Articles tagged with Allergens
Allergen immunotherapy (AIT) is showing promising results in reducing clinical symptoms and severity of allergic diseases, including asthma and allergic rhinitis. The latest advances in AIT include innovative technologies and biomarkers that predict and monitor treatment response.
Children's Hospital Colorado has launched a Sublingual Immunotherapy Program to treat children with 10 common food allergies, including milk, egg, peanut, and sesame. The program involves daily liquid drops under the tongue and may gradually build tolerance and provide greater protection against accidental exposure.
Researchers developed a new allergen-specific IgE test to detect functional antibodies capable of triggering immune responses in food allergies. The improved AlphaCL method overcomes limitations of conventional tests, maintaining strong signal responses even with serum components present.
A large-scale study on Swedish children with asthma found that living with cats did not worsen asthma outcomes. The study of 30,277 children over 24 months showed similar asthma severity and lung function in cat-exposed and non-exposed groups.
A study using a mouse model demonstrates that microplastics can exacerbate respiratory tract inflammation and alter immune responses associated with allergies. The researchers found that the particles remained detectable in the lungs for at least 14 days, leading to an increased migration of lymphocytes and eosinophils.
Researchers at McGill University have discovered that brief cold plasma treatment can significantly reduce the potential of peanuts to cause allergic reactions. The process alters protein structure and improves functional properties, enabling hypoallergenic peanut protein powder development for new products.
Researchers have identified three new proteins, called epitopes, that help the body determine 'safe' foods, aiding in food tolerance and allergy understanding. The epitopes were found in seed proteins from corn, wheat, and soybean, and interact with regulatory T cells to inform tolerance-or-rejection decisions.
Researchers at North Carolina State University found a strong link between cockroach infestations and high levels of allergens and endotoxins in homes. Eliminating cockroaches significantly reduced these health risks, with most infested homes without extermination showing large amounts of both allergens and endotoxins.
Researchers investigate the role of mast cells in eosinophilic esophagitis, a chronic disease causing inflammation and scarring. The study aims to identify new treatments to improve quality of life for patients with EoE.
Researchers have identified specialized immune cells in the intestine that produce chemical messengers triggering anaphylaxis. Targeting these chemicals, like zileuton, may offer a new approach to preventing food-triggered anaphylaxis.
A study identified eight additional foods frequently involved in food-induced anaphylaxis, including goat's and sheep's milk, buckwheat, and pine nut. The research proposes that these foods be considered for inclusion on the European mandatory labelling of foods list due to their frequency, severity, and potential for hidden exposure.
A Northwestern University study found that Zileuton nearly eliminated life-threatening allergic reactions to food allergens in mice by targeting a previously unknown gene called DPEP1. The discovery could lead to a new, simple pill-based treatment for food allergies.
A Northwestern University study finds disparities in peanut allergy prevention guidance, with low-income and minority parents less likely to receive accurate advice. Early peanut introduction cuts allergy risk by over 80%, but guidance is often inadequate for these families.
Research led by the University of Michigan finds fungal spore seasons advancing three weeks earlier in the US over two decades due to climate change. The study reveals significant implications for both ecosystem processes and human health.
A recent study published in Cell revealed that a specific intestinal immune cell prevents food allergies by breaking the threshold between friend and foe in the gut. Researchers at WashU Medicine identified this cell as RORγt+ dendritic cells, which maintain tolerance to harmless food allergens, preventing allergic reactions.
A review concludes that exposing preschool-aged children to small amounts of food allergens is safer than avoiding them, reducing the risk of severe reactions. Delaying exposure can prolong unnecessary dietary restrictions and increase anxiety related to food allergies.
Researchers found that omalizumab significantly improved treatment outcomes for multi-food allergy patients compared to oral immunotherapy. A total of 36% of omalizumab recipients could tolerate at least 2 grams of multiple food allergens, while only 19% of oral immunotherapy participants achieved this threshold.
Researchers have developed two therapeutic cocktails that inhibit key molecules, stopping immune cells from overreacting to allergens. The treatments reduced asthma attacks in mice by erasing the immune system's memory of asthma-causing allergens.
Research from RIKEN Center for Integrative Medical Sciences found that infant gut bacteria are associated with food sensitivities and allergies, particularly to eggs. The study suggests that probiotic supplements, such as Bifidobacterium, may help prevent food allergies in at-risk infants.
A new study explains how scratching aggravates inflammation and swelling in a type of eczema called allergic contact dermatitis. Scratching activates mast cells, which drive itchiness and inflammation, but also triggers the release of substance P, which protects against bacteria.
A new study finds that excess RELMb protein in the intestine disrupts tolerance to triggering foods and increases the risk of food allergy. Inhibiting RELMb may lead to a cure or prevention of food allergy, offering a promising therapeutic approach.
