Researchers at the University of São Paulo's Institute of Biosciences successfully developed blastoids from bovine pluripotent stem cells, creating an accessible in vitro model for studying embryogenesis. This breakthrough could lead to improved farm animal reproduction and enable breeding cattle with desirable characteristics.
A study found that taking more daily steps improves symptoms and physical limitations for people with heart failure, with little association seen beyond 5,000 steps. Participants who increased their step counts experienced improved symptom control and physical function.
Researchers analyzed data from 2014-2022 to calculate cumulative incidence rates of mass shooting event types. The study found that social-related mass shootings account for 27% of incidents, while domestic violence-related shootings are underreported, highlighting the need for awareness and support.
A Mount Sinai study published in Nicotine & Tobacco Research found that cigarette smokers are more likely to experience tobacco dependence compared to those who use smokeless tobacco or multiple products. The researchers identified three distinct groups of tobacco users and suggested tailored cessation programs for each group.
Researchers discovered that nine percent of esophageal adenocarcinoma patients harbor cancer-predisposing gene mutations, which may trigger progression from Barrett's esophagus. This finding supports the idea that genetic testing can help risk-stratify EAC patients and potentially accelerate development of new treatments.
Researchers developed a method to reduce platinum-group metal loadings in fuel cells, resulting in competitive performance and better durability. The new process could enable mass production of fuel cell electric vehicles, offering zero emissions and higher energy density.
Researchers found that prolonged droughts have led to Steamboat Geyser's dry spells by clogging pathways for trees to respire and grow. The team matched tree growth periods to regional climate records, revealing a connection between environmental conditions and reduced water supply.
A third of children with a history of social care in England faced school exclusion, according to a new study. The research found that those with special educational needs services or child protection plans were excluded at significantly higher rates than others.
Researchers review the cavity-controlled principle in zeolite-catalyzed MTO reactions, highlighting its impact on product distribution, catalyst deactivation, and diffusion behavior. Control strategies for improved stability and selectivity are also discussed.
Researchers at Technical University of Munich have developed an automated analysis method for identifying and quantifying microplastics. The new process uses Raman microspectroscopy to analyze plastic particles directly, allowing for quick and reliable detection of their size, shape, and composition.
Dual-atom catalysts (DACs) face challenges in converting carbon dioxide into multicarbon products due to C-C coupling difficulties. Researchers at Tohoku University uncovered the causes of this failure through advanced theoretical calculations.
A genetic analysis of individuals buried at Machu Picchu suggests a highly heterogeneous population with diverse ethnic origins. The study finds that many retainers were of Amazonian origin and had mixed ancestries, indicating selective mate choice.
Researchers at Mount Sinai discovered a new family of locally secreted molecules called 'mammokines' that play a crucial role in controlling mammary gland fat abundance. These findings have significant implications for breast health, lactation-related disorders, and metabolic syndromes.
A secondary analysis of a randomized clinical trial found that daily low-dose aspirin increases the risk of intracranial bleeding in healthy older adults, but does not reduce ischemic stroke risk. The study's findings have particular relevance to individuals prone to developing intracranial bleeding after head trauma.
A new approach boosts light absorption in thin silicon photodetectors with photon-trapping structures, increasing the absorption efficiency over a wide band in the NIR spectrum. The findings demonstrate a promising strategy to enhance the performance of Si-based photodetectors for emerging photonics applications.
A study by Ohio State University researchers uses mobile cameras installed on campus buses to count vehicles, detect objects in the road, and track movements. The AI-powered YOLOv4 model provides accurate measurements with high spatial and temporal coverage, which could enhance current traffic systems and improve efficiency.
Researchers at Nagoya University identified a genetic sequence in thale cress crucial for plant reproduction and fertilization. The discovery of the Synergid-specific Activation Element of MYB98 (SaeM) is expected to improve seed production, increase plant yields, and enhance crossbreeding between plant species.
Scientists at the University of Pittsburgh Center for Vaccine Research have identified a protein responsible for lethal liver disease in mice infected with Rift Valley fever virus. Removing this protein, Lrp1, from the liver prevented viral replication and extended mouse lifespan.
Researchers at Massachusetts General Hospital discovered a critical protein, NLRP11, that alerts the body to bacterial infections and initiates an effective immune response. This finding may lead to improved 'humanized' mouse models of infections and diseases involving the immune system.
Researchers propose lab-on-a-chip platforms to continuously monitor stored RBC quality and match units to patient needs. This technology aims to improve transfusion safety and efficacy, particularly for critically ill patients and those on chronic transfusion regimens.
