Background :
Chemotherapeutic drugs and biomedicines need to be delivered effectively to their targets. This is especially true of drugs with an electric charge. In these cases, the use of the direct delivery method can result in adverse effects such as poor biodistribution, drug degradation, and short circulation. The use of liposomes in drug delivery minimizes these side effects. The use of liposomes also improves drug concentration, increases circulation time, and reduces the doses required. Currently, lipid-based drug delivery methods face challenges related to lipid properties, such as charge. These difficulties cause the charged drugs to adhere to certain body surfaces, making delivery inefficient. The use of asymmetric Large Unilamellar Vesicles (LUVs) would allow for different charges on the inside and outside of the vesicles. Thus, allowing flexibility to maximize the amount of a drug that can be loaded.
Technology Overview :
Lipid vesicles, liposomes, are artificial membranes that contain an aqueous interior surrounded by a bilayered lipid shell. The process allows for the creation of asymmetric LUVs. This would allow for the inner and outer lipid layers to have different properties, such as charge. The flexibility of this property can address the limited payload capacity of liposomal drug delivery.
Advantages :
Applications :
Intellectual Property Summary : US20230338288A1
Licensing Status : Available
Licensing Potential : Development partner - Commercial partner - Licensing
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