Articles tagged with Allergens
Researchers have found that C5aR blockade promotes Th2 sensitization upon first exposure to inhaled allergen, while during established inflammation suppresses the cardinal features of asthma. This study provides new insights into the role of the anaphylatoxin C5a receptor in type 2 immunity and asthma.
Researchers block C5a receptor to prevent or induce asthma-like symptoms in mice, identifying mechanism by which C5aR signaling prevents response. C5aR blockade also reduces severity of asthma-like symptoms after allergen exposure.
Researchers found that a protein called alpha4-beta1 integrin promotes the homing of bone marrow-derived progenitor cells to tumor-associated blood vessels. Inhibiting this process could be useful in suppressing new blood vessel formation in tumors.
A new HRCT technique shows that cat allergen exposure can lead to persistent inflammation in small airways, increasing the risk of severe asthma attacks. The study's findings highlight the importance of targeting these regions with treatments.
A new study shows that home-based environmental interventions can significantly reduce asthma symptoms and healthcare costs in children. The program, which targeted six major allergen classes, resulted in a 19% decrease in unscheduled clinic visits and a 13% reduction in albuterol inhaler use.
Researchers at National Jewish Health conducted the first human studies on bleach's ability to neutralize mold allergens. The study showed that dilute household bleach solutions significantly reduced allergic health effects in patients with Aspergillus allergies.
A new study by researchers at NIEHS found that over half of the US population is sensitive to one or more allergens. The prevalence of positive skin test responses was significantly higher in NHANES III than in NHANES II, coinciding with an increase in asthma cases between 1980 and 1996.
A new research consortium will investigate basic immunologic mechanisms associated with food allergy and test novel therapies to treat peanut allergy. The consortium will conduct clinical studies, observational studies, and develop educational programs for parents, children, and healthcare providers.
A recent study found that day care centers are a major source of indoor allergens, with detectable levels of various allergens present in every facility. The study also discovered significant differences between carpeted and non-carpeted surfaces, with lower concentrations of allergens on non-carpeted surfaces.
Researchers from Imperial College London identified a population of T cells that can suppress the proliferation of allergen-reactive T cells in vitro. This finding suggests a potential new approach to treating cat allergy, which has become more frequent in industrialized countries.
Researchers develop injectable treatment that blocks release of histamine, a key chemical causing allergy symptoms. The treatment, GFD, successfully prevents immune cells from reacting to cat allergen in both passively and actively allergic mice.
A new study suggests that family physicians can effectively use a definitive blood test to screen for actual allergies in patients with hay fever or allergic rhinitis. The test evaluates the reaction of Immunoglobulin E (IgE) to specific allergens, such as pollen from grass and trees.
A new study published in the Journal of Allergy and Clinical Immunology found that cockroach allergens are a primary contributor to childhood asthma in inner-city home environments. The study suggests that general cleaning practices, extermination techniques, and maintenance methods can reduce allergen levels.
A new study found that inner city children in the US are exposed to different levels of indoor allergens depending on their location and home type. Cockroaches were found to have the greatest impact on asthma morbidity, causing more severe symptoms and increased healthcare visits.
A recent study found that indoor allergen levels vary significantly across the country, with cockroach allergens exacerbating asthma symptoms in inner-city children. Exposure to dust mite allergens was not found to have a significant impact on asthma symptoms.
Researchers discovered high levels of airborne mouse allergen in inner-city homes, increasing the risk of asthma symptoms and attacks in children. To control this allergen, parents can seal cracks and holes, dispose of food remains, and have pest exterminators treat their home.
Research suggests that changes in gut microflora can intensify immune reactions to common allergens, increasing the risk of chronic allergies or asthma. A mouse model study found that antibiotic treatment led to an overzealous allergic response in the lung.
A team of scientists has developed a novel method to detect the culprits behind dust allergies, using PNA-encoded protease substrate microarrays. This innovative approach reveals the specific proteins responsible for triggering allergic reactions in humans, providing new insights into the mechanisms underlying dust allergy.
A National Institutes of Health study found that reducing indoor allergens in the home significantly improves asthma symptoms in inner-city children. By targeting common allergens like dust mites, cockroaches, and tobacco smoke, researchers helped alleviate symptoms comparable to those achieved with asthma inhalers.
A study found that a customized environmental intervention reduced asthma symptoms in children by 21 days per year, with rapid improvements starting just 2 months after the program began. The program, which included measures to reduce allergens and tobacco smoke, was more effective than previous studies.
A study published in the New England Journal of Medicine found that reducing allergens and tobacco smoke in the home can significantly reduce asthma symptoms in African-American and Hispanic children. The research involved over 900 children aged 5-11, who were randomly assigned to either an intervention group or a control group.
Researchers found that a new ointment, applied inside the nose, significantly reduced symptom scores in patients with allergic rhinitis. The treatment improved airflow by nearly 20 percent and reduced symptoms by about 60 percent compared to a placebo.
