Research on asthma and respiratory disease. Covers brain-structure links, prevention trials, weight-loss drugs, and exercise for symptom control.
Extracellular vesicles (EVs) are key players in the pathogenesis of chronic lung diseases, modulating cellular senescence and immune-inflammatory responses. EVs facilitate aberrant intercellular communication, deliver pathogenic miRNAs and proteins, and promote chronic inflammation.
Love Your Lungs Day draws attention to the critical importance of respiratory health in Phoenix residents, with over 410,000 cases of adult asthma and 187,000 cases of COPD in Maricopa County. The event aims to promote education, research, prevention, and access to quality respiratory care.
A national trial found that treating young children with an oral bacterial extract did not reduce the risk of severe wheezing and respiratory illnesses that can precede asthma. The ORBEX trial, led by the University of Arizona, tested the preventive potential of OM-85, a treatment that had shown promise in earlier, smaller studies.
Researchers found changes in brain structure, including white matter organization and region size, in people with severe asthma compared to those with well-controlled mild or moderate asthma. Inflammation levels were also linked to white matter changes, suggesting a possible connection between inflammation and brain changes.
A new study found that weight loss injection semaglutide may reduce asthma attacks by up to 40% in people with airways diseases like asthma and COPD. Semaglutide also led to a 20% reduction in COPD flare-ups.
A clinical trial demonstrated that increasing daily steps is as effective as aerobic exercise in managing asthma, improving quality of life and alleviating respiratory and anxiety symptoms in the medium term. Both approaches provide flexible, accessible, non-pharmacological treatment alternatives.
A study found that overuse of reliever inhalers increases the risk of cardiovascular disease, including heart failure, heart attack, and ischemic stroke, in asthma and COPD patients. Using three or more inhalers per year is associated with increased risk of death, particularly in patients without a prior history of cardiovascular disease.
A nationwide cohort study found that continued ICS use during early pregnancy was not associated with increased risks of maternal or neonatal outcomes. The study highlights the importance of individualized risk assessment while maintaining asthma control, providing reassuring evidence for current guideline recommendations.
A new computational tool called DANDELION has identified 21 genes related to asthma, most of which haven't been discovered by other methods. The tool focuses on trans-gene regulation and successfully validated the impact of these genes on asthma phenotypes in cell models and human data.
A multidisciplinary project combines computer modeling, particle science, and pharmaceutical science to create more effective inhalers for people who can't inhale deeply. Researchers found that improved designs can reduce deposition in the mouth and throat, increase penetration of particles into the lungs.
A study found that Nirsevimab was associated with a substantial reduction in respiratory syncytial virus-lower respiratory tract infection hospitalizations during the first year. It was not linked to reduced hospitalizations due to non-RSV infections or asthma, nor during the second year of follow-up.
Researchers explore bacterial extracellular vesicles as a tool for cancer diagnosis and treatment, with potential for targeted delivery of therapeutic molecules and immunotherapy. However, consistency and safety remain major challenges in this emerging field.
Researchers have uncovered a key mechanism explaining how allergic inflammation in the skin can progress to a body-wide allergic response. IL-13 acts on dendritic cells, enhancing their ability to present allergens and promoting immune responses that produce antibodies.
Researchers have found that stimulating a nerve in the external ear may help to ease inflammation in the lungs of mice. The study suggests a novel device could be developed to target inflammatory pathways and treat diseases like asthma, pulmonary fibrosis, and rheumatoid arthritis.
A team of researchers has developed chimeric allergen receptors that can suppress the immune system's response to common allergens, reducing or preventing asthma symptoms in mice. The technique could eventually be used to treat a wide variety of allergies in humans.
Researchers developed an app to monitor daily voice changes, which can detect early signs of exacerbations in asthma and COPD. By analyzing tone, pitch, pauses, and voice quality, the TACTICAS study found that voice deteriorates as symptoms worsen, allowing for potential treatment.
Research examines air quality and respiratory health among children in communities surrounding the Salton Sea, finding that outdoor dust events significantly affect indoor air quality. Families describe daily challenges of protecting children from dust and pollution, which can impact school attendance and overall quality of life.
A new study has identified biological pathways that explain why air pollution affects some people with asthma more than others. Researchers found that individuals with specific genetic variants are more susceptible to the harmful effects of fine particulate matter, and that targeted interventions may be able to blunt these effects.
Two studies found that certain fungal species in the gut play a key role in immune dysregulation and pediatric allergic diseases, positioning the infant mycobiome as a promising target for therapies. Infants' early-life antibiotic use may have a direct impact on these fungi, leading to immune dysregulation and allergic asthma.
