Researchers developed a novel biomarker-based indicator of the Mediterranean diet, which incorporates levels of fatty acids and carotenoids in blood. The study found that those with higher scores had lower risk of developing type 2 diabetes, suggesting a stronger link than self-reported diet adherence.
The University of Liverpool is conducting a Phase I trial of a new Zika virus vaccine designed for pregnant women, which has shown promising results in animal studies. The vaccine aims to generate highly protective and long-lasting immunity against the mosquito-borne virus that can cause severe foetal birth defects.
A new therapy delivery method, using modified viruses engineered with fusogens Myomaker and Myomerger, shows promise as a treatment for Duchenne muscular dystrophy. The vector can deliver a vital gene needed for muscle function to cells, potentially providing a lifelong supply of the missing gene.
A team of researchers developed a self-checking deep learning system that accurately extracts information from gravitational-wave data. The algorithm, called DINGO, has been trained to interpret real data and can cross-check its own results for accuracy.
A research team from Université Laval and Université Clermont Auvergne has shown that clouds harbor antibiotic resistance genes of bacterial origin. The concentrations vary widely, ranging from 330 to over 30,000 bacteria per milliliter of cloud water.
A new study reveals that a Cas protein and a membrane protein work together to enhance anti-viral defense in bacteria. The team found that the membrane protein forms a pore-like structure that disrupts energy production and hinders virus replication, effectively 'pulling the plug' on viral infections.
A research team from the Medical University of South Carolina identified a protein called TACC3 that enables cancer cells to successfully divide despite an abnormality that should lead to their death. This discovery offers new hope for developing targeted therapies to selectively kill cancer cells while leaving normal cells intact.
Researchers have discovered ultra-thin metal-organic layers that prevent ice crystal formation in red blood cells during freezing and thawing. These nanolayers, made from metal-organic frameworks based on hafnium, show excellent cryoprotection at minimal concentrations, potentially leading to new and efficient cryoprotectants.
Researchers have created a new manual to study human diseases, using evolutionary genomics to analyze genetic risk. The manual reveals the importance of highly constrained genes that unite mammals, providing insights into neurological disorders and psychiatric conditions.
A University of Houston team has discovered new biomarkers for early detection of bladder cancer, including D-dimer and IL-8, which may identify disease progression. The study's findings could lead to a simple urine test as the new standard for bladder cancer diagnosis.
A team of researchers from Carnegie Mellon University has developed an AI-based system to help clinicians make decisions quickly and precisely in the ICU. The system, called the AI Clinician Explorer, provides recommendations for treating sepsis based on data from over 18,000 patients.
Researchers engineered a synthetic gene oscillator in yeast cells, manipulating the expression of two transcriptional regulators to create sustained oscillations between cellular degeneration states. This delay enhances lifespan by 82%, offering a proof-of-concept for using synthetic biology to reprogram cellular aging. The findings ma...
Scientists are developing a high-resolution landslides susceptibility map to forecast future landslides in eastern Oklahoma. The project uses remote sensing data, machine learning, and LiDAR topographic data to understand the causes, mechanics, and associated hazards of landslides.
Researchers analyzed genetic changes in organs of recently deceased patients with metastatic cutaneous melanoma to understand how the disease spreads and evolves. They found that cancer cells take advantage of specific organ environments, pointing to the need for distinct treatment approaches.
A molecular autopsy revealed that a young child with mild COVID-19 symptoms died from cardiac arrest due to an atypical coronary artery anomaly and underlying Noonan syndrome, a rare genetic disorder.
Researchers from Saarland University and Stanford University have gained new insights into the manifestations of aging at the molecular level. They found that the process of reading genetic information does not run as smoothly in older individuals, leading to physiological alterations in metabolism.
New research reveals that ant mounds on Danish heathlands are crucial for biodiversity. The heat and nutrients from these structures create a unique environment that allows certain plant species to thrive. This finding highlights the importance of preserving ant mounds as part of efforts to mitigate the biodiversity crisis.
Researchers have identified a potential therapeutic target and developed a unique delivery system to treat osteosarcoma, a bone cancer primarily affecting children and adolescents. The novel combination of gene therapy and chemotherapy may improve treatment outcomes and aid in the repair of damaged bones during chemotherapy.
Scientists have found a rare yeast pathogen, Lodderomyces elongisporus, causing neonatal outbreaks in India despite strong disinfectant bleach. The fungus is rapidly evolving and has been linked to hospital equipment and apples treated with fungicides.
