Study deciphers the biosynthetic pathway of the antidepressant orcinol glucoside from the plant Curculigo orchioides and engineers the production of orcinol glucoside in the biotech-friendly yeast Yarrowia lipolytica, with yields over 6,400-fold higher th

The high-quality Bougainvillea genome assembly provides new insights into the species' evolutionary history, genetic duplication events, and pigment biosynthetic pathways. The study's findings suggest that bract coloration requires high levels of expression for the betacyanin biosynthetic pathway.

Researchers at the Max Planck Institute for Chemical Ecology elucidated the biosynthetic pathway of ipecacuanha alkaloids in two distantly related plant species. The study reveals that both species developed the same pathway independently, with a surprising twist: the first step does not involve an enzyme, but occurs spontaneously.

Research reveals that the hexosamine biosynthetic pathway promotes O-GlcNAc glycosylation of SNAP25, enhancing SNARE complex assembly and facilitating exosome release. Elevated glucose availability increases SNAP25 O-GlcNAcylation levels, strengthening its interaction with other SNARE partners.

Researchers have created a yeast platform capable of producing calycosin-7-glucoside, a valuable isoflavonoid from Astragalus membranaceus. The optimized strain achieved a titer of 0.22 mg/L within 48 hours, providing a scalable alternative to plant-derived production and reducing dependence on medicinal plant cultivation.

Researchers demonstrated a method to enhance biosynthetic capacity in Saccharomyces cerevisiae by extending cellular lifespan, resulting in increased sclareol production. The strategy combines lifespan engineering with metabolic pathway optimization, showing improved product synthesis and robustness.

Researchers proposed PIANO, an operator learning framework that deciphers and incorporates physical invariants from PDE series via self-supervised learning and attention technique. This approach achieves superior performance in scenarios with different physical mechanisms.