Researchers have identified podoplanin as a key protein driving the spread of mucosal melanoma, a rare and aggressive form of skin cancer. Eliminating this protein could lead to a potential treatment through antibody therapy, offering hope for patients with this devastating disease.
The American Heart Association has funded seven new scientific research projects to explore the connection between migraines, strokes, and cardiovascular disease. The studies will analyze existing datasets using machine learning and aim to create a collaborative group of experts to uncover the causes of increased risk.
A new study reveals that rapid state law changes mean many families will need to drive longer distances to access gender-affirming care for their transgender children. The restrictions have led to 25% of Americans aged 10-17 living more than a day's drive away from a clinic offering such care.
A study using wastewater metrics found accurate assessments of county SARS-CoV-2 incidence and may be the best metric for monitoring virus circulation. Home testing increases and vaccination treatment decrease disease acuity, making wastewater surveillance a reliable option.
Researchers identified 12 rare genetic variants associated with QT interval prolongation, increasing the risk of severe heart rhythm abnormalities and sudden cardiac death. These variants can lead to a more precise clinical approach through improved identification and risk stratification, aligning with precision medicine principles.
A new study uses machine learning to analyze data from DrugAge, a database of chemical compounds modulating lifespan in model organisms. The researchers create four types of datasets to predict whether or not a compound extends the lifespan of C. elegans, using features such as compound-protein interactions and Gene Ontology terms.
Researchers evaluated blood biomarkers for Alzheimer's disease in a multicenter study of 817 Chinese Han samples. The study found that combining APOE genotype with plasma pTau and serum GFAP distinguished Aβ status effectively.
A study published in PLOS ONE found that children's ability to recognize dog emotions, especially aggression, improves with age. Four-year-olds were less able to recognize aggressive dog expressions than six-year-olds and adults. As children grow older and gain experience with dogs, they become better at reading canine facial expressions.
Researchers found that consumers react differently to university-co-developed products and key factors influence these perceptions. Firms can leverage university collaboration to increase product attractiveness, but effective marketing is crucial.
A genetic study has found that a captive-bred population of the Orinoco crocodile, one of the world's most endangered species, possesses sufficient genetic diversity and is suitable for reintroduction efforts. The Colombian government can use this research to initiate new populations in areas where the species has been depleted.
Researchers found that aphid-infested tropical milkweed is less inviting to monarch butterflies, with reduced egg-laying and slower caterpillar development. Aphid-free plants, on the other hand, provide a better chance for monarchs to thrive.
Researchers have identified KIAA0930 as a key factor causing muscle atrophy in cancer cells, which could lead to the development of new anti-cachexia therapies. The study found that KIAA0930 knockdown cells showed increased muscle mass and weight compared to control cells.
A study by I.R.C.C.S. Neuromed found that high consumption of ultra-processed foods significantly increases mortality risk among people with type 2 diabetes. Even those following a Mediterranean diet are at increased risk if ultra-processed foods account for a large share of their diet.
Researchers developed new methods for detecting drug-induced hepatotoxicity using 3D cell cultures and mass spectrometry imaging, identifying biomarkers and effective interventions. A zeolite-based protein corona method was also used to characterize plasma proteins, enabling the identification of low-abundance proteins and their potent...
The Bioaction project leverages bacteria as allies in promoting tissue regeneration, offering a paradigm shift in addressing infections. By developing functional bio-hydrogels, the project aims to accelerate healing and stimulate bone growth, reducing reliance on extended antibiotic therapies.
The National Institutes of Health (NIH) invested approximately $164 billion in project funding prior to first drug approval, with only 0.59% ($0.95/$164 billion) associated with patents providing market exclusivity. This research highlights the limited public interest protections for NIH-funded research on new drugs approved between 20...
A study by Cold Spring Harbor Laboratory researchers found that breast cancer cells trick the immune system using a molecule called MHC-II, allowing them to spread faster and evade treatment. Targeting this molecule may lead to new therapeutics and improve patient outcomes.
Researchers successfully modified the ethylene synthesis pathway in the Japanese luxury melon to increase its shelf-life. The study found that introducing a mutation into the CmACO1 gene reduced ethylene generation, resulting in firmer fruit and longer shelf life.
Research highlights an unexpected disparity in survival for Asian adults compared to white adults in the US, with lower survival rates despite comparable bystander CPR rates. The study, published in the Journal of the American Heart Association, analyzed data from nearly 279,000 out-of-hospital cardiac arrests.
Researchers developed a new type of battery using sheet-like hard carbon and activated carbon with improved structural stability. The materials showed high specific energy and power output, lasting almost no loss in performance after 1,000 charge-discharge cycles.
