Researchers identified a higher rate of clonal hematopoiesis in pediatric cancer survivors compared to age-matched controls. Treatment-induced STAT3 gene mutations were also found at a higher prevalence among survivors of certain childhood cancers, such as Hodgkin lymphoma.
Ultrafast MRI provides beneficial information for predicting DCIS upgrade to invasive cancer, including time to enhancement and lesion size. A study found that UF-MRI can accurately predict lesions diagnosed as DCIS at percutaneous biopsy that will be upgraded to invasive cancer at surgery.
Researchers used unconventional methods to study fruit fly phenotypes, finding that loss of epigenetic mark led to changes in behavior, gene expression, metabolism, and offspring production. This knowledge can aid in predicting ecological patterns of change in wild animal populations.
Researchers have synthesized the first aromatic chloroosmacyclopentatriene featuring a unique M=ClC bond, characterized by a shortest Os–ClC bond distance among the three types of Os–Cl bonds. The compound has been found to exhibit aromatic properties through DFT calculations.
Researchers from Portugal and Cape Verde discover a unique shark nursery in the Sal Rey bay on Boa Vista island, home to juveniles of several endangered species. The area is crucial for shark conservation and also protects marine mammals and turtles, highlighting the importance of its protection.
A study by the American Academy of Neurology found that people with primary central nervous system tumors who are unemployed experience more severe symptoms of pain, discomfort, anxiety, and depression compared to those employed. The research also highlights disparities in unemployment rates among different demographics, such as Hispan...
A University of Utah-led study explores using space dust as a shield to reduce solar radiation and slow global warming. Launching lunar dust from the moon instead of Earth's way station at L1 could be an effective and cheap solution.
Researchers have discovered licorice leaf extract as a potent bactericide and fungicide, offering a sustainable alternative to synthetic pesticides. The extract modulates plant immune responses to pathogens and acts against resistant oomycetes, making it a potential solution for naturally controlling plant diseases.
Scientists have identified small molecules that can target the 'Achilles' heel' of SARS-CoV-2, a less mutation-prone segment of the spike protein. These compounds could serve as a starting point for developing effective treatments for COVID-19.
A severe begomovirus-satellite DNA disease complex has been detected in okra fields in the lower Rio Grande Valley area of Texas, posing a significant threat to cotton production. The complex involves the exotic cotton leaf curl Gezira virus and its associated satellite DNA molecules.
The Cleveland Clinic has launched a phase 1b clinical trial to evaluate the safety and immune response of a preventive breast cancer vaccine in high-risk individuals who have undergone prophylactic mastectomy. The study aims to recruit 6-12 patients and is expected to be completed by the end of 2023.
The grant aims to eliminate barriers and facilitate access to early phase cancer clinical trials for medically underserved communities. Researchers will develop and implement a multilevel program to improve referrals and enrollment, exploring the impact of remote clinical trials on enhancing diversity in trials.
A team of A*STAR scientists has successfully upcycled waste polyethylene terephthalate (PET) plastic into polymer electrolytes, key components for safer lithium-ion batteries. The study achieved room temperature conductivity comparable to existing commercial systems and showed promising performance in repeatedly charged and discharged ...
Researchers at the University of East Anglia found that the Bahama Warbler may only survive on Abaco island after Hurricane Dorian devastated its forest habitat on Grand Bahama. The study, published in Bird Conservation International, reveals that the bird prefers areas with taller, more mature trees and can adapt to burnt vegetation.
Dust from the Moon could be fired into space to attentuate the Sun's rays, a potential solution for climate change mitigation. The study, published in PLOS Climate, calculates the feasibility of this approach.
A new economic model estimates the health benefits and budget impact of Fracture Liaison Services, showing significant reductions in fragility fractures, hospital bed days, and social care costs. The model suggests that FLS implementation would lead to improved patient outcomes and cost-effectiveness.
Researchers from Northwestern University have developed a new biosensor device that accurately detects toxic levels of fluoride in water, allowing for easy use outside of a lab. The device has been field-tested in rural Kenya, showing excellent accuracy and usability results.
A Phase 2 clinical trial found that patients with notalgia paresthetica experienced a significant reduction in itch intensity after taking oral difelikefalin. The medication, currently approved for chronic kidney disease, has the potential to become the first FDA-approved treatment specifically for this condition.
Researchers at the University of Surrey have found promising results for using edge-decorated nano carbons as metal-free catalysts for direct conversion of methane into hydrogen. The study shows strong resistance to carbon poisoning, a common issue with catalysts in this process.
