Researchers at UNC School of Medicine discovered the detailed protein structure of the TAS2R14 bitter taste receptor, revealing how it identifies and activates bitter tastants. The discovery has potential applications in drug development for metabolic diseases like obesity and diabetes.
A team of researchers used a single-cell transcriptomic map to investigate the role of androgens in shaping sex differences. They identified genes influenced by androgens and found that group 2 innate lymphoid cells play a role in inflammation and disease susceptibility.
Researchers at the University of Eastern Finland have identified coregulator proteins as an alternative target to prevent drug resistance in prostate cancer. By inhibiting these proteins, the growth of drug-resistant cancer cells can be inhibited, and the activity of the glucocorticoid receptor can be limited.
Researchers found termites use humidity to guide their nest-building activity, not relying on pheromones. The study used artificial structures with varying heights and shapes, tracking termite behavior and correlating it with changes in the 3D structure.
A new machine-learning approach outperforms human testers in generating diverse prompts that trigger a wider range of undesirable responses from chatbots. The technique provides a faster and more effective way to ensure the safety of large language models.
Researchers at Tokyo Medical and Dental University have developed a novel method for coating engineered messenger RNA molecules with polyethylene glycol (PEG), allowing selective delivery to the spleen. This breakthrough enables fine-tuned control over mRNA therapy, facilitating effective treatment of diseases previously considered inc...
UCI researchers have found that axons in the hippocampus play a role in generating slow waves and sleep spindles, crucial for deep sleep. The study suggests that these oscillations occur independently of neuronal spiking activity, offering new insights into memory processing during sleep.
A new study suggests that the benefits of hormone therapy for women over 65 years old differ greatly depending on the type, route, and dose prescribed. The use of estrogen monotherapy beyond age 65 was associated with significant risk reductions in mortality, breast cancer, and other health issues.
Researchers developed a bioinspired mechanical reinforcement strategy to improve polysaccharide-based membrane properties. The dual-scale network nanocomposite membrane exhibited excellent wet mechanical properties and good biological properties, indicating its large biomedical application potential.
A single low dose injection of esketamine given immediately after childbirth reduces major depressive episodes in individuals with depressive symptoms during pregnancy. The results suggest that low dose esketamine should be considered in new mothers with prenatal depressive symptoms, potentially preventing one major depressive episode ...
Researchers at Columbia University Irving Medical Center have discovered a genetic variant in the fibronectin gene that protects against Alzheimer's disease. The variant, found in APOEe4 carriers, reduces the odds of developing Alzheimer's by up to 70% and may help prevent or treat the disease.
A new study found that climate change has led to changes in ant species in Gregory Canyon, Colorado, with some species expanding their habitats and others becoming less widespread. The research suggests that these changes could have implications for ecosystem stability and biodiversity.
Researchers at IRB Barcelona have identified 'coldspots' in the cancer genome with lower mutation rates, linked to low DNA methylation. This discovery could facilitate targeted therapies and diagnostic tools to monitor specific genomic regions and prevent cancer development.
A new three-step prostate cancer screening method can detect aggressive cancers while minimizing the detection of insignificant ones. The study found that this approach reduces unnecessary diagnoses and may lead to improved mortality rates.
Researchers have discovered a direct link between the C122Y mutation in the Kir2.1 potassium channel and life-threatening arrhythmias in Andersen-Tawil syndrome, which affects fewer than 1 in a million people. The study highlights the importance of understanding the molecular mechanisms underlying cardiac arrhythmias.
A new study analyzing building footprints in US metropolitan areas identifies five distinct neighborhood types associated with varying socioeconomic and demographic traits. These neighborhoods differ in footprint size, shape, and placement, reflecting differences in population density, homeownership rates, and commuting habits.
As Gen X individuals aged, their attitudes toward evolution solidified, with education and civic scientific literacy strong predictors of increased acceptance. Fundamentalist religious beliefs were associated with rejection of evolution.
A team of scientists at Scripps Research and Calibr-Skaggs Institute has developed a lung-targeted drug to stimulate the growth of lung stem cells. The new findings provide a biological proof of concept for activating regenerative pathways and restoring damaged lung tissue.
A recent NIH study found that children living near natural spaces from birth experience fewer emotional issues between ages 2 and 5. Higher levels of green spaces were linked to lower anxiety and depression symptoms during this period.
Researchers have identified the first inhibitors of the cancer-related RNA-modifier METTL16, which prevent its interaction with RNA. This breakthrough lays the foundation for novel RNA-targeting therapeutics and better investigation of METTL16's role in disease and health.
