Articles tagged with Fatty Acids
A study of 332 adolescents found that higher levels of DHA were associated with better selective and sustained attention, while ALA was linked to lower impulsivity. The results suggest the importance of a diet rich in omega-3 fatty acids for healthy brain development.
Researchers explored how differences in skin composition affect susceptibility to diseases like psoriasis and atopic dermatitis. The study found that body site determines skin structure and function, with specific lipids and proteins playing a crucial role in disease diagnosis.
Researchers have identified two new unique molecular trends in fingerprint oils that can help estimate the age of a fingerprint. The presence of epoxides and an increase in medium-length fatty acids were found to be indicative of fingerprint aging.
Researchers found that fatty acids in cooking emissions form a stable film on surfaces, protecting trapped pollutants from breakdown. This film can become rougher and attract water, trapping toxins underneath.
A recent study led by Veronika Somoza found that egg powder is a valuable source of essential nutrients, including vitamins and indispensable amino acids. The researchers discovered that the drying process did not lead to contamination with heavy metals and that egg powder can provide up to 61% of a child's daily requirement for selenium.
Researchers discover two specific enzymes that assemble medium-chain fatty acids in marine microalgae Nannochloropsis oceanica, elevating MCT production and enabling customizable oils. The study paves the way for engineering industrial microalgae into efficient sustainable feedstock.
Neuroblastoma cells with extra copies of the MYCN gene rely on fatty acids for survival and growth. Inhibiting fatty acid uptake selectively blocks tumor growth in these cells.
Researchers at Okayama University discovered EPA's molecular target, which blocks purinergic chemical transmission and reduces pain perception. The study suggests EPA can be used as a therapeutic strategy for managing chronic pain with fewer side effects.
Engineers yeast Ogataea polymorpha for efficient productions of free fatty acids from sole methanol, achieving high levels of FFA accumulation. The research uncovers mechanisms of methanol toxicity during bio-productions and develops a sustainable route for fatty acid production.
Researchers discover G6PD's pivotal role in activating pentose phosphate pathway to counter oxidative stress, leading to increased cell death and tumor shrinkage. Ovarian cancer cells' reliance on fatty acid metabolism fuels oxidative compound production, which can be offset by G6PD inhibition.
Researchers at Hokkaido University identified over 1,300 types of ceramides in the top layer of human skin, including their chain lengths and fatty acid compositions. The discovery could improve understanding of skin barrier function and disease pathology.
Scientists discover that SARS-CoV-2 creates cellular storehouses of fat to replicate and cause disease. Compounds cutting off fatty fuel stop the virus from replicating in lab tests.
Researchers at University of Southern Denmark discover that certain fatty acids can neutralize disease-causing bacteria by turning off their ability to infect and spread. The discovery has potential implications for developing new treatments for antibiotic-resistant infections.
The Global Organization for EPA and DHA Omega-3s (GOED) has introduced an interactive tool to catalog all human studies on EPA and DHA omega-3s. The Clinical Study Database (CSD) provides a comprehensive searchable database with over 45,000 studies, allowing users to filter by outcome, population demographics, study size or dosage.
A new study published in Nutrients found that individuals with higher red blood cell DHA levels have a 49% lower risk of developing Alzheimer's disease. The study, conducted on 1,490 participants aged 65 and older, suggests that increasing dietary omega-3 DHA levels may slow the development of the disease.
Researchers at Brigham and Women's Hospital have identified LIPE, a lipase that degrades triglycerides, as a promising candidate therapeutic target for Parkinson's disease. Inhibiting LIPE reduced alpha-synuclein inclusions and alleviated neurodegeneration in patient-derived neurons and a C. elegans model of toxicity.
A recent review of 71 clinical trials found that consuming about 3 grams of omega-3 fatty acids per day can modestly lower blood pressure in adults. The analysis suggests that this daily dose may be an optimal amount to help reduce the risk of coronary heart disease.
Researchers found microbes influence which genes are used for fat digestion and absorption, leading to changes in epithelial cells. The study also showed microbes promote lipid absorption and impact systemic processes like weight gain.
A team of researchers developed a simple yet powerful strategy for creating new enzymes with novel reactivity that can produce valuable chemical compounds. They used photobiocatalysis to repurpose naturally occurring enzymes and achieved an enantioselective biocatalytic reaction.
Researchers used lipidomics to identify lipids associated with cardiovascular disease and Type 2 diabetes, finding a link between unsaturated fatty acids in the diet and reduced risk. The study's findings support replacing saturated fats with unsaturated ones for preventing these diseases.
Researchers at NTU Singapore's Lee Kong Chian School of Medicine found that saturated fatty acids degrade protein FIT2, leading to insulin-producing cells' loss of function and death. This impairs the body's ability to secrete enough insulin, resulting in diabetes.
