Articles tagged with Allergens
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A new study identifies a handful of regional allergen molecules that predict the onset and persistence of respiratory allergic diseases. The findings suggest a potential for developing individualized risk prediction charts and could accelerate preventive strategies and novel treatments.
A study finds that children with eczema or atopic dermatitis and sensitization to an allergen at age 1 are significantly more likely to develop asthma and a food allergy by age three. The CHILD Study also found that early introduction of common allergenic foods may reduce the risk of allergic sensitization and food allergy.
La Jolla Institute researchers find Histamine-Releasing Factor (HRF) exacerbates both asthma and food allergies. Inhibiting HRF may prevent allergic reactions, offering a new treatment avenue.
Two studies present evidence suggesting that exposure to dogs during pregnancy and early childhood may reduce the risk of developing eczema and asthma. While exposure to dog allergens can exacerbate symptoms in children with allergies, non-allergen-related factors associated with dogs may provide a protective effect.
A new NIH-funded study finds that children exposed to high indoor levels of pet or pest allergens during infancy have a lower risk of developing asthma by age 7. The study suggests that exposure to certain allergens early in life may prevent asthma from developing, and may provide clues for the design of strategies to prevent asthma.
A new research paper suggests that human cell- and computer-based test methods can help identify chemical respiratory allergens, which cause serious immune reactions. These methods have the potential to speed up testing, lower costs, and reduce animal testing.
Researchers developed a $40 portable allergen-detection system called iEAT, which can detect five common allergens in under 10 minutes. The device extracts allergens from food and uses an electronic keychain reader to sense and transmit results wirelessly.
Researchers have discovered a new family of proteins involved in cross-reactivity between cypress pollen and certain fruits, leading to improved allergy diagnosis and treatment. This finding, published in Journal of Allergy and Clinical Immunology, sheds light on the underlying mechanisms behind pollen food associated syndrome.
Researchers at the University of Notre Dame have developed a novel platform using nanoparticles to detect peanut allergies. The technology mimics natural allergens and evaluates the potency of allergic responses using antibodies from patient blood samples.
A new study by McMaster University has found that delaying the introduction of potentially allergenic foods until after a baby's first year may increase the likelihood of a food allergy later on. Infants who avoided cow's milk products, egg, and peanut during their first year were more likely to be sensitized to these foods at age one.
Researchers have successfully 'turned off' the immune response that causes allergic reactions in animals using gene therapy. The treatment, which targets specific immune cells, has shown promise in de-sensitizing the immune system to proteins, potentially treating severe allergies like asthma and peanut allergies.
Researchers found that commercial preparations for allergy shots often lack sufficient levels of key allergens, which could affect treatment success. Customized immunotherapy tailored to individual patients' reactions is a promising approach, but its development is still in its infancy.
Airborne allergens are found at variable elevations, up to 2000 meters, contradicting the long-held assumption that they only originate from local sources. The study suggests the formation of aeroallergen clouds at high altitudes.
A new study published in the Journal of the American Medical Association found that a professional pest management intervention was no better at decreasing asthma symptoms in children allergic to mice than teaching families how to reduce mouse allergens on their own. Both groups showed substantial reductions in mouse allergen levels an...
A two-year course of immunotherapy did not significantly improve nasal symptoms in patients with moderate to severe seasonal allergic rhinitis at three-year follow-up. Long-term benefits are unknown, but a shorter treatment duration may reduce costs and inconvenience.
A study found that exposure to mouse allergen in schools was associated with increased asthma symptoms and lower lung function. The study also found that other airborne allergens, such as cat and dog allergens, did not have a significant impact on asthma outcomes.
A study by Ohio State University researchers found significant changes in the brain makeup of fetuses and newborn rats exposed to allergens during pregnancy. Animals exposed before birth showed signs of hyperactivity, antisocial behavior, and decreased anxiety, similar to ADHD. The study could help explain the links between maternal al...
A study found that up to 40% of consumers with food allergy concerns buy products with 'may contain' or 'manufactured on shared equipment' labels despite the risk. Food allergy affects approximately 8% of children and 2% of adults, with nearly 40% of children experiencing life-threatening reactions.
Children develop IgE-antibodies to specific dust mite molecules early in life, often before disease onset, with 'molecular spreading' increasing risk of allergic rhinitis and asthma. Early sensitization and parental hay fever are key risk factors.
