A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka of the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, found that docosahexaenoic acid (DHA), which is abundant in fish oil, suppresses gastric fundus smooth muscle contractions induced by physiologically active substances such as bradykinin. Although DHA has previously been shown to inhibit voltage-dependent Ca 2+ channels (VDCCs), the research group found a new pharmacological action of DHA to inhibit the Orai1 channel, which is one of store-operated Ca 2+ channels (SOCCs). These findings suggest that DHA prevents and improves excessive gastric motility by inhibiting two types of Ca 2+ entry channels. The results of this research were published in the journal Scientific Reports on May 22, 2024.
Scientific Reports
Experimental study
Animals
Inhibitory mechanisms of docosahexaenoic acid on carbachol-, angiotensin II-, and bradykinin-induced contractions in guinea pig gastric fundus smooth muscle
22-May-2024
All authors declare that they have no conflicts of interest.