In a related commentary, Dontscho Kerjaschki writes, "these findings add yet another facet to the plasticity of macrophages, which are already known to transform from naïve monocytes into VEGF-producing cells. Thus, macrophages support lymphangiogenesis in 2 different ways, either by transdifferentiating and directly incorporating into the endothelial layer or by stimulating division of preexistent local lymphatic endothelial cells."
TITLE : Inflammation induced lymphangiogenesis in the cornea arises fromCD11b-positive macrophages
AUTHOR CONTACT :
Joan Stein-Streilein
Schepens Eye Research Institute, Boston, MA USA
Phone: 617-912-7494; Fax: 617-912-0105; E-mail: jstein@vision.eri.harvard.edu
View the PDF of this article at : https://www.the-jci.org/article.php?id=23874
ACCOMPANYING COMMENTARY :
Title : The crucial role of macrophages in lymphangiogenesis
AUTHOR CONTACT :
Dontscho Kerjaschki
University of Vienna, Vienna, Austria
Phone: 43-1-40400-5176; Fax: 43-1-40400-5193; E-mail: dontscho.kerjaschki@meduniwien.ac.at
View the PDF of this article at : https://www.the-jci.org/article.php?id=26354
Journal of Clinical Investigation