Articles tagged with Developmental Disorders
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Virginia Tech researchers identified a malformed area in the corpus callosum and pattern of bad connections that may help doctors diagnose Leigh syndrome earlier. The study found that developmental defects can be seen before symptoms appear, suggesting potential for earlier intervention.
Boston Children's Hospital will provide clinical research coordination for the IMPACT Network, a multisite clinical trial infrastructure enabling rapid and effective therapeutic development for autism. The grant, from ARIA, will support the development of study design protocols, recruitment strategies, and efficient workflows.
A new study by researchers in Canada and Italy suggests that young adolescents who participated in organized sports between ages 6 and 10 are less likely to defy authority figures. The study found that structured extracurricular activities can promote behavioral resilience and reduce the burden of disruptive behavior disorders.
Researchers identified a molecular mechanism linking early-life environments with memory by activating AP-1, which regulates genes involved in neuronal plasticity and learning. Early-life experiences produce long-lasting modulation of AP-1 activity, boosting gene networks that strengthen neuronal connections.
Researchers have discovered that Batten disease progression varies by sex and age, with male mice showing early auditory problems that improve with age, while female mice experience persistent difficulties. The study provides a new model for tracking brain function over time and testing treatments for this devastating disease.
A comprehensive systematic review and meta-analysis published in the Journal of the American Academy of Child & Adolescent Psychiatry found no association between prenatal acetaminophen exposure and the risk of neurodevelopmental disorders, including autism and ADHD. The study offers reassurance for pregnant women, public health agenci...
A new study reveals how prenatal alcohol exposure impairs key brain cells and circuits, leading to cognitive inflexibility and increased risk of compulsive alcohol use. Researchers identified a specific brain cell affected by early alcohol exposure, providing a clear target for developing more effective treatments of FASD.
A study found that child welfare system involvement in Pennsylvania increased the likelihood of developmental delay diagnoses for infants and toddlers, particularly those in foster care. Early intervention services were also more accessible to these children.
Researchers have identified four distinct profiles of Nonverbal Learning Disability, each with different strengths and challenges. The study suggests that current diagnostic criteria may be too broad, highlighting the importance of individualized approaches to care for children with NVLD.
A $8.6 million NIH grant has renewed funding for the Rare Disease Clinical Research Network project, focusing on cognition, communication, and neuropsychiatric symptoms in individuals with rare diseases. The initiative aims to develop biomarkers, support pilot projects, and foster skilled investigators.
A systematic review of over 9 million pregnancies found that gestational diabetes is associated with cognitive decline in mothers and an increased risk of neurodevelopmental disorders in children. Children born to mothers with gestational diabetes have a 36% higher risk of ADHD and a 56% higher risk of autism spectrum disorders compare...
The study reveals that enzymes KDM1A and KDM5C collaborate to prevent neurons from activating inappropriate genes, ensuring their proper function. This discovery opens new avenues to understand the origin of neurological disorders associated with intellectual disability.
A new study suggests that the high prevalence of Autism Spectrum Disorder in humans is linked to the rapid evolution of specific brain cell types and genes. The research found that human brains contain a unique array of neuronal cell types that evolved rapidly compared to other primates.
A study by Professor Chunxiu Gong's team identified the clinical presentation of Cornelia de Lange syndrome (CdLS) and genetic alterations in Chinese pediatric patients. The researchers found that 12 patients presented with classic CdLS, while others showed global developmental delays and growth retardation.
A new UK review reveals that 89-97% of autistic adults aged 40+ are undiagnosed, leading to a higher risk of age-related health problems. Middle-aged and older autistic adults face significant challenges in employment, relationships, and wellbeing.
Researchers found that preterm infants scored lower on both language comprehension and expression compared to full-term peers. The earlier the birth and lower the birth weight, the weaker the child's performance in language comprehension.
A Rutgers University study found that exposure to green spaces during critical periods of early childhood development is associated with a reduced risk of neurodevelopmental disorders, including ADHD and autism spectrum disorder. Higher levels of green space exposure were linked to lower risks across different exposure windows.
Researchers assess ligament maturation and movement impact on scoliotic conditions, providing new insights into the structural hallmarks of embryonic spinal ligaments. The study aims to identify potential connections between embryonic movement and spinal deformities in adolescent idiopathic scoliosis.
Researchers found that co-exposure to bisphenol A and retinoic acid disrupts neurodevelopmental gene signaling, leading to brain abnormalities. The study suggests a potential link between chemical exposure and neurodevelopmental disorders like autism spectrum disorder and attention deficit hyperactivity disorder.
