Oak Brook, IL - The January edition of SLAS Discovery features the cover article, "Cryo-EM: The Resolution Revolution and Drug Discovery" by Taiana Maia de Oliveira, Ph.D., Lotte van Beek, Ph.D., Fiona Shilliday, Ph.D., Judit E. Debreczeni, Ph.D., and Chris Phillips, Ph.D., from AstraZeneca.
Cryo-EM, a fast-growing technique in the pharmaceutical industry, enables structure determination of sought-after targets such as large multiprotein complexes and membrane proteins that eluded other structural biology methods. The intricate interactions between compounds and proteins are crucial in accelerating the drug discovery process. The cover article reviews how the structural understanding gained through Cryo-EM is influencing drug discovery projects focused on TRP channels, GPCRs, ribosomes and other high value targets.
The January issues of SLAS Discovery includes 13 articles of Original Research in addition to the cover article.
Articles of Original Research include:
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Access to January's SLAS Discovery issue is available at https://journals.sagepub.com/toc/jbxb/25/11 . For more information about SLAS and its journals, visit http://www.slas.org/journals . Access a "behind the scenes" look at the latest issue with the SLAS Discovery Author Insights podcast. Tune in by visiting https://www.buzzsprout.com/1099559 .
SLAS (Society for Laboratory Automation and Screening) is an international community of professionals and students dedicated to life sciences discovery and technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building.
SLAS Discovery: Advancing the Science of Drug Discovery , 2019 Impact Factor 2.195. Editor-in-Chief Robert M. Campbell, Ph.D., Twentyeight-Seven Therapeutics, Boston, MA (USA).
SLAS Technology: Translating Life Sciences Innovation , 2019 Impact Factor 2.174. Editor-in-Chief Edward Kai-Hua Chow, Ph.D., National University of Singapore (Singapore).
SLAS DISCOVERY