Researchers developed a nanomedicine that attacks bacteria at the molecular level, reducing antibiotic resistance and side effects. The technology releases medication only when required, ensuring patients take exact amounts to fight infections.
A new class of 1D perovskitoids enables robust stability and high photodetector performance. The π-conjugated cations improve carrier separation and transport capacity, leading to exceptional photocurrent on/off ratios.
A team of University of Houston engineers developed an AI tool to predict and control pandemic spread by analyzing international air travel. The analysis found that reducing flights in Western Europe can lead to fewer global COVID-19 cases, making it a key strategy for controlling the pandemic.
The Endocrine Society's new statement highlights research gaps on opioids' effects on the endocrine system, which can lead to conditions like male hypogonadism and secondary adrenal insufficiency. Clinicians need to monitor patients using opioids for signs of these health consequences.
Metabolic dysfunction-associated steatohepatitis (MASLD) exhibits persistent activation of the DNA damage response (DDR) and its primary transcription factor P53 even after dietary reversal. Elevated P53 levels correlate with hepatocyte ballooning, suggesting a link between DDR signaling and MASLD recurrence.
A study by FSU researchers has found a potential link between an infection caused by gut bacteria and the progression of Alzheimer's disease. The research suggests that antibiotic exposure can lead to issues not just in the gut but also in the brain, triggering neuroinflammation and neurocognitive impairment.
A cohort study of children with vesicoureteral reflux found that glomerular filtration rate changes after urinary tract infections. The study used data from the Children With Vesicoureteral Reflux trial to assess estimated glomerular filtration rate changes in participants with vs without recurrent UTIs.
Researchers designed a skin patch that uses imperceptible electric currents to control microbes, stopping 99% of biofilm formation in bacteria. The device, called Bioelectronic Localized Antimicrobial Stimulation Therapy, could lead to a wearable patch with a wireless circuit to control infections without drugs.
A new approach to lyotropic chromonic liquid crystal assembly has been developed using charged π-electronic molecules. The assembled materials exhibit optical anisotropy, magnetic susceptibility, and temperature-dependent orientation, enabling the design of materials with specific properties.
TYRA-300 shows promise in treating metastatic bladder cancer patients with FGFR3 gene mutations, achieving a 50% overall response rate and 100% disease control rate. The treatment also displays improved tolerability with lower side effects compared to existing pan-FGFR inhibitors.
A new study reveals widespread resistance of Pseudomonas aeruginosa to commonly used cleaning agents, including quaternary ammonium compounds. The researchers identify biocides that work well against the pathogen, highlighting the need for revised sanitation protocols in hospitals and homes.
Commercial gambling poses a threat to public health, with 448.7 million adults worldwide experiencing risk gambling and 80 million experiencing gambling disorder. The new Commission report calls for increased regulation to tackle these harms, particularly among children and adolescents.
Researchers have developed Rastermap, a visualization tool that enables scientists to uncover activity patterns in thousands of neurons. The tool sorts neuronal activity into clusters based on similarity and maps them onto a graphical representation, allowing for the identification of patterns that can be further tested in the lab.
Scientists at UCLA have engineered an experimental therapy that shows promise in enhancing heart repair following a heart attack, preventing the onset of heart failure. The new single-dose therapy targets the protein ENPP1, which is responsible for increasing inflammation and scar tissue formation.
Researchers developed an in vitro model of murine peritoneal macrophage aging to study molecular mechanisms and develop innovative strategies. Chronic treatment with CB3 completely prevented the increase of p21CIP1 and maintained proliferative activity in day 14 macrophages.
Researchers developed a mouse model mimicking the liver symptoms of myotonic dystrophy type 1, revealing fatty liver disease and hypersensitivity to medications. The study found that a gene regulating fat synthesis is misspliced in affected livers, providing potential treatment pathways.
The study proposes an innovative DNA Palette coding scheme for efficient storage of digital information in DNA. The code uses unordered combinations of index-free oligos to construct a bijective mapping between binary information and oligos, offering high net information density and data recovery capabilities.
A study of 292 species reveals that even large animals like whales and elephants are not immune to cancer, challenging Peto's paradox. The data suggests that different strategies, such as lower somatic mutation rates or unique tumor suppressor genes, may be responsible for some species' exceptional resistance to cancer.
Non-Hispanic Black patients are more likely to receive inadequate care and experience poor survival outcomes due to delays in treatment initiation. Guideline-concordant care is crucial in improving survival rates among these patients.
A study by Chapman University scientists assesses how much land can be restored, carbon captured, and water required to support ecosystems. The findings provide a nuanced understanding of trade-offs between carbon sequestration and water security.