ADHD researcher Barbara Franke's work transforms understanding of neurodevelopmental disorders through innovative molecular approaches. Her research combines cutting-edge bioinformatics with experimental models to identify genes and pathways underlying behavioral differences.
Researchers at KAIST have developed an AI-powered app called AACessTalk that enables meaningful communication between children with autism and their parents. The app uses personalized vocabulary cards and customized prompts to foster mutual engagement in dialogue.
The MyoStep project represents a significant advancement in pediatric mobility aids for children with cerebral palsy, addressing motor impairments that restrict participation in physical activities. The soft power suit provides a lightweight, discreet solution tailored to fit seamlessly into the lives of children and their families.
Researchers developed a coupled system model for liquid-fueled molten salt reactors, incorporating xenon and void transport. The validated model reveals how initiating events affect reactor safety and offers insights for future reactor designs.
Juvenile-onset recurrent respiratory papillomatosis (JORRP) is a rare disease causing chronic hoarseness and breathing difficulties in children. New clinical guidelines provide actionable recommendations for early recognition, diagnosis, and treatment to improve long-term outcomes.
Dr. Rhonda Winegar investigates the effectiveness of music therapy in supporting neurological care, including its ability to reduce anxiety and depression in Alzheimer's patients. Her research also highlights its potential to regulate heart rate and blood pressure, as well as improve motor function in individuals with Parkinson's disease.
Researchers at the University of Missouri's Thompson Center for Autism and Neurodevelopment have found that behavior at 9 months old can indicate a 1-year-old's likelihood of being at risk for autism. Parent surveys reported fussiness, irritability, and difficulty calming down were associated with early signs of autism by 12 months.
Young adults face anxiety due to conflicting pressures to accelerate their maturation and assume adult responsibilities earlier, while also encountering limitations that slow or limit their ability to take on these roles. This double bind creates a difficult navigation process for youths, with many things often outside of their control.
A comprehensive natural history study of SCN8A-related disorders has been completed, revealing a range of seizure types and neurodevelopmental features. The findings identify potential targets for future clinical trials, including the use of sodium channel blockers to manage epilepsy.
Scientists at UNIGE identified a defect in communication pathway between two brain structures, leading to rapid redirection of attention deficits. The discovery paves the way for better prediction of development and more targeted interventions.
Severe RSV disease among children is more likely those aged 2 or older with pulmonary or neurologic conditions. Younger children under 6 months and prematurity are high-risk factors for severe RSV in younger kids.
Neuro-immunologist Stephen Hauser has won the 2025 Breakthrough Prize in Life Sciences for his role in identifying the immune system's primary driver of damage to nerve cells in multiple sclerosis. His B-cell theory has led to the development of therapies that have transformed treatment, reducing relapses and improving prognosis.
A new study has revealed that Beagle dogs carrying mutations in the Shank3 gene exhibit face processing abnormalities, similar to those observed in human ASD patients. The research provides direct experimental evidence that mutations in Shank3 lead to ASD-like deficits in face processing, contributing to social impairments.
A new study reveals that tomato plants adapt to heat stress by delaying shoot apical stem cell development, allowing for stable yields. This redox-controlled mechanism enables the plant to temporarily suspend its maturation program during adverse conditions, resulting in significant yield losses prevention.
A research group has uncovered a potential mechanism linking maternal inflammation to delayed neurodevelopment in infants. CD11c-positive microglia, crucial for myelination, play a key role in this process.
A groundbreaking study reveals that autistic children exhibit social attention patterns similar to their typically developing peers during play, with a primary focus on toys rather than faces. This challenges the longstanding assumption that reduced eye contact is a definitive marker of autism.
A new study from the University of Colorado Anschutz Medical Campus identified significant mitochondrial dysfunction in lymphoblast cell lines from children with Dravet syndrome, a severe form of epilepsy. The findings suggest that mitochondrial defects play a role in the metabolic dysfunction observed in Dravet syndrome.
Exclusive or longer breastfeeding duration is associated with lower risk of developmental delays and social/neurodevelopmental conditions. This finding may inform parents, caregivers, and public health initiatives promoting early child development.
The review article examines the relationship between anemia and retinopathy of prematurity, focusing on iron deficiency and underlying molecular mechanisms. Anemia reduces oxygen delivery to the retina, exacerbating hypoxia and promoting pathological neovascularization.
Researchers at Baylor College of Medicine have identified new variants of CDKL2 and CDKL1 genes associated with developmental disorders, including epilepsy. The study proposes a mechanism by which defective variants cause neurological symptoms in affected individuals.
The COVID-19 pandemic has been associated with negative developmental trends in kindergarteners, persisting beyond the pandemic's onset. The study highlights troubling trends in kindergarteners' development before and during the pandemic, underscoring the need for further research.