A large-scale study on Swedish children with asthma found that living with cats did not worsen asthma outcomes. The study of 30,277 children over 24 months showed similar asthma severity and lung function in cat-exposed and non-exposed groups.
The Phase 3 SUNRISE trial shows that tezepelumab nearly triples the likelihood of reducing daily oral corticosteroid dose in patients with severe, oral corticosteroid-dependent asthma. Patients treated with tezepelumab achieve greater reductions in oral steroid use while maintaining asthma control and improving key clinical outcomes.
Experts from Mount Sinai will present a new AI model that predicts lung nodule risk and assesses the impact of air pollution during pregnancy. The researchers also explore cognitive consequences of sleep-disordered breathing and reevaluate asthma guidelines to integrate both conditions.
Researchers found that a common asthma drug can help fight aggressive cancers by blocking the CysLTR1 molecule. The study used mouse models and human tissue samples to demonstrate its potential in treating triple-negative breast cancer and other tough tumors.
A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.
A new study presents tezepelumab as a safe and effective treatment for severe asthma in underrepresented populations. The therapy reduces exacerbations by 70% and improves lung function, quality of life scores, and asthma control. It is particularly effective in patients with Type 2 asthma and those with comorbid COPD.
A study led by University of Arizona researchers found that azithromycin did not improve symptoms in preschool children with severe wheezing. The trial results challenge the idea that certain types of bacteria contribute to wheezing and asthma, suggesting that viral infections play a more significant role.
A new study shows that New York City's public housing mold intervention program significantly reduces asthma-related emergency department visits. The program, Mold Busters, improved ventilation and trained staff in evidence-based mold removal, leading to a 9 fewer asthma-related ED visits per thousand people.
A nationwide self-controlled cohort study found that GLP-1 class of obesity drugs were associated with a 26% fall in asthma exacerbations and a 14% drop in use of asthma inhaler reliever. The study suggests that weight loss, modulation of airway inflammation, and improvements in metabolic functions may improve asthma outcomes.
New research from Johns Hopkins University finds that nighttime temperature swings are key predictors of asthma-related ER cases. The study suggests that updating Code Red alerts to include nighttime temperatures could help protect vulnerable communities.
The Colorado Asthma-Friendly Schools initiative recognizes 221 schools for their comprehensive asthma management and student health efforts. Over 120,000 students have benefited from the implementation of evidence-based asthma management practices at school.
A new study finds that pregnant women with low levels of a specific fatty acid molecule are more likely to have children with childhood asthma. The researchers also found that children of these mothers are more prone to respiratory infections and altered lung microbiomes.
A recent study found a significant link between very high PFAS exposure and an increased incidence of asthma in children. Researchers analyzed data from over 11,000 children born in Sweden and discovered that the risk of developing asthma was around 40% higher among those with very high PFAS exposure.
A Swedish study found that high prenatal PFAS exposure is associated with a higher incidence of asthma in childhood. The research used a register-based cohort of children born between 2006 and 2013 to assess the relationship between maternal exposure and asthma outcomes.
A long-term study found children living near the Salton Sea have slower lung function growth, with effects comparable to freeway exposure. The researchers controlled for various factors and found that dust exposure was linked to lower lung capacity, suggesting potential long-term health implications.
Researchers discovered that targeting the Dectin-1 receptor can restore functional pathways of dysfunctional immune cells like Tregs, offering a promising novel therapeutic avenue for treating allergic asthma. The study showed that this approach can reduce airway inflammation and renew immunoregulatory capacity.
A study in mice suggests that matcha may reduce the need to sneeze in people with nasal allergies, suppressing brainstem neuronal activation without changing major immune markers. The findings provide a potential, food-based option to complement standard care for allergic rhinitis symptoms.
A large survey of Texas adults with asthma found that improving airflow, using air purifiers, and minimizing allergens can significantly reduce asthma attacks. The study also highlights disparities in asthma burden among certain groups, including women, older adults, and Black adults.
New research suggests that inhaled microplastics can cause inflammation and damage to the lungs, potentially increasing the risk of respiratory diseases such as asthma and COPD. Microplastics can also trigger inflammatory responses and deliver toxins directly into the lungs, highlighting a growing concern for lung health.
A new study found that children growing up in homes with water damage and exposed to high levels of outdoor air pollution have a greater risk of developing asthma. The study also revealed that having a dog during infancy can reduce the risk of asthma in children.
