Researchers at Karolinska Institutet have identified a new potential risk marker for cardiovascular disease in older women. Low levels of an anti-inflammatory antibody are associated with a higher risk of heart attack and coronary heart disease, independent of other known risk factors.
Researchers at UConn have discovered a novel miRNA-141-3p inhibitor that successfully reduces stroke damage and extinguishes inflammatory fires in the brain. The treatment has shown swift restoration of motor function and memory in mouse models, offering new hope for patients affected by strokes.
Researchers at University of Freiburg developed AI models that generate high-quality doctor's letters with 93.1% usability, significantly simplifying clinical practice. The study evaluated 90,000 real clinical documents and found that adapted language models are crucial for practical use.
A study by UCL researchers found that the number of adults vaping in England who have never regularly smoked increased sharply since 2021, with most vaping daily. The study estimated that about one million adults who had never regularly smoked now vape in England, a sevenfold increase since 2021.
A new study aims to increase follow-up care for patients who receive abnormal stool-based fecal immunochemical tests, focusing on improving coordination between primary and specialty clinics. The goal is to improve colorectal cancer screening processes in underserved populations, increasing survival and reducing mortality.
A new study found that 75% of women experience hot flashes during menopause but often receive inadequate attention in primary care. The study suggests a need for better methods to identify midlife women with bothersome symptoms and provides insights into the importance of documenting symptoms and offering effective treatment options.
Researchers developed glucose-responsive micelles that encapsulate and protect glucagon, releasing it when blood sugar levels drop below a certain threshold. The micelles prevented hypoglycemia in mouse trials, achieving normal blood sugar levels within 40 minutes.
Scientists have found that the Pinnacles in Western Australia were formed about 100,000 years ago during a wet period, distinct from the current Mediterranean climate. The iron-rich nodules trapped helium from radioactive decay, providing a precise record of their formation.
A new study found a significant link between intimate partner violence and certain climate shocks, such as storms and floods, in 156 countries. Countries with higher GDP had lower rates of intimate partner violence, highlighting the need for climate mitigation efforts to reduce violence against women.
Researchers have identified a 'forcefield-like' defense system in solid tumors, which uses small extracellular vesicles to block nanoparticle-based therapies. The study found that tumor cells release sEVs carrying proteins that block the activity of cytotoxic T cells and intercept nanoparticles like a decoy.
This study reveals a higher prevalence of mental disorders and suicidal behavior among transgender and gender-diverse individuals. The findings align with previous research, indicating significantly higher rates of mental health-related health service use among this group.
The study found that individuals with higher melanin levels experience decreased signal quality and lower oxygen saturation readings. To enhance reliability, researchers advocate for incorporating melanin level measurements and using specific wavelengths less absorbed by melanin.
A Dartmouth-led study found that people are more skilled at inferring past events from conversations than predicting future events. This phenomenon is attributed to the asymmetrical nature of human knowledge about their own lives and experiences, which influences how people converse.
Researchers have created the largest and most complete map of the fruit fly brain, detailing over 50 million connections between neurons. The study provides critical information about brain wiring and underlying signals, paving the way for future studies on larger-brained animals.
A Stanford Medicine study suggests that targeting the glucose transporter GLUT4 protein may help reactivate neural stem cells in older brains, leading to increased neuron production. The research also identified other genetic pathways associated with neural stem cell activation, offering potential avenues for developing new therapies.
Morgan's research focuses on the exploitation of enslaved women, highlighting their role in the economic foundations of slavery. Her work deepens understanding of the intertwined issues of racism, capitalism, and gender in early America.
The U.S. Department of Energy has selected Kate Petersen Mace as the project director for the High Performance Data Facility (HPDF), a first-of-its-kind project providing resources for data-intensive science. Mace will lead the team in developing transformational capabilities to serve the DOE community.
Researchers at Texas Biomedical Institute have developed a TB therapy that does not interfere with combined antiretroviral therapy (cART) in patients with HIV. The host-directed therapy blocks an immune system protein and has shown improved control of TB when used with antibiotics.
For the first time, researchers have demonstrated how mechanical forces affect gene expression by showing that RNAP polymerase remains on the DNA template and can be pulled to start a subsequent cycle of transcription. This force-directed recycling mechanism can change the relative abundance of adjacent genes.
A Southwest Research Institute-led team has detected carbon dioxide and hydrogen peroxide on Charon's surface, revealing insights into the moon's geological processes and formation. The presence of these substances suggests that Charon's surface is altered by solar ultraviolet light and energetic particles.