A study in Hainan Province, China, evaluates the progress of green and sustainable agriculture, finding improvements in socioeconomic development and agricultural productivity. However, environmental degradation remains a challenge, with high resource input and waste management issues hindering sustainable development.
The COVID-19 pandemic highlighted the need for high-quality dementia care in nursing homes, where residents face social isolation and staff challenges. Experts emphasize person-centered care, resident involvement, and community connections to improve outcomes.
Researchers have developed an innovative underwater vest that captures disturbances in water flow caused by fish movements, enabling precise monitoring of their natural behaviors. The device's pseudocapacitive pressure-sensing units offer a robust and noninvasive approach to studying aquatic behaviors.
Chemists develop new reactions using model systems and substrates to demonstrate versatility. A new computer-aided method reduces subjective bias by analyzing real pharmaceutical compounds' complexity and structural properties. This improves data quality and facilitates machine learning applications.
Researchers at the University of Montana have found a novel method to generate human cartilage using neural crest cells. This breakthrough could lead to effective treatments for repairing craniofacial cartilage damage and improving the lives of 230,000 children born annually with craniofacial defects.
A new national poll finds that 60% of people aged 50-80 have visited urgent care clinics or retail clinics for medical care in the past two years. Many sought immediate attention, vaccinations, or tests, and 75% plan to use these sites again in the next two years.
Researchers from NTU Singapore have created a method to extract over 80% of the available protein in grain leftovers from brewing beer, commonly known as brewers' spent grain. The extracted proteins could be used commercially to enrich human diets and cosmetic products, providing an eco-friendly alternative to conventional ingredients.
A review of current research on Australia's non-perennial rivers highlights the need for a new type of research attention due to emerging threats from climate change and human impacts. The study emphasizes the importance of addressing knowledge gaps to preserve and protect these vital waterways.
Researchers at NIH developed a novel AI-based method called P-GAN to improve next-generation imaging of cells in the retina. The technique reduces imaging acquisition and processing time by 100-fold, yielding greater contrast and improving image quality.
The review found women report lower sleep quality, more fluctuations, and higher likelihoods of developing restless legs syndrome and sleep-related eating disorder. Women's brains respond differently to food images after sleep deprivation, with increased emotional processing and activation.
Researchers found that feline sprayed urine originates solely from the bladder, but its strong and pungent odor is caused by enhanced adhesion to vertical surfaces. The specific urinary protein cauxin plays a crucial role in scent marking by producing cat-specific odorants and increasing wettability of sprayed urine.
A new study by SMU psychologists reveals that interpersonal racial discrimination has a significant impact on the mental health of adolescents in the US justice system. The research emphasizes the importance of considering these intersecting factors when providing support systems to meet the unique needs of adolescents of color.
A new study from the Keck School of Medicine of USC found that genome-wide association studies' imputation technique works better for European, African American, and Latino groups than others. The researchers evaluated over 100 global populations, finding that imputation is less reliable for those farther away from Europe.
Researchers at Linképing University have developed a digital display screen where LEDs react to touch, light, fingerprints, and the user's pulse, among other things. The screen can also be charged through the screen due to its ability to act as solar cells.
The World Cybercrime Index ranks countries by cybercrime threat level, identifying Russia as the top hotspot. The study's findings suggest that a small number of countries house the greatest cybercrime threats, with the UK coming in at number eight.
A team of Australian scientists has developed a step-by-step guide to ageing octopus, using growth rings on beaks and stylets to validate age. This tool helps estimate growth rates, reproduction, and maturity, ensuring sustainable fisheries and conservation.
Researchers found that larger pretzels are consumed more quickly with larger bites, while smaller pretzels are eaten slower with smaller bites. Despite this, people still consume more sodium when eating smaller pretzels due to their higher surface area.
Researchers have developed a waterproof 'e-glove' that transmits hand gestures made underwater to a computer, translating them into messages with 99.8% accuracy. The technology could help scuba divers communicate better with each other and boat crews on the surface.
Researchers from USP produced maps showing areas of highest air pollution concentration and peak emissions periods; bus drivers have higher exposure levels than car or subway users. The study also found that green spaces have the best air quality, while high-rise buildings negatively affect dispersion.
Researchers at The University of Tokyo successfully connected lab-grown brain-mimicking tissue using axonal bundles, mimicking natural brain connections. This breakthrough enables the study of complex brain networks and their role in various neurological and psychiatric conditions.
