Articles tagged with Mouse Models
A new study reveals that astrocytes actively participate in motor-learning circuit rewiring by eliminating synapses in the striatum. The research identifies MEGF10 as a key molecular mediator of this process, which is regulated by dopamine signaling and neural activity.
A study by RIKEN researchers identifies a MYCN-driven biomarker that predicts the risk of liver cancer. The biomarker, known as the MYCN niche score, uses machine learning to analyze gene expression patterns and indicates whether a tumor-free liver is at high risk for developing tumors.
Researchers found that inhibiting microglia activity improved young mice's recall of fearful experiences. Microglia markers were also increased in brain areas related to memory formation, suggesting enhanced memory recall. This study may provide insight into preventing infantile amnesia and understanding human memory loss.
A two-step genome editing method integrates large human genomic fragments into mice, mimicking human regulatory landscapes. This platform enables the creation of physiologically relevant humanized models for therapeutic targets and disease research.
A multidisciplinary team of world-leading experts is developing an off-the-shelf engineered product that could address liver failure in millions of patients. The ImPLANT project aims to create synthetic biology-based gene circuits in human induced pluripotent stem cells to drive cell differentiation into all required liver cell types.
Scientists discovered that the brain sorts emotionally significant stimuli into three independent channels: salience, valence, and value. This allows the brain to evaluate information efficiently and guide decisions.
A Northwestern University study found an injectable regenerative nanomaterial helps protect the brain during a vulnerable window after most common type of stroke. The therapy successfully crossed the blood-brain barrier and reduced brain damage, showing no signs of side effects.
Early gastric cancer cells become self-sufficient by producing WNT7B, creating a self-sustaining loop and activating WNT signaling internally. This mechanism is triggered by MAPK signaling activation and has been validated in genetically engineered mouse models and human patient-derived organoids.
Researchers developed a new approach using the microbial protein Archaerhodopsin-3 to induce apoptosis in cancer cells, leading to significant tumor shrinkage when exposed to green light. The findings, published by Okayama University, show great potential for this light-activated molecule as a novel cancer therapy.
Researchers discovered a low-dose mixture of zinc, serine, and branch-chain amino acids can alleviate behavioral deficits in mouse models of autism by promoting neuronal communication and improving social behaviors. The combination was found to be effective at low doses, whereas individual supplements had no effect.
A study from Gladstone Institutes finds that dysfunctional mitochondria can initiate Parkinson's disease. The researchers used a unique mouse model to demonstrate the link between mitochondrial dysfunction and energy breakdown in cells, shedding light on potential new treatments.
Researchers at UC Riverside and City of Hope have developed a novel Pin1 degrading compound that suppresses pancreatic cancer peritoneal metastases. The treatment targets not only cancer cells but also tumor-supporting cells, potentially overcoming treatment resistance.
A team of researchers led by Dr. Michele Ardolino is bridging scientific fields to unlock the mechanisms behind effective immune responses in cancer patients. They will study the interactions between the immune system, nervous system, and gut microbiome to design more personalized treatment strategies.
A study found that reducing amino acids methionine and cysteine in lab mice' diets led to significant weight loss through increased thermogenesis, similar to cold-induced methods. The research team believes this could be a promising approach for obesity treatments and developing functional food products.
A compound found in rosemary leaves may significantly improve the healing of skin wounds and reduce scarring, according to new research. The study found that carnosic acid, a naturally occurring antioxidant in rosemary, can shift the healing process from scarring to healthy skin regeneration.
The acquisition unifies genetics and stem cell research expertise to accelerate discovery and translate science into therapies. Researchers will gain access to advanced platforms, including the NYSCF Global Stem Cell Array, to study disease mechanisms and test treatments.
Researchers at UZH have identified a new function of checkpoint inhibitors in promoting tissue healing, which could help treat fibrosis and chronic wounds. The study found that TIGIT upregulates a growth factor critical for repairing tissue after viral infections.
Long-term exposure to fine air pollutants like PM2.5 can impair metabolic health by disrupting the normal function of brown fat through complex epigenetic changes. The study identified two enzymes, HDAC9 and KDM2B, as key drivers of this process.
A new technology allows for clear observation of living retina and microglia's behavior, revealing their increased activity before tissue damage in diabetic mice. The study found that the diabetes drug liraglutide reduced microglia's activity in healthy mice too, suggesting a direct modulation mechanism.
Researchers at Champalimaud Centre for the Unknown used machine learning techniques to show that mice's facial movements reflect their hidden thoughts. This discovery could offer unprecedented insight into brain function and potential new research tools.