A study of 13,287 children found that early-life adversity was strongly associated with poorer mental health across all ages from 3 to 14 years. Adversity also predicted poorer working memory at age 11 and vocabulary at age 14.
Researchers at the University of Arizona found that rock ants follow a methodical search strategy, combining systematized meandering with random movement to efficiently explore new areas. This unique behavior may provide insights into the evolution of exploration strategies in other species.
A study of over 2,500 U.S. respondents found that most would remove posts spreading misinformation about democratic elections, vaccinations, the Holocaust, and climate change. Characteristics like topic, severity, and repetition had a stronger impact on decisions than account characteristics.
A new study found widespread support for second look sentencing, with respondents backing the approach regardless of age. Factors such as petitioners' intent to reform and victim support increased support for release. The study suggests that releasing reformed individuals can reduce costs and enhance public safety.
Researchers developed an eye-tracking test that accurately identifies toddlers with ASD based on their level of attention to motherese. Toddlers with low attention to motherese showed weaker social and language abilities.
A new study by researchers from Lund University in Sweden has found that women with pregnancy complications are at an increased risk of heart disease. The study revealed that women with pre-eclampsia and gestational hypertension had visible atherosclerosis of the coronary arteries, compared to those without complications.
Researchers from Nanjing University have proposed the first scheme to practically generate N-photon states deterministically using a lithium-niobate-on-insulator platform. The scheme involves deterministic parametric down-conversion and demonstrates feasibility for generating multiphoton qubit states.
Male giraffes test female sexual receptivity by nudging them to urinate, then inhaling their scent with flehmen. This behavior is crucial for mating and understanding giraffe anatomy supports it.
Researchers at Princeton University have developed a new solar absorber gel technology that can filter pollutants from water, producing almost fourfold more filtration rate than its predecessor. The device can provide enough clean water to meet daily demand in many parts of the world.
A new study from Linköping University found that cognitive ability levels do not differentiate wages among top earners, contrary to common defenses of their extraordinary earnings. Average ability plates at a modest level of +1 standard deviation above average cognitive ability for those earning above €60,000 annual wage.
Dr. Carl H. June is recognized for his pioneering work in developing gene-edited cell therapy for cancer and demonstrating its potential to induce remission and cure patients with advanced cancer. His technology has led to the FDA approval of six CAR T-cell therapies for multiple blood cancers.
Researchers propose using brain scans to measure similarity in trademark cases, reducing inconsistencies and bias. This approach provides a reliable method for determining similarity without relying on subjective surveys or expert opinions.
A phase 3 clinical trial of nearly 700 patients with early-stage lung cancer found that sublobar resection surgery, removing part of the affected lobe, was as effective as traditional lobectomy in terms of disease-free and overall survival. Patients who underwent sublobar resection also showed modestly better lung function.
The study uses artificial intelligence to generate new molecules with optimized properties, applicable to various industries. The method enables finding Pareto-optimal solutions, leading to more efficient materials for optoelectronics, solar energy, and other fields.
A national study found that only 19% of hospitals were fully compliant with the federal price transparency checklist, with teaching and non-profit hospitals slightly more adherent. Hospitals in competitive markets had lower compliance rates compared to non-competitive markets.
Conflicts between divergent goals can continue indefinitely through evolutionary time, causing devastating damage to complex organisms and social structures. Modular design is a crucial enabler of complex adaptation and transformative changes in social organisation.
A study published in International Journal of Environmental Research and Public Health found that breastfeeding can reduce arsenic exposure in infants compared to formula feeding. Researchers measured arsenic levels in mothers, babies, and breast milk, revealing a clear association between maternal and neonatal arsenic exposure.
Researchers at the University of Pennsylvania's Working Dog Center trained dogs to distinguish between healthy and diseased deer feces. The dogs showed great specificity in detecting CWD-positive samples, suggesting a potential asset in managing the highly contagious disease.
A new study in Management Science finds that direct load control contracts can reduce peak-demand energy costs by about 5% and summer peak demand by 4,000 megawatt hours. By controlling air conditioners and other devices in residential and commercial units, utilities can increase grid reliability and reduce electricity costs.
A national study found that common risk factors for cognitive decline, such as socioeconomic status and education, explained a modest 38% of the variation in mental abilities among older Americans. Health behaviors like exercise had a small effect on functioning, with only 5.6% explaining the rate of cognitive decline.
Researchers developed a novel material, Cu(I)Cu(II)-BTC, to separate hydrogen isotopes with high efficiency. The unique Cu(I) structure enables synergistic kinetic and chemical affinity quantum sieving, facilitating D2/H2 separation.