Researchers have reconstructed the mouth of an ancient jawless fish using CT scanning techniques, suggesting it was a filter-feeder rather than a scavenger or hunter. The study reveals that early vertebrates had a diverse range of feeding behaviors before jawed animals evolved.
The RUBY reporter uses a vivid red betalain pigment to visually confirm gene expression in soybean plants, allowing for quick assessment of genetic modifications. Transgene-free homozygous mutants exhibit distinct green coloration, simplifying selection from transformed seedlings.
Researchers demonstrate how a simple mirror design can amplify radiative cooling processes for buildings. The mirror structure effectively guides thermal radiation towards the most transmissive portion of the atmosphere, increasing cooling power.
A new study published in the Journal of the American Heart Association suggests that treating gum disease after a heart rhythm ablation procedure can lower oral inflammation and reduce the risk of AFib recurrence. Researchers found that an index measuring the severity of gum inflammation was associated with the return of AFib, highligh...
A new study found a link between midlife racial discrimination and increased levels of Alzheimer's disease markers, including phosphorylated tau181 and neurofilament light, in older age. Researchers analyzed data from 255 Black Americans over 17 years, revealing that chronic stress from racism contributed to dementia risk.
Researchers achieve tunable ultrafast laser state active controlling by utilizing anisotropic quasi-1D material Ta2PdS6. The material enables the sustainment of two distinct laser states: conventional soliton (CS) and noise-like pulse (NLP). Numerical simulation reveals the mechanism behind the switchable laser state.
This study evaluated somatic copy number alterations (SCNAs) and mutation landscapes in malignant rhabdoid tumors before and after treatment. The results revealed recurrent SCNAs harboring genes involved in tumorigenesis, with some correlations between gene expression and tumor progression.
A new generative AI tool models the infant microbiome, predicting neurodevelopmental deficits. The Q-net model predicts which babies are at risk for cognitive deficits with high accuracy, identifying potential treatment targets.
A new study from Australian National University reveals that Pacific cities were established around AD 300, 700 years earlier than previously thought. This discovery sheds light on the indigenous innovation of urbanisation in the Pacific, which developed before Western influence.
Researchers deciphered the molecular structure of bulevirtide in complex with HBV/HDV receptor NTCP, revealing a unique 'plug' that inhibits virus entry. The study also sheds light on evolutionary adaptation of HBVs to host species and provides insights for developing smaller, more effective active agents.
Scientists developed a force-controlled release system harnessing natural forces to trigger targeted release of molecules, advancing medical treatment and smart materials. The breakthrough uses rotaxane technology to release multiple functional molecules simultaneously, including medicines and healing agents.
FAPESP aims to create new opportunities for scientific and technological cooperation between researchers from Brazil and the US Midwest, focusing on areas such as health, sustainability, and climate change. The initiative also promotes transdisciplinary research collaborations to address global challenges.
Zero trust architecture (ZTA) aims to prevent internal attacks by restricting behavior based on resource-based security policies. AI-powered automation and orchestration can help overcome implementation challenges, relieving security personnel from manual tasks.
Researchers from Aalto University found that individuals who gave up their smartphones had to adapt to life without the convenience of mobile apps. They employed technical workarounds such as using stand-alone devices or borrowing friends' phones to overcome limitations in daily life.
A new study from China found that higher GDP per capita and lower income inequality are associated with increased subjective well-being. However, when income inequality becomes too high, the link between economy and mental health disappears. The researchers advocate for a balanced approach to economic planning.
Researchers found that autocratic regimes have a higher degree of control over transit networks, enabling state-led monitoring and control of internet traffic. This is achieved through state-owned entities dominating transit networks in poorer but politically similar countries.
Researchers found that cardiologists who received payments from LVAD manufacturers were more likely to use those devices during percutaneous coronary intervention procedures. The study highlights the need to reevaluate industry gifts and their potential impact on clinical decision-making.
Researchers at FAMU-FSU have created a sustainable polymer product from CO2 and lignin, fully degradable without microplastics or toxic substances. The material can be recycled repeatedly without losing properties, enabling a true circular economy.
A study found an association between climate change and stroke deaths, with most strokes linked to lower-than-optimal temperatures. The research highlights the need for further investigation into the impact of temperature changes on stroke and potential health policies to address climate-related health inequalities.
A new database of 1,500 Indigenous Australian message sticks has been analyzed for the first time, revealing details about the symbols and markings used to convey messages over long distances. The study provides valuable insights into the ancient communication methods employed by Australia's indigenous peoples.