A study found that measuring three potential biomarkers on day three after a stem cell transplant can identify patients at risk of sinusoidal obstruction syndrome (SOS). Patients with positive scores were 9.3 times more likely to develop SOS and more likely to die within 100 days.
A new study suggests that modular production techniques can minimize construction delays caused by weather, resulting in cost savings for builders. The research estimates that using modular construction can reduce costs by approximately AUD$40,000 on a $6.4 million project.
Scientists found ceramic artefacts with wine residues from a Spanish olive jar dated between 1490-1520 AD on Isla de Mona, Puerto Rico. This discovery suggests that European wine was consumed by both Europeans and indigenous people shortly after the arrival of Spanish colonists.
Hanna Kokko, a renowned theoretical evolutionary biologist, has been awarded the Alexander von Humboldt Professorship for her groundbreaking research on the interplay between evolutionary and ecological factors. She will receive EUR 3.5 million to establish her research team and obtain necessary equipment and facilities.
A new study shows that the Montreal Protocol is delaying the occurrence of the first ice-free Arctic summer by as much as 15 years. The treaty's implementation has postponed the melting of Arctic sea ice at this very moment, yielding measurable results within a few decades of its implementation.
A new study by Potsdam Institute for Climate Impact Research and Mercator Research Institute finds that the current difference between savings and lending rates results in additional global heating of 0.2 degrees Celsius. Governments can effectively counteract high interest rates on loans by subsidising investment, leading to more foss...
Research reveals that age-dependent changes in germinal centres lead to reduced vaccine response in older people. The study demonstrates that reversing these changes can be achieved through interventions.
Women who experience adverse pregnancy outcomes are at a higher risk of developing stroke, with those having recurrent issues facing a twofold increase. Lifestyle interventions and sharing pregnancy history with doctors may help reduce this risk, according to the study published in the journal Stroke.
New research shows that the Montreal Protocol is delaying the first ice-free Arctic summer by up to 15 years. The treaty's regulation of ozone-depleting substances has slowed global warming and preserved the ozone layer.
A University of Gothenburg study found that individuals who engaged in regular physical activity had smaller hemorrhages upon arrival at the hospital. Physically active patients experienced 50% less bleeding volume compared to inactive ones.
A recent study published in JAMA Pediatrics monitored the safety of Pfizer-BioNTech COVID-19 vaccine in over 3 million children, identifying only rare cases of myocarditis or pericarditis, consistent with previous reports. The results provide additional evidence supporting the safety of COVID-19 vaccines in children ages 5 to 17.
Cell death is a crucial process in organisms, preventing tumor development and pathogen spread. Researchers at the University of Basel have now elucidated the exact mechanism of cell death, revealing that a specific protein called ninjurin-1 assembles into filaments that open the cell membrane, leading to its disintegration.
The study found a significant increase in mental health diagnoses among female youth, especially adolescents, during the COVID-19 pandemic. This trend was most pronounced for eating disorders, with vulnerable populations showing marked increases.
A new study suggests that curbside recycling can compensate for greenhouse gas emissions from landfills, providing a return on investment similar to or better than electric vehicles. The authors recommend restructuring programs to target high-value materials and implementing policies to relieve cost burdens on local governments.
Researchers identified TAp63 as a key protein in rheumatoid arthritis, which is targeted by methotrexate. Lowering TAp63 expression improves autoimmune arthritis in mice.
Researchers have found that craniospinal radiation can control metastasis in diffuse midline gliomas, leading to improved treatment options for patients. The study suggests that this approach may lead to long-term survival and potentially curative effects for these children.
Research finds that piecemeal feedback increases consumer impatience when provided at a fixed pace after specific behaviors. This association strengthens the connection between actions and outcomes, motivating consumers to pursue prompt results and leading to increased frustration.
Researchers aim to understand and utilize quasiparticles called excitons, which can transport energy without a net electric charge. The goal is to design energy-efficient systems that detect and emit light across a wide range of frequencies.
A comprehensive review of consumer research journals reveals growth in non-marketing journals focusing on consumer research, particularly since 2019. Emerging topics such as food waste, technology, and sustainability reflect contemporary issues pertinent to consumers.
Researchers discover a molecule that destroys aged cells without affecting healthy ones, paving the way for delaying tissue ageing. Testing with animal models will now begin to explore its potential anti-cancer effects and improve life expectancy.
A study by NIST and University of Colorado Boulder collected breath samples from participants before and after smoking high-THC cannabis, revealing that distinguishing between recent use and past use remains challenging. The research aimed to develop a reproducible protocol for breath measurements, which will help answer key questions ...