A new study from the University of Illinois shows that severe flu infection in pregnant mice leads to a breakdown in placental and brain barriers, allowing potentially harmful molecules to accumulate in the fetal brain. Fibrinogen accumulation has also been linked to neuroinflammatory conditions, and researchers found it accumulated in...
This study reveals that GPNMB modifies the tumor microenvironment by repurposing macrophages into immunosuppressive tumor-associated macrophages. The interaction between GPNMB and Siglec-9 enables this reprogramming, leading to increased cancer cell motility and invasiveness.
Researchers at Kobe University have discovered a specific set of neurons that direct mice's attention to peers in need and those who are friends. These 'PV interneurons' play a crucial role in modulating social behavior, including empathy and preference for social targets.
A new study published in Molecular Nutrition and Food Research found that red meat consumption causes an imbalance of bacteria in the intestinal microbiota, leading to exacerbated colonic inflammation. The diets resulted in a decrease in beneficial bacterial strains and an increase in pro-inflammatory cells.
Researchers discovered a multi-faceted mechanism behind ASD, revealing the gut microbiota and host immune system's influence on disease progression. Precision-selected probiotics restored metabolic balance, reduced neuroinflammation, and ameliorated behavioral abnormalities in ASD mouse models.
A team of researchers from Okayama University has identified SNAP25 as a key component in the transmission of sour taste signals and the long-term survival of type III taste cells. The study found that mice deficient in SNAP25 had impaired responses to sour-tasting substances, highlighting the importance of this protein in maintaining ...
A study in mice found that high triglyceride levels directly cause abdominal aortic aneurysms, challenging the notion that they are merely biomarkers of vascular disease. Researchers identified specific proteins and lipoproteins as causal drivers of aneurysm development and growth.
Researchers from FAU and the Sensing Institute created a detailed computer model of the mouse brain's vasculature, simulating how brain blood vessels respond to hemodynamics and vasodynamics. The model shows that transitional vessels play a critical role in regulating flow and protecting the brain during increased activity.
Researchers at Harvard Medical School found that lithium loss in the brain is an early change leading to Alzheimer's, while a novel lithium compound can reverse memory in mice. The study suggests a new theory of the disease and a potential strategy for diagnosis and treatment.
Researchers mapped the frequencies used by Staphylococcus bacteria to communicate, identifying a signal from another species as potent against MRSA. This alternative technique weakens bacterial ability to coordinate attacks on hosts without killing them.
Researchers at OIST introduce a mouse motion capture method using marker-based approach to track high-quality data on complex movements. The method avoids pitfalls associated with smaller animals, enabling detailed studies of neuroscientific and physiological foundations of mouse movement.
Male mice displayed increased aggression when the instigator was a novel individual or one with whom they had no established dominance relationship. In contrast, aggression was not observed when the instigator was a familiar opponent with a known hierarchical relationship.
Researchers found that accumulated mitochondrial DNA mutations do not impair respiratory function in mice, contradicting the 'mitochondrial theory of aging'. This study suggests a reevaluation of the relationship between mtDNA mutations and premature aging symptoms.
Researchers at the Francis Crick Institute found that mice recognize and compare their own social rank to an unfamiliar opponent's using chemical cues. The study showed that both olfactory and vomeronasal systems are used to process this information, allowing mice to compensate if one system is missing.
Researchers at Osaka Metropolitan University found that plasma-activated medium reduces synovial sarcoma tumor growth in human cells and mice, with no obvious side effects. The treatment was verified through in vitro and in vivo tests, offering a new potential treatment option for this rare form of cancer.
A new brain atlas developed by researchers at Duke University will increase precision in measuring changes in brain structure, making it easier to share results. The tool, the Duke Mouse Brain Atlas, provides a detailed map of the entire mouse brain, from large structures down to individual cells and circuits.
A new study reveals that protein sources in an animal's diet significantly alter the gut microbiome, with some having extreme effects. The researchers found that diets high in brown rice, yeast, or egg whites led to changes in amino acid metabolism and complex sugar degradation.
A recent study discovered that simultaneously targeting PIKfyve and KRAS-MAPK can eliminate tumors in preclinical human and mouse models. This approach shows promise for treating pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer, which is challenging to treat due to its cellular environment.
A new collaboration aims to develop an affordable and accessible monoclonal antibody therapeutic for CCHFV, treating thousands globally. USAMRIID discovered the antibody in mice, and LifeArc is supporting development of a fully humanized antibody.
This study reveals NAT10 is crucial for spermatogonial proliferation and differentiation. In Nat10-deficient mice, infertility occurs with reduced testicular sizes, germ cell depletion, and a loss of spermatogonial homeostasis.
Researchers found that combining imipridones with radiation therapy and temozolomide slowed glioblastoma growth and prolonged survival in mice. The treatment also boosted immune responses and suppressed MGMT protein expression, making it more effective.