Researchers discovered a cluster of enzymes in bacteria that can be reprogrammed to edit proteins and potentially treat human diseases such as Parkinson's and Crohn's. The study also identified key components of the bacterial immune system, including two on-off switches, that could be targeted therapeutically.
Researchers at the University of Notre Dame have successfully developed an allergen-specific inhibitor that prevents peanut allergic reactions in mice. The inhibitor effectively masks the immune system's ability to recognize the allergen, allowing it to fly under the radar without initiating a dangerous response.
The updated guidance emphasizes the importance of healthy skin and nails, as well as easy access to alcohol-based hand sanitizers. Only 7% of healthcare personnel fully clean their hands, highlighting the need for ongoing training in proper technique and glove use.
Researchers at Columbia University's Mailman School of Public Health have identified differences in gut microbiomes between people with ME/CFS and healthy controls. Gut bacteria Faecalibacterium prausnitzii and Eubacterium rectale, which are normally health-promoting, were reduced in ME/CFS participants. The study found a deficient mic...
Female residents face higher risk of unintended attrition, while underrepresented groups also experience elevated risk. The study highlights the need for strategies to support and retain diverse surgical residents.
Researchers have identified a new protein in the cerebrospinal fluid that can reliably detect endothelial injury, a key contributor to cognitive impairment in pre-symptomatic stages of Alzheimer's. The discovery offers hope for improving diagnostic tests and potentially preventing damage to the brain endothelium.
Excessive trabeculation of the left ventricle does not coalesce into a compact myocardial wall, making 'LV non-compaction' an inaccurate term that should be discouraged. The review recommends using 'excessive trabeculation', which can be observed across various health and disease states.
Researchers found differences in gut microbiomes of people with ME/CFS compared to healthy controls, indicating a potential role for the microbiome in the disease. Abnormal levels of specific bacteria and metabolites were associated with reduced butyrate production, which is essential for gut health.
This project aims to identify conditions necessary for abandoning climate-damaging social norms and test their effectiveness on representative samples in different countries. The goal is to find solutions for large-scale sustainable changes in individual and social behavior.
A recent study found that dry scooping, ingesting pre-workout powders without water, is common among adolescent boys and young adult men in Canada. The study analyzed data from over 2,700 participants and showed a significant association between social media use and gym culture participation and dry scooping behavior.
A new webcast from the American Phytopathological Society provides insights into soil biophysical properties and nitrogen application rates in predicting cotton yield and quality. The study suggests including soil biophysical information in making N recommendations to maximize profits and reduce environmental impact.
A new game theory study by Professor Claudius Gros finds that unregulated competition can lead to catastrophic poverty for investors, with profits scaling as 1/N². Cooperation among investors can avoid this damage, resulting in a net profit corresponding to the number of investors.
University of Michigan researchers used artificial intelligence and data science to reduce molecule synthesis time from 7-26 steps to just three steps. The breakthrough has powerful implications for developing medicines, agrichemicals, and materials.
An analysis of cases in Beijing found that two existing Omicron sub-variants, BA.5.2 and BF.7, accounted for more than 90% of local infections between November 14 and December 20, 2022. The study suggests these variants are chiefly responsible for the current surge in Beijing, likely China as a whole.
A scoping review found evidence-based practices improve patient outcomes and reduce healthcare costs. The study also identified areas for improvement in EBP adoption and implementation.
Scientists at Cornell University have discovered a way to precisely locate magma storage in volcanoes, offering improved risk assessment for eruptions. By analyzing carbon dioxide-rich fluids trapped within cooled crystals, they can determine the depth of magma storage and scorching reservoirs with unprecedented accuracy.
A single-dose of the antiviral drug peginterferon lambda reduced the risk of hospitalization or Emergency Department visit due to COVID-19 by half in high-risk patients. The treatment was effective across different variants of concern, including Omicron, and showed minimal side effects.
Researchers found a signal of extreme climate change from 50 million years ago in turbidite deposits, which are evidence of ancient rapid submarine water currents. This suggests that extreme weather events and exacerbated global climatic conditions can amplify delivery of sand into the deep ocean.
A comprehensive registry study found that infants whose mothers used snus during pregnancy were three times more likely to experience sudden infant death. Quitting snus early on lowered the risk, highlighting the need for women to avoid all types of nicotine products during pregnancy.
Researchers from the University of Sussex and Universal Quantum have successfully connected quantum microchips, enabling powerful quantum computers. The breakthrough demonstrates a modular approach to scaling up quantum computing and unlocking its applications in industries such as medicine, materials science, and climate crisis solution.