Articles tagged with Fatty Acids
Hepatocellular carcinoma (HCC) cells upregulate lipid uptake, de novo lipogenesis, and fatty acid oxidation, supporting tumour growth and metastasis. Targeting lipid metabolism, including CE synthesis and lipid biosynthetic enzymes, shows synergistic effects with antitumour drugs.
Researchers from Shinshu University discovered that pterostilbene, a natural polyphenol, stabilizes PPARδ, enhancing fatty acid oxidation and promoting lipolysis in skeletal muscle cells. This finding has potential implications for developing functional foods and nutritional supplements to target muscle fat metabolism.
Researchers found that fatty acids and hydroxy acids can combine to create stronger and more stable structures than either molecule can form alone. This cooperative effect suggests that simple molecules may have been helping each other create more organized chemical systems, which could eventually lead to the emergence of life.
A large European study found a correlation between ultra-processed food consumption and increased levels of harmful fatty acids in the blood. The study, which analyzed data from 15,200 participants, suggests that ultra-processed foods may contribute to metabolic stress and potential health risks.
A new study finds that pregnant women with low levels of a specific fatty acid molecule are more likely to have children with childhood asthma. The researchers also found that children of these mothers are more prone to respiratory infections and altered lung microbiomes.
A team of researchers has developed a new microbial method for producing medium-chain fatty acids, which are used in various industries, including cosmetics and detergents. The breakthrough enables the use of waste materials as feedstock for fermentation, reducing reliance on palm oil.
A new study from the University of Minnesota Medical School has identified certain naturally occurring polyunsaturated lipids that selectively induce death in senescent cells, which are old and damaged cells that accumulate with age. These lipids trigger a process called ferroptosis, which can be used as a potential treatment for age-r...
Scientists developed a compound that targets Liver X Receptor specifically in liver and gut to lower triglycerides. In first-in-human clinical trial, participants showed significant drops in triglycerides and remnant cholesterol after taking the drug.
Researchers found that blocking Caspase-2 enzyme in mice increased chronic liver damage and cancer risk as they aged. The study highlights the need for caution when targeting this pathway to treat fatty liver disease.
Scientists create designer enzymes in yeast cells, enabling sustainable production of industrially important fatty acids. The new method reduces environmental issues associated with palm oil extraction.
Estrogen activates previously unknown pathways in the colon, triggering pain and increasing sensitivity to certain foods. This explains why women are more likely to suffer from IBS and provides potential new ways to treat the condition.
A Northwestern University study found that Chicago parents have low intake of omega-3 fatty acids, specifically EPA and DHA, with women consuming even lower amounts. This deficiency may have direct negative effects on children's health, including preterm birth risk.
Dr. Peter Tontonoz, a distinguished UCLA professor, will receive the American Heart Association's Basic Research Prize for his groundbreaking contributions to understanding lipid metabolism and its role in cardiometabolic disease. His work has transformed the scientific understanding of this critical heart health factor.
A recent study published in the Journal of Bone and Mineral Research found that blood fatty acid composition can predict bone mineral density from childhood to adolescence. The study, which included 480 children, found that higher proportions of certain fatty acids were linked to higher bone density.
Researchers at UC San Diego developed a computational method to determine omega positions of lipids in complex biological samples. This breakthrough makes omega position information accessible even for lipids in low concentrations, significantly advancing lipid research.
Researchers at Osaka Metropolitan University discovered a new way to block cancer cell energy production by suppressing de novo fatty acid synthesis with ethyl p-methoxycinnamate. This natural substance inhibits ATP production, leading to increased glycolysis as a possible survival mechanism in tumor cells.
A new study found that excessive oleic acid in olive oil drives fat cell growth, increasing the risk of obesity. High levels of oleic acid stimulate the proliferation of precursor cells that form new fat cells, leading to a larger capacity for storing excess nutrients.
Researchers at URV develop system to monitor oxidation of hazelnuts using hyperspectral camera, confirming atmosphere and light exposure as main causes of oxidation. The method allows for quality standards to be set and improves packaging techniques.
A preclinical study found that linoleic acid, an omega-6 fatty acid, activates a major growth pathway in tumor cells, particularly in triple-negative breast cancer subtypes. A high-linoleic-acid diet enhanced tumor growth in mice with triple-negative breast cancer.
Researchers found that administration of fish oil reduced insulin resistance and improved blood sugar levels in non-obese rats, reversing a condition similar to type 2 diabetes. The study suggests that omega-3 fatty acids may be a key factor in reducing inflammation and improving glucose metabolism.
