The 2026 release expands coverage of emerging novel psychoactive substances, including synthetic cannabinoids, fentanyl analogs, and pharmaceutical drugs. The database provides comprehensive and up-to-date support for forensic, toxicology, and drug surveillance workflows.
States adopting recreational cannabis laws in addition to medical cannabis laws experienced a 45% relative reduction in cannabis seizure counts. This decline suggests a reduction in illegal cannabis supply and changes in law enforcement priorities.
Researchers at Hokkaido University developed a new platform to evaluate male reproductive function in living mice, enabling non-invasive, real-time monitoring of fertility. This approach reduces animal use and costs, while providing continuous and long-term data, and has potential applications in oncofertility research.
A new international survey reveals distinct differences in how veterinarians and animal welfare scientists in Japan and the UK perceive animal welfare, particularly animal behavior. The study found that cultural values, such as Japan's interdependence-oriented culture and the UK's individualistic society, influence attitudes towards an...
A novel framework uses multimodal large language models to predict ischemia and reperfusion risk, achieving high sensitivity and specificity in large-scale datasets. The system outperforms baseline models with a 4.8-9.5% relative improvement and maintains consistent performance across diverse subgroups.
The Global Physics Summit will feature over 12,000 individual presentations on new research in astrophysics, particle physics, and quantum information science. Registered journalists and public information officers will receive daily emails with information during the meeting.
A new EEG domain generalization method achieves state-of-the-art accuracy across three public datasets, outperforming baseline methods in noise robustness. The model uses domain-invariant feature and data augmentation to enhance cross-subject generalization, demonstrating robust solutions for BCI technology applications.
JMIR Publications has partnered with the University of Turku to provide unlimited open-access publishing, eliminating financial barriers and administrative hurdles for researchers. The partnership offers APC waivers for corresponding authors affiliated with the university, allowing them to publish in prestigious titles at no cost.
Seabirds have a significant impact on plant growth and dune formation on uninhabited islands, with guano providing essential nutrients. The research highlights the importance of protecting seabird habitats to maintain ecosystem balance.
Astronomers detect rare cosmic burst from colliding galaxies, which sheds light on how the universe creates heavy elements like gold and platinum. The burst, known as GRB 230906A, is believed to have been triggered by the collision of two neutron stars, releasing a flood of energy and forging heavy elements.
A new optimization method for solar cells reduces voltage drops in transport layers, enabling efficient charge separation even with high extraction barriers. Researchers achieved a 24.6% efficiency by optimizing TL thickness and carrier mobility.
A new study finds that the amount of time per year that extreme heat makes it unsafe to go about daily life has doubled since the 1950s, with younger adults facing 2x more hours of heat-related limitations, while older adults face 50% more
In Ethiopia's city of Mekelle, spotted hyenas consume organic waste, reducing greenhouse gas emissions and preventing disease. By doing so, they save the city over $100,000 in waste management costs, highlighting the vital ecosystem service they provide.
Researchers developed Zephyrus, an AI agent capable of analyzing and answering questions in natural language about weather and climate data. The agent can handle language-based queries, translating them into code and generating plain language answers.
Researchers at Washington State University have discovered the microscopic landscape of proteins in plant leaf cells, revealing how they convert sunlight into bioenergy. The study provides a new view of the molecular engine of photosynthesis and its potential for future fine-tuning of crops.
The ARLIS initiative aims to apply Zero Trust Architecture principles to quantum systems, evaluating security postures and developing recommendations for future security standards. By aligning emerging quantum technologies with national security standards, ARLIS seeks to enable rapid government adoption of quantum systems.
Research suggests that modernization can increase cultural differences, rather than reducing them. Thomas Talhelm's study of China's rice- and wheat-growing regions found that families in rice-growing areas tend to be more collectivistic, living in large multigenerational households and less likely to live alone.
A new study reveals that deep-sea microbes like Nitrosopumilus maritimus can adapt to warmer, nutrient-poor waters, maintaining their role in nitrogen cycling and primary production. This finding suggests that these microbes may play an important role in reshaping ocean-nutrient distribution in a changing climate.
A new study found that cannabis intoxication disrupts many types of memory, including verbal, visuospatial, and episodic content memory. Participants who consumed cannabis performed significantly worse than the placebo group on most measures, with significant differences appearing in 15 of the 21 tests.
A study found that high heat stress does not reduce prosocial behavior, but cultural and gender differences significantly impact egalitarianism, resource maximization, and competitiveness. Women tend to exhibit more egalitarian behavior than men, while cultural differences affect specific elements of prosociality.
Researchers compared mineralization of calcium phosphate on titanium dioxide nanoparticles coated with zein and polydopamine, finding PDA-coated particles accumulated more mineral mass. The study's findings could guide the design of better implants, water purification materials, and sensing technologies.