Researchers at the University of Chicago and UC San Diego have developed a cutting-edge bioelectronic device that harnesses the natural electrical activity of certain bacteria to manage infections. The device achieves remarkable results by delivering gentle electrical signals, reducing bacterial colonization nearly tenfold.
Researchers found that patients taking semaglutide had a significantly lower risk of developing Alzheimer's disease compared to those on other anti-diabetic medications. The study suggests potential benefits for preventing neurodegeneration and neuroinflammation.
Researchers at Penn State and MIT have discovered a room-temperature non-reciprocal Hall effect, which challenges fundamental principles of physics. The finding has potential implications for developing new technologies such as quantum communication, energy harvesting, and terahertz imaging.
Researchers developed a new system to produce high-yield proteins in lettuce by silencing specific genes. This method increases recombinant protein expression by over two times, making it a promising alternative for large-scale production.
A study found that 4.6% of Nigerian participants with COVID-19 experienced neurologic symptoms, with some still experiencing symptoms two years after their initial episode. Researchers plan to treat these patients using similar techniques used in the US, aiming to alleviate their suffering.
Sedimentary organic carbon distribution varies by region in eastern China seas, with higher concentrations in mud areas. Organic carbon burial fluxes are calculated to be 8.20 Mt C a⁻¹, accounting for 5.3% of global seabed burial flux.
Researchers at Lund University successfully produced livermorium atoms using a new method, opening the door to creating even heavier elements like number 120. The discovery was made possible by a custom-built detector system called SHREC, which allowed for efficient registration of the atoms.
US wildfires have surged in growth rates over the last 2 decades, with fast fires accounting for 89% of structures damaged or destroyed. These rapid-growing fires present significant challenges to evacuation efforts and firefighting operations, resulting in greater loss of life and infrastructure damage.
Researchers analyzed opioid industry documents and found that 15 key articles were cited to support unsubstantiated claims about prescription opioids' safety and effectiveness. The study highlights the need for regulatory safeguards to protect public health, particularly for potentially addictive pharmaceuticals.
A new study from UT Arlington found that setting reminders can significantly reduce age-related declines in memory, particularly in prospective memory. The study suggests that reminders help counteract cognitive strain by making memory retrieval less reliant on internal processes.
A study published in Water Biology and Security reveals spatial and temporal patterns of biodiversity in four taxonomic groups along the Za'gya Zangbo River. The findings emphasize the importance of considering multiple biological groups in biomonitoring high-altitude rivers, and highlight areas that require targeted conservation efforts.
A new predictive model estimates that up to 95 million Americans may rely on contaminated groundwater for drinking water before treatment. This highlights the need for increased monitoring and awareness of Per- and polyfluoroalkyl substances (PFAS), which are linked to adverse environmental and health effects.
A study in mice reveals that individualistic reward-seeking strategies predict responses to nicotine, with profiles influenced by personality traits and dopamine activity. The findings suggest environmental adaptations shape behavioral traits and sensitivity to nicotine, potentially contributing to addiction susceptibility.
A study by Washington State University found that rural adolescents in Washington state generally engage in pro-social firearm-related behaviors, such as hunting and recreation. The study used a mix of qualitative and quantitative research to understand rural youths' interactions with firearms and their perceptions of firearm-related s...
Prolonged exposure to incense smoke can cause headaches, respiratory dysfunction, dermatologic sensitivity, and allergic reactions in individuals with pre-existing conditions like asthma. Switching to electric or aromatic vapors, improved ventilation, and limiting burn time may help mitigate these risks.
Researchers discovered that sea urchin larvae open their pylorus and anus entrances in response to different wavelengths of light, allowing for efficient digestion and nutrient absorption. This light-regulated control of the digestive tract may have evolved to help metazoans adapt to changes in their environment.
This study investigates the role of GPX4 methylation in ferroptosis during hepatic ischemia-reperfusion injury. Ferroptosis is observed in oxygen and glucose deprivation, characterized by decreased cellular viability and increased lipid peroxidation.
Advances in biointegrated flexible and stretchable optoelectronics enable physiological monitoring and treatment for cardiovascular disease. Novel strategies focus on stretchable design, device-biological tissue interface design, and encapsulation of biointegrated optoelectronic devices.
Researchers develop innovative technology to capture large amounts of water from the air in low humidities, addressing water scarcity in drought-stressed Southwest. The device can generate up to three times more water than existing approaches, with potential for solar power and commercial use.
Results from the DanGer Shock trial show a 12.7% reduction in all-cause mortality with routine use of Impella CP in STEMI and cardiogenic shock patients. The Impella ECP pivotal study will also be presented, demonstrating safety and survival benefits for high-risk PCI patients.
