Researchers at LMU and Helmholtz Munich have shown that epigenetic modifications enable the reprogramming of glial cells into functional neurons. A novel protein, YingYang1, is necessary for this process, interacting with a transcription factor to open up chromatin.
Researchers at the University of Toronto have developed a new catalyst that efficiently converts captured carbon into valuable products in the presence of contaminants like SO2. The discovery is an important step toward more economically favorable techniques for carbon capture and storage.
Researchers discovered that phage viruses have weaponized mobile introns to sabotage competing viruses' reproduction. This finding has significant implications for understanding the evolution of genomes and developing effective phage therapy against antibiotic-resistant bacteria.
Research reveals TRPV4 complex promotes sweat secretion in mouse foot pads, suggesting its potential role in human perspiration. The study also suggests that TRPV4 may regulate friction forces, which could impact traction on hind paws.
Researchers uncover a critical genetic mechanism boosting plants' ability to withstand drought, using the transcription factor PbERF3 and protein PbHsfC1a. This breakthrough could inform the cultivation of crops with superior resilience to water shortages, ensuring food security and sustainable agricultural practices.
Researchers used first-principles calculations to investigate antigorite's structure under high pressure and temperature conditions. The study found that antigorite gradually dehydrates as pressure increases, changing into a structure with a shorter wavelength, affecting the distribution of intermediate-depth earthquakes.
Scientists have developed a new technique to create four-dimensional qudits that can transmit more data in a single go, promising a future quantum internet with faster data transfer rates and increased resistance to errors.
A new machine learning technique called Dual-Channel Prototype Network (DCPN) can efficiently classify pathological images with limited data, which is essential for diagnosing rare diseases. The DCPN uses few-shot learning to make predictions and achieves noticeable advantages over other methods on three public datasets.
A large-scale genetic survey found that genes can influence the risk of developing atrial fibrillation. Researchers analyzed over 400,000 individuals and identified six genes whose genetic changes significantly affect a person's risk.
A recent Bar-Ilan University study found extreme polarization in public opinion regarding the Israeli judicial reform, with most individuals strongly supporting or opposing it. Motivated reasoning played a significant role in shaping people's views on this issue.
A recent study mapped the evolution of Pseudomonas aeruginosa, a deadly bacterium that causes devastating infections in people with underlying lung conditions. The researchers found that almost seven in ten infections are caused by just 21 genetic clones, which have rapidly evolved and spread globally over the last 200 years.
The fourth SELINA Thematic Workshop in Trondheim built on progress since the second workshop and featured presentations on 11 work packages, breakout sessions, and a city walk. Participants explored methods and knowledge needs identified by 15 demonstration projects.
This study compared the effects of augmented reality (AR) visual and auditory instructions on space station astronauts completing procedural tasks. The results showed that AR visual guidance was superior to auditory guidance in terms of task completion time, operation error frequency, and eye movement data.
A new study challenges the idea that academically selective schools are necessary for clever pupils to thrive. The research found that students from selective and non-selective schools had similar educational and employment outcomes at ages 19 and 25, except for a small difference in life satisfaction scores.
The Spanish Public University System (SUPE) has seen a decrease in the number of permanent lecturers, while private universities (SUEPr) have experienced growth. Productivity per lecturer also varies between the two systems, with SUPE showing an annual increase until 2021 and SUEPr remaining stagnant.
A UNIGE team has successfully determined the exact moment when the brain detects another person's gaze direction. The study enhances our understanding of autism spectrum disorders and offers therapeutic prospects for people affected by Alzheimer's disease.
A recent study identified the NF-YA3b gene as a critical regulator of flowering time in tomatoes. The gene's role was confirmed through CRISPR/Cas9 technology, which showed that knocking out or overexpressing SlNF-YA3b delayed or accelerated flowering, respectively.
A study found that suvorexant, an orexin receptor antagonist, increased fat oxidation and decreased protein catabolism during sleep in healthy men. The effect persisted after waking up, suggesting a potential clinical use for orexin receptor antagonists in managing energy metabolism.
Researchers develop photoluminescent biomass aerogel with high solar reflectance, achieving up to 104% visible light reflectance and 16°Celsius cooling under high solar irradiance. The biodegradable material boasts impressive reparability, recyclability, and environmental friendliness.
Researchers aim to develop universal genetic circuits that can be transferred to various organisms, overcame host-specific gene expression machinery and metabolism limitations. Expanding regulatory toolbox and integrating computer-aided design tools will enable automatic design of universal circuits for non-model organisms.
