Researchers developed an organic molecule that simultaneously emits light suitable for displays and absorbs photons for deep-tissue bioimaging, overcoming a long-standing design challenge. The compound achieved high efficiency in both applications, paving the way for next-generation multifunctional materials.
TDCPP's binding to the membrane thyroid hormone receptor impairs motor neuron development and causes locomotor dysfunction in zebrafish. The study establishes a novel adverse outcome pathway framework for predicting TDCPP's neurotoxicity.
A cross-sectional study found that white populations use more prescription drugs than Asian or Pacific Islander and Hispanic populations. After adjusting for age and disease prevalence, Black populations have lower prescription fill rates compared to the overall population average.
Newly developed DNA nanostructures form flexible, fluid, and stimuli-responsive condensates without chemical cross-linking. These findings pave the way for adaptive soft materials with potential applications in drug delivery, artificial organelles, and bioengineering platforms.
The study resolved cryo-EM structures of the Nipah virus polymerase complex, unveiling binding modes between RdRp/PRNTase domains and the P tetramer. Two conserved zinc-binding sites were identified essential for polymerase activity.
A new project funded by the Weston Family Foundation's Homegrown Innovation Challenge will continue advancing indoor blueberry trials while expanding to include raspberries and blackberries. The goal is to develop compact, high-yield berry varieties and modular growing systems that support Canadian farmers year-round.
A recent study analyzed hourly data from nearly 750 low-cost and regulatory air pollution sensors throughout LA to understand the impact of wildfires on air quality. The findings suggest that combining different data sources, including ground-based sensors and satellite data, can provide more accurate and comprehensive information.
A mobile phone app designed to deliver suicide-specific therapy reduced suicidal behavior among psychiatric inpatients by 58.3%. Users experienced sustained reductions in suicidal thoughts for up to 24 weeks after hospitalization.
The report warns that immigration enforcement is a public health emergency for millions of children, causing constant anxiety and harm to their emotional development and academic performance. Clinical case studies reveal how trauma is transmitted across generations, shaping the mental health of immigrant children.
A team of researchers identified a complex network of regulatory proteins responsible for triggering the most appropriate immune response in macrophages. This study offers new insights into macrophage biology and sheds light on how these cells coordinate their responses to various pathogens.
Researchers investigate regional-specific gut microbial distribution, revealing its critical role in metabolic and immune regulation. Key findings include duodenal mucosal resection reducing small intestinal bacterial overgrowth and machine learning integrating multi-omics data to predict microbial dynamics.
Insects rely on carbon dioxide emissions from host plants to identify ideal egg-laying sites. Rising atmospheric CO₂ levels interfere with this natural signal, leading to maladaptive choices that threaten insect survival. The study highlights the urgent need for both emissions reductions and innovative agricultural adaptation.
Researchers aim to widen ADCs' therapeutic window and application scope by integrating AI, single-cell sequencing, and combination therapies. Precise antigen selection is crucial to minimize toxicity and improve efficacy in targeted cancer therapy.
Anish Sapkota is researching abiotic stressors like drought, heat, and soil nutrients in crops such as wheat and alfalfa to improve precision agriculture. Variable rate application of water and fertilizer can help farmers save money and products by targeting specific areas of the field.
A study by the University of Jyväskylä reveals an intergenerational link between parents' and their children's school commuting habits. Parents' own experiences and attitudes towards walking or cycling to school influence how they support and enable their children's physically active commuting.
A recent review paper on meditation apps, led by Carnegie Mellon University's J. David Creswell, found that these digital platforms can lead to benefits in reduced depression, anxiety, and stress. The study also highlights the potential for meditation apps to incorporate biometrics and AI-driven personalization.
Researchers found that children unexposed to HIV had higher taxonomic turnover in their oral microbiomes, indicating less adaptability to environmental changes. Children living with HIV had more stable oral microbiomes and higher frequencies of cavity-causing bacteria.
A new resource, EuPRI, maps RNA sequences for nearly 35,000 RBPs across nearly 700 species, offering insights into evolutionary history and potential therapeutic targets. Researchers also uncover how oxygen sensors regulate ferroptosis and how a specific transcription factor influences natural killer cell responses.
Neuroblastoma is often difficult to treat due to its ability to enter a dormant state when the MYCN gene is located outside chromosomes. A new study proposes targeting these dormant tumor cells with a combination of chemotherapy and a second drug, showing promising results in mouse models.
Scientists have decoded the complex genome of sweetpotato, revealing an intricate origin story and providing a powerful tool for improvement. The research showed that sweetpotato is a 'segmental allopolyploid,' with six sets of chromosomes that contribute to its remarkable adaptability and disease resistance.
