In an accompanying commentary, Bart N. Lambrecht from Erasmus University Medical Center in The Netherlands states that these studies "show that C5aR blockade promotes Th2 sensitization upon first exposure to inhaled allergen, whereas C5aR blockade during established inflammation suppresses the cardinal features of asthma."
TITLE: A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
AUTHOR CONTACT:
Jörg Köhl
Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, USA
Phone: (513) 636-1219; Fax: (513) 636-5355; E-mail: joerg.koehl@chmcc.org
View the PDF of this article at: https://www.the-jci.org/article.php?id=26582
ACCOMPANYING COMMENTARY:
TITLE: An unexpected role for the anaphylatoxin C5a receptor in allergic sensitization
AUTHOR CONTACT:
Bart N. Lambrecht
Erasmus University Medical Center, Rotterdam, The Netherlands
Phone: 31-10-408-77-03; Fax: 31-10-408-94-53; E-mail: B.Lambrecht@erasmusmc.nl
View the PDF of this article at: https://www.the-jci.org/article.php?id=27876
Journal of Clinical Investigation