Scientists have developed a new approach to predict pollution from cooking emissions by analyzing the behavior of oleic acid nanostructures. By identifying the molecular properties that control their transformation in the atmosphere, researchers can better understand and model the impact of cooking aerosols on human-made climate change.
Researchers at Mount Sinai have developed a reproducible method to advance the maturation of human pluripotent stem cell-derived cardiomyocytes, which support heart muscle contraction. The new protocol enables efficient energy generation from both carbohydrates and fatty acids, improving disease modeling and regenerative therapies.
A study found a shift in the profile of specialized lipid mediators from pro-resolving to pro-inflammatory in patients with cognitive impairment, correlating with severity of cognition impairment. The researchers identified novel mechanisms of brain health and potential therapeutic targets for slowing down Alzheimer's disease onset.
A new study found that omega-3 fatty acid supplementation can broadly improve immunotherapy and other anti-cancer drugs in the clinical setting. In mice, diets enriched with omega-3s blocked tumor growth when combined with immunotherapy or anti-inflammatory treatment, indicating possible synergistic anti-tumor activity.
A new app called Metaboseek has been developed to streamline the analysis of comparative metabolomics data, helping researchers identify valuable compounds. The app was created by a postdoctoral research associate and is now essential to his lab's work.
A comprehensive literature review found that consuming plant-based alpha-linolenic acid (ALA) rich in walnuts and flaxseeds can lower cardiovascular disease risk by 10% and fatal coronary heart disease risk by 20%. ALA may also benefit heart health when combined with other omega-3s.
Scientists analyzed ancient vessels from India and discovered that prehistoric people used a variety of ingredients, including foraged plants, cultivated crops, and traded goods. The study found no evidence of cultural change impacting food processing during the Copper Age to Indus Valley Civilization transition.
Scientists at NTU Singapore have developed a method to produce and extract oils from a type of common microalgae, which are edible and have superior properties as those found in palm oil. The newly discovered method would serve as a healthier and greener alternative to palm oil.
A new analysis by University of Copenhagen researchers found that a Nordic diet has positive health benefits regardless of weight loss. The diet's unique fat composition, high in omega-3 and omega-6 unsaturated fats, plays a significant role in lowering blood sugar and cholesterol levels.
Researchers at Michigan Medicine found that a medium-chain fatty acid called octanoic acid can reduce further injury and improve heart function after a heart attack. This discovery could lead to the development of a new therapy to treat heart attacks, targeting the interplay between energy metabolism and epigenetics.
A U-M study defines how a cytokine and fatty acid combination triggers ferroptosis, a type of cell death previously studied with synthetic molecules. This natural mechanism could make immunotherapy treatments more effective, particularly for cancers where the treatments currently work for only about 30% of patients.
Research reveals SARS-CoV-2 can have multiple variants in one person, with some hiding in specific cells like kidneys or spleens. This can make complete virus clearance more difficult, as the body struggles to defend against dominant strains.
Scientists from Tokyo Institute of Technology have created a method to boost KODA production in plants, utilizing biotechnology. This technique involves introducing key genes into two plant species and optimizing their localization to improve yield. The findings may lead to mass-producing diverse oxylipins for fertilizers and pesticides.
A trial of older US adults found that vitamin D and omega-3 fish oil supplements reduced the risk of autoimmune diseases by 22-30% compared to placebo. The effects were more pronounced after two years of supplementation.
Researchers found that vitamin D and/or omega-3 fatty acid supplements significantly lowered the rate of autoimmune diseases like rheumatoid arthritis, polymyalgia rheumatica, and psoriasis. The largest benefit was seen after two years of supplementation with daily doses of vitamin D (2000 IU) and marine omega-3 fatty acids (1000 mg).
Scientists at Nanyang Technological University have developed a novel therapeutic approach to tackle obesity, reducing body fat and improving blood markers through a hydrogel injection and near infrared light treatment. The treatment shows significant promise in lab trials, with mice experiencing reduced body mass and improved metabolism.
Researchers at Weill Cornell Medicine discovered that deleting the EtfD Mtb enzyme renders Mycobacterium tuberculosis unable to sustain an infection in mice. The enzyme plays a critical role in fatty acid breakdown, making it an attractive target for TB treatment.
Researchers at Karolinska Institutet discovered that omega-3 fatty acids activate the GPR32 receptor, which reduces inflammation in blood vessels and prevents atherosclerosis. This breakthrough discovery paves the way for new strategies to treat and prevent cardiovascular disease using omega-3 fatty acids.
A study led by LSU Health found how late-onset retinal degeneration develops and identified a surprising potential therapeutic, metformin. The research suggests that an enzyme called AMPK activates the protein CTRP5 to regulate fatty acid metabolism and energy stability.