A McGill University-led study found patterns between triggers and symptoms of anaphylaxis, revealing a strong link between tree nuts and throat tightness. The research also suggests that drinking alcohol may increase the risk of severe reactions to nut allergies.
Researchers at Osaka Metropolitan University have discovered yeast cell wall-derived proteins that exhibit high emulsifying activity, comparable to commercial casein emulsifier. These easily released protein molecules could potentially replace emulsifiers derived from milk, eggs, and soybeans, reducing allergenic concerns.
Researchers at Tokyo University of Science found that kaempferol increases RALDH2 levels in dendritic cells, promoting regulatory T-cell development and reducing inflammation. The study suggests that flavonoids like kaempferol may serve as natural remedies to alleviate allergic symptoms.
A global survey of over 4,700 food allergy patients and families found airline travel to be a significant source of worry and anxiety. The study suggests that reasonable accommodations, such as pre-boarding and allergen-free zones, can reduce stress for travelers with food allergies.
Researchers at the University of Pittsburgh have discovered a molecular pathway involving protein BLIMP1 that generates Th2 cells in response to inhaled house dust mite, driving allergic asthma. The study also found signaling molecules IL2 and IL10 are required for BLIMP1 expression, offering new therapeutic options.
The new CAMP 2.0 tool provides personalized medicine for managing allergic contact dermatitis by generating safe lists based on individual patch testing results. It offers thousands of product options and interactive tools to help patients find safe products, track their quality of life, and understand their allergens.
A recent study in Chicago reveals a significant increase in sensitization to pollens and molds among patients with nasal allergies. The researchers found that tree pollen, weed pollen, grass pollen, and mold sensitizations all increased post-COVID compared to pre-COVID.
A study found that anxiety related to food allergies increased significantly in children, leading to an average of 2.1 allergens per patient and a 69% incidence of food-related anxiety. Psychology referrals for these patients increased by 50% over four years, with 60% completing at least one appointment.
A new test mimics allergic reactions in a test tube, showing higher diagnostic accuracy than standard tests for peanut allergy and potentially other allergies. The Hoxb8 Mast Cell Activation Test (Hoxb8 MAT) has been shown to have an exceptionally high diagnostic accuracy of 95% and leads to fewer false negative results.
A recent review published in Clinical & Experimental Allergy suggests that intravenous adrenaline infusions can prevent fatal anaphylaxis, but adrenaline autoinjectors may have little impact in such deadly cases. Fatal anaphylaxis is rare, with a population incidence of 0.03–0.51 per million per year.
Researchers have identified a specific immune cell type and signaling pathway that leads to itching in people with allergies. By targeting this pathway, they hope to develop novel therapeutics for preventing allergic responses and sensitization.
Researchers found that mice lacking the G900 region exhibit reduced inflammatory response and suppressed Th2 differentiation when exposed to allergens. This discovery highlights the importance of the G900 gene enhancer in regulating immune responses and has implications for personalized treatments and asthma care.
A new study found that feeding children peanut products regularly from infancy to age 5 reduced the rate of peanut allergy in adolescence. The results showed a 71% reduction in peanut allergy, even when children ate or avoided peanut products later on.
Australian researchers have identified biomarkers that can predict which children are likely to outgrow their peanut allergy. The study found that two-thirds of children with a peanut allergy remain allergic by age 10, but most who naturally outgrew their allergy did so by age six.
Researchers have discovered a new way to inhibit immune cells that drive allergic asthma by targeting the Piezo1 protein. The study found that switching on Piezo1 channels can reduce lung inflammation and alleviate symptoms of airway hyperreactivity in mice with ILC2-dependent airway inflammation.
Researchers at RIKEN found that gut bacteria, particularly Bifidobacterium, are associated with higher chances of successful milk-allergy treatment. However, only 7 out of 28 children who underwent oral immunotherapy passed the food challenge after a two-week milk avoidance period.
A new study from the University of British Columbia has found that sublingual immunotherapy (SLIT) is safe and effective for older children with multiple food allergies, who cannot risk consuming allergens orally. The treatment involves placing smaller amounts of food allergens under the tongue, allowing patients to build up their resi...
A recent study by Binghamton University researchers found that 90% of commercial tattoo inks in the US market contain major discrepancies between their actual and labeled contents. The study analyzed 54 inks from nine manufacturers and discovered unlisted polyethylene glycol, propylene glycol, and other contaminants.
The American Academy of Otolaryngology has released a new clinical practice guideline supporting clinicians with evidence-based recommendations on immunotherapy for inhalant allergies. The guideline provides 12 key action statements to guide treatment, aiming to optimize patient care and reduce unnecessary variation in management.
