The latest special issue of PLOS Medicine features five studies outlining novel strategies for detecting cancer and for identifying minimal residual disease—when a small amount of tumor cells survive treatment, potentially leading to recurrence of cancer. The studies were selected by PLOS Medicine ’s editorial team and guest editors Chris Abbosh, Sarah-Jane Dawson, and Charles Swanton.
Last year, more than 19 million people around the world were newly diagnosed with cancer, and more than 10 million died from the disease. The ability to detect cancer early and to identify minimal residual disease could help improve timely treatment and lower these numbers.
Two of the featured studies discuss innovations in early detection. One, led by Jeffrey Szymanski of Washington University School of Medicine, United States demonstrates the potential for an approach called plasma cell-free DNA ultra-low-pass whole genome sequencing to distinguish between benign and malignant tumors caused by the condition neurofibromatosis type 1—and to help monitor the effectiveness of treatment. The other, led by Brian Nicholson of the University of Oxford, UK outlines how routine clinical tests could be widely used to estimate the risk of cancer for people with unexpected weight loss.
The other three studies address minimal residual disease. Yaqi Wang of Fudan University Shanghai Cancer Center, China and colleagues showed that combining magnetic resonance imaging with measurements of circulating tumor DNA (ctDNA)—tumor DNA found in the bloodstream—can help predict treatment effectiveness and risk of recurrence for people with locally advanced rectal cancer. Meanwhile, Jeanne Tie of the Walter and Eliza Hall Institute of Medical Research, Australia and colleagues demonstrated that post-treatment ctDNA measurements can help predict risk of relapse for people with colorectal cancer that has spread to the liver.
Lastly, Pradeep Chauhan of Washington University School of Medicine, United States and colleagues showed how next-generation sequencing of tumor DNA found in urine could aid in detecting minimal residual disease and guide personalized treatment for people with bladder cancer that has invaded the bladder wall.
The methods outlined in all five studies have the potential to be widely applied and could help inform the future of cancer care and research.
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In your coverage please use this URL to provide access to the freely available papers:
http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003728
http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003732 http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003734
http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003741
Chauhan et al. article information:
Citation : Chauhan PS, Chen K, Babbra RK, Feng W, Pejovic N, Nallicheri A, et al. (2021) Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study. PLoS Med 18(8): e1003732. https://doi.org/10.1371/journal.pmed.1003732
Funding : This work was supported by the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) under award number TL1TR002344 (Principal Investigator, Jay F. Piccirillo; K.C.), the Radiological Society of North America (RSNA) Medical Student Research Grant (K.C.), the Midwest Stone Institute (Z.L.S.), the Rabushka Bladder Cancer Research Fund (Z.L.S., V.K.A.), the Damon Runyon Clinical Investigator Award (V.K.A), the Alvin J. Siteman Cancer Research Fund (A.A.C.), the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS) under award number UL1TR002345 (Principal Investigator, Bradley Evanoff; A.A.C.), the National Cancer Institute (NCI) under award number K08CA238711 (A.A.C.), the Cancer Research Foundation Young Investigator Award (A.A.C.), and the V Foundation V Scholar Award (A.A.C.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests : I have read the journal’s policy and the authors of this manuscript have the following competing interests: A.A.C. has patent filings related to cancer biomarkers, and has served as a consultant/advisor to Roche, Tempus, Geneoscopy, NuProbe, Daiichi Sankyo, AstraZeneca, Fenix Group International and Guidepoint; A.A.C. has stock options in Geneoscopy, research support from Roche, and ownership interests in Droplet Biosciences. V.K.A. has received research funding from ORIC Pharmaceuticals and currently serves as an employee of Bristol Myers Squibb; V.K.A. has stock options in both companies. Z.L.S. serves as a consultant/advisor for Photocure, outside of the submitted work. B.C.B. discloses honoraria from Mevion Medical Systems and consulting work for Regeneron/Sanofi, outside of the submitted work. R.K.B. is employed as a hospital medicine physician for SSM Health St. Louis. F.Q. has stock options in Centene, Gilead, and Horizon Therapeutics. No potential conflicts of interest were disclosed by the other authors.
PLOS Medicine
Observational study
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I have read the journal’s policy and the authors of this manuscript have the following competing interests: A.A.C. has patent filings related to cancer biomarkers, and has served as a consultant/advisor to Roche, Tempus, Geneoscopy, NuProbe, Daiichi Sankyo, AstraZeneca, Fenix Group International and Guidepoint; A.A.C. has stock options in Geneoscopy, research support from Roche, and ownership interests in Droplet Biosciences. V.K.A. has received research funding from ORIC Pharmaceuticals and currently serves as an employee of Bristol Myers Squibb; V.K.A. has stock options in both companies. Z.L.S. serves as a consultant/advisor for Photocure, outside of the submitted work. B.C.B. discloses honoraria from Mevion Medical Systems and consulting work for Regeneron/Sanofi, outside of the submitted work. R.K.B. is employed as a hospital medicine physician for SSM Health St. Louis. F.Q. has stock options in Centene, Gilead, and Horizon Therapeutics. No potential conflicts of interest were disclosed by the other authors.