A study found that 94% of recommended Tropical Ecology authors are white and 80% are from universities outside the tropics. Dr. Stewart White aims to decolonize the curriculum by promoting local research and increasing diversity among authors.
A previously unknown mechanism in the brain causes migraine attacks by carrying proteins to specific nerve cells, explaining one-sided headaches. The discovery may lead to new treatment options and help understand other headache diseases.
Developed by University of Tsukuba researchers, the wearable patch accurately measures insensible perspiration, allowing for real-time hydration monitoring. The patch also detects variations in pH levels and chemical components, making it a promising tool for dehydration management, stress monitoring, and disease detection.
A mouse study identifies a novel non-synaptic signaling mechanism between the brain and peripheral sensory system in migraine. The study suggests that CSF influx activates neurons, triggering aural migraine headaches and providing potential pharmacological targets for treating the disorder.
The integration of point clouds and images is vital for accurate environmental object detection in autonomous vehicles. A survey on the fusion of point clouds and images aims to provide a comprehensive understanding of this critical component in digital simulation technology applications.
Researchers describe how a spreading wave of disruption and brain fluid flow triggers headaches, detailing the connection between aura symptoms and migraine pain. The study identifies potential new drug targets for migraines, including proteins that bind with sensory nerves in the trigeminal ganglion.
Scientists at Stanford University discovered that pancreatic cancer cells become resistant to chemotherapy due to stiff tissue and high hyaluronic acid levels. By altering the matrix, they found it possible to make cancer cells sensitive to chemotherapy again.
Researchers from the Max Born Institute have developed a method to manipulate magnetism using circularly polarized XUV radiation, generating large magnetization changes without thermal effects. The study demonstrates an effective non-thermal approach to controlling magnetism on ultrafast time scales.
Scientists develop effective approach to enhance EL efficiency and color purity of hyperfluorescence OLEDs using blue MR-TADF emitters. By separating TADF sensitizer and emitter into adjacent layers, they achieve outstanding external quantum efficiencies of up to 38.8%.
A study found that air pollution in India is extremely high, with daily mortality rates increasing rapidly at lower pollution levels and then leveling off. The study estimated that 7.2% of all deaths in ten major cities were linked to PM2.5 levels exceeding the WHO limit value.
The BeiDou system's high-precision services have achieved decimeter-level accuracy within minutes, enhancing global coverage and convergence time for autonomous driving, robotic navigation, and smart city infrastructures. A proposed LEO constellation can improve positioning accuracy to better than 5 cm within one minute, overcoming cur...
Researchers at NUS found that the blood of caterpillars contains factors promoting the inheritance of new smell preferences, which are then passed on to their offspring. This phenomenon may facilitate host switching and the formation of new species.
The study reveals that the electric blue spots of the bluespotted ribbontail ray are produced by unique skin cells with a stable 3D arrangement of nanoscale spheres containing reflecting nanocrystals. The team believes this colouration provides camouflage benefits to the stingrays, allowing them to blend with their surroundings.
A study by Norwegian researchers reveals that around 758 kilotons of plastics enter the Norwegian market every year, while only 2.4% ends up in the environment. The country's high plastic consumption rates pose a significant threat to marine ecosystems, and efforts to reduce plastic waste are crucial.
The US federal grid reforms aim to improve the integration of renewable energy sources like wind and solar into the national electric grid. However, despite these efforts, fundamental issues remain unaddressed, including the need for centralized planning and better integration of interconnection and transmission policies.
A recent study finds semi-natural habitats play a crucial role in conserving pollinator diversity, outpacing the impact of pesticide use. The research suggests that prioritizing habitat conservation can be more effective than reducing pesticide application in rice fields.
The Antarctic ice sheet formed around 34 million years ago in the eastern region of the continent, rather than the entire continent as previously thought. The study reveals that different regions of the ice sheet react differently to external influences and climatic changes.
Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.
A new study finds that cool roofs are the most effective way to cool cities like London, with a potential reduction of 1.2-2 degrees C in outdoor temperatures. In contrast, green roofs and street-level vegetation have negligible net cooling effects.
A new research proposes partially-hiding functional encryption schemes with fine-grained access control, enabling ciphertexts to be generated according to an access policy and secret keys associated with attributes and functions. This framework achieves semi-adaptive, simulation-based security under standard assumptions.
