New research highlights how parental awe and pride can significantly enhance parental well-being. Awe has been shown to strengthen parental life satisfaction, make parents feel happier, and connect them to something larger than themselves.
A team of researchers has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer. The study highlights how the metabolic environment of tumors influences T cell function, opening new possibilities for improving cancer immunotherapy by targeting tumor metabolism.
Researchers investigated the therapeutic mechanisms of ursolic acid on metabolic dysfunction-associated steatotic liver disease. Ursolic acid was found to reduce inflammation by modulating estrogen conversion via HSD17B14, a crucial enzyme regulating estrogen balance.
A new study by University of Illinois researchers found that a balanced vegan diet has no effect on muscle protein synthesis or muscle gain compared to an omnivorous diet. Protein distribution throughout the day also made no difference in muscle building, contrary to previous assumptions.
Scientists have uncovered a genetic link between autism spectrum disorder and myotonic dystrophy type 1, suggesting a new mechanism for social behaviors in ASD. The study found that the genetic variation causing DM1 affects brain development and leads to protein imbalance, mis-splicing of genes involved in brain function.
Researchers found that pheasants released in the UK can carry Lyme disease bacteria in ticks, increasing the risk of human exposure. The study suggests 'spillback' from non-native species can lead to the emergence of zoonoses.
A study by Johns Hopkins Medicine found that older adults with cancer benefit equally from immunotherapy treatments as younger patients, with key differences in their immune responses and cells. Researchers hope to develop new therapies tailored to different age groups' needs and improve treatment success.
A national poll suggests parents are evenly split on when to start talking about puberty, with some fearing embarrassment or saying the wrong thing. Parents' own experiences may influence their approach, with many having had limited discussions themselves.
A new study estimates that 2.7% of NYC electronic dance music-nightclub attending adults used Tusi in the past year, with risks of adverse or unexpected effects due to its often adulterated nature. The use of Tusi has been reported in Latin America and Europe since the past decade.
A new study reveals that the Neolithic Revolution in the southern Levant was triggered by catastrophic wildfires and climate-driven soil erosion, forcing early communities to adopt agriculture. Fertile soils formed in valley basins after hillslope degradation became hotspots for settlement and farming.
A new study found that prenatal stress alters the expression of tiny RNA molecules in newborn blood, particularly in female children, affecting key enzymes in the brain's stress-regulation system. This may explain why some children are more vulnerable to developmental or psychiatric challenges.
The article provides a comprehensive overview of anaplastic thyroid cancer's molecular mechanisms, diagnostic approaches, and therapeutic strategies. Key findings include the significance of targeted therapies, such as BRAF and MEK inhibitors, and the potential of immunotherapy and novel agents to enhance treatment outcomes.
Researchers found that a thicker preoperative macular layer in the right eye was associated with an increased risk of postoperative delirium. The study suggests that retinal imaging may serve as a non-invasive biomarker to identify individuals at risk, particularly after anesthesia and surgery.
Citrullination, driven by peptidyl arginine deiminases (PADs), converts arginine to citrulline, altering protein structure and function. PAD2 and PAD4 play pivotal roles in epigenetic regulation, affecting transcriptional activity through histone modification and interaction with transcription factors.
FMRP plays a dual role in cancer, acting as both a tumor suppressor and promoter, influencing tumor growth, metastasis, and therapy resistance. Its ability to regulate mRNA stability, translation, and transport positions it as a crucial factor in the intricate network of gene expression that governs cancer progression.
Research from the University of Sydney finds that high-fat, high-sugar diets can impair brain function, specifically location memory and spatial navigation. Participants who consumed fewer fatty and sugary foods were better able to navigate virtual reality mazes and recall locations.
Research highlights the biological functions of small noncoding RNAs in modulating gene expression, cell signaling, and physiological homeostasis. These RNA molecules play significant roles in cardiovascular health, engaging processes like inflammation, apoptosis, and vascular remodeling.
Researchers highlight microRNAs' role in regulating adipose tissue function and potentially reversing fibrosis. Engineered stem cells with targeted miRNAs offer a precise molecular intervention strategy to combat fibrosis in various organs.
A new ZnxZrO catalyst selectively cleaves ethane's C–H bonds while efficiently activating CO2, enabling an eco-friendly ethylene production process. This breakthrough enhances carbon neutrality initiatives and establishes sustainable chemical production systems.
Research reveals Nrf2's role in chemoradiotherapy resistance and multi-drug resistance in osteosarcoma cells. Elevated Nrf2 expression correlates with reduced survival rates.
Achondroplasia stems from FGFR3 gain-of-function mutations disrupting skeletal development, leading to stunted growth, skeletal deformities, and joint complications. Emerging therapies target the FGFR3 pathway with biological drugs, small molecule inhibitors, gene-editing technologies, and downstream signaling compounds.