Researchers are exploring the effects of herring roe omega-3 on exercise metabolism and recovery in active females. The study aims to investigate its benefits for supporting a healthy lifestyle across all ages, including muscle function, metabolism, and cognitive health.
Researchers at Chalmers University of Technology have developed a novel approach to packaging canned tuna, using a water-based solution of amino acid cysteine, which removes up to 35% of accumulated mercury. This technology has the potential to improve food safety and reduce human exposure to mercury via food.
A recent study led by Heike Bischoff-Ferrari found that taking omega-3 fatty acids slowed down biological aging across several epigenetic clocks by up to four months. The combination of omega-3, vitamin D, and strength training proved to be even more effective in slowing down the biological aging process.
A new study from DTU National Food Institute finds that temperature and light intensity play a crucial role in the yield of various nutrients produced by the microalga Nannochloropsis oceanica. The research suggests a two-stage cultivation process to optimize nutrient production, paving the way for sustainable food production.
A team of scientists discovered polar bear sebum's anti-icing properties, making it harder for ice to stick. The study sheds light on polar bear ecology and may lead to sustainable anti-ice surface coatings.
Furan fatty acids have been found to exist in all samples of rubber tree latex, with varying concentrations. The study identifies specific genotypes with high FuFA content, offering potential for enhanced economic value and sustainability.
Juvenile dolphins possess specialized receptors for detecting fatty acids in their mother's milk, which plays a crucial role in energy and brain development. This 'fat taste' system may provide an evolutionary advantage in selecting high-quality milk from mothers.
A new study reveals that cooking sulfur-containing vegetables like garlic and onions can transform into harmful trans-fats when heated above 140°C. The study found that antioxidants can reduce the risk of trans-fat formation, but excessive caution is still necessary.
Researchers developed a non-invasive way to assess fat composition around the heart using magnetic resonance imaging. This technique may help doctors identify patients at greatest risk for cardiac problems and predict treatment outcomes.
Researchers at King's College London developed a new method to produce biofuels from fatty acids in cooking oil, making it as effective as diesel with improved efficiency. The technology uses enzymes to break down fatty acids into alkenes, reducing the need for conventional catalysts and toxic chemicals.
Researchers develop innovative hybrid control strategy to improve product yields in biosynthetic processes. The new approach combines model-based optimization with in-cell feedback control, outperforming traditional methods and promising reduced costs and environmental impact.
Researchers at Osaka University identified ARMC5 as a degradation factor for SREBP1, essential for maintaining balance in adipose tissue. This discovery may lead to the development of novel drugs regulating saturated and unsaturated fatty acid levels.
A study published in the International Journal of Cancer found that high levels of omega-3 and omega-6 fatty acids were linked to lower rates of various cancers. The research, which analyzed data from over 250,000 people, suggests that increasing these essential fatty acids through diet or supplements may help reduce cancer risk.
Researchers at Hokkaido University discovered unique lipids in sorghum that have anti-diabetic and anti-inflammatory properties. The study suggests that incorporating sorghum into diets could promote cardiovascular health, reduce inflammation, and enhance metabolic health.
The study found that a decrease in insect and spider biodiversity is accompanied by a decline in biomass and key fatty acid content. Aquatic ecosystems show less pronounced land use effects, whereas terrestrial ecosystems exhibit significant differences depending on land use.
MASLD's complex molecular mechanisms underpin fat accumulation and progression. Targeting lipid metabolism with GLP-1 agonists, FXR agonists, and CPMs holds promise for effective treatments.
Researchers at Osaka Metropolitan University used CRISPR/Cas9 to create a strain of Euglena that produces wax esters with shorter carbon chains, improving their cold flow and suitability as a biofuel feedstock. This breakthrough could potentially replace petroleum-based production of wax esters with biological sources.
A new study funded by the National Institutes of Health found that consuming fish during pregnancy was associated with a lower likelihood of autism spectrum disorder (ASD) diagnosis, particularly in females. The study also found no significant association between omega-3 supplements and autism diagnosis.
Researchers found that omega-3 fatty acid EPA can rescue changes caused by saturated fats in cardiomyocytes, indicating a potential protective effect on heart health. The study highlights the importance of dietary choices in preventing arrhythmias.
Researchers found high expression of OLAH linked to fatal disease outcomes, while low levels were associated with recovery. The enzyme drives severe disease through inflammatory responses and fatty acid production.
Researchers found that Megamonas degrades intestinal myo-inositol, enhances lipid absorption, and contributes to obesity. The study suggests potential strategies for future obesity management by illustrating the bacterium's mechanism.