Researchers discovered that blood stem cells use high-energy fatty acids from the body's fat stores to power up their response to infection. This finding could lead to new approaches in treating bacterial infections, particularly in vulnerable and older individuals.
The Zinc Status Index is a new evaluation method developed by Cornell food scientists that uses biomarkers to calculate the physiological status of a subject. It aims to provide a comprehensive assessment tool for zinc deficiency, which affects over 1 billion people worldwide.
Severely malnourished children who consumed ready-to-use therapeutic food fortified with DHA showed significant improvement in gross and fine motor abilities, language proficiencies, and social skills. The findings suggest that reducing omega-6 fatty acid levels can also aid neurological development.
A study in rats found that a diet of highly processed foods led to inflammation and behavioral signs of memory loss in the brain. Supplementing with omega-3 fatty acid DHA prevented these effects almost entirely. The study suggests that limiting processed foods and increasing DHA consumption may help prevent rapid memory decline in old...
A high intake of alpha linolenic acid (ALA), found in nuts, seeds, and plant oils, is associated with a lower risk of death from all causes and diseases of the heart and blood vessels. However, further studies are needed to confirm the association with cancer mortality.
A study by researchers at the University of Virginia Health System has linked American Indigenous ancestry to an increased risk of omega-3 fatty acid deficiency among Hispanic Americans. The genetic variation associated with this deficiency can be used to identify patients at risk and provide personalized nutritional guidance.
Researchers found Prozac reduces lipid concentrations in monkey brains, linked to potential side effects in young patients. The study suggests dietary changes may alleviate adverse effects by influencing lipid synthesis.
Researchers found a mutation in ELOVL4 enzyme impairs communication between neurons, leading to impaired motor control and coordination. The study provides new insights into the essential role of ELOVL4 in motor function and synaptic plasticity, suggesting potential therapeutic strategies for patients with spinocerebellar ataxia.
Researchers have developed poly-ion complex (PIC) nanomicelles loaded with CPT1A inhibitors to deliver drugs into brain cells, reducing fatty acid oxidation and improving treatment for glioblastoma. The delivery system successfully increased cellular concentration of the cargo and biological activity.
A study by Van Andel Institute scientists found that surplus sugar causes mitochondria to become less efficient, reducing their energy output. A low-sugar ketogenic diet reversed this effect, supporting healthy mitochondrial integrity and function.
A study found that higher omega-3 acid levels in the blood are associated with a significant increase in life expectancy, similar to quitting smoking. The researchers analyzed data from over 2,200 people aged 65 and found that four types of fatty acids, including omega-3, can predict mortality risk.
A new method developed by Institute for Systems Biology allows researchers to show how fatty acids are absorbed by single cells. The study reveals that fatty acid uptake is differentially regulated by two downstream effectors of the mTOR pathway in brain cancer cells, uncovering a novel combination therapy to block tumor growth.
Researchers have identified distinct metabolic phenotypes in hepatocellular carcinoma subtypes, providing insights into precise personalized treatment options. The study revealed a poor prognosis subtype strongly correlated with immune pathway up-regulation and unsaturated fatty acid accumulation.
Researchers identified genetic markers to control fatty acid content in sunflower oil, a key source of vegetable fats. The study used genomic selection to create new crop varieties with tailored properties suitable for different uses.
A new study published in The BMJ found that patients diagnosed with migraines experienced less pain when following a diet rich in omega-3 fatty acids and low in omega-6 fatty acids. Participants reported fewer days of headaches per month, but not a change in quality of life.
A recent trial found that consuming a diet high in omega 3 fatty acids significantly reduces headache frequency and severity compared to a typical diet. The study, published in The BMJ, suggests that increasing omega 3 intake can lead to reduced levels of pain-reducing oxylipins and improved quality of life for those with migraines.
Research reveals that saturated fatty acids play a key role in forming memories, particularly in the amygdala region of the brain. The study found that levels of myristic acid, found in coconut oil and butter, increased significantly as new memories were formed.
A new study found that a low Omega-3 Index is associated with increased risk of early death, comparable to the risk of smoking. The research used data from the Framingham Heart Study and suggested that biomarkers integrating lifestyle choices could help identify individuals at risk and inform treatment approaches.
A study published in Nature Metabolism suggests that a Western high-fat diet can increase the risk of painful disorders, such as arthritis and diabetes-related neuropathic pain. By altering diet or developing drugs that block fatty acid release, chronic pain patients may find relief.
Researchers at Duke-NUS Medical School have made significant breakthroughs in understanding the transport of omega-3 fatty acids across the blood-brain barrier. The study revealed the structure and function of a protein called MFSD2A, which plays a crucial role in delivering essential fatty acids to the brain.