Below please find a summary and link(s) of new coronavirus-related content published today in Annals of Internal Medicine . The summary below is not intended to substitute for the full article as a source of information. A collection of coronavirus-related content is free to the public at https://www.acpjournals.org/topic/category/coronavirus . Rapid, Living Practice Points from ACP: Update on remdesivir use for hospitalized COVID-19 patients
Rapid, Living Practice Points from ACP: Update on remdesivir use for hospitalized COVID-19 patients
In updated Rapid, Living Practice Points ( https://www.acpjournals.org/doi/10.7326/M20-8101 ), the American College of Physicians (ACP) addresses emerging evidence regarding the effectiveness of remdesivir in hospitalized patients with COVID-19 and whether benefits and harms vary by symptom duration, disease severity, and treatment duration. The paper, developed by the Scientific Medical Policy Committee of the ACP, Should Remdesivir Be Used for the Treatment of Patients with COVID-19? Rapid, Living Practice Points from the American College of Physicians (Version 2), was published today in Annals of Internal Medicine .
The ACP's updated Practice Points aim to target patients who will most benefit from the use of remdesivir and now suggests the following:
Based on a systematic review conducted by the Minneapolis VA Evidence Synthesis Program that has been updated through Dec. 7, 2020, this version represents a change from the previous classifications of "moderate" and "severe" disease to now describe disease severity according to respiratory support requirements [e.g. no requirement, supplemental oxygen, mechanical ventilation/ECMO].
Remdesivir is a broad-spectrum antiviral agent administered intravenously. It was authorized on Oct. 22, 2020, for emergency use for the treatment of COVID-19 in the U.S. by the Food and Drug Administration and in other countries.
ACP's Practice Points are developed by ACP's Scientific Medical Policy Committee and provide advice to improve the health of individuals and populations and promote high value care based on the best available evidence derived from assessment of scientific work (e.g. clinical guidelines, systematic reviews, individual studies). ACP Practice Points aim to address the value of screening and diagnostic tests and therapeutic interventions for various diseases, and consider known determinants of health, including but not limited to genetic variability, environment, and lifestyle.
The ACP Practice Points will be maintained as a "living" document and ACP's Scientific Medical Policy Committee will monitor emerging evidence to determine its impact on the main findings and conclusions, and issue updates as needed.
Media Contacts: The full text of the article is free to the public. Click on the link above to access the text. To speak with someone from ACP, please contact Andrew Hachadorian at AHachadorian@acponline.org or (215) 351-2514.
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Annals of Internal Medicine