Researchers developed a detector that senses and analyzes antineutrinos emitted by nuclear reactors, enabling detection of reactor use even from hundreds of miles away. The device exploits Cherenkov radiation to characterize energy profiles and can distinguish between operational cycles and specific isotopes in spent fuel.
Scientists at St. Jude Children's Research Hospital studied the structure of Fanzor2, a eukaryotic genome-editing protein, to understand its potential for gene editing. The findings reveal that Fanzor2 has a unique RNA-guided nuclease system, which could be harnessed to create more functional and smaller proteins.
Researchers at the Max Planck Institute have made a groundbreaking discovery in chiral materials, enabling the creation of orbital electronics. The study reveals that certain materials naturally possess orbital angular momentum monopoles, which can be harnessed for memory devices and other applications.
A study by Osaka Metropolitan University found that ChatGPT's diagnostic performance for brain tumors was comparable to that of neuroradiologists, with an accuracy rate of 73%. The model's performance varied depending on the type of clinical report written, with higher accuracy when using reports from neuroradiologist writers.
Researchers have developed a sustainable synthesis route for covalent organic frameworks (COFs) that can capture carbon dioxide (CO2) efficiently. The frameworks are stable in water and electrolytes, making them suitable for waste gas cleaning and reducing greenhouse gas emissions.
Researchers from University of Texas at Arlington have identified 206 systems of interest for potential habitability, including one system where the planet is always situated in the HZ. The team analyzed data from NASA Exoplanet Archive and found F-type stars to be a promising case for life beyond Earth.
Researchers at University of Pittsburgh discover that deep brain stimulation instantly improves arm and hand strength and function weakened by traumatic brain injury or stroke. The therapy stimulates the motor thalamus, a key relay hub of movement control, and significantly improves activation of muscles and grip force.
Researchers at Tampere University have observed hidden deformations in complex light fields for the first time. These deformations carry significant information about the object, such as its material properties. The study has implications for measuring material properties with structured waves and will inspire new optical technologies.
Researchers developed a heat-adjusting material inspired by squid skin, allowing for user-adjusted warmth and breathability. The fabric is breathable, washable, and can be integrated into flexible clothing, making it suitable for cold weather applications.
A pre-registered experiment found that seven nudges aimed at reducing hateful speech online had no effect, but unexpectedly increased engagement with harmless posts. The study recruited over 4,000 Americans and showed participants one of the nudges before engaging with a website featuring varied content.
Researchers create synthetic sourdough communities with varying acetic acid bacteria strains to study their effects on flavor formation. The study reveals high variation in metabolites even among closely related strains, offering new insights for bread makers to shape sourdough flavor and texture.
A new study reveals that climate experts believe the Earth is headed for a rise in global temperatures far higher than the 2015 Paris Agreement targets. Two-thirds of respondents think we may succeed in achieving net zero CO2 emissions during the second half of this century, indicating some optimism about mitigation efforts.
A study by researchers at the University of Rochester Medical Center found that high levels of specific antibodies in breast milk provide protection against rotavirus, a common gastrointestinal disease. The findings highlight the importance of optimized breastfeeding practices to improve infant health globally.
Researchers have elucidated the structures of GLUT9 and URAT1 transporters at high resolution, highlighting their substrate preferences and interactions with inhibitors. The findings provide an excellent starting point for developing targeted therapies for hyperuricemia and gout.
Researchers at Baylor University found that coyotes possess a well-developed muscle for raising their inner eyebrow, similar to dogs, contradicting the idea that this feature evolved specifically during domestication. The study suggests that 'puppy dog eyes' may be an ancestral trait shared by multiple species in the Canis genus.
Researchers have developed a low-coherence Brillouin optical correlation-domain reflectometry system that overcomes spatial resolution and measurement range trade-offs. The new method uses periodic pseudo-random modulation, achieving accurate distributed strain measurements without a variable delay line.
Researchers have made a promising breakthrough in understanding the origins of mirror movements disorder by identifying the cellular mechanism behind the condition. A defect in axon guidance is revealed to be the underlying cause of the disorder, which can lead to difficulties in performing tasks requiring left-right coordination.
A new epigenetic clock based on cheek cells accurately predicts mortality risk, outperforming previous clocks trained on blood data. The study found that specific methylation sites are linked to human mortality, and future research is needed to identify associations with age-related diseases.
A retrospective analysis of over 2,600 patients found that Black children were more likely to suffer severe graft-versus-host disease but overall survival rates improved across all racial groups. The study suggests that cord blood transplants are a vital lifeline for many patients and improve care for those without a matched donor.
