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Science News for April 27, 2024


Global cervical cancer vaccine roll-out shows it to be very effective in reducing cervical cancer and other HPV-related disease, but huge variations between countries in coverage

The global cervical cancer vaccine roll-out has shown significant effectiveness in reducing HPV-related diseases. However, there are huge variations in coverage between countries, with high-income nations leading the way and many low- and middle-income countries lagging behind. Globally, only 44% of girls have received at least one dos...

Electro-optic tuning in composite silicon photonics based on ferroionic 2D materials

Researchers have demonstrated a novel approach to actively manipulate light using ferroionic 2D materials. These devices exhibit exceptional modulation efficiency and low optical losses, enabling applications in telecommunications, neuromorphic computing, and beyond.

Lower dose of mpox vaccine is safe and generates six-week antibody response equivalent to standard regimen

Researchers developed a dose-sparing intradermal mpox vaccination regimen that was safe and generated an antibody response equivalent to the standard regimen at six weeks. The results suggest this regimen could be used during future outbreaks to extend limited vaccine supply, but more study is needed to confirm its efficacy.

USTC reveals molecular mechanism of transmembrane bilirubin transport by human ABCC2 transporter

Researchers from USTC have successfully revealed the three-dimensional structure and working mechanism of the human bilirubin transporter ABCC2. The study proposes a unique regulatory domain that controls substrate recognition and transport, providing new insights into bilirubin metabolism and potential targeted treatment of related ge...

SourceUniversity of Science and Technology of China·JournalNature Communications·DateApr 27, 2024

USTC reveals interaction mechanism between intestinal microbial environment and tumor immune microenvironment

Researchers have identified a novel pathway of interaction between the intestinal microbial ecosystem and the tumor immune microenvironment. They discovered that certain bacteria, such as C. scindens, produce secondary bile acids that suppress the effector function of CD8+ T cells, promoting colorectal cancer growth.

USTC constructs sophisticated synthetic system using self-replicating nanostructures

Researchers at USTC construct a synthetic system using self-replicating nanostructures, overcoming existing challenges in programmable assembly. The system demonstrates remarkable accuracy in recognizing and transmitting template information during replication, facilitating the creation of large-scale ordered nanomaterials.

SourceUniversity of Science and Technology of China·JournalAngewandte Chemie·DateApr 27, 2024