuals with higher body mass indexes have impaired connections between the hippocampus and hypothalamus, leading to an inability to control eating habits. The study suggests that targeting this brain circuit may lead to new treatments for obesity and related disordered eating conditions.
Experts recommend avoiding cannabis during adolescence, pregnancy, and driving due to links to psychosis, depression, and motor vehicle accidents. However, cannabidiol shows promise in reducing seizures and managing chronic pain.
A University of Missouri researcher created an evidence-based, online professional development curriculum to help teachers recognize, respond to, and prevent bullying towards students with disabilities. The curriculum emphasizes building rapport, social skills, and communication skills to improve classroom climates and reduce bullying.
Researchers discovered a gut bacteria that helps reduce insulin resistance and protect against diabetes. The study found that a specific bacteria, Alistipes indistinctus, consumed excess monosaccharides in the gut, lowering blood sugar levels and reducing insulin resistance.
A study published in mSystems found associations between the gut microbiome and eczema in infancy, with alterations in gut bacteria preceding eczema development. The research revealed changes in gut microbiota composition and diversity over the first 3 years of life, influenced by mode of delivery and feeding patterns.
Researchers discovered that specific enzymes on immune cells can predict patient survival and response to immunotherapies. High levels of CD39 on cytotoxic T cells located within tumors are associated with increased survival and better response to treatment.
Researchers at University of Galway and MIT have developed an intelligent implantable device that can sense its environment, adapt to release drugs as required, and bypass scar tissue buildup. The device uses AI to tailor drug delivery to individual patients, reducing fibrotic encapsulation and ensuring consistent dosing.
A pioneering study published in Cancer Cell finds that brain metastasis alters the brain's chemistry and disrupts neuronal communication. Researchers discovered a molecule, EGR1, that may play a role in this process, paving the way for potential drug development to alleviate neurocognitive effects.
Climate extremes have a disproportionate impact on already stressed economies, leading to increased costs for households and reduced resilience to future shocks. The study's findings highlight the need for increased economic resilience to cope with climate-related disasters and mitigate non-climate related crises.
Research at Columbia University's Mailman School of Public Health detected significant levels of metals in the blood and urine of marijuana users, suggesting that marijuana is a source of lead and cadmium exposure. Measurements reported by participants showed higher lead levels in blood and urine among exclusive marijuana users compare...
Researchers from Vienna University of Technology and Leibniz University of Hannover have found the solution to the wild boar paradox. The radioactivity in wild boar meat remains high due to the accumulation of cesium-137 from nuclear weapons tests, which is also present in deer truffles that are particularly favored by wild boars.
Researchers have developed an electrochemical cell that can easily capture and release CO2, a major contributor to industrial emissions. The device operates at room temperature and requires less energy than traditional methods, making it a promising alternative for industries that struggle with electrification.
A new study reveals that boys who smoke in their early teens may damage the genes of their future children, leading to increased risks of developing asthma, obesity, and low lung function. Researchers investigated epigenetic profiles of 875 people aged 7-50 and found changes associated with fathers' teenage smoking.