A Chinese Neurosurgical Journal study developed a radiomics-based machine learning model to identify high-risk patients with traumatic brain injury who require emergency decompressive surgery. The model accurately distinguished patients who later required secondary surgery, suggesting its potential to complement clinical judgment.
Researchers develop world's first DNA aptamer that binds to neurofilament light chain, a protein released into the blood with neurodegeneration. The aptamer, MN711, shows high affinity and specificity comparable to commercially available antibodies.
Researchers discover SMAD7 acts as a positive regulator of Wnt/β-catenin signaling, promoting dental pulp stem cell regeneration and tissue repair. The study provides new insights into the molecular mechanisms governing tooth regeneration and holds promise for regenerative endodontic procedures.
A novel AI-based framework, EDGCN, decodes dynamic variations in EEG patterns for better brain-computer interface technology. The model outperforms current state-of-the-art methods with high classification accuracies and decoding accuracy, enabling more seamless communication between the human brain and machines.
Researchers found that Gracixalus weii treefrog's call is similar to a bird-like chirp of the Black-Breasted Thrush, highlighting the evolution of acoustic symbols in amphibians influenced by ecological interactions with birds. This phenomenon provides a reliable alternative to morphological or molecular diagnosis for cryptic species
Subway systems are consistently reporting thermal discomfort due to the rising heat, with complaints increasing by 10-27% for every 1 degree Celsius above 10 degrees Celsius in Boston, New York, and London respectively. The study aims to help transit agencies anticipate extreme heat and implement targeted mitigation strategies.
Researchers developed a method to use PFAS to extract lithium from high-salinity brine pools, reducing environmental damage and costs. The process, which uses electrothermal heating, recovers 82% of lithium fluoride at 99% purity, outperforming traditional methods in terms of energy efficiency and water usage.
A research team has made a breakthrough in breeding winter-hardy faba beans, an ancient crop high in protein and nitrogen-fixing ability. The team identified a single gene that distinguishes between winter and summer varieties, offering a sustainable alternative to soy in Europe and accelerating the breeding of robust winter field beans.
A study found that radiologists who reviewed imaging tests twice after AI flagged them as abnormal were 53% less likely to be held liable in court compared to those who reviewed once. This suggests that changes to radiologist workflow could reduce legal risk, but may also come with increased costs.
A new biotech company, Ibnova Therapeutics, will accelerate treatments for heart disease through cellular therapies, backed by Australian and Danish partnerships. The company aims to conduct human clinical trials within three to five years.
A UNIGE study shows that connected devices can gather valuable data to help prevent neurological and mental disorders. The study found that AI-analysed data from smartwatch and smartphone data can accurately predict emotional and cognitive fluctuations, with error rates ranging from 5-20%.
Researchers at ETH Zurich have developed a new boron-based coupling method that enables the rapid production of key proteins for cancer therapies, overcoming the concentration barrier in chemical protein synthesis. This breakthrough allows for the creation of new peptide and protein medications, as well as unnatural amino acids with sp...
Researchers at OIST identified 80 plasma membrane repair proteins in budding yeast, revealing a coordinated sequence of molecular events. The study provides a foundation for investigating plasma membrane repair mechanisms in higher eukaryotes, including human cells.
Emerging research across conceptual frameworks, biomarker science, digital phenotyping, and artificial intelligence synthesizes a translational pathway toward a more biologically grounded and clinically useful approach to psychiatric diagnosis. The current system falls short due to standardized clinical language and lack of biological ...
Researchers mapped GLP-1 expression in 25 brain regions in each sex, uncovering striking differences in key circuits. The atlas reveals sex-biased expression in certain medullary nuclei, with higher Glp1 densities and numbers of Glp1-expressing neurons in females compared to males.
A new study found that voluntary exercise reshapes the gut microbiota, leading to changes in tryptophan metabolism and serotonin signaling. Exercise decreased the relative abundance of certain bacterial genera, shifting neuroactive signaling and lowering a key receptor in the memory center of the brain.
Researchers have successfully reconstructed videos from mouse brain activity, allowing them to understand how the brain processes visual information. By analyzing the neural activity in the visual cortex, the team created high-quality reconstructions of 10-second video clips, revealing the brain's representation of visual cues.
A mini-review synthesizes large-scale genomic findings to illuminate the polygenic architecture underlying common epilepsies. Rare genetic variants contribute to epilepsy risk, with shared biological pathways involving ion channel function and synaptic excitability
A new study suggests that chemical weathering beneath thick continental ice sheets may have consumed atmospheric carbon dioxide and prolonged global glaciations during the snowball Earth event. This process could have slowed atmospheric warming and delayed deglaciation, helping to explain the long durations of some snowball Earth events.
