Endocannabinoids are similar to the cannabinoids present in cannabis, but they are found naturally in the body. Endocannabinoids—and cannabinoids—work through a signaling system that supports neurodevelopment, but whether manipulating this system prenatally has long-lasting effects remains unclear. In a new JNeurosci paper, researchers led by Ismael Galve-Roperh, from the Complutense University of Madrid, used mice to explore this unknown.
The researchers decreased expression of an endocannabinoid receptor in the prefrontal cortex of prenatal mice and assessed the impact of this manipulation on gene expression, neural properties, and behavior after the mice were born. Cortical neurons of the offspring did not migrate to their proper locations in the brain. Additionally, these mice had altered expression of genes related to cortex development, neuron structure, and neural signaling. On a behavioral level, the prenatal manipulation that lowered expression of this endocannabinoid receptor impaired social interaction and movement in offspring. These behavioral differences were reflective of the genetic and cellular changes that the researchers observed.
According to the researchers, this work suggests that hindering development by manipulating this system prenatally may lead to neuropsychiatric conditions, especially those involving social deficits. Because cannabis acts through the same receptor the authors manipulated in this study, this work has implications on the understanding of prenatal cannabis exposure.
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About JNeurosci
JNeurosci was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors' changing publishing needs, representing breadth of the field and diversity in authorship.
About The Society for Neuroscience
The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 35,000 members in more than 95 countries.
JNeurosci
10.1523/JNEUROSCI.0120-25.2025
Prenatal Downregulation of CB1 Cannabinoid Receptors in the Mouse Prefrontal Cortex Disrupts Cortical Lamination and Induces a Transcriptional Signature Associated with Social Interaction Deficits
22-Sep-2025
The authors declare no competing financial interests.