Researchers have discovered large underwater ice formations at the edge of the Canadian Beaufort Sea, revealing an unanticipated mechanism for submarine permafrost ice formation. The newly formed ice is created by melting ancient permafrost and refreezing as brackish groundwater approaches the seafloor.
A study by the University of Córdoba found that 98% of women in Spain experience street harassment, with 80% reporting monthly incidents. The research highlights the impact on women's psychological well-being, including increased anxiety and fear of rape, as well as self-esteem drops.
In Dominica, Hurricane Maria killed most Purple-throated caribs, allowing other birds to pollinate heliconia plants. Researchers found that specialized pollination systems can become generalized after natural disturbances, showing resilience in ecosystems.
Materials scientists at Stanford employed a novel electron microscopic technique to study the structural microstructure and electrochemical properties of organic mixed ionic-electronic conductors, revealing how they maintain electronic functionality despite swelling by up to 300%.
The BICAN Rapid Release Inventory provides early access to single-cell transcriptomic and epigenomic profiles from humans and other mammalian species. This open data release aims to accelerate discoveries in neuroscience by facilitating collaboration and data reuse among researchers.
Researchers used accelerometers to observe the movement and behavior of green turtle hatchlings as they emerge from their nests. The findings show that hatchlings maintain a head-up orientation and move vertically through the sand by rocking forwards and backwards.
Researchers propose reevaluating nomenclature for low-grade prostate cancer, a condition that rarely metastasizes or causes symptoms. This shift aims to balance detection with treatment to reduce harms of overdiagnosis and overtreatment.
A mathematical model suggests vaccinating children and teens against the flu can protect the elderly in tropical countries. Vaccination strategies focus on age-specific groups, with a particular emphasis on protecting older adults when vaccine supplies are limited.
Researchers found that individual PFAS have relatively low cytotoxicity and neurotoxicity levels, but the chemicals act together to make mixtures toxic. PFOA and PFOS were found to be major contributors to mixture toxicity.
Researchers at the University of Wisconsin-Madison have imaged the structure of RSV proteins, which are crucial for the virus's interaction with host cells. The images reveal that pairs of F proteins may be a key target for destabilizing the virus and preventing infection.
Two populations of the same wild species, Brassica fruticulosa, have evolved differently under similar environmental conditions, revealing distinct adaptation strategies to soil salinity. The study identifies two adaptive responses, one involving sodium restriction and the other through efficient osmotic adjustment mechanisms.
A new study published in Scientific Reports reveals the importance of foot movement in early infant development and interaction. By using machine and deep learning techniques, researchers found that AI can accurately classify five-second clips of 3D infant movements, with foot movements showing the highest accuracy rates.
A decade-long analysis of wildlife rescue records in NSW reveals a bias towards larger reptiles, with two species accounting for almost two-thirds of all rescues. Human behavior and environment play significant roles in shaping these interactions.
A study analyzing 1.6 million social media posts found that Ukrainian solidarity posts received significantly more online engagement than derogatory posts about Russia. After the invasion, posts celebrating unity gained a 92% increase on Facebook and a 68% increase on Twitter.
Researchers found that humans slow their speech when talking to dogs to match the pets' receptive abilities, allowing for better understanding of commands. The study also revealed that dogs respond well to slower tempos and prosody in human speech.
A large proportion of gene variants previously classified as 'variants of uncertain significance' (VUS) have been reclassified as benign, according to a study published in the American Journal of Human Genetics. This reduces the total number of VUS by 37%, providing relief for carriers worldwide.
Researchers created the largest atlas of how tumor architecture changes in response to immune checkpoint therapy. The study found that multiple T cells recognize different neoantigens, altering the tumor ecosystem, and challenged prevailing theories on immunotherapy.
Scientists at German Cancer Research Center developed a convoy of millimeter-sized robots to transport heavy surgical instruments. The robotic unit successfully performed an electric surgical procedure on a bile duct obstruction experimentally.
A new spatio-temporal fusion method called RES-STF combines VIIRS LST and Landsat LST data to create high-resolution images with both spatial and temporal details. This approach offers improved accuracy and robustness compared to traditional methods, providing critical data for studying urban heat environment changes and guiding agricu...
A nationwide study found that Australians are buying too many clothes and need guidance on responsible disposal. The study revealed that age was the most significant factor in determining consumer clothing practices, with younger generations more likely to buy second-hand and repair clothes.
A new study reveals that bais, vast treeless clearings in the Congo Basin, are home to numerous endangered species, including Western lowland gorillas and African forest elephants. The researchers found over 2,000 distinct bais, covering less than 0.2% of the national park's landscape.