Researchers have identified Laccase2 as essential for darkening and hardening overwintering eggs in pea aphids. Disrupting this gene eliminates egg protection, making them susceptible to infection and hindering hatching.
Dynamin 1 regulates EMT progression, cell polarity and migration through N-cadherin endocytosis and recycling, promoting ovarian cancer metastasis. The study identifies DNM1 as a critical regulator of EMT-associated metastasis.
A team of researchers found that a rare South African cycad's leaves owe their bluish color to a wax-based optical effect produced by lipid compounds. The coating of epicuticular wax on the leaves forms tubular crystals that reflect light, giving the plant its unique sheen.
Combining federal monitors, low-cost sensors, and satellite data can provide a more complete picture of local air quality, enabling people to make safer choices in real-time. The study highlights the importance of timely and accurate air quality information during wildfire events.
Researchers identify key symptom categories and biomarkers for anti-NMDAR encephalitis, a rare autoimmune brain condition. Clinical manifestations suggest the presence of anti-NMDAR encephalitis through NMDA antibody checks, uric acid levels, C-reactive protein, and thyroid-related hormones.
Researchers propose a quality management system for quantum technologies to ensure security, interoperability, transparency and accountability. International standards can facilitate cooperation among countries like China, the US, and Europe, creating trust in new technologies.
Scientists have discovered that MYOD protein can act as a gene silencer, clearing out old 'furniture' to reset the cell's identity. This finding challenges dogma and opens up new avenues for understanding cellular reprogramming and regenerative medicine therapies.
Researchers at Penn State have simulated a new class of protein misfolding using atomic-scale models, revealing a type of entanglement that disrupts protein function and persists in cells. The findings support the existence of this long-lasting type of misfolding, which is thought to contribute to aging and disease.
HTGAnalyzer is an automated tool simplifying complex transcriptomic workflows, enabling clinicians without bioinformatics expertise to perform essential analyses in precision medicine. The tool has been validated using multiple datasets and identified differentially expressed genes linked to cancer diagnosis, treatment, and prognosis.
A research team led by Professor Teruyuki Niimi has developed a new gene function analysis method for the Japanese rhinoceros beetle using electroporation. This advancement will significantly deepen our understanding of how the rhinoceros beetle's horn forms and evolves.
Researchers at ETH Zurich create a novel three-dimensional heart patch for intraventricular implantation, integrating into existing heart tissue. The RCPatch combines a fine mesh, 3D-printed scaffold, and hydrogel with living cells to promote complete repair and regeneration of damaged heart tissue.
A new American Heart Association Science Advisory highlights the negative impact of excessive ultraprocessed food consumption on cardiometabolic health. Research found a strong dose-response relationship between UPF intake and increased risk of cardiovascular events, Type 2 diabetes, obesity, and mortality.
The UCI-OC Poll finds a strong preference for flexibility in work arrangements, with many workers willing to relocate for remote job opportunities. However, there is also concern about the impact of artificial intelligence on jobs, highlighting the need for thoughtful integration and policy considerations.
Researchers at Osaka Metropolitan University have directly observed the quantum Kelvin-Helmholtz instability, producing eccentric fractional skyrmions. These exotic vortex patterns are governed by quantum mechanics and topology, challenging traditional classifications.
Scientists at Kyushu University have created a solid oxide fuel cell that operates at a low temperature of 300°C, overcoming a major hurdle in their development. The breakthrough uses scandium to create a 'ScO6 highway' for protons to travel efficiently, enabling the production of affordable hydrogen power.
A study found that social robots like Luka can become deeply embedded in families over time, taking on emotional and symbolic roles. Children often reinterpret their relationship with the robot as they grow older, repurposing it as a companion or keepsake.
A new study finds that up to 18% of women are advised to stop breastfeeding due to medication, while chronic illness increases this number to 58%. The research highlights the need for accurate and balanced information about medication safety during breastfeeding.
A recent study found that Arizona Bald Eagles migrate north instead of south, unlike most migratory birds in temperate zones. This adaptability allows them to take advantage of ephemeral food sources, such as spawning salmon or ungulate carcasses.
A new statistical model using GPS tracking data accurately predicted nest success for the California Condor, demonstrating its potential to inform conservation decisions. The model's results were corroborated by field observations and camera footage, allowing researchers to assess nest fate with high accuracy.
