Researchers develop strategy to deliver mRNA directly into bone marrow stem cells to edit genetic defects and repopulate with healthy blood cells. The technique shows promise for treating blood cell malignancies and certain non-malignant disorders, bypassing traditional transplantation processes.
Researchers at Harvard developed a fiber-infused ink that allows 3D-printed heart muscle cells to align and contract like human heart cells, enabling the creation of functional heart ventricles. The innovation can be used to build life-like heart tissues with thicker muscle walls, paving the way for regenerative therapeutics.
Researchers at Kyoto University have developed a new fusion model that accurately predicts the rotational temperature of hydrogen molecules near the walls of tokamaks. This innovation enables the effective management of heat load and extends the lifetime of future fusion devices.
Researchers at NYU College of Dentistry developed a gene therapy that regulates sodium ion channel activity to alleviate chronic pain. By targeting the specific region where CRMP2 binds to NaV1.7, they were able to reduce sodium influx and quiet down neurons, providing relief from pain in cell and animal studies.
Scientists at North Carolina State University have successfully grown high-quality thin films of the recently discovered superconductor material KTaO3. The researchers found that the material retains its superconducting properties even when exposed to extremely high magnetic fields.
A new complex-domain neural network enhances large-scale coherent imaging by exploiting latent coupling information between amplitude and phase components. The technique reduces exposure time and data volume significantly while maintaining high-quality reconstructions.
The study found shorter wait times for telehealth appointments compared to in-person visits and no increase in community care requests after program implementation. The program improved access to timely neurological assessment and treatment for rural veterans, overcoming physical, geographical, and financial barriers.
A University of Maryland study found that tree species diversity increases spider populations, providing a natural pest regulation service. Spider populations in diverse plots increased by 23-50% compared to single-species plots during late summer months.
Researchers at the University of Manchester's National Graphene Institute discover new physics in ancient graphite, finding a 2.5D Hofstadter’s butterfly effect that modifies both surface and bulk states.
Researchers mapped the 3D structure of kappa opioid receptors, discovering how they change shape to bind to opioid drugs. This finding could lead to the development of next-generation pain relievers that target specific opioid receptors and minimize side effects.
New prediction models developed at MSK effectively identify patients at higher risk of developing lymphedema, allowing for interventions to reduce risk before surgery and closer follow-up. The models take racial differences in disease incidence into consideration, improving accuracy.
A recent study found that travel-related barriers significantly impact access to healthcare, particularly for marginalized communities. The research emphasizes the need to remove these barriers to achieve health equity.
A new study by Brighton and Sussex Medical School finds that 24% of autistic doctors have attempted suicide, while 77% have considered it. The study highlights the need for workplaces to provide better support and awareness of autistic healthcare professionals.
Researchers have developed an innovative RNA-based strategy to activate dendritic cells, which play a key role in immune response. The approach, called CATCH, eradicated tumors and prevented their recurrence in mouse models of melanoma, suggesting its potential effectiveness against different cancer types.
The Phase 2a trial of OVX836 showed a notable signal of protection against influenza symptoms with an 84% level of protection compared to placebo. The vaccine candidate elicited significant humoral and cellular immune responses, highlighting its potential as a universal influenza vaccine.
A breakthrough treatment targeting bone marrow cancer cells destroyed 90% of multiple myeloma cells in laboratory tests and 60% in human tissue samples. Researchers developed lipid-based nanoparticles containing RNA molecules that silence the CKAP5 gene, inhibiting cancer cell division.
Researchers combined linguistics and genetics to propose a new origin theory for the Indo-European languages, suggesting an ultimate homeland south of the Caucasus. The study estimated the family to be approximately 8100 years old, with five main branches split off by around 7000 years ago.
Researchers develop new algorithm to effectively investigate long-range interacting systems, reducing runtime from quadratic to linear with system size. The new method opens up new questions and applications in nonequilibrium processes, including phase separation and structure formation in cosmology and solid state physics.
A study found that pdm09 influenza A virus has crossed from humans to swine nearly 370 times since 2009, resulting in evolutionary changes and potential for zoonotic transmission. The analysis suggests managing human infection can help prevent pig-to-human transmission.
A soil nematode was reanimated from 46,000-year-old Siberian permafrost, shedding light on its ability to survive harsh conditions. The species, Panagrolaimus kolymaensis, shares molecular tools for survival with C. elegans.
Researchers at Queensland University of Technology have developed a new approach to designing molecular ON-OFF switches based on proteins, which can be used in various biotechnological and biomedical applications. The novel technique allows for faster and more accurate diagnostic tests for detecting diseases and monitoring water quality.
