Researchers at Buck Institute for Research on Aging propose an alternate strategy for reversing memory problems in Alzheimer's disease by targeting the KIBRA protein. The findings suggest that KIBRA can rescue mechanisms that promote synapse resilience, potentially leading to improved memory function.
A new machine learning model has provided new insights into early language acquisition by analyzing video and audio recordings of a single child over 1.5 years. The model, trained on the child's first-person perspective, showed that it could learn word-referent mappings present in the child's everyday experience.
The study found that prices for unbranded generic drugs are about 67% of the average cost in comparison nations, while name-brand drug prices are 4.22 times higher. The US accounted for 62% of sales but just 24% of volume in 2022, with total drug spending reaching $989 billion.
A new study by Massachusetts General Hospital researchers uses advanced brain recording techniques to identify cells involved in language production, allowing them to predict speech sounds. This finding could lead to the development of artificial prosthetics or brain-machine interfaces capable of producing synthetic speech.
Researchers identified 180,940 people who had suffered a recent stroke and matched them to control groups to evaluate dementia risk after stroke. The study found that the rate of post-stroke dementia was higher than the rate of recurrent stroke over the same time period.
A systematic review and meta-analysis of 104 studies with 341,000 participants found that physical activity was associated with better late-life cognition, although the association was weak. The findings suggest that even a weak link between physical activity and cognitive decline is still important from a population health perspective.
Scientists have imaged microtubule formation in unprecedented detail, revealing a complex process that involves the gamma-tubulin ring complex and a newly-discovered latch mechanism. The findings hold promise for developing targeted therapies for various diseases, including cancer and neurodevelopmental disorders.
Researchers at OHSU-PSU School of Public Health developed guidelines for measuring key demographic variables and promoting inclusive demographic data practices across student-serving programs. The study aims to address inequities and support recruitment and retention of underrepresented students in STEM fields.
Researchers at TU Dortmund University have developed a highly durable time crystal that outlasts previous experiments by tens of thousands of times. The team discovered a way to stabilize the crystal using nuclear spins, enabling it to maintain its periodic behavior for up to 40 minutes.
A new study found that structured telephone-based psychological care can significantly reduce depression levels and combat loneliness. The trial, which lasted eight weeks, showed benefits even after the phone calls ceased.
New research reveals that governments and businesses rely on unsustainable amounts of future CO2 removal, posing risks to food security, human rights, and natural ecosystems. The study calls for policymakers to set separate targets for emission reductions and removals, prioritizing restoring natural ecosystems.
A new RAND report finds that US insulin prices are more than nine times higher than in 33 high-income countries. After accounting for rebates and discounts, US net prices remained 2.3 times higher. The study updates earlier findings on US insulin prices and highlights the need for policy changes to address these disparities.
Research from the University of Bath found that people who view stressful situations as threats are more likely to experience health problems, including depression and physical illnesses. In contrast, those who see challenges may report better health and wellbeing, with a suppressed immune system being a key factor.
Researchers found that Black women who develop high blood pressure before age 45 are twice as likely to suffer a stroke. The study, presented at the American Stroke Association’s International Stroke Conference 2024, highlights the disparity in stroke rates among Black and white women.
Researchers have developed a mussel-inspired antimicrobial coating that can effectively protect healthcare fabrics from pathogens and reduce the risk of infection. The coating has been shown to exhibit high efficacy against a broad spectrum of microbial species, including multi-resistant microorganisms.
Scientists at Helmholtz Institute for RNA-based Infection Research developed a new method called SHIFTR, enabling the discovery of interactions between specific RNA regions and proteins in live cells. This breakthrough has shed light on SARS-CoV-2 replication and identified potential targets for innovative antiviral therapies.
A recent study found that a stroke or combined with a neck artery tear significantly increases the risk of heart attack within a year. The researchers analyzed health data from over 800,000 adults and discovered that carotid or vertebral artery dissections without a stroke do not raise heart attack risk.
A study found that tenecteplase is safe and effective for treating ischemic stroke in mobile stroke units, offering a simpler alternative to alteplase. The new medication requires only a single injection, reducing administration time and complications.
Researchers developed a mathematical model showing how cicadas come to a consensus about local average temperature, leading to large-scale swarms. The model is related to those describing 'avalanches' in decision-making among stock market traders, highlighting the importance of communication in collective behavior.
The UK Centre for Multimodal Correlative Microscopy and Spectroscopy (CoreMiS) will enable researchers to analyze environmental samples with unprecedented detail. CoreMiS has already been used to study ancient artifacts, detect pollutants in drinking water, and investigate antimicrobial resistance.
According to Amy Muise's research, the Five Love Languages theory doesn't hold up, as people tend to rate all expressions of love highly. Instead, she suggests a 'balanced diet' approach, where partners need multiple expressions of love simultaneously.
Researchers have identified two genetic factors, LSH1/LSH2, that promote the production of specialized root cells required for nitrogen-fixing bacteria to thrive in legumes. This discovery brings us closer to engineering non-legume crops to develop root nodule organs and reduce our reliance on industrial nitrogen fertilizers.
Researchers found that X-chromosome inactivation can lead to autoimmune disorders, but other factors also cause them. The study suggests that the unique combination of proteins generated during this process may trigger a strong immune response, increasing the risk of autoimmunity in women.
Researchers from Columbia University found that bacteria in biofilms have a highly structured arrangement, allowing them to control physiological states and survive during antibiotic treatment. This discovery could lead to developing new drugs targeting antibiotic-resistant bacteria.
A machine learning technique called LASSO was used to analyze blood samples from six countries, identifying seven genes that can predict the risk of developing a secondary respiratory bacterial infection. The findings aim to guide clinicians in making more informed decisions about antibiotic use.