A new study finds that combining an inhibitor of a metabolic pathway with chemotherapy could improve treatment outcomes in triple negative breast cancer brain metastases. Inhibiting fatty acid synthase, an enzyme critical for cancer cell survival, shows promise in improving chemotherapy efficacy.
Following a Mediterranean diet and taking omega-3 fatty acid supplements, participants experienced significant reductions in inflammatory and non-inflammatory skin lesions. Those who reached target omega-3 levels showed the most substantial improvement in acne severity.
Researchers found that individual responses to proteins and fats can drive insulin production, challenging the long-held belief that fats have negligible effects on insulin release. This study has implications for tailored dietary guidance to manage blood sugar and insulin levels in individuals with diabetes or those at risk.
Researchers develop an artificial fusion protein combining UndB with catalase, creating a whole cell biocatalyst that converts fatty acids to alkenes with high efficiency. The biocatalyst produces pure 1-alkene as a valuable biofuel and can be used to generate a large number of hydrocarbons.
Researchers have identified SEMA3A as a critical player in the development of fatty liver disease, where it closes blood vessel 'windows' hindering fat transport. Inhibiting SEMA3A reduces liver fat and improves function.
A study found that lower levels of omega-3 polyunsaturated fatty acids (PUFAs) were associated with poorer outcomes in patients with liver cirrhosis and hepatocellular carcinoma. The researchers suggest that supplementing with n-3 PUFAs may help prevent sarcopenia and improve quality of life in these patients.
A study by Columbia University researchers found that an injectable omega-3 emulsion can prevent brain damage in newborn rodents after oxygen deprivation near birth. The therapy, which enhances omega-3 fatty acids' ability to penetrate the blood-brain barrier, reduced brain damage and preserved neurologic function.
Researchers found that gut bacteria-generated linoleic acid metabolite KetoC markedly reduced inflammation and immune cell expansion. gKetoC also suppressed prolonged T-cell proliferation and dendritic cell activation. The study suggests a potential molecular axis governing the immunomodulatory effects of gKetoC.
Researchers found a genetic link between higher circulating levels of arachidonic acid and lower risk for bipolar disorder. The study suggests that altering arachidonic acid synthesis pathways may reduce bipolar disorder risk, particularly in those with compromised pathways.
Researchers identified a genetic link between higher levels of arachidonic acid and lower risk of bipolar disorder. Arachidonic acid, found in meat, seafood, and human milk, may hold potential for lifestyle or dietary interventions to prevent or treat the condition.
Researchers found that spinal cord injury triggers abnormal neuronal activity that causes abdominal fat tissue compounds to leak and pool in the liver and other organs. A short course of gabapentin, commonly prescribed for nerve pain, prevented this damaging metabolic effect.
A study published in Frontiers in Plant Science reveals that leaf lipid droplets contain myosin-binding proteins and enzymes associated with furan-containing fatty acid biosynthesis. This discovery paves the way for future research into leaf lipid droplet functions, potentially leading to advancements in lipid production technology.
A recent study by Tohoku University researchers investigated the association between dairy product consumption and odd-number carbon chain fatty acids (odd-FA) within the Japanese population. The study found a correlation between dairy consumption and odd-FA, which was previously confirmed in Europe and Oceania.
A review of mitochondrial energy metabolism in diabetic cardiomyopathy reveals disrupted dynamics and oxidative stress as key triggers. Targeted therapies, such as antioxidants and ketogenic diets, show promise in combating this debilitating condition.
A recent study highlights the importance of considering lamb's nutritional value when comparing its carbon footprint. The research found that lambs finished on grass diets had a lower carbon footprint per unit of omega-3 polyunsaturated fatty acids content, making them a more sustainable option.
A nationwide cohort study found that 25% of pregnant women don't eat fish during pregnancy and only 16% take omega-3 supplements. The study suggests that supplement use is less common among those who consume less fish, increasing their risk for insufficient intake.
Scientists discovered a plausible pathway for the formation of protocells, suggesting that phosphorylation may have occurred earlier than expected. This finding helps understand how early evolution took place and sheds light on the origins of life.
Recent research by scientists at Boyce Thompson Institute reveals that a specific fatty acid produced by gut bacteria directly influences fat metabolism in animals. This discovery sheds light on the complex interplay between diet, gut microbiota, and host metabolic health.
Researchers have identified the molecular mechanism behind memory creation and found that saturated fatty acids interact with a protein called STXBP1. This interaction coordinates the release of fatty acids and directs communication at synapses in the brain.