The discovery of 'blockbuster T cells' in the gut offers a powerful approach to treating multiple diseases. By understanding how these T cells interact with bacteria, researchers can develop innovative therapeutic interventions.
Since 1950, melody complexity in popular songs has decreased, with the average number of notes played per second increasing. The study identified two significant decreases in melodic complexity in 1975 and 2000, which may be attributed to the rise of genres like new wave and hip-hop.
The study reveals a functional hierarchy of beta cells, with a small group acting as 'first responders' to initiate the glucose response. These cells produce and supply Vitamin B6 to regulate the activity of other beta cells, offering new insights into diabetes pathology and potential treatments.
Researchers isolated three bacterial strains that produce amylase enzymes from sugar factory waste, showing great potential for production. The optimal conditions for amylase production were found to be 37°C and pH 7.0, leading to increased enzyme activity.
Researchers at Lancaster University and others are building the most sensitive dark matter detectors using quantum technologies. They aim to detect dark matter particles weighing between 0.01 to a few hydrogen atoms, which could reveal the mass and interactions of these mysterious particles.
A team of Penn State researchers has created a modular genetic circuit that turns cancer cells into a 'Trojan horse,' causing them to self-destruct and kill nearby drug-resistant cancer cells. The circuit outsmarts resistance and eliminates it before the cancer cells can evolve.
Scientists at Yokohama National University developed innovative catalysts using noble metals Rhodium and Ruthenium to facilitate cross-dehydrogenative coupling reactions. These reactions utilize oxygen as the sole oxidant, producing aryl esters with minimal waste.
A new machine learning-based method uses 3D structure of protein backbone with large language models to predict molecular changes that lead to better antibody drugs. The approach resulted in a 25-fold improvement against a virus, outperforming traditional methods that rely on generating huge amounts of data about protein sequences.
Physicists at Aalto University have developed a method to align bacterial cells using magnetic fields. By mixing bacteria into a liquid with millions of magnetic nanoparticles, the researchers can control the alignment of the rod-shaped bacteria in response to magnetic field strength. The findings offer insights into active matter phys...
Researchers investigate the impact of Fe on the corrosion behavior of Gd2Zr2O7 coatings under Fe-rich environmental sediments. The study reveals that high Fe contents promote degradation and crystallization product precipitation, affecting melt viscosity and infiltration rate.
Researchers have identified a novel type of T cell that can recognize and respond to multiple bacterial strains in the gut. This breakthrough finding has significant implications for treating diseases such as cancer and inflammatory bowel disease. The discovery was made by Kazuki Nagashima, winner of the NOSTER & Science Microbiome Prize.
A new study by the University of Toronto Nursing found that over one million industry-sponsored events took place in the US in 2022, with a focus on physician and nurse practitioner interactions. These events were linked to specific pharmaceutical products, indicating their potential impact on prescribing practices.
Research reveals that pregnancy-related brain impairment affects live-bearing fish, particularly in decision-making and sensory reception. Unlike mammals, pregnant fish show decreased cell proliferation in olfactory regions, compromising scent interpretation.
Researchers develop new method to create azetidines, a stable form of heterocycle that don't oxidize under physiological conditions, expanding toolkit for drug developers to improve medication safety and reduce side effects. This breakthrough enables the creation of more useful chemical transformations with better medical functions.
New research reveals surprising differences in songbirds' diets and gut microbiomes in the Chornobyl Exclusion Zone. Contrary to expectations, birds growing up in radiologically contaminated habitats have a higher diversity of insects in their diet.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center have received a $1.8 million grant to advance personalized cancer therapy for prostate cancer patients. They aim to predict and prevent long-term side effects from radiation treatment, improving quality of life for men diagnosed with the disease.
Researchers tested hundreds of milk products from dozens of states and found no infectious H5N1 virus, but detected viral genetic material in 20% of samples.
Researchers discovered Pradimicin A's molecular basis for binding to viral N-glycan, showing promise as an anti-SARS-CoV-2 drug. The compound inhibits SARS-CoV-2 infectivity by interacting with branched oligomannose-containing glycans.
Researchers propose two strategies to reduce energy loss and increase efficiency: adjusting irrigation schedules to daytime hours when solar energy is produced, and selling surplus energy. These approaches aim to create a sustainable irrigation model that combines environmental protection with economic profitability.
Researchers at Nano Life Science Institute have successfully extended atomic force microscopy to three-dimensional imaging, enabling the visualization of flexible molecular structures. The technique uses a specially designed sample and two modes: static and dynamic mode, which produce different friction values.