Researchers investigated the inactivation efficacy of different UV wavelengths against SARS-CoV-2 Omicron variants, finding similar inactivation properties across various wavelengths. The study highlights the potential of far-UVC light as a safe germicidal option for mitigating airborne virus transmission.
Scientists at Max Delbrück Center discovered two lead compounds that inhibit activation of IKK/NF-κB pathway only when triggered by DNA double-strand breaks. These substances make cancer cells more sensitive to chemotherapy, potentially increasing the success rate of genotoxic cancer therapies.
Researchers at MPFI discovered Protein Kinase C delta's (PKCd) role in regulating cell-wide gene expression through synaptic plasticity. The study found that PKCd activates biochemical reactions that spread throughout the neuron, influencing gene transcription and memory formation.
Researchers at the University of Copenhagen used a new method to collect airborne DNA particles and found evidence of 64 different animal species in a single football field-sized area. The findings suggest that this technique could be a valuable tool for monitoring biodiversity and tracking the spread of diseases.
Researchers at the University of Leeds have developed tiny surgical robots that can travel deep into the lungs to detect and treat early signs of cancer. The ultra-soft tentacle robot reaches 37% deeper than standard equipment and causes less tissue damage, paving the way for a more precise approach to treatment.
A team of scientists has discovered that auto-aggressive T cells are activated in the gut microbiome-dependent manner in a specific area of the intestinal canal. The researchers used two-photon imaging to visualize the activity of these cells and found that activation is required for multiple sclerosis development.
Researchers from IU School of Medicine have diagnosed a Sumatran Orangutan named Mila at the Indianapolis Zoo with Alkaptonuria, a rare autosomal recessive disorder. The diagnosis was confirmed through molecular analysis of DNA, providing veterinarians with crucial information on Mila's health and treatment options.
A new study suggests Indo-European languages first arose south of the Caucasus and then branched northward to the Steppe regions before expanding throughout Eurasia. The 'hybrid' hypothesis, supported by a large dataset of modern and non-modern languages, challenges previous agriculture or pastoralism-based origin theories.
Two new studies suggest online shopping for activewear may harm women's body image due to body-focused marketing. The research found that women who browsed activewear websites showed lower body gaze and experienced negative self-esteem compared to those browsing casualwear or homewares websites.
Researchers discovered a new nematode species in Siberian permafrost with molecular toolkit for survival, sharing similarities with Caenorhabditis elegans. The species, Panagrolaimus kolymaensis, can survive extreme conditions by producing trehalose and mild dehydration exposure.
Astronomers have created the first computer simulations showing how convection in the cores of massive stars generates waves that result in flickering starlight. The effect is different from the visible twinkling of stars in the night sky and could be observed with improved telescopes.
CHOP and Penn Medicine researchers have developed a proof-of-concept model for delivering gene editing tools directly into diseased blood cells within the body. This approach aims to reduce costs and increase access to gene therapies for blood disorders, which currently require chemotherapy and stem cell transplants.
A study by University of Toronto researchers found that child language development and language evolution share a common cognitive foundation, based on a core knowledge base. The team built a computational model that predicts word meaning extension patterns across languages and time scales, highlighting the role of visual, associative,...
A new study reveals that illicit drug use is involved in nearly one in three sudden cardiac deaths (SCDs) among young adults in Victoria, Australia. The analysis of data from a statewide registry found higher levels of illicit drugs and multiple substance use among SCD patients.
A Northwestern University-led team developed the first 3D simulations of energy rippling from a massive star's core to its outer surface. The researchers determined how much stars should innately twinkle and converted these waves into sound waves, allowing listeners to hear both what the insides of stars and their twinkling sound like.
Researchers at the University of Konstanz have developed a biodegradable mineral plastic with self-healing properties, replacing polyacrylic acid with sustainable polyglutamic acid. The new material retains its positive properties and has been shown to degrade in just 32 days using microorganisms from forest soils.
A new study by Thomas Brochhagen and colleagues reveals that individual and population-level word meaning extension rely on the same cognitive foundation, involving knowledge of objects, events, properties, and relations. The study examined over 1,400 languages and developed a computational framework to understand this process.
A University College Dublin researcher has received a European Research Council Proof of Concept grant to investigate the disruptive power of macromolecular crowding in cell culture systems. The project aims to develop novel approaches for regenerative medicine by accelerating tissue development and improving therapeutic potential.
Researchers found a genetic link that explains how certain individuals store fat at the abdomen but remain protected from type 2 diabetes. This discovery could pave the way for personalized medicine, tailoring treatments to individual genetic variations.