A team of researchers developed a DNA-based fluorescent reporter that can efficiently target endosomes and lysosomes in live cells to monitor zinc ion levels. The study found a positive correlation between zinc levels and Alzheimer's disease markers, including A° aggregation and learning/memory impairments.
Researchers identified a key gene pathway involving zinc that improves survival and weight gain in mouse models with short bowel syndrome. Zinc-based supplements were shown to improve intestinal function, absorb nutrients, and fluids, leading to better recovery rates.
Researchers have developed a technology called FarrSight-Twin that creates digital twins of real cancer patients to predict treatment response. The approach was tested on published clinical trials and showed accurate predictions in all simulated studies, with 75% response rate among patients receiving the predicted best treatment.
Researchers analyzed a thermophotovoltaic system paired with phase-change materials for energy storage and found slight reductions in costs. The study identified key factors affecting TPV system costs, highlighting the need for future research to improve adoption and efficiency.
Two studies reveal that anaphylaxis management remains unclear, with only 14% of respondents confident in using epinephrine. EMS protocols also vary widely, with outdated definitions and inadequate recommendations for treatment.
A new study shows that syphilis patients labeled as penicillin allergic but low risk can safely have their allergy label removed, avoiding treatment failure and negative health consequences. This delabeling helps to improve treatment outcomes and reduce healthcare utilization.
A stroke damages the body's natural repair system, which generates newborn neurons to replace damaged cells. This disruption is caused by activated microglial cells in the subventricular zone, leading to reduced survival of newborn neurons compared to healthy brains.
Researchers argue that current cannabis policies are driven by politics, not science, and call for a shift towards harm reduction and health promotion. The field should use the social ecological model as a framework for developing comprehensive policies.
A Mayo Clinic study found that standing on one leg shows the highest rate of decline with age, indicating balance as a crucial aging indicator. The research suggests people can train their balance without special equipment to maintain independence and well-being.
Researchers at UC Santa Cruz have developed a highly accurate and affordable spectrometer that can be customized for specific applications. The device uses machine learning algorithms to reconstruct images with high accuracy, enabling astronomers to study phenomena such as exoplanet atmospheres and dark matter in faint galaxies.
Researchers found specific gene mutations in barley affect starch synthesis, forming elongated starch granules with altered properties. Mutations disrupt enzymes, altering glucose chain formation and branching.
A new study led by Dr. Jasmine Weiss found that HBCU students face three major themes in navigating medical school: complex institutional relationships, preferential treatment concerns, and the importance of a 'village mindset'. The study highlights opportunities for medical schools to engage with HBCUs and attract diverse student bodies.
Scientists have discovered a long non-coding RNA called CHASERR that regulates the production of the CHD2 gene, which is associated with neurodevelopmental disorders. The study found that patients with a deletion of this RNA had excessive CHD2 protein production, leading to severe intellectual delays and other symptoms.
A three-decade study found polar bears exposed to increased pathogens due to environmental changes, with females at higher risk. The study, published in PLOS ONE, highlights the need for further disease screening in polar bear populations.
The use of GLP-1 receptor agonists (GLP-1RAs) and SGLT2 inhibitors in people with type 1 diabetes has significantly increased between 2010 and 2023. This trend is driven by their benefits in weight management and cardiorenal protection, but caution is advised due to concerns about euglycemic diabetic ketoacidosis.
Researchers analyzed 8,455 cells from 65 human embryos, finding sex chromosomes play a dominant role in early development but diminish over time. Sex differences are driven by X chromosome inactivation and lineage differentiation, influencing growth, hormone production, and immune system development.
Researchers say implementing established strategies is critical to addressing the physician well-being crisis, including reducing workload and facilitating timely mental health treatment. The review also highlights the need for policies supporting diverse perspectives to improve well-being among underrepresented groups.
A study led by Graciela Pineyro and Tomas Paus found that cannabis use in adolescence can lead to thinning of the cerebral cortex, affecting communication between neurons. The researchers used a combination of methods to demonstrate THC's impact on brain cells and identified genes associated with cortical thinning.
A new study has found that rifaximin, an antibiotic commonly prescribed for liver disease patients, is driving the emergence of a deadly superbug. The antibiotic triggers specific changes in bacteria that make them resistant to last-resort antibiotics like daptomycin.
A new study from the University of Texas at Arlington suggests that analyzing RNA in urine can show changes in cell types, revealing early signs of cancer and other diseases. This method could help clinicians detect problems earlier when they are more easily treated without invasive procedures.