As delayed pregnancies become more common, poor ovarian response (POR) is a growing challenge for assisted reproductive technology (ART). A new study conducted by researchers from Xiamen University and Huaqiao University, China explores the potential of Jinfeng pill, a traditional Chinese medicine, to improve ovarian function in rats with induced POR.
The study, published in Reproductive and Developmental Medicine , investigates how Jinfeng pill affects ovarian size, follicle development, and hormone levels of POR rats. They were treated with estradiol (E2), Jinfeng pill, or both.
The results showed that Jinfeng pill treatment—either alone or combined with estradiol—led to larger ovaries, more follicles at various stages of development, and enhanced ovarian blood flow in POR rat model. The combination therapy produced the most significant improvements, including increased vascular endothelial growth factor (VEGF) expression, which is associated with better blood circulation in the ovaries.
In terms of hormones, the combined treatment lowered follicle-stimulating hormone (FSH) levels and slightly increased anti-Müllerian hormone (AMH), a key marker of ovarian reserve. While the changes were not statistically significant in all groups, they suggest that the Jinfeng pill can support ovarian function by balancing hormones and improving follicular health.
The corresponding authors of this study commented, "Our study provides valuable insights into how Jinfeng pill could enhance ovarian function of POR rat, especially by improving blood flow and hormone regulation. With further research, we hope to expand these findings to human clinical trials, offering more effective treatments for women with poor ovarian response."
Reproductive and Developmental Medicine
Effect of Jinfeng Pill on ovarian function of Tripterygium wilfordii polyglycoside tablets induced poor ovarian response rats
17-Dec-2024