Researchers at Duke University and NIEHS discover that dust mite allergens are both more abundant and stable than non-allergenic proteins, which may lead to new allergy treatments or predict allergenic potential of artificially added proteins. This discovery could also help characterize disease states and study drug mode-of-action.
A NIH/National Institute of Environmental Health Sciences study found that dust mite allergens are more stable and abundant than other dust mite proteins. This discovery may lead to the development of new approaches for treating dust mite allergies, a common trigger for asthma.
Researchers identified thicker airway smooth muscle and a stronger immune response to allergens in patients with asthma compared to those without. This study used innovative imaging technology to analyze the structure and function of airway cells, shedding new light on the underlying causes of asthma.
Researchers found that a protein called NOD2 plays a critical role in determining the strength of anaphylactic reactions to food allergens. A changed immune reaction leads to more Th2 helper cells and increased antibody immunoglobulin E production, triggering allergic reactions.
A joint University of Adelaide-Shanghai Jiao Tong University study provides the first broad picture of pollen allergen evolution and possible functions. The researchers' findings may help with reducing or preventing allergic diseases like asthma and hay fever.
Researchers at the University of Southampton have found a potential method for preventing asthma by targeting the ADAM33 gene, which is associated with airway remodelling and inflammation. Stopping the rogue gene can significantly reduce asthma symptoms in mice, suggesting a new approach to disease modification therapy.
Researchers at Aarhus University have developed individual profiles of allergy reactivity in patients who are not protected after immunotherapy. They created artificial allergens that perfectly mimic the allergens in insect venom, which can be used to improve medical treatment for people allergic to insect stings.
A study found that a house dust mite immunotherapy tablet improved time to first moderate or severe asthma exacerbation when added to maintenance medications. The treatment reduced the risk of exacerbations and increased allergen-specific antibodies.
A new study found that anaphylaxis rates among Canadian children have doubled over four years, highlighting the need for increased awareness and proper use of epinephrine auto-injectors. The majority of cases were triggered by food, particularly peanut and tree nut allergies.
A biodegradable nanoparticle acts like a Trojan horse to convince the immune system not to attack an allergen, shutting down allergic reactions and preventing asthma attacks. The technology also shows promise in treating food allergies.
A Massachusetts General Hospital study confirms the safety of allergy immunotherapy with no evidence of infections related to administration. The study analyzed 10 years of data from over 135,000 patients and found no soft-tissue or systemic infections attributed to AIT.
Scientists have developed a method to purify cashew proteins, shedding light on their effects and potential treatments for allergies. The study found differences in how allergens bind to antibodies in children and adults, highlighting the importance of geography and age in allergies.
A study published in Journal of Food Science found that seed germination can degrade allergenic proteins in peanuts, reducing their allergenicity. By altering environmental factors, researchers may have discovered a simple method to produce hypoallergenic peanut food.
Research found that exposure to dust mite and cockroach allergens triggers distinct asthma responses, with eosinophilic and neutrophilic asthma requiring separate treatment options. The study suggests that current 'blanket approach' to asthma treatment may not be ideal.
The study found that households using the test kits had a consistent reduction in dust mite allergens over the course of the 12-month study period. A significant number of parents reported adopting behaviors to reduce dust mites after seeing their test kit results, such as using special pillow covers and vacuuming with HEPA filters.
Researchers developed nanoparticles that deliver allergens to specific cells, reducing side effects. The new approach could lead to safer and more effective treatments for allergies and other conditions.
Aimmune Therapeutics' lead investigational product, AR101, appears to be a well-tolerated and effective treatment option for peanut allergy in a controlled desensitization regimen. The Phase 2 study demonstrated that all 23 patients who completed the active treatment regimen met the primary desensitization endpoint.
Researchers at the University of the Basque Country have developed three capillary electrophoresis-based methods to analyze various compounds in cosmetics, ensuring consumer safety. The methods allow for the simultaneous separation of multiple components and are 'green' techniques that use little organic solvent.
The study found that exposure to traffic-related air pollution during infancy increased the risk of developing allergies to food, mould, pets, and pests. Children who attended daycare or had older siblings in the household were less likely to develop allergic sensitization.
A new study reveals a direct correlation between seasonal allergens and dry eye cases, with both conditions peaking in April. Dry eye can significantly impact quality of life, affecting millions in the US annually.
Researchers find that nitrogen dioxide and ground-level ozone can increase the potency of airborne allergens, contributing to rising allergy rates. The study suggests chemical modifications of allergenic proteins may play a key role in the increasing prevalence of allergies worldwide.