The study assesses autonomous vehicle adaptability on small-radius circular curves, showing ride comfort degrades to
Scientists create a spatiotemporal light system that emulates the behavior of potential-free Schrödinger equations, generating localized wavepackets without potential energy constraints. This breakthrough could provide new insights into quantum physics and applications in studying light-matter interactions.
Scientists have created a new process to break down per- and polyfluoroalkyl substances (PFAS) in water, producing harmless fluoride components. The breakthrough offers a low-energy solution for PFAS remediation with potential applications in water treatment and environmental cleanup.
A new bioactive wound dressing combining miR-221-3p and GelMA hydrogel promotes blood vessel formation, accelerating diabetic wound healing. The study shows a 90% wound closure rate within 12 days in animal trials.
A novel hydrogel has been developed to accelerate wound healing in infected wounds by regulating the skin microbiota. The hydrogel, PSG15, inhibited bacterial growth and promoted tissue regeneration, enhancing angiogenesis and collagen deposition.
SUTD researchers create lightweight, aerodynamic monocopter with passive stability, achieving 26 minutes of sustained flight. The design reverses traditional quadcopter inefficiencies by leveraging autorotation and minimising thrust.
A new study by Newcastle University found that most patients with a rare kidney disease can stop treatment after six months without relapse. This breakthrough could significantly change the way aHUS is managed, freeing patients from regular intravenous injections and reducing risk of serious infection.
The University of Osaka's Center for Quantum Information and Quantum Biology successfully launched a fully domestically produced quantum computer. The achievement demonstrates Japan's capacity to design, manufacture, and integrate a complete quantum system, showcasing its mastery of quantum technologies.
The study uses Rapid Precision Run-On Sequencing (rPRO-seq) to uncover molecular drivers of cellular differentiation, offering a paradigm shift in understanding regenerative therapies. The technique allows doctors to analyze patients' disease states and treatment response in real-time.
Researchers have developed a synthetic biology platform called T7-ORACLE that enables rapid protein evolution, allowing for the creation of therapeutic proteins with improved functions in a matter of days. This breakthrough has significant implications for various disease areas, including cancer and neurodegeneration.
Researchers found that translocating Cooper's Hawks away from Los Angeles airports can reduce the risk of aircraft collisions. The study, published in Journal of Raptor Research, showed that age and sex of individual hawks impact return rates to their airport of origin.
A new study sponsored by Neurotech Pharmaceuticals and led by Scripps Research confirms that a neuroprotective surgical implant can slow vision loss in people with macular telangiectasia type 2 (MacTel). The implant, ENCELTO, delivers a therapeutic protein to preserve vision.
The Illinois Tech EV Readiness Community Awards celebrate local governments leading the transition to electric vehicles, with a focus on energy innovation and sustainability. The university's campus-wide transformation showcases its resilience and sustainability as a model for urban energy systems of the future.
A new study by University of Cincinnati researcher Ashley Merianos reveals a troubling connection between adverse childhood experiences and tobacco smoke exposure in US school-aged children. Adverse childhood experiences, such as parental divorce or financial hardship, increase the likelihood of children living with tobacco users and b...
Researchers have developed a research pipeline to create 'universal vaccines' that can address broad viral families and mutated variants. The vaccine design aims to neutralize emerging SARS-CoV-2 variants and other viruses with pandemic potential.
A study by Boston University School of Public Health and the University of Helsinki estimates that the Los Angeles wildfires in January 2025 resulted in at least 440 excess deaths, nearly 15 times higher than the official 31 deaths reported. The fires caused widespread destruction and disrupted healthcare services.
A new study found that self-reported physical activity is associated with reduced risk of all-cause mortality and major adverse cardiac events in individuals recently diagnosed with type 2 diabetes. Higher levels of physical activity were linked to lower risks of cardiovascular disease and death, even after adjusting for other risk fac...
A new study by Simon Fraser University researchers has identified a critical period in early childhood as a key indicator of future attention difficulties. The research found that children who exhibit organized brain networks similar to social connections have better attention skills.
A Connecticut College study found that fungus metabolites may boost the survival of ghost shrimp in freshwater ecosystems. The study showed a 48% lower mortality rate and altered behavior among shrimp exposed to these byproducts.
A study by University of Miami business professor Kevin Hong found that big crowds on synchronous content platforms like Twitch and YouTube Live can inhibit participation due to cognitive bedlam and emotional polarity. AI-powered bots may hold promise in moderating conversations and making them more coherent.
A study by University of Miami researchers found that organizations are experiencing increased conflicts over social issues like racism, climate change, and LGBTQ rights. The 'MOB mentality' is leading to decreased productivity and employee turnover.