Victims of sexual assault are often blamed for not fighting back, but neuroscientific research suggests this may be due to involuntary immobility. Thirty per cent of women experience sexual assault or rape in their lifetime, and 70% report being 'frozen' during the ordeal.
New research suggests that fine particulate matter catalyzes oxidative stress in the lungs by converting peroxides into highly reactive hydroxyl radicals. This study challenges current paradigms for assessing air pollution's differential toxicity.
Researchers have cloned the wheat rust resistance genes Lr9 and Sr43, revealing that they encode unusual kinase fusion proteins. This breakthrough enables new options for addressing disease resistance in bread wheat and could lead to heat-resistant versions of the Sr43 gene to adapt to climate change.
An international consortium led by Amsterdam UMC has developed an improved version of the wireless pacemaker, enabling placement in both the atrium and ventricle of the heart. This innovation expands treatment options for patients with slow heart rhythms, improving contraction and reducing the need for multiple mini pacemakers.
Researchers developed a mathematical model that accounts for variables such as helicopter resources and operational range to optimize air movement tasks. The model can perform planning functions in under an hour, saving commanders three to five hours compared to traditional methods.
A new study reveals that increased sugar intake and elevated blood glucose levels can cause amyloid plaque buildup in the brain, increasing the risk of Alzheimer's disease. Researchers identified a metabolic sensor on neurons linked to this process, suggesting potential therapeutic benefits for diabetic patients.
Researchers from the UCLA Jonsson Comprehensive Cancer Center are presenting findings on combination therapies for breast cancer and a potential new treatment for patients with recurrent glioma. A phase 3 study evaluating vorasidenib versus placebo in patients with residual or recurrent grade 2 glioma with an IDH1/2 mutation is also be...
Brackish groundwater has the potential to replace fresh water for cooling coal- and natural gas-fired power plants, but treatment can be energy intensive. The study found that retrofitting power plants to use brackish water could nearly eliminate fresh water usage, but increase electricity generation costs by 8-10%.
Researchers at Duke University have discovered a class of compounds called argyrodites that could lead to the development of safer and more efficient solid-state batteries. The materials' unique crystalline structures allow for fast ion conduction, making them promising candidates for energy storage applications.
Researchers discovered that students working with a social robot featuring a charismatic voice produced more original and elaborate ideas compared to those who interacted with an identical robot using a flat voice. The study found that the charismatic robot's engaging tone increased team positivity, perceived effectiveness, and creativ...
New research published in Social Psychological and Personality Science found that guilt-prone people are less likely to accept bribes, especially when the act would cause obvious harm to other people. The study highlights the importance of assessing candidates' guilt proneness in personnel selection, particularly for leadership positions.
An international team found that volcanic eruptions can produce equatorial plasma bubbles in the ionosphere, disrupting satellite-based communications. The Tonga eruption triggered an irregular structure of electron density across the equator, delaying radio waves and degrading GPS performance.
Research suggests that brain's electrical activity tunes sub-cellular components to optimize network stability and efficiency. This 'Cytoelectric Coupling' hypothesis proposes that electric fields influence neurons' physical configuration to fine-tune information processing.
Researchers at Heidelberg University have identified a molecular mechanism controlling root branching in plants, which involves the activity of the target of rapamycin (TOR) protein. The study found that glucose plays a crucial role in forming lateral roots, and TOR acts as a gatekeeper to regulate this process.
Researchers at HSE MIEM develop mathematical model to enhance supercapacitor electrical capacitance by utilizing polymers with large pore sizes. This enables storing more energy and preventing potential adverse effects.
The researchers developed a Revealed Preference Argumentation framework and an Integrated Preference Argumentation framework, which unify two main approaches to RPT. They also created comprehensive algorithms for IPA frameworks and tested the tool on RPT-based consumer behavior analysis.
Researchers found that hydrocortisone was associated with a decrease in the need for vasopressor drugs and improvement in survival when used in combination with other corticosteroids. The study also suggests that combining fludrocortisone with hydrocortisone may provide a greater benefit in terms of survival.
Researchers comprehensively reviewed recent discoveries in 2D material mechanics, highlighting elastic properties, failure, and interfacial behaviors. Computational advancements are crucial for understanding dynamic behaviors and practical applications.
A new paper analyzes the olive shrub Phillyrea angustifolia's mating system using Kuhn's paradigm shift framework. The discovery of diallelic self-incompatibility resolves a long-standing paradox, demonstrating how science can undergo significant changes in response to emerging data.