A monoclonal antibody, omalizumab, increased the tolerance threshold for multiple food allergens, allowing children to consume larger amounts without a reaction. The treatment showed significant benefits in reducing allergic reactions, particularly for peanut and egg, with potential protection against accidental exposure.
Scientists have created a new therapy using nanoparticles to target specific immune cells responsible for allergic responses. The approach, which combines an allergen with antibodies that selectively inhibit mast cells, has shown promising results in a mouse study, preventing allergic reactions without causing side effects.
New research shows that measuring airborne grass allergen levels is more consistently associated with hay fever symptoms than grass pollen counts. This approach may allow people with serious allergies to be better prepared during peak pollen seasons, reducing the risk of severe asthma attacks.
A new study finds that people with antibodies to common foods like dairy and peanuts are at a higher risk of cardiovascular-related death. The research suggests that these subtle immune responses may lead to inflammation and contribute to heart disease over time.
Researchers from Juntendo University discovered that pollen shells trigger the rapid formation of goblet cell-associated antigen passages, which enable swift allergen transport to the conjunctiva. The study highlights the complex interplay between sensory nerves and the immune response in allergic conjunctivitis.
Researchers from Karolinska Institutet challenge the hygiene hypothesis by showing that mice with high infectious exposures have a similar ability to develop allergic immune responses as laboratory mice. Despite this, they developed strong signs of pathological inflammation and allergic responses when exposed to allergens.
Eosinophilic esophagitis (EoE) is triggered by food allergies or airborne allergens, causing inflammation and damage to the esophagus. A new study found that inhibiting the NLRP3 pathway and releasing Interleukin-18 prevents EoE development.
Researchers at Yale University have discovered that the immune system plays a crucial role in changing behavior in response to allergens and toxins. By manipulating immune system variables, scientists were able to alter the behavior of sensitized mice, demonstrating the importance of immune recognition in controlling defensive behaviors.
A new study found that food allergy affects all racial and ethnic groups, but is most prevalent among Hispanic, non-Hispanic Black, and Asian individuals. Food allergy rates are also lower in households with higher incomes.
UCF researcher Dr. Justine Tigno-Aranjuez has discovered a new receptor that recognizes house dust mite allergens, opening up potential for broad-spectrum therapy. The finding could lead to improved treatments for common allergies, including asthma.
Researchers found that blocking histamine-releasing factor (HRF) and immunoglobulin E (IgE) interactions may provide relief for patients with severe asthma. The study, published in The Journal of Allergy and Clinical Immunology, suggests two potential therapies, including HRF-2CA and a therapeutic antibody called SPF7-1.
Scientists have developed a method to create less-allergenic shrimp by altering protein structures, reducing inflammation, and preventing antibody binding. The technique, known as reverse-pressure sterilization, was tested on mice with shrimp allergies and showed promising results.
Researchers at the University of Illinois developed a new method using NIR spectroscopy to detect three types of allergens in quinoa flour. The method is non-destructive, non-invasive, and highly accurate, providing real-time results that can be performed with minimal training.
Researchers found that IL-6 signaling in allergen-specific T cells was needed to suppress commitment to the harmful Th2 lineage. SOCS3 upregulation by IL-6 inhibits JAK/STAT internal signaling pathway, preventing Th2 cell priming.
Acylceramides and protein-bound ceramides play a vital role in forming the oral barrier, similar to their function in the skin. Researchers found that these molecules protect against pathogens, chemicals, and allergens in mice.
Researchers from Japan create a new model for estimating transepidermal water loss, providing a more realistic picture of skin water loss. The new method uses confocal laser microscopy and Raman spectroscopy to measure stratum corneum thickness and water content.
A comprehensive European allergy atlas has been compiled, revealing regional and climate-related differences in sensitisation to allergens. The study found varying sensitisation patterns across Europe, with certain regions having lower sensitivity to house dust mites and higher sensitivity to peanut and fruit allergens.
A study by researchers from the University of Liège shows that group 2 innate lymphoid cells educate alveolar macrophages, reprogramming them to protect against respiratory allergens. This discovery highlights the central role of ILC2s in shaping the alveolar niche and modulating immune responses.
Scientists at Indiana University School of Medicine have developed a new treatment that blocks anaphylaxis caused by peanut allergies, potentially saving lives. The covalent heterobivalent inhibitor (cHBI) was tested in animal models and showed promise in preventing allergic reactions for over two weeks.
Researchers at the University of Notre Dame have successfully developed an allergen-specific inhibitor that prevents peanut allergic reactions in mice. The inhibitor effectively masks the immune system's ability to recognize the allergen, allowing it to fly under the radar without initiating a dangerous response.