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Science News for November 10, 2024


Researchers reveal new mechanisms of how fructose promotes colorectal cancer

A study published in Cell Metabolism reveals that fructose inhibits the polarization of M1-type tumor-associated macrophages, promoting colorectal cancer development. Fructose interacts with hexokinase 2 and inositol 1,4,5-trisphosphate receptor type 3 to suppress calcium levels and activate p38 MAPK and STAT1.

SourceDalian Institute of Chemical Physics, Chinese Academy Sciences·JournalCell Metabolism·TypeCommentary/editorial·DateNov 10, 2024