The study found that managing nitrogen pollution requires coordinated strategies, as reducing one type of nitrogen compound can increase another's deposition to the oceans. Future emission changes could alter oceanic nitrogen deposition by 24-6% depending on emission pathways.
Recent scientific progress in nanotechnology has led to the development of engineered nanomaterials that can remove, transform, or immobilize heavy metals in contaminated environments. These nanomaterials possess unique properties that make them highly reactive and efficient at interacting with contaminants.
Generative AI in medical imaging enables data synthesis, image enhancement, and modality translation to improve diagnosis and treatment outcomes. The review discusses challenges and future prospects, including convergence with large-scale foundation models and multimodal information for holistic understanding.
The LeaN On platform offers a 12-step journey to educate users on lymphoedema signs, actions, and when to seek professional support. It will be tested in a research project to evaluate online lymphoedema support, including nurse-supported and self-directed options.
Researchers found that removing typhoon-induced precipitation leads to sharply declining soil moisture and more severe drought conditions worldwide. The effect of typhoons varies by region, acting as a condition that exacerbates drought in some areas, while mitigating it in others.
Researchers developed an undercoordinated chromium single-atom catalyst that enhances sulfur electrocatalytic activity and lithium-sulfur battery performance. The unique design regulates electronic states, increasing sulfur electrocatalytic activity and achieving outstanding cycling stability and rate capability.
Researchers propose Mo6+ doping to stabilize LNO cathodes under deep delithiation conditions through grain boundary strengthening. The strategy addresses mechanical degradation and enhances electrochemical stability.
A Ru-based porphyrin covalent organic framework catalyst enhances the epoxidation of inert olefins by air, producing high-value epoxides. The catalyst activates benzylic C-H bonds to generate peroxy species, regulating oxygen transfer for selective epoxidation.
Researchers at Tsinghua University Press have developed a novel nanodrop therapy to treat corneal neovascularization, a condition where new blood vessels grow on the cornea. The therapy, which is non-invasive and can be administered via eyedrops, has shown promising results in animal models and could pave the way for clinical translation.
Mn-doped MoS2-based nano-cored-yarn electrodes exhibit high capacitance and conductivity, leading to improved energy storage performance. The electrodes achieve a maximum energy density of 13.84 mWh/cm² and maximum power density of 5866.85 mW/cm².
Researchers summarize advances, challenges, and prospects in light management for all-perovskite tandem solar cells. Strategies focus on minimizing external optical losses and enhancing photon capture capability to improve photon-to-carrier conversion efficiency.
A new study reveals that volcanic eruptions can trigger rainfall patterns similar to those produced by natural climate variability, effectively 'projecting' their influence onto the ocean-driven cycles. The research identifies a complex interplay between natural climate phenomena and volcanic forcing, with implications for climate inte...
Researchers developed an integrated NMR and LC–MS approach to distinguish between stereochemical variants of methionine oxidation in antibody drugs. The method resolves subtle structural variations relevant to biologic drug quality, strengthening stability testing and quality assessment.
Researchers developed a novel NMR approach to analyze the structure of therapeutic antibodies without isotope labeling. The technique uses site-specific methyl signals to detect subtle structural variations, including glycosylation patterns and local flexibility. This method has significant implications for ensuring the quality of biol...
Researchers developed the Simplified Adolescent Factors for Endometriosis (SAFE) score, a 5-minute questionnaire to identify at-risk patients and fast-track specialist referrals. The test aims to reduce the average 6-8 year diagnostic delay, allowing for early treatment and improved quality of life.
A new study reveals that early breast cancer cells use intense mechanical pressure to their advantage, hijacking a sensor to multiply rapidly and migrate away from the primary tumour. The pressure also triggers a series of signals that promote aggressive behaviour in cancer cells, leaving a lasting mechanical memory.
Researchers developed an antibody test for Mpox that accurately identifies those with infection and vaccine-derived antibodies, helping authorities prioritize vaccine use and study disease transmission. The test, validated in Rwanda, uses only four key antibody signatures to ensure affordability and accessibility.
Researchers at Scripps Research have developed a blood-based approach that examines protein shape in the bloodstream, distinguishing cognitively normal individuals from those with Alzheimer's and mild cognitive impairment with high accuracy. The new test could help move diagnosis and intervention to an earlier stage.
A team of researchers achieved efficient bicarbonate-mediated integrated carbon dioxide capture and electrolysis to produce CO, reducing energy consumption and improving process performance. The new process couples CO2 capture with electrocatalytic conversion, enabling a closed-loop cycle.
A study from the University of Oregon found that virtual reality games can increase players' sense of altruism and influence levels of empathy. Participants in the game 'Empathy in Action' showed higher ratings of cognitive empathy but a decline in affective empathy, suggesting that players may feel motivated to help without directly e...