Researchers have developed a method to extract valuable metals from old mining waste using microbes, reducing greenhouse gas emissions by up to 30%. This process also captures carbon dioxide from the air and stores it in the tailings as new minerals.
Researchers have developed a 'vein-on-a-chip' device that mimics the human vein, eliminating the need for animal models in some studies. The device, which includes structures called valves and endothelial cells, allows scientists to study mechanisms of blood clot formation in a realistic manner.
A recent study found that American children are experiencing higher rates of autism and attention deficit/hyperactivity disorder, with special education services increasing by 10.4%. Poor nutrition and heavy metal exposure, particularly in ultra-processed foods, are thought to be primary epigenetic factors contributing to the developme...
The Zoonomia Project has cataloged the diversity in the genomes of 240 mammalian species, providing insights into human health and disease. The research identifies regions of the human genome that have remained unchanged for millions of years and reveals genetic variants linked to rare and common diseases.
Researchers developed a new photonic blockchain called LightHash that uses a silicon photonics chip to reduce energy consumption in cryptocurrency mining. The approach could enable low-energy optical computing, reducing data centers' energy consumption and paving the way for more eco-friendly cryptocurrencies.
Researchers have compared the genes of 240 species of mammals, including a famous sled dog named Balto, to gain insights into biological and evolutionary processes. The study identifies pinpointing genes that underlie complex traits like hibernation and brain size.
Researchers at Harvard Medical School discovered a new cellular sensor that allows dormant bacteria to detect nutrients and quickly spring back to life. This breakthrough could inform the design of ways to prevent dangerous bacterial spores from lying dormant for months before waking up again and causing outbreaks.
Researchers have developed a novel support material called BaAl2O4-xHy that enhances the catalytic activity of cobalt nanoparticles, allowing for record-breaking ammonia production at low temperatures. The catalyst demonstrates improved activation energy and high reusability.
Researchers at POSTECH developed seawater batteries with improved performance by incorporating chelating agents, overcoming limitations of traditional lithium-ion batteries. The new design achieved high energy efficiency and capacity, making it a promising candidate for next-generation energy storage systems.
A team of astronomers detected a massive superflare and prominence eruption on the star V1355 Orionis, which was capable of breaking free from the star's gravity and developing into Coronal Mass Ejections. The event released trillions of tons of material, making it one of the most massive ever observed.
Researchers from UCLA will deliver presentations on innovative approaches to pediatric care, including a trauma-informed care assessment tool and a weight bias curriculum. A mobile phone pilot intervention is also being explored as a potential solution for preventing obesity in Latino preschool children.
Researchers found that vaping in the presence of supplemental oxygen can ignite oxygen, leading to burns, fires, or explosions. The risk is particularly concerning for patients with end-stage COPD on oxygen who want to quit smoking by switching to vaping.
A recent study analyzing 46 million births across nearly three decades reveals a concerning pattern of maltreatment of non-white pregnant women, including disregarding their birthing wishes. The research suggests that medical induction of labor nearly tripled between 1990 and 2017 in the U.S., with no clear association with increased r...
A new analysis of three decades of US food policies defines junk food based on a combination of product categories, processing, nutrients, and place. The study identifies common criteria used in existing policies, including exemptions for staple foods and favoring products with lower levels of processing and additives.
Researchers found that male sea lions have increased in size and strengthened muscles for fighting, while females' body size remained stable. They also diversified their diets to overcome food shortages and adapt to changing prey availability.
Researchers have developed a new germanium-tin transistor that exhibits improved electronic properties compared to silicon-based transistors. The material combines the benefits of germanium and tin, resulting in enhanced performance at low temperatures.
Rice University scientists developed a screening technique to identify high-performing biomaterials for encapsulating insulin-secreting cells, providing long-term blood sugar level control in diabetic mice. The study's findings have the potential to open the door to a more sustainable and self-regulating way to treat Type 1 diabetes.
Heat stress indices, such as humidex and apparent temperature, can provide a more accurate representation of health risks than expected temperatures alone. The study found that areas with critical conditions often differed from regions with the highest temperatures, emphasizing the need for improved communication of heat wave dangers.
The grant aims to develop accurate household food waste measurement methodologies and metrics. Innovative technologies will help create impactful interventions to minimize and eliminate food waste in the United States and globally.
Researchers from China develop a clean and green synthesis of isothioureas via electrochemical three-component reaction using thiols, isocyanides, and amines. This method avoids heavy metal catalysis and stoichiometric oxidants, offering advantages in energy efficiency and waste minimization.