R-loops are essential regulatory elements in gene expression, DNA replication, and repair mechanisms. However, when dysregulated, they pose risks to genome integrity, threatening diseases such as cancer and neurodegeneration.
Researchers highlight GOT2 as a compelling therapeutic target for treating pancreatic cancer, exploiting its role in regulating cellular redox balance and energy production pathways. Early candidates like amino oxyacetate show promise in disrupting GOT2 activity, leading to cellular senescence and loss of proliferative capacity.
Scientists have created a compact device that enables ultra-narrow spectral linewidth of superradiant Smith-Purcell radiation, overcoming limitations in free electron accelerators. The device, called pump-induced stimulated S-SPR (PIS-SPR), uses a three-section system to pre-bunch electrons and emit radiation at a specific frequency.
The review highlights how disruptions in lipid regulation can significantly influence breast cancer cell behavior, impacting growth, metastasis, and response to treatment. Lipid reprogramming promotes epithelial-mesenchymal transition, a process associated with enhanced migratory ability and drug resistance.
Researchers developed a new technique using indocyanine green-soaked fiducial markers (ICG-F) to mark peripheral pulmonary lesions before surgery. The study found that this approach improved the accuracy of surgical resection, resulting in smaller and lighter resected specimens compared to unmarked lesions.
Research from Rutgers Health finds that children exposed to paternal depression at kindergarten entry are more likely to have behavioral difficulties and poor social skills at age 9. Fathers' mental health is crucial in supporting their children's development, and early intervention can help improve well-being for both parents and kids.
Researchers at Tokyo Metropolitan University have created a novel technique using phase-contrast microscopy to track and analyze the motion of unlabeled cells. This allows for the accurate differentiation of cancerous cells with up to 94% accuracy, opening new avenues for diagnosis and research on cell motility related functions.
Research found that MPO promotes inflammation and inhibits protective mechanisms in perivascular adipose tissue, leading to poorer vascular function. Inhibiting MPO could be a promising therapeutic approach for obesity-related cardiovascular risk reduction.
Researchers at Penn's School of Dental Medicine and Perelman School of Medicine found that ACE inhibitors can inhibit the activity of ACE2, a critical cardioprotective enzyme. This discovery has implications for human patients prescribed these medications, who may benefit from additional ACE2 treatment.
Researchers used phased genome assemblies to show complex chromosomal rearrangements are key drivers of repeated adaptive evolution in a stick insect. The study found that millions of DNA bases were flipped backwards and moved within chromosomes, independently in populations on different mountains.
A new study identifies that the internationally recognized body mass index (BMI) cut-off points overestimate overweight and obesity in male athletes. The researchers propose new cut-off points of 28.2 kg/m² for overweight and 33.7 kg/m² for obesity, taking into account lower body fat percentages typical of athletes.
A Monell Center study found that GLP-1 receptor agonists can effectively manage metabolic complications associated with Bardet-Biedl Syndrome, a rare genetic disorder characterized by early-onset obesity and cognitive impairments. The therapy significantly reduced food intake, caused weight loss, improved glucose tolerance, and normali...
Insilico Medicine's Pharma.AI Day 2025 will showcase the latest AI breakthroughs and updates, including precision target discovery engine PandaOmics and generative biologics platform Generative Biologics. The company aims to accelerate drug discovery and advance life sciences research with its proprietary platform.
A study of over 300,000 adults found that those with diabetes are 25% more likely to lose their health insurance. Insurance instability is particularly concerning for those with complex needs, as many struggle to regain coverage after losing Medicaid or private insurance.
Researchers develop a new coronagraph that can detect exoplanets obscured by light from their parent stars, providing insights into the possibility of life beyond Earth. The device uses spatial mode sorters to isolate and eliminate starlight, capturing images of exoplanets with unprecedented sensitivity.
Wei Kang, a Naval Postgraduate School professor in Applied Mathematics, was honored as a 2025 SIAM Fellow for his contributions to dynamic systems and controls. He is recognized for his work on analyzing, controlling, and estimating nonlinear dynamical systems and their applications.
Researchers at Carnegie Mellon University are developing a VR/AR system to simulate stressful situations, allowing users to practice stress-relief strategies in a realistic environment. The system was tested on a group of participants, who found it helpful in gaining awareness and learning self-sufficiency skills.
Researchers investigated how brains process language during real-life conversations, employing AI to analyze neural activity and linguistic features. They found that speaking and listening engage widespread networks of brain areas in the frontal and temporal lobes, with highly specific patterns changing depending on words and context.
Researchers found that the brain's visual system adapts in real-time to make sense of information, depending on current tasks. This challenges traditional views and opens new approaches for designing AI systems with adaptive capabilities.