A new research project, LC-H2, will develop next-generation electrodes to boost energy efficiency in electrolysis. This will help reduce grey hydrogen's carbon footprint and increase the share of green hydrogen in European energy systems.
A new AI method accurately predicts enzyme-substrate pairs, opening doors for efficient drug discovery and biotechnology. The ESP model, developed by a team of researchers, can work with any combination of an enzyme and over 1,000 substrates.
A new study shows public acceptance of phage therapy is moderately high and can be increased through education. The study found that describing phage therapy in a more positive light increases its acceptance, while exposure to information about antibiotic resistance also plays a role.
Researchers used a multiomics approach to analyze changes in transposable elements after influenza A virus infection, identifying transcription factors contributing to individual responses. The study provides insights into the variable severity of illness among individuals infected with the same virus.
Researchers have recorded pain-related data from inside the brains of individuals with chronic pain disorders, identifying an area associated with chronic pain and objective biomarkers. The findings, published in Nature Neuroscience, represent a step towards developing novel methods for tracking and treating chronic pain.
A team of researchers developed a deep-learning model called WearNet that uses Fitbit data to detect depression and anxiety. The study found that WearNet performed better than state-of-the-art machine learning models in detecting these conditions, producing individual-level predictions.
A recently discovered protein domain, MOTH, has been found to regulate collagen transport between cells and organelles. This domain, which evolved over several hundred million years, is responsible for identifying and transporting the collagen protein.
Researchers discovered that marsupial brains exhibit region-specific patterns of cortical activity during early development. This finding provides valuable information about human brain development and may inform strategies for improving cognitive function in humans.
A team of researchers at NYU College of Dentistry has successfully modified an existing anti-nausea drug to target the endosomes within cells, thereby providing a more prolonged analgesic effect. The modified netupitant showed improved pain-relieving properties compared to its original form and other drugs targeting similar receptors.
Researchers have found that honokiol, a compound from magnolia tree bark, inhibits SARS-CoV-2 replication in several cell types, reducing infectious particle production. The compound also shows broad-spectrum activity against other highly pathogenic coronaviruses.
Researchers have developed a new method to study ant brain chemistry, revealing differences in neuropeptide distribution between two species. The approach integrates 3D chemical data with high-definition anatomical models, providing unbiased visualization of neurochemistry.
Researchers at UC San Diego have created a wearable ultrasound system that can monitor deep tissue vital signs continuously, even in subjects on the go. The device uses machine learning to track movement and adjust its focus, providing real-time cardiovascular data.
Necrotizing Enterocolitis (NEC) Awareness Day is now recognized by California, thanks to advocacy efforts led by the NEC Society. The state's declaration aims to accelerate prevention and treatment options for this devastating disease affecting medically fragile infants.
A large population-based randomized controlled trial found that providing better opportunities for exercise and group training can prevent falls and fall-related injuries among older women. The study showed a significant reduction in recurrent falls, fall-related injuries, and fractures caused by falls.
A recent study published in Archives of Sexual Behavior found that married individuals who cheat report high levels of sexual and emotional satisfaction, but low levels of regret. The survey of over 2,000 Ashley Madison users revealed that fundamental problems with the relationship are often less cited as motivations for infidelity.
Researchers developed a rapid mixing reaction method to synthesize trifluoromethyl intermediate from fluoroform, taking less than a second. The new technique allows for improved yield of fluoride-based compounds and introduces a robust synthesis method for fluorine-based drugs.
The Zhurong rover has provided direct in-situ evidence of ancient oceans in the northern plains of Mars, with sedimentary structures forming during the regression of a paleo-ocean. The discovery sheds new light on the early history of Mars and its habitability.
The PARAGLIDE-HF trial found that sacubitril/valsartan significantly reduces plasma NT-proBNP levels compared to valsartan alone in patients with an ejection fraction above 40%. The study also showed a larger treatment effect in those with EF ≤60%, suggesting potential benefits for this population.
A deep learning-based Transformer model, Bloomformer-1, has been developed to identify the driving factors of algal growth in the Middle Route of the South-to-North Water Diversion Project. The results reveal that total phosphorus is the most significant factor affecting algal growth, especially in the Henan section, while total nitrog...
A new AI-enabled forecasting model can predict ENSO events for up to 22 months, overcoming the limitations of previous models. The Spatio-Temporal Information Extraction and Fusion (STIEF) model uses deep learning to extract space and time features and fuse them together, providing a more accurate prediction length.