A new study using satellite data confirms that California's shift to electric vehicles is making measurable differences in air quality and public health. For every 200 ZEVs added, nitrogen dioxide levels dropped 1.1%.
A recent study by King's College London found that diagnosis rates for depression, asthma, and osteoporosis remained lower than expected after the COVID-19 pandemic. The study analyzed data from over 29 million people in England and found that diagnosis rates recovered differently across ethnic and socioeconomic groups.
The American College of Chest Physicians (CHEST) received the 2025 Glenview Environmental Sustainability Award for Innovation, recognizing its commitment to clean energy and reduced emissions. The organization's solar panel installation at its headquarters powers medical simulation facilities using renewable energy.
Researchers have identified a new method to predict asthma exacerbations using sphingolipid and steroid ratios, allowing for accurate identification of high-risk patients. The method has the potential to revolutionize asthma treatment by enabling clinicians to intervene before an attack occurs.
Researchers have identified a new method to predict asthma exacerbations with a high degree of accuracy, analyzing data from three large asthma cohorts. The study found that the ratio between sphingolipids and steroids was the most powerful predictor of future health.
Adults with asthma who experience depressive symptoms have elevated blood levels of brain-derived neurotrophic factor (BDNF), a protein typically reduced in major depressive disorder. Physical activity may also play a role in depression management, as lower activity levels are linked to worse moods.
Researchers have identified a previously unknown mechanism that can reduce the risk of allergies and asthma in children. Certain bifidobacteria produce a substance called 4-hydroxyphenyl lactate (4-OH-PLA), which dampens immune responses to allergens, reducing the production of IgE antibodies.
The American College of Chest Physicians released a new clinical guideline on biologic management in severe asthma. The guideline provides evidence-based recommendations for selecting biologics for different patient populations, considering factors such as baseline oral corticosteroid use and comorbid conditions.
A recent study found that adolescents with overweight or obesity who take glucagonlike peptide-1 receptor agonists (GLP-1RA) have a lower risk of acute asthma exacerbations. This association suggests a potential dual benefit, where GLP-1RA use could address both weight management and asthma prevention in this population.
Research from University of Vermont reveals exposure to Canadian wildfire smoke worsened asthma symptoms in children in the US Northeast. The study found that smoke from hundreds of miles away affected children's health, highlighting growing health risks for the region as climate change fuels more smoke-filled summers.
Research found a heightened risk of preschool wheeze and school age asthma associated with maternal eating disorders. The study suggests including dedicated support for these disorders in maternal healthcare to improve respiratory health.
A monthly injection has helped 90% of severe asthma patients reduce their reliance on daily steroid tablets. Treatment with tezepelumab improved asthma symptoms, lung function, and overall quality of life, with two-thirds of patients experiencing no asthma attacks.
A new phase 3b clinical trial found that nearly 90% of severe asthma patients were able to reduce their steroid dose to a low dose after one year of treatment with the biologic medication Tezepelumab. The treatment also significantly improved asthma symptoms, lung function, and overall quality of life, while minimizing steroid use.
Exercise now considered a key component of asthma management, with aerobic, resistance, and flexibility training recommended. Wearable devices and home spirometry monitor lung function and exercise intensity for personalized plans.
Case Western Reserve University researchers discovered pseudo leukotrienes, which may be the dominant players in the inflammatory cascade that causes disease. The findings open new avenues for treating asthma and other inflammatory diseases.
Scientists found that breathing dusty air from the Salton Sea can alter the lung microbiome and trigger immune responses in mice. The study suggests that chronic exposure to such dust could have significant health effects, including asthma.
The analysis of 2024 English voting patterns suggests that poorer health is associated with higher proportions of votes for Reform UK. This finding highlights the need for policymakers to address health inequalities and improve public health.
The American College of Chest Physicians has designated October 19, 2025, as 'Love Your Lungs Day' in recognition of respiratory health. This initiative aims to raise awareness about lung diseases such as asthma and COPD, promoting equity and supporting healthcare providers.
Researchers developed a more accurate cough-detection model using wearable health monitors' audio and movement data. The new model can distinguish between coughs and nonverbal sounds, improving the accuracy of respiratory disease tracking.
A study of 200 classrooms found that HEPA purifiers did not significantly reduce respiratory viral exposures, suggesting additional interventions are needed. Maintaining classroom humidity between 40% and 60% may help lower viral exposures and improve comfort for students and teachers.
A recent study found no association between mould damage in schools and the development of asthma among students. Despite extensive mould damage in some schools, the health of over 30,000 students was tracked over a 16-year period, showing no increase in asthma cases.