These cells were isolated from bone marrow and stimulated in cell culture to become effective killer cells. Mice that had been previously implanted with tumors were injected with these activated cells. In contrast to cells that were not anti-tumor–specific, the cell-culture activated T cells were now very effective at infiltrating tumor transplants and in reducing tumor size.
These results present a potential immunotherapy strategy for cancer treatment with appropriately reactivated anti-tumor–specific T cell subsets that already exist in patients' own body.
View the PDF of this article at: http://www.jci.org/cgi/content/full/114/1/67
Journal of Clinical Investigation