Researchers at the University of Colorado Cancer Center have made a breakthrough in treating pancreatic cancer by combining radiation and immunotherapy. The treatment eradicates tumors while stopping the cancer from spreading, offering new hope for patients. Clinical trials are planned to further develop this therapy.
A machine learning model combines clinical and genetic data to predict the number of eggs retrieved in patients undergoing ovarian stimulation. This study aims to improve IVF procedures by providing personalized predictions, potentially increasing success rates.
Researchers found that first-person photos best represent physical experiences, while third-person photos depict deeper meanings. People intuitively choose perspective for self-representational goals, affecting photo satisfaction and personal motives.
Researchers developed a high-throughput assay to analyze CAR-T cells' effects on 3D tumor spheroid models using plate-based image cytometry. This study demonstrates the potential benefits of this method for assessing potency, specificity, and location of CAR-T cells in relation to spheroids.
A Rutgers University study finds that inhaling plastic particles can disrupt sex hormones in female lab rats, leading to impaired vascular function and decreased reproductive hormone levels. The researchers used a commercially available food-grade nylon powder and aerosolized it for the rats to breathe in.
A team of IUPUI researchers has developed an AI-powered approach to classify insect species, tackling the challenge of discovering new species. The method uses deep hierarchical Bayesian learning to distinguish between known and unknown species, providing insight into their taxonomy and ecosystem impacts.
A new article in Science challenges the notion that fish growth slows down when they spawn. Research by Dr. Pauly and Dr. Froese found that fish actually grow faster after reproducing, as their energy is redirected towards other activities. The study also notes that reproduction does not impact growth in mammals.
A worldwide decline in insect populations is attributed to land-use intensification, climate change, and the spread of invasive animal species. The consequences of this trend include a loss of biodiversity, reduced pollination services, and increased risk to food sources for animals.
Researchers at IOCB Prague have determined the first cryo-EM structures of a surface receptor of Trypanosoma brucei gambiense in complex with human complement factor C3. This discovery sheds light on how the parasite avoids clearance from the human bloodstream and survives within the immune system.
A long-term analysis reveals that approximately one-third of CTEPH patients also have left heart disease, which can worsen breathing symptoms and requires more comprehensive diagnostic approaches. The study suggests that treatment options for both conditions may overlap, necessitating further research to find effective therapies.
The study found that dose-escalated radiotherapy with short-term androgen deprivation therapy improved rates of biochemical failure, distant metastases, and prostate cancer-specific mortality. However, the trial did not meet its primary endpoint of improving overall survival for men with intermediate-risk prostate cancer.
A new test has identified several effective antibiotics rejected by standard testing, suggesting the gold-standard test is incorrect ~15% of the time. This study provides a potential solution to address the disparity between recommended antibiotics and actual patient outcomes.
KIORA's treatment demonstrates restoration of visual function in patients with retinitis pigmentosa. KIO-301 shows promise as a potential cure for blindness due to the degenerative eye disease.
A Cornell University-led project has reconstructed Balto's phenotype using ancient DNA extraction and analysis. The research reveals that Balto had a genetically healthier and less inbred lineage than modern breeds, with characteristics adapted to the extreme environment of 1920s Alaska.
A new study reveals Ukraine's population is declining at an alarming rate due to low fertility, high mortality, and emigration. The crisis has worsened since the Russian invasion, leaving cities devastated and residents displaced.
A new study reveals that analyzing DNA can help predict which animals are most at risk of extinction. By examining the genomes of 240 mammal species, scientists found that those with smaller historical populations carry higher burdens of damaging mutations and are more likely to face extinction.
The Zoonomia Project, involving over 150 collaborators, has cataloged the diversity in mammalian genomes by comparing DNA sequences from 240 species. The project reveals that transposable elements (TEs) are present in all placental mammals and have been transferred to bats via viruses.
A recent study found that early-nesting ducks are vulnerable to habitat destruction and predators when nesting in agricultural fields with debris from previous harvests. Climate change may exacerbate this issue, making it harder for ducks to adapt to the changing landscape.
Climate change could cause a 20-40% reduction in twilight zone life by the end of the century. The study predicts that life in the twilight zone could be severely depleted within 150 years, with no recovery for thousands of years.
Researchers have generalized the traditional Hall-Petch and inverse Hall-Petch relations to a two-variable function, revealing how grain size and grain boundary thickness affect material strength. The study provides insights into the strengthening stage of polycrystals with thick disordered grain boundaries.
A new type of floatable photocatalytic platform composed of hydrogel nanocomposites efficiently proceeds hydrogen evolution reaction. The platform exhibits clear advantages over conventional systems, including efficient solar energy conversion and easy gas diffusion.