A new study warns that climate change could reduce global wheat production by 13% by 2050 due to the spread of the fungal disease wheat blast. The affected regions will include South America, southern Africa and Asia, where up to 75% of total wheat acreage could be at risk.
Researchers developed a transmissive thin scintillator using perovskite nanocrystals to track and count single protons with exceptional sensitivity. The new detectors offer unparalleled sensitivity and could revolutionize proton therapy and radiography.
Scientists at the Garvan Institute of Medical Research have identified unique DNA methylation patterns in phyllodes tumours, allowing for accurate diagnosis and distinction from other cancers. The discovery could lead to improved diagnosis and treatment options for patients with this rare disease.
Researchers have discovered a key enzyme that stops cancer cell death and found it plays a pro-survival function in cancer cells. This finding provides crucial information for developing new cancer-fighting strategies.
Research at Columbia University Mailman School of Public Health found that social inequity contributes to lower use of epidural analgesia among non-Hispanic White and African American women. In counties with high social inequity, labor neuraxial analgesia was used by 72% of African American women, compared to 78% in low-equality counties.
Scientists found that short-chain fatty acids produced by gut bacteria suppress allergic reactions by modulating mast cell activation and epigenetic modifications. This study provides new insights into the relationship between diet and immune system regulation, with potential applications in allergy treatment.
Novel research by University of Oklahoma-led team improves understanding of ammonia oxidation, a critical component of the global nitrogen cycle. Different AOM lineages employ varying regulatory strategies to minimize competition, allowing coexistence in the same environment.
The latest APA journals issue highlights new developments in understanding and treating opioid and cannabis use disorders. The focus also includes trends in telepsychiatry and emerging topics in reproductive psychiatry.
Researchers identified a next-generation BTK degrader that can destroy cellular targets and shrink tumors in drug-resistant CLL patients. The compound, NX-2127, showed promising results in laboratory studies and a phase 1 clinical trial.
A new study published in Science found that eradicating non-native animals to protect plant species can be a flawed practice, costing millions and slaughtering healthy wild animals. The research compared the effects of native and introduced large herbivores on plant communities, finding no significant differences.
New research finds that Black, Indigenous, and People of Color (BIPOC) individuals experience greater negative impacts on their health status, activity levels, and ability to work after COVID-19 infection compared to white participants. The study highlights the need for equitable health interventions for underserved populations.
A systematic analysis by MedUni Vienna's Center for Public Health found that people experiencing homelessness are twice as likely to develop cancer due to increased exposure to risk factors. Key barriers include lack of access to preventive services, inadequate support from healthcare systems, and traumatic experiences.
A recent study explores the genetic and metabolic diversity of microbial communities in hypersaline lakes, uncovering novel biological compounds and pathways. The research reveals over 3,000 unclassified microbial species, most of which are new to science, with vast potential for biotechnological innovation and environmental remediation.
The team proposed a novel machine learning model with data augmentation, which accurately predicts the plastic anisotropic properties of wrought Mg alloys. The model showed significantly better robustness and generalizability than other models, paving the way for improved design and manufacturing of metal products.
Researchers at UW-Madison have developed a groundbreaking method for 3D printing functional human brain tissue, which can grow and function like typical brain tissue. The printed cells form connections, send signals, and interact with each other through neurotransmitters, mimicking the complexity of human brains.
A preliminary study found that most stroke survivors can safely take two common types of antidepressants without increasing the risk of hemorrhagic stroke. However, patients on dual anti-platelet therapy may be at increased risk of bleeding.
The Butantan-DV vaccine has been shown to be effective in preventing dengue development in 79.6% of vaccinated individuals, regardless of age group or prior exposure history. The vaccine also demonstrated safety for all participants, with mild to moderate side effects reported.
A new study found that relocated songbird chicks can successfully learn the diversity of songs they need to communicate and survive. Despite an initial lack of song diversity, the population recovered as it increased in size, suggesting that translocating nestlings may not lead to long-term problems.
A recent study published in Environmental Science and Ecotechnology explores the impact of reduced building occupancy on water quality. The research found that prolonged stagnation led to significant variations in water quality, including changes in heavy metal and chlorine levels.
A recent study published in PNAS suggests that impaired macrophage function plays a key role in the development of type 2 diabetes in obese individuals. The research found that collagen breakdown is handled by macrophages, which become deactivated in obesity and insulin resistance, leading to the accumulation of collagen fragments.
A novel bypass configuration eliminates temperature matching constraints, achieving energy flow field synergy and significantly improving efficiency. The system outperforms existing HDTRs, comparable to double-effect absorption refrigerators.
Researchers have discovered that plant immune receptors and growth-related proteins share a common evolutionary ancestry, allowing for the creation of hybrid receptors with enhanced functionality. This breakthrough could lead to the development of disease-resistant crops by isolating and engineering immune receptors from various plants.
A team of researchers found that diffuse anaplasia (DA) subtype of Wilms tumor grows despite high DNA damage and TP53 mutation, leading to resistance to chemotherapy. The study suggests that DA histology emerges through accumulating DNA damage and CNAs, creating selection pressure for TP53 mutations.
The EIC is a unique facility that will collide high-energy polarized electrons with protons or heavier ions, revealing the structure and properties of atomic nuclei. France's National Center for Scientific Research and U.S. Department of Energy have signed a Statement of Interest to strengthen their joint interest in advancing fundamen...
Researchers found that resistant bacteria like Klebsiella pneumoniae and Escherichia coli can remain in the body for up to nine years after initial infection. The study's key findings highlight the need for tailored treatment approaches to combat persistent infections.