A new study led by the University of South Florida reveals a correlation between opioid misuse and domestic violence, with opioid control programs contributing to a 10% reduction in simple assaults. The effect was strongest in states with higher opioid prescription rates.
Arup K. SenGupta, a renowned water scientist at Lehigh University, has been honored with the ASCE Freese Award and Lecture for his pioneering work in ion exchange science and technology. He will present on 'Development and Global Application of Hybrid Ion Exchange Processes' during the 2025 World Environmental & Water Resources Congress.
Researchers found that only about 1.3% of Titan's large rivers have deltas, unlike Earth where nearly every similar-sized river has one. The absence of deltas may be due to rapid sea level changes or strong winds and tidal currents on Titan's coasts.
Researchers at Nagoya University found that patients with high-risk stigmata and invasive nodules in their pancreatic cysts had a significant impact on their survival. The presence of invasive nodules led to improved survival rates after surgery, while those without invasive nodules had favorable outcomes even without surgery.
Scientists at EPFL create a flexible auditory brainstem implant that closely conforms to the curved surface of the brainstem, enabling better tissue contact and reducing side effects. The device has been successfully demonstrated in macaques, showing promising results for high-resolution prosthetic hearing.
A new study published in JAMA Network Open highlights the need for tailored prevention strategies for at-risk women. The research found that less than one-third of women who died by firearm suicide had documented evidence of mental health treatment.
Researchers have found that targeting PGM3 can help stop the growth of glioblastoma, a fast-growing brain tumor. By blocking this enzyme, tumors can be effectively suppressed.
Two previously unknown ribosome-arresting peptides (RAPs), PepNL and NanCL, were identified in E. coli, inducing translation arrest through a unique mini-hairpin conformation in the exit tunnel of the ribosome. This discovery provides valuable insights into deciphering the hidden genetic codes within polypeptide sequences.
Researchers developed a novel anode material combining hard carbon with tin, enhancing energy storage and stability. The composite structure shows excellent performance in lithium-ion and sodium-ion batteries, promising applications in electric vehicles and grid-scale energy storage.
A leadership trap known as the 'accidental dictator' can be avoided by embracing circumscribed empowerment, shared vision, and long-term perspective. Leaders must empower their team members within defined boundaries, engage them in the process of creating a shared vision, and prioritize a long-term perspective to build effective teams.
A new study models cholera transmission after interventions in the Democratic Republic of the Congo, highlighting the importance of environmental reservoirs in maintaining endemic diseases. The research suggests that vaccination may have a smaller impact on preventing transmission compared to water, sanitation, and hygiene improvements.
Researchers at Georgetown University found that claim denials for cancer-related advanced genetic testing increased between 2016 and 2021, despite a recent Medicare national coverage determination. The study analyzed nearly 30,000 claims filed by over 25,000 unique Medicare beneficiaries and suggests uncertainty remains around coverage...
Researchers developed a novel protein, LSUBP, to enhance uranium extraction from seawater. The engineered protein achieves high adsorption capacity, offering a promising new material for effective uranium extraction.
John N. Weinstein, MD, PhD, chair of Bioinformatics and Computational Biology at MD Anderson Cancer Center, has been elected Fellow of the American Association for Cancer Research (AACR) Academy. He made significant contributions to advancing our knowledge of molecular profiles of cancer through multi-omic studies and data analysis.
Researchers have discovered how a mitochondrial pyruvate carrier transports a molecule vital for energy production into the cell's powerhouses. Blocking this process could lead to new treatments for various conditions, including diabetes, Parkinson's disease, and cancer.
A new study by Hokkaido University found that colder temperatures significantly increase the risk of gastroenteritis among Rohingya refugees in Bangladesh's Kutupalong and Nayapara camps. The study reveals a link between temperature changes and gastroenteritis risk, with both extreme cold and heat contributing to higher numbers of cases.
The study reveals that centromeric R-loops play a critical role in ensuring chromosome alignment during oocyte meiotic divisions. Disruption of R-loop homeostasis leads to spindle assembly defects and chromosomal misalignment, highlighting the importance of R-loops in maintaining genomic stability.
A new study by Texas A&M University researchers has revealed insights into Mars' geological history and potential for ancient life. The team analyzed diverse volcanic rocks in the Jezero Crater, providing a window into the planet's distant past and signs of altered olivine.
A serial cross-sectional study found that legalization of cannabis edibles and extracts was associated with an increase in edible cannabis use, cannabis smoking, and overall cannabis use among adolescents. The study highlights the need for stricter policy measures to curb adolescents' access to cannabis edibles and extracts.
A pangenome study has constructed an unprecedented map of wild and cultivated rice, decoding the genetic architecture and diversity of rice. The researchers found 3.87 billion base pairs of novel genetic sequences absent from the single acknowledged reference genome, as well as 69,531 genes spanning the pangenome.