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Antibody neutralizes Zika virus in mice

01.14.19 | Proceedings of the National Academy of Sciences

Structure of mature flaviviruses. Surface view of mature ZIKV showing the E proteins arranged in a herringbone pattern. The three E protomers within one icosahedral asymmetric unit are shown in blue, red and green. Three E dimers form a raft. Credit: Image courtesy of Feng Long.

A study of Zika virus in murine models found that mice injected with a single dose of ZIKV-195, a neutralizing monoclonal antibody, 5 days after viral exposure were protected against the virus; the findings suggest that ZIKV-195 cross-links viral envelope proteins that are critical for viral and cellular membrane fusion, which in turn neutralizes Zika virus, according to the authors.

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Article #18-15432: "Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope," by Feng Long et al .

MEDIA CONTACT: Michael G. Rossmann, Purdue University, West Lafayette, IN; tel: 765-494-4911, 765-409-0238, 765-494-4909; email: mr@purdue.edu

Proceedings of the National Academy of Sciences

Additional Media

Structure of ZIKV in complex with Fab ZIKV-195. The cryo-EM map at a contour level of 1.5σ is radially colored from green (inside) to red (outside). Credit: Image courtesy of Feng Long

Keywords

Monoclonal Antibodies Mouse Models Viruses

Article Information

Journal

Proceedings of the National Academy of Sciences

Contact Information

Michael G. Rossmann

mr@purdue.edu

How to Cite This Article

APA:

Proceedings of the National Academy of Sciences. (2019, January 14). Antibody neutralizes Zika virus in mice. Brightsurf News. https://www.brightsurf.com/news/L554757L/antibody-neutralizes-zika-virus-in-mice.html

MLA:

"Antibody neutralizes Zika virus in mice." Brightsurf News, Jan. 14 2019, https://www.brightsurf.com/news/L554757L/antibody-neutralizes-zika-virus-in-mice.html.