Researchers at Osaka University identify a specific molecule, HLA-DRB1, that can be targeted by CAR-based therapy for AML. Engineered CAR T cells showed strong and specific anti-AML effects in vitro and in vivo with mice, without overt toxicity.
A new study by UCLA Health has discovered a drug that fully reproduces the effects of physical stroke rehabilitation in model mice. The drug, DDL-920, excites parvalbumin neurons, leading to significant recovery in movement control after stroke.
Researchers found that disrupting bacterial metabolism can help the body tolerate infection and heal more effectively. By inhibiting a specific metabolic pathway, they successfully reduced tissue damage in a mouse model of necrotizing skin infection.
Researchers have discovered column-like structures in the visual cortex of mice, where neurons processing stimuli from the same eye form clusters. This finding sheds light on the structural organization of the brain and may help solve the mystery of cortical columns' function.
Researchers studied mRNA length variations during atherosclerosis progression in mice, discovering shorter mRNAs as the disease advances. The findings suggest alternative splicing mechanisms may play a role in generating diverse mRNA sequences related to the disease.
Researchers have discovered a critical link between a cholesterol byproduct and Parkinson's disease development in mice. The study highlights the role of 24-OHC in forming Lewy bodies and killing dopamine neurons, with potential therapeutic targets emerging as drugs that prevent its production.
Researchers developed novel antibiotic BTZ-043 to target drug-resistant tuberculosis. The study showed that BTZ-043 effectively penetrates TB lesions and accumulates there in high concentrations, making it a promising treatment option for TB patients.
Researchers have successfully modeled a treatment-resistant form of asthma in mice, shedding light on the role of CD4+T resident memory cells and MHC-II molecules in lung inflammation. The study's findings may lead to new treatments for this severe and debilitating condition.
A new gene therapy has shown promise in treating a rare form of epilepsy, specifically Dravet syndrome, by replacing the SCN1B gene variant. The therapy increased survival rates, reduced seizure severity, and restored brain neuron excitability in mice with the condition.
Researchers discovered that mismatch repair genes are critical in eliciting damages to neurons vulnerable to Huntington's disease, triggering downstream pathologies and motor impairment. Targeting these genes may offer novel therapeutic approaches, including improving locomotor and gait deficits and reducing neuronal cell death.
Researchers at Tokyo University of Science have found that opioid delta-receptor agonists can alleviate stress-induced IBS symptoms in a validated mouse model by targeting the central nervous system. The study suggests that these drugs could provide a more definitive solution for IBS with minimal adverse effects.
Researchers successfully reversed existing inguinal hernias in male mice using an anti-estrogen drug, restoring their anatomy without surgery. Human tissue samples also showed identical molecular markers as in the mouse model, suggesting a promising treatment target for inguinal hernia repair.
A new study identified USP5 as an enzyme crucial for breaking down unneeded or damaged proteins in the heart. Low levels of USP5 lead to protein buildup, triggering dilated cardiomyopathy in animal models. Increasing USP5 levels helps clear protein 'junk', improving heart function and reducing disease progression.
A new drug developed by the Centre for Addiction and Mental Health (CAMH) has shown significant promise in reversing memory loss in a mouse model of Alzheimer's disease. The drug, GL-II-73, selectively targets GABA receptors to restore brain function and repair damaged neural connections.
Researchers from Osaka University found that selenoproteins are essential for counteracting lipid peroxides and maintaining hematopoiesis in human cells. The study also showed that dietary Vitamin E can protect hematopoiesis and repair impaired B cell differentiation, providing potential strategies for fighting age-related diseases.
A new study from University of Florida researchers finds that heatstroke can lead to lasting, multi-organ damage and obesity in mice for months afterward. The animals' hearts metabolically crashed two weeks after the initial injury, leading to chronic deterioration and weight gain.
Researchers at the University of Pittsburgh have developed a new way to grow T cells that can live longer and better destroy cancer cells in mice. By adding a compound called dichloroacetate to growth media, they created T cells less reliant on glucose and more efficient at using other energy sources.
This study used a senescence-accelerated prone strain 8 (SAMP8) male mice model to observe the protective effects of acupuncture on different brain regions in Alzheimer's disease. Acupuncture treatment improved learning and memory abilities, as well as depression-like behavior, by reducing apoptosis and decreasing tau protein deposition.
A new study identifies the molecular mechanisms underlying increased osteoarthritis risk in postmenopausal females, revealing that menopause-induced changes in sex hormone levels contribute to joint degeneration. Restoring these hormones may protect against cartilage degeneration, paving the way for novel treatments.