A large cohort study found that a low intake of dietary fiber during pregnancy is associated with neurodevelopmental delays in children. The study analyzed data from over 76,000 mother-infant pairs and found that children of mothers who consumed less fiber were more likely to show delays in brain function development.
A team of roboticists developed a 3D printed soft robotic gripper that can pick and release objects without electronics. The device is printed in one go and features built-in gravity and touch sensors.
Researchers at Hebrew University of Jerusalem discovered supershear tensile cracks that surpass classical speed limits and transition to near-supersonic velocities. These findings challenge traditional understanding of fracture mechanics, offering new avenues for studying material properties.
Researchers have developed a new electrode system that can triple the areal power density of existing capacitive systems. The system retains 90% of its capacity after 50,000 charging/discharging cycles, making it economically viable for harnessing abundant renewable energy.
The study reveals that women physicians prioritize family building over career advancement, leading to a shift in their professional paths. Women in medicine experience significant alterations to their careers due to fertility concerns and family planning, contributing to ongoing gender disparities.
A new research method has determined the health impacts of heat and air quality, finding that even moderate temperature increases can lead to increased hospital visits and death for vulnerable populations. The study aims to help municipalities make informed decisions about climate mitigation and adaptation measures.
Researchers isolated antibodies from a vaccinated SARS patient that can stop nearly all related coronaviruses tested. The most powerful antibody, E7, neutralizes SARS-CoV and Omicron variants, showing a unique mechanism of binding to the virus's spike protein.
A new study by Texas A&M University researchers found substantial public support for shifting administrative burdens away from individuals and improving communication on Medicaid enrollment procedures. The survey-based study showed that people with experience in Medicaid, political liberalism, and those who struggle with administrative...
A study examining Facebook users' news feeds found that reducing exposure to content from politically 'like-minded' sources had no measurable effect on political beliefs or attitudes during the 2020 US presidential election. The study also found that participants were exposed to more cross-cutting sources and less uncivil content after...
TRIM11 protein levels decreased in Alzheimer's disease models, suggesting replenishment may improve cognitive and motor function. The study reveals that TRIM11 plays a key role in removing tau protein tangles that cause neurodegenerative diseases like AD.
A study of 22,000 adults found that small amounts of vigorous intermittent lifestyle physical activity were associated with a lower incident cancer risk. This finding suggests that daily vigorous intermittent lifestyle physical activity may be a promising intervention for cancer prevention in populations unable or unmotivated to exercise.
Researchers from Sahmyook University found that phyllodulcin, a natural sweetener found in hydrangeas, can efficiently inhibit amyloid beta (Aβ) aggregation and dissociate its aggregates in an animal model study. The study suggests that phyllodulcin may be useful in delaying the onset and progression of Alzheimer's disease.
A new reference database, Greengenes2, allows researchers to combine 16S and shotgun sequencing data, improving the reproducibility of microbiome studies. This enables the reuse of millions of samples in older studies, strengthening physicians' ability to draw clinical conclusions.
Researchers found that expression of transcription factors contributes to different subtypes of colorectal cancers. The degree of DNA methylation varies across tissue types, with some cancers having high and others low frequency of methylation gains. Studying transcription factor expression may help determine overall survival in patien...
A new preclinical study reveals that mitochondrial transplantation can lessen the damage to renal cells and kidneys, improving their function. The technology, where healthy mitochondria are injected into damaged tissue or organ, has the potential to transform renal transplant medicine.
A new study by Flinders University researchers suggests that only 1% of dormant pathogens could cause major ecological harm, leading to the loss of host organisms worldwide. The simulations showed that these ancient microbes can survive, evolve, and become dominant in modern ecosystems, posing a substantial danger.
Scientists have discovered ancient ocean water trapped in mineral deposits in the Himalayas, providing insights into Earth's past climate and oxygen levels. The deposits suggest that slow-growing cyanobacteria may have triggered a major oxygenation event around 700-500 million years ago.
Researchers at ISTA use swimming bacteria to assemble materials, introducing a novel strategy for fabricating soft materials. The study demonstrates the potential sustainability benefits of harnessing energy from bacteria in material production.
Researchers at the University of Copenhagen have discovered how a bacterium called Vibrio alginolyticus moves using sodium ions, which could lead to new targets for antibiotics. The study provides insights into the flagellum's movement and may help develop novel antibiotics to combat antibiotic resistance.
A recent study published in Nature Mental Health reveals that amotivation and anhedonia are key factors in determining social functioning among individuals with psychiatric disorders. The research found that these negative symptoms have a stronger impact on social functioning than expressive dysfunction, especially in patients with sch...