FINDINGS
A study published April 12 in Nature Communications identifies a protein that helps prevent excessive scarring. The protein, called fibromodulin (FMOD) forms a complex of molecules with interleukin 1β that stops myofibroblasts from forming excessive scar tissue.
IMPACT
The findings could lead to a new way to reduce or prevent excessive scarring, which could benefit patients recovering from surgery, injuries, or burns.
BACKGROUND
In previous studies, the researchers had described the critical role of FMOD in enabling scarless fetal-type repair as well as preventing excessive scarring during adult-type repair. For this new study, the researchers investigated the effects of FMOD on myofibroblasts, a key cell in healing and scar formation. Myofibroblasts should die off after a wound heals, but they can continue forming tissue long afterwards, leading to excessive scarring. The fibromodulin-based complex promotes the death of myofibroblasts.
COMMENT
“Dr. Eric Kang Ting and I have been studying how to reduce skin scarring for the past two decades at UCLA,” said Dr. Chia Soo, professor of surgery and vice chair for research for the UCLA Division of Plastic and Reconstructive Surgery. “This publication explores the crucial role of naturally occurring fibromodulin in regulating a key scar-forming cell, the myofibroblast. This, combined with our team’s FDA-approved clinical study led by Dr. Zhong Zheng using a fibromodulin-derived peptide in 54 patients for scar reduction, demonstrates a significant leap in potential treatments for patients with excessive scarring.”
AUTHORS
Study co-authors are Wenlu Jiang, Xiaoxiao Pang, Pin Ha, Chenshuang Li, Grace Xinlian Chang, Yuxin Zhang, and Lawrence A. Bossong, Eric Kang Ting, and Zhong Zheng.
FUNDING
National Institute of Dental and Craniofacial Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, UCLA CTSI grant (UL1TR000124), UCLA Operation Mend, UCLA Orthopaedic Hospital, UCLA Orthopaedic Hospital Research Center, the International Orthodontics Foundation, China Postdoctoral Science Foundation, Natural Science Foundation of Chongqing, China, and Chongqing Medical University Program for Youth Innovation in Future Medicine.
DISCLOSURES
Eric Kang Ting, Chia Soo, and Zhong Zheng are inventors of fibromodulin-related patents assigned to UCLA; founded Scarless Laboratories Inc. and Saint Therapeutics Inc., which sublicense fibromodulin-related patents from the UC Regents, who also hold equity in the company, and are also past or present officers of Scarless Laboratories, Inc. and Saint Therapeutics Inc.
Nature Communications
Experimental study
People
Fibromodulin selectively accelerates myofibroblast apoptosis in cutaneous wounds by enhancing interleukin 1β signaling
12-Apr-2025