A national estimate suggests that 795,000 Americans die or are permanently disabled by diagnostic error each year. The top causes of serious harm include stroke, sepsis, and pneumonia.
A new study from UEA found that friendly interactions with people from diverse groups can significantly reduce the endorsement and tolerance of conspiracy theories. Positive intergroup contact has been shown to decrease prejudice towards targeted groups, including Jewish people and immigrants.
Researchers discovered a bacterial protein that contributes to genomic instability and birth defects. The study found that mice exposed to the protein experienced reduced fertility and increased birth defects, shedding light on potential cancer connections.
Researchers found that BUB1 protein regulates EGFR signaling by reducing receptor internalization, which may lead to new therapeutic interventions for EGFR-driven cancers. The study also showed that BUB1 impacts receptor recycling and degradation, affecting signaling amplitude and duration.
A study of 800 Dutch children found that modified treatment protocols increased the five-year survival rate for all children with acute lymphatic leukemia to 94%. The modifications resulted in a three times lower risk of disease recurrence, especially in children with an aggressive form of leukemia.
Researchers have developed an intelligent metasurface design using forward and reverse algorithms, reducing computational time and improving physical accuracy. Machine learning and physics-informed neural networks are used to optimize metasurface properties and overcome limitations of traditional methods.
A study by Gladstone Institutes researchers found that tight junctions between cells may play a critical role in gastrulation in human embryos. By suppressing tight junction formation, the team was able to create primordial germ cell-like cells, which are stem cells resembling human precursors of sperm and egg cells.
The PhRMA Foundation is launching a grant program to fund research on the use of digital health technologies in diverse populations. The program aims to advance regulatory decision-making and promote health equity. Eligible applicants must submit letters of intent by September 29, 2023.
Research reveals that asymptomatic throat carriage of Streptococcus pyogenes is the primary source of Group A Streptococcus (GAS) infections in high-risk communities. This discovery challenges previous understanding of GAS transmission and has significant implications for public health approaches, vaccine development, and future research.
The Canadian Medical Association Journal recommends prescribing psychostimulants to help reduce illegal stimulant use. This approach is based on growing evidence from clinical trials in Australia, Europe, and the United States. Implementing this practice can help address the ongoing unregulated drug poisoning crisis in Canada.
The latest Alzheimer's drug, donanemab, has shown encouraging results in slowing cognitive decline by 35% compared to placebo in patients with low-to-intermediate levels of tau. However, its effectiveness is limited for those with more advanced disease, and risks include serious side effects such as amyloid-related imaging abnormalities.
A KAUST-led team has developed a proton-mediated approach that produces multiple phase transitions in ferroelectric materials, potentially leading to high-performance memory devices. The method enables the creation of multilevel memory devices with substantial storage capacity, operating below 0.4 volts.
Researchers identify genes that directly influence what we eat and find foods that can boost brain health and protect the planet. New insights into genetic basis for food preferences could help improve personalized nutrition.
A new study analyzed existing research on bee-protective measures and found that many common methods are backed by minimal scientific evidence. Researchers urge stronger testing to evaluate effective measures and warn of potential waste of time if ineffective.
A new study reveals that Black patients with ICDs have a significantly higher rate of post-implant cardiac events and risk of death compared to white patients. The study also shows that Black patients are more likely to discontinue medications after one year, but the reasons for this are unknown.
A new study published in Circulation journal found that Black adults living in areas historically affected by discriminatory housing practices had a higher heart failure risk. The analysis included over 2.3 million adults from 2014-2019 and mapped historical redlining maps onto modern day maps of US zip codes.
Researchers have discovered how MCV initiates DNA replication in host cells, allowing the virus to make hundreds of new copies of itself. This process is different from normal cellular DNA replication and can lead to cancer if not controlled.
Research review finds scent dogs can successfully sniff out COVID-19 in symptomatic, pre-symptomatic, and asymptomatic cases, as well as new variants and long COVID. Scent dogs demonstrate similar or better sensitivity and specificity than current gold-standard tests.
A study published in Nature Cell Biology found that blood stem cell diversity arises during embryonic development and can be manipulated in childhood to improve overall health. The researchers used zebrafish and human pluripotent stem cells to demonstrate the potential of enhancing blood stem cell production.
The study reveals that quantum thermal machines exhibit distinct synchronization behavior, with cooperation and competition emerging among different components. The researchers found that cooperation manifests in harmony-like synchrony, while competition thrives in chaotic conditions.
