The researchers find that accumulated liver lipids come from serum fatty acids, newly made fatty acids within the liver, and dietary fatty acids. These fats build up in NAFLD because the liver is unable to regulate changes in fat metabolism that normally occur when one alternates between fasted and fed states. In an accompanying commentary, Shinji Tamura and Iichiro Shimomura write, "In light of these findings, it seems possible that the reduction of oxidative stress as well as the use of insulin-sensitizing agents…may prove to be successful treatments for NAFLD."
TITLE: Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
AUTHOR CONTACT:
Elizabeth Parks
University of Minnesota, St. Paul, MN USA
Phone: (612) 625-1785; Fax: (612) 625-5272; E-mail: eparks@umn.edu
View the PDF of this article at: https://www.the-jci.org/article.php?id=23621
ACCOMPANYING COMMENTARY:
TITLE: Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease
AUTHOR CONTACT:
Shinji Tamura
Osaka University, Osaka, Japan
Phone: 81-6-6879-3732; Fax: 81-6-6879-3739; E-mail: tamuras@imed2.med.osaka-u.ac.jp
View the PDF of this article at: https://www.the-jci.org/article.php?id=24930
Journal of Clinical Investigation