Published in the Advanced Functional Materials , University of Minnesota researcher Hongbo Pang led a cross-institutional study on improving the efficacy of nucleotide-based drugs against prostate cancer and bone metastasis.
In this study, Pang and his research team looked at whether liposomes, when integrated with the iRGD peptide, will help concentrate antisense oligonucleotides (ASOs) into primary prostate tumors and its bone metastases. Liposomes are used as a drug carrier system, and ASOs are a type of nucleotide drug.
More importantly, they investigated whether this system helps more drugs across the vessel wall and deeply into the tumor tissue. This is critical because, although nucleotide drugs offer unique advantages in treating tumors and other diseases, they often suffer from a poor efficiency of crossing the blood vessels and entering the tumor tissue, where their targets reside. This problem greatly limits their clinical applicability and efficacy.
"Our system demonstrates a good ability to deliver more ASOs into both primary tumor tissue and bone metastases -- which is the primary site for prostate cancer metastasis," said Pang, an assistant professor in the College of Pharmacy and a member of the Masonic Cancer Center. "This further translates into a significant improvement of ASO efficacy to inhibit the growth of primary tumor and bone metastases. We expect this system to become a universal carrier system, to improve the clinical efficacy of ASOs and other nucleotide drugs."
The study found that:
Pang and his team say that iRGD-liposomes are proven as a desirable delivery system for ASOs, and hold the promise to improve the clinical efficacy of nucleotide drugs in cancer therapies.
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This study was funded by the National Institute of Health and the State of Minnesota.
Advanced Functional Materials