A study investigates how product manufacturers can mitigate key core technology loss risks in global competition by implementing independent research and development (IR&D). The analysis reveals that enterprises investing in IR&D can create a strategic advantage, weakening the rival country's control over the situation.
In a post-truth era, Americans tend to trust information sources with good intentions over those with malicious intent. When presented with claims of fact, participants classified them as true more often if the source was trying to provide an approximate account rather than a precise one.
A team of researchers has developed a scalable and efficient method to fabricate chitin hydrogels, which show promise for biomedical applications due to their biocompatibility and biodegradability. The fabricated chitin hydrogels possess excellent mechanical properties, high water content, and antifouling performance.
A new combination treatment of GVAX vaccine, nivolumab, and urelemab has shown to increase the amount of cancer-killing immune cells in tumors and appear effective when given two weeks prior to surgery. The study found a median disease-free survival of 33.51 months and a median overall survival of 35.5 months.
A new biodegradable film was developed by Brazilian researchers using a derivative of limonene and chitosan to improve the preservation of food quality. The film outperformed those with limonene alone, exhibiting enhanced antioxidant activity and stability.
A study by University of Barcelona found that poorer districts in Barcelona were more likely to close schools during the pandemic, exacerbating existing health inequities. The researchers stress the importance of considering socioeconomic inequalities when designing public policies to prevent future pandemics.
Researchers develop isothermal-FLUCS, a technique that controls intracellular flows while minimizing heating impact. The new method achieves thermoviscous flows with magnitudes exceeding natural streaming in Caenorhabditis elegans zygotes.
A large-scale study shows that repeated liver stiffness measurements can predict patient outcomes in chronic liver disease. The researchers found that monitoring changes in liver stiffness over time provides a more accurate assessment of patient risk than single measurements.
Researchers at Columbia University found that babies' immune cells develop slowly and are not fully mature until around 4-6 years old. This makes them more susceptible to respiratory infections, but also enables them to respond to new pathogens in a unique way, such as the formation of bronchus-associated lymphoid tissue (BALT).
A new study published in Pest Management Science reveals that an apple snail invasion could be disastrous for rice production and food security in Kenya. The invasive species reduces rice yields by up to 14% and net rice income by up to 60% for farmers experiencing moderate levels of infestation.
In a phase 3 clinical trial, donanemab significantly slowed clinical progression in patients with low/medium tau and high tau pathology. The treatment cleared brain amyloid plaque, demonstrating its potential to slow Alzheimer disease progression.
Researchers at Rice University have created a new type of storage container that effectively prevents surface contamination for at least six weeks. The technology relies on an ultraclean wall with tiny bumps and divots, which attracts VOCs in air inside the containers.
A significant rise in ADHD diagnoses and prescriptions was observed in the UK over the past two decades, with a higher increase among adults. The study found that ADHD was more commonly diagnosed in children and boys than girls and women, and that the number of individuals receiving medication for ADHD increased significantly.
Scientists have uncovered how gamma delta T cells develop in the body and produce an immune response. The discovery could lead to the development of more preventive treatments for cancer and highly infectious diseases.
A group of global oncologists and patient advocates argue that cancer care is driven by commercial interests, not patient needs. The 'Common Sense Oncology' movement aims to prioritize patient outcomes over profit-driven research and treatment development.
A study reveals high levels of insecticide resistance among Aedes aegypti populations in Dhaka, compromising mosquito control and increasing dengue burden. Researchers recommend non-insecticidal approaches, such as Wolbachia-infected mosquitoes, to effectively manage dengue vectors.
Researchers from Edith Cowan University developed software to analyze bone density scans, detecting abdominal aortic calcification (AAC) at high accuracy. The AI can predict cardiovascular disease events and late-life dementia, allowing for early interventions.
Researchers found nightingales can flexibly adjust the pitch of certain song parts over a wide range of frequencies to imitate competitors. This strategy is thought to increase their mating chances during the breeding season. The birds can also adjust their songs in real-time to auditory stimuli, suggesting a robust neural circuitry.
A USTC research team introduces a novel dehydroaromatisation and hydrogenolysis tandem strategy to convert HDPE plastics into cyclic hydrocarbons without solvents or hydrogen. The method guarantees the continuity and stability of the catalytic reaction, making it suitable for various polyethylene plastics.
Research reveals NADPH's crucial role in accurate chromosome segregation and genomic integrity in aneuploid tumor cells. The study identifies potential targets for novel therapies by intervening in metabolic pathways, providing new biomarkers for selective inhibition of aneuploid tumors.