A new study in rodents reveals that oxytocin can delay an embryo's development for days to weeks after conception, a phenomenon known as diapause. This finding may offer new insights into pregnancy and fertility issues faced by humans.
A POSTECH research team developed a photoacoustic computed tomography (PACT) system that non-invasively monitors cerebrovascular changes in small animals with early stages of an ischemic stroke. The technology also measures oxygen saturation in blood vessels, allowing precise tracking of vascular recovery after stroke.
Researchers found that brain connectivity related to cognitive control predicted substance use initiation, while cognitive control behavior did not. Stronger connectivity between the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex was associated with delayed substance use onset.
A McMaster University research team identified several small molecules in blood that inversely associate with developmental outcomes. The study highlights the complex connections between diet, gut health and a child's growth and cognitive milestones.
Researchers developed an AI approach to identify genes contributing to neurodevelopmental disorders like autism spectrum disorder, epilepsy, and developmental delay. The tool enhances gene discovery by predicting additional genes involved in these conditions.
A University of Turku study reveals that mothers' weight and diet during pregnancy influence their child's motor skills up to age 5-6. Children of overweight or obese mothers are almost three times more likely to develop a developmental coordination disorder, highlighting the importance of healthy prenatal nutrition.
Researchers at Tel Aviv University have developed a novel method to measure PTEN gene activity, which is associated with cancer and autism. This breakthrough may lead to personalized therapeutics and earlier disease detection.
Researchers found that negative early life experiences can lead to delayed brain development in adolescents, increasing vulnerability to mental health disorders. The study suggests brain connectivity rather than cognitive control behavior is a stronger predictor of future substance use.
Researchers developed innovative techniques and optical solutions to overcome long-standing challenges in facial projection mapping. They achieved unprecedented speed in dynamic facial projection mapping while maintaining high accuracy, and proposed methods to simulate video annotations and minimize alignment artifacts.
A pioneering study demonstrates the feasibility of treating SMA prenatally using risdiplam, a drug administered to an expectant mother during pregnancy. No identifiable features of SMA have been observed in a 2.5-year-old child, suggesting a promising outcome for future research.
Researchers found that a rare genetic syndrome causes different damage mechanisms in male and female brains, affecting neurogenesis and energy production. The study suggests that the ADNP protein plays a crucial role in brain development and aging, with distinct functions in males and females.
A recent study found that estrogen can partially restore progesterone levels and improve ovarian health in Mcoln1−/− mice, a model for human mucolipidosis type IV. The research also showed that hormone therapies including estrogen improved luteal cell morphology and lysosomal function.
Researchers at Baylor College of Medicine have identified a rare genetic diagnosis in a child with Lennox-Gastaut syndrome, a severe form of epilepsy and developmental delay. The study reports a highly complex rearrangement of chromosomes 3 and 5, leading to a rare condition known as 5q14.3 microdeletion syndrome.
A Dartmouth-led study reveals that cystic fibrosis disrupts the maturation of the gut microbiome in infants, leading to a depletion of health-associated bacteria and potentially poor health outcomes. The study found that the microbiomes of infants with CF remained stunted or delayed in their development compared to healthy infants.
The Syngap Research Fund's 2024 Impact Report showcases the organization's progress in accelerating SYNGAP1 research, collaborating with academia and industry, and advocating for patients' rights. The report highlights seven core scientific programs and over $6M in funding for SYNGAP1-related disorders science.
Two comprehensive datasets from the Gabriella Miller Kids First Pediatric Research Program explore childhood cancers and congenital disorders. The new datasets aim to identify genetic causes and links between these diseases in children, ultimately supporting the development of improved treatments.
A new drug developed by the Centre for Addiction and Mental Health (CAMH) has shown significant promise in reversing memory loss in a mouse model of Alzheimer's disease. The drug, GL-II-73, selectively targets GABA receptors to restore brain function and repair damaged neural connections.
Dental implant surgeries require optimal mechanical stress levels for successful bone healing and long-term implant success. Researchers are developing a hybrid biomechanical model using machine learning to provide precise, patient-specific predictions of mechanical stress.
A study found that people with delayed REM sleep have higher levels of toxic proteins amyloid and tau, and lower levels of healthy protein BDNF, which can increase the risk of developing Alzheimer's. Practicing healthy sleep habits may help mitigate this risk.
A West Virginia University legal scholar argues that current laws favor biologic drugs with longer exclusivity periods, affecting their pricing. The scholar suggests reducing exclusivity for biologics to bring them in line with small-molecule drugs, which could lower drug costs.