The AAO-HNSF clinical practice guideline for allergic rhinitis aims to improve diagnosis and treatment, addressing quality improvement opportunities and reducing harmful variations in care. It affects about 1 in every 6 Americans, generating an estimated $2 to $5 billion in expenditures each year.
Hay fever sufferers can benefit from state-of-the-science treatments like sublingual immunotherapy. The American Academy of Otolaryngology recommends this treatment for patients with specific allergies who don't respond to other treatments, with a completion period of up to five years. Other key recommendations include diagnosing and t...
A genetic study found shared mutations between house dust mite populations in the US and South Asia, indicating migration across continents. The discovery highlights the potential for these tiny creatures to travel long distances and establish new populations.
Scientists have developed a novel approach to treating asthma by targeting the trigger - dust mite allergens. The newly created compound significantly dampened immune responses in rats exposed to various allergens, suggesting a potential breakthrough in asthma treatment.
A study published in Journal of Clinical Investigation found that skin exposure to peanut proteins can lead to sensitization and severe allergic reactions in mice. Researchers believe this mechanism may explain why peanut allergies are a common cause of food allergy in children.
The institute aims to discover a biomarker that predicts the onset of allergy and leads to novel vaccine approaches, aiming to develop a simple blood test to predict likelihood of resolution or development of an allergy.
A new study in mice finds that common gut bacteria protect against food allergies by inducing immune responses that prevent allergen exposure. Reintroducing Clostridia bacteria reverses sensitization to peanut allergens, indicating a unique protective role.
Scientists are developing a method to process cashews that could make them safer for people with nut allergies. Researchers are using sodium sulfite and enzymes to disrupt the structure of cashew allergens, reducing IgE binding.
The patented process, developed by N.C. A&T researchers, reduces allergens in peanuts by 98%, making them safer for people with allergies. The technology can be used to create hypoallergenic peanut butter and other products, and has been demonstrated in human clinical trials.
A new study published in the Journal of Allergy and Clinical Immunology found that infants exposed to a diverse range of bacterial species in house dust during the first year of life are less likely to develop asthma in early childhood. The study, led by UCSF researchers, suggests that immune responses may be shaped by exposures during...
A NIH-funded study found that early life exposure to specific combinations of allergens and bacteria protects against wheezing and allergic disease. The Urban Environment and Childhood Asthma (URECA) study revealed that cockroach, mouse, and cat exposure during the first year of life is associated with a lower risk of recurrent wheezing.
A new study confirms that children who live in homes with high levels of roach and mouse allergens and pollutants have higher overall allergy and asthma rates. However, those who encounter such substances before their first birthdays seem to benefit rather than suffer from them.
Researchers find birch pollen protein 'Bet v 1' manipulates immune cells towards allergy, disrupting balance between Th1 and Th2 responses. Iron loading may be key to triggering allergic reactions, suggesting potential treatment targets for immunotherapy.
Researchers at McMaster University have successfully tested an antibody that can improve the quality of life for individuals with asthma by relieving inflammation in the lungs. The study found that blocking a specific protein in the lungs with an antibody alleviates baseline inflammation and provides resistance to allergens.
A nationwide study found that allergy prevalence is consistent across the US, with regional variations in specific types of allergies. Children under 5 in southern states showed a higher prevalence of allergies to dust mites and cockroaches.
A recent study suggests that exposure to dust from homes with dogs can alter the immune response to allergens, reducing allergic inflammation. The researchers found that mice fed dog-associated dust were protected against airway inflammation triggered by cockroach allergen and respiratory syncytial virus.
Studies by Helmholtz Centre for Environmental Research and University of Leipzig reveal species-specific allergens in Nile perch and shellfish, potentially allowing diagnosis and treatment tailored to individual allergies. Researchers identify parvalbumin as a common allergen, but also discover new proteins with low allergenic potential.
Researchers at the University of Notre Dame have made progress toward a treatment for dangerous allergies by designing a special molecule that can out-compete allergens in their race to attach to mast cell receptors. The team has demonstrated the effectiveness of their inhibitor molecule on allergic reactions using animal models.
The Integrated Approaches to Food Allergen and Allergy Risk Management (iFAAM) project will develop a standardized management process for companies involved in food manufacturing. New risk models will predict who is likely to suffer severe reactions, while tools to measure allergens will support efficient labeling and monitoring.
Babies born by C-section are five times more likely to develop allergies when exposed to common allergens. The study suggests that early childhood exposure to microorganisms affects the immune system's development and onset of allergies.