The study reveals that LLSVPs exhibit higher densities at the bottom of the lower mantle, while displaying lower densities above a depth of approximately 2700 kilometers. Elevated temperatures and enriched concentrations of iron and bridgmanite are also detected.
Researchers at the University of Hong Kong have made a breakthrough in understanding how memories are consolidated in the brain. Using functional MRI, they found that thalamic spindle activities can improve memory retention and activate specific areas of the brain.
Researchers used coupled cluster theory and multi-structural canonical variational transition state theory to investigate the unimolecular reaction of anti-glycolaldehyde oxide and its bimolecular reactions with atmospheric water vapor. The study found that the OH substituent increases reactivity and a specific reaction path dominates ...
Research team at USTC identifies impaired loss aversion and altered functional connectivity in IGD patients. The study's findings could contribute to the diagnosis and treatment of this disorder by exploiting changes in edge-centric brain networks.
Researchers at Tokyo Metropolitan University have discovered that 5-aminolevulinic acid can selectively boost Complex II and IV to counteract Complex I deficiency, a common cause of mitochondrial disorders. This finding offers new hope for the development of treatments for debilitating conditions such as MELAS syndrome.
Climate change poses significant risks to heroic viticulture sites in Italy, Portugal, and Spain, including soil degradation and drought. The authors argue that farmers, scientists, and consumers must work together to protect these unique wine regions and their cultural heritage.
A new study reveals that even colonies affected by Stony Coral Tissue Loss Disease (SCTLD) can contribute to the restoration of susceptible species through assisted sexual reproduction. The study found high fertilization and settlement success rates, with survivorship rates reaching up to 44% after being outplanted on a degraded reef.
ROSE, a novel soft gripping robotic gripper, boasts remarkable durability, scalability and effectiveness in handling fragile objects, with potential applications in harvesting, sorting and cluttered environments.
Researchers use virtual reality to simulate urban scenarios, allowing them to measure the implicit effects of urban planning measures on human stress levels. The method has shown that higher traffic volumes can upset test subjects, paving the way for more climate-friendly and inclusive urban planning.
A nationwide study found that residing in a highly segregated neighborhood was associated with a statistically significant four-year decrease in life expectancy. Socioeconomic factors partially mediated this effect, highlighting the role of residential segregation in perpetuating racial inequities.
A large-scale study found that exercise programs for dialysis patients lead to significant improvements in physical fitness, quality of life, and reduced hospital stays. Personalized exercise plans showed low costs per training unit, making them a viable option for standard healthcare coverage.
Researchers at Georgetown University Medical Center discovered the biological mechanism of TTP488, an experimental drug that impairs aggressive triple-negative breast cancer from metastasizing. The finding enables clinical trials to explore the drug's effectiveness in preventing TNBCs from spreading, offering new hope for patients with...
A team of scientists mapped the cell-type taxonomy in the macaque cortex using Stereo-seq and snRNA-seq technology. They found distinct cortical and regional specificity in glutamatergic neurons, GABAergic neurons, and non-neuronal cells, with significant correlations between cell composition and brain region structure.
Scientists from MSU have developed a new geochemical approach to studying phosphorus and its impact on oxygen accumulation in the past, shedding light on how life evolved on Earth. This research aims to better understand planetary conditions that sustain life, particularly in the context of searching for life beyond Earth.
Researchers used ALMA to study a distant galaxy, detecting structures of star formation and possible death sites within the surrounding nebulae. The findings suggest a complex environment where many stars may form together as massive clusters.
The DBST algorithm proposes a novel generalized Feistel variant structure and key-dependent dynamic S-box model to improve diffusion effects. It has demonstrated high security, high throughput rate, and low hardware resources in experiments.
A new Northwestern Medicine study has furthered the understanding of metabolic pathways underlying organ development, specifically eye development. The research found that aerobic glycolysis and production of lactate regulate critical genes required for early eye development.
Researchers at Nagoya University developed a method to process cholesteric liquid crystals into micrometer-sized spherical particles, creating a unique anti-counterfeiting QR code that can only be displayed under a specific circular polarizer. The use of chirality in these particles enables the creation of more secure codes with potent...
Scientists used Insilico Medicine's generative AI platform to identify actionable drug targets for cystinosis and validate them in preclinical models. The study found that hyperactive mTOR signaling drives kidney tubular cell dysfunction, making it a targetable pathway.
Researchers have discovered a mechanism leading to resistance in luminal breast cancer and propose using the approved osteoporosis drug denosumab to block RANK protein, promoting effectiveness of CDK4/6 inhibitors. This could lead to new treatment options for patients with metastatic breast cancer.