A new study suggests that replacing traditional protein sources with mealworms in high-fat diets can slow weight gain and improve immune response, inflammation, energy metabolism, and cholesterol profiles. Mealworm protein also beneficially alters the ratio of good to bad cholesterol.
The grant investigates the unknown relationship between myopia and glaucoma by analyzing their effects on the ganglion cell complex. The research aims to identify early markers of glaucoma in myopic eyes, potentially reducing vision loss and improving quality of life.
The American Academy of Neurology has developed an Emerging Issues in Neurology article providing timely guidance on new therapies for early Alzheimer's disease. The guidance explains the eligibility criteria, potential side effects, and limitations of these treatments, which are not a cure for the disease.
The study found that subsurface microbial communities regulate refractory DOM flux to the overlying seawater. Humic-like FDOM components were more strongly correlated with microbes in energy-limiting deep-sea sediments than in eutrophic coastal sediments.
A new study led by UCL researchers found that Caenorhabditis elegans' lifespan is limited by its reproductive self-destruction. The finding raises questions about the validity of insights from this model organism for human ageing advances.
A team of physicists and medical doctors developed a portable Magnetic Particle Imaging (MPI) scanner that can visualize dynamic processes in the human body, such as blood flow, without using radiation. The scanner is designed for real-time endovascular interventions and has the potential to change the field of intervention.
Octapharma's Balfaxar, a prothrombin complex concentrate, has received FDA approval for the urgent reversal of acquired coagulation factor deficiency induced by vitamin K antagonist therapy. The product demonstrated effective hemostasis in 94.6% of patients and was non-inferior to comparator Kcentra.
A study by Spanish researchers outlines the optimal strategy for China to achieve carbon neutrality by 2060, focusing on photovoltaic and wind power. The plan involves deploying 3,844 new commercial-scale plants, expanding ultra-high-voltage transmission systems, and optimizing energy loads.
A new species of armored reptile, Mambachiton, shows that the precursor to dinosaurs and pterosaurs had bony plates on its backbone, indicating that armor was ancestrally present in bird-line archosaurs. The loss and re-evolution of armor is an important aspect of dinosaur evolution.
A recent brain single-cell study found that certain genes are expressed at varying levels in the dorsolateral prefrontal cortex of individuals with PTSD and MDD, suggesting dysregulated pathways. The research could lead to novel diagnostic markers and targeted treatments for these conditions.
A recent study found that increased skin cancer screening is not enough to address racial disparities in melanoma survival rates. Researchers suggest that educating physicians about presentation of melanoma in skin of color and making sure people have access to a dermatologist when they have a suspicious lesion could be more effective.
Researchers warn that unsustainable wildlife trade could alter key ecological processes in biodiverse regions, leading to losses of evolutionary history. The study highlights the need for conservation resources to be directed towards tropical hotspots to prevent extinctions.
A new study by Simon Fraser University researchers highlights the urgent need for immediate methane emission reductions to meet global climate change goals. Delaying efforts will increase the risk of exceeding the 2°C temperature limit, even if CO2 emissions are reduced to net-zero.
An international team of scientists has detected a quasi-periodic oscillation (QPO) signal in the radio band from a Galactic black hole system, revealing features that have never been seen before. The QPO signal may provide the first evidence of activity from a jet launched by a Galactic stellar-mass black hole.
Researchers developed a new method for capturing turbulent flame behavior, providing detailed insights into flame dynamics, ignition processes and combustion efficiency. The high-speed 3D imaging approach can be used to optimize energy production processes and improve fire safety measures.
A first-in-human study demonstrates the efficacy of a novel PRMT5 inhibitor, JNJ-64619178, in treating advanced solid tumors. The treatment showed manageable dose-dependent toxicity and achieved preliminary antitumor activity in patients with various cancer types.
A team of scientists has developed an optically transparent terahertz cavity to manipulate phonon vibrations in semiconducting perovskites. This design allows for on-demand adjustment of ultrafast THz field modulation, benefiting photonic integrated devices and optical communications.
A new study shows that earlier transfer to specialized care is associated with better outcomes for infants with NOWS, including shorter hospital stays and less exposure to medication. The study found that nonpharmacologic interventions, such as swaddling and pacifier use, are critical to clinical outcomes.
A new study finds that climate change poses a significant threat to all listed plant and lichen species, with only a minority of conservation plans taking direct action to address this issue. The researchers urge policymakers to use their findings to inform conservation planning and recovery efforts for these endangered species.
A Washington State University study found that popular health-related videos on TikTok primarily cover sexual health, diet, and exercise topics. Influencer role models and aesthetic details dominate the content, lacking attainable behavior change advice.