A national survey of 831 US homes found that dog and cat allergen levels were higher among households with more dog or cat owners. This exposure may be particularly challenging for pet-allergic individuals living in areas with high dog and cat ownership rates.
Researchers have developed new tests that can detect trace amounts of common tree nut allergens, such as almonds, cashews, and walnuts. These tests could lead to more accurate food labeling and reduced risk of cross-contamination in processed foods.
A recent study by Cohn et al. found that 82 percent of U.S. homes contain mouse allergens, with kitchen floors being the most contaminated area. The study, conducted across the entire country, highlights the need for clinicians to consider rodent and cockroach problems as risk factors when treating allergy and asthma patients.
Researchers found that antibiotics can alter the gut microbiome, leading to increased lung sensitivity to allergens. This disruption can trigger a hyperactive immune response, producing allergy symptoms or even asthma. The study suggests that maintaining a healthy balance of gut microbes is crucial in regulating the immune system.
A Hopkins study found that most household cleaners effectively removed peanut allergen Ara h 1 from surfaces. However, the use of hand sanitizers was shown to leave residual allergen on hands and potentially spread it around.
A new study from the University of North Carolina Health Care found that exposure to ozone and endotoxin can make asthmatics more sensitive to house dust mites, worsening their symptoms. The research involved 14 participants with mild asthma who inhaled low levels of endotoxin, followed by an allergen challenge test.
Researchers found that 8 out of 20 commonly used NSAIDs can selectively lower Abeta42 levels in mice, with flurbiprofen showing the most promise. Additionally, studies revealed increased T cell reactivity to Abeta protein in older humans and patients with Alzheimer's disease, which could inform the design of future vaccines.
Early detection and treatment of allergies can prevent serious complications and modify the progression of pediatric allergies. A specific IgE blood test can accurately diagnose atopy and guide treatment, including avoidance therapy and medication.
Researchers have developed a canine model of nasal congestion and allergic rhinitis that closely resembles human conditions. The study found that histamine-induced nasal congestion in dogs was alleviated by α-adrenergic agonists, paving the way for testing new treatments.
A new study reveals that dogs cause a stronger reaction in asthmatics than cats, even though more people are allergic to cats. The study found that dogs triggered a combination of reactions that included reduced air exhalation and increased nitric oxide release due to inflammation.
A new study reveals that peanut allergies are on the rise in Quebec, affecting approximately 1.5% of Montreal schoolchildren, compared to previous estimates of 0.5%. The Association québécoise des allergies alimentaires has also launched a certification program for allergen-free food products.
Researchers are conducting studies on shrimp to better understand the genetic basis for proteins causing allergic responses. By altering the epitopes in shrimp allergens, binding action could be stopped, potentially leading to allergen-free foods.
A severe allergic anaphylactic reaction was triggered in a woman with shellfish allergy after kissing her boyfriend, who had eaten shrimp hours earlier. The incident highlights the importance of counseling patients to avoid exposure to food allergens through all potential routes, including kissing and touching.
A new experimental approach has been developed to treat allergic diseases, with scientists creating a genetically engineered molecule called GE2 that connects two receptors on key immune system cells. The molecule short-circuits allergic reactions, including asthma and anaphylaxis, by cross-linking receptor molecules.
Two new studies found a relationship between high cat allergen concentrations in the home and increased asthma symptoms among sensitized women. Researchers also discovered common delays in TB diagnosis and treatment, as well as abnormal pulmonary function linked to bacterial infection in cystic fibrosis patients.
A new study found that caregivers with higher perceived stress levels had infants who experienced more wheezing episodes during the first 14 months of life. Additionally, exposure to German cockroach allergen was associated with increased risk of asthma attacks in susceptible children. Researchers also developed a molecular model of th...
Researchers at the University of Melbourne have developed a potential allergy vaccine using a modified rye grass protein that reduces allergenic response while boosting immune system. The vaccine, delivered in its pure form, may significantly reduce risk of anaphylactic shock and increase immunotherapy efficacy.
Research found that regular alcohol intake higher than 70 grams per week is associated with increased total serum IgE levels. Moderate drinking may also lead to abnormal immune responses, affecting the control of the immune system's response to allergens.
Researchers found that encasing pillows and mattresses with allergen-proof covers, washing bedding weekly, and vacuuming carpets reduced dust mite allergen concentrations. Dry steam cleaning also lowered allergen levels in upholstered furniture.
A new study establishes a link between gastroesophageal reflux and allergies, including environmental allergens like pollens and molds. The discovery could lead to new treatments for children with eosinophilic esophagitis and adults with refractory reflux.
A study found high levels of dust mite and cockroach allergens in U.S. homes, linked to asthma symptoms. In Canada, almost six in ten asthmatics lack effective control of their condition, despite feeling well-managed, according to recent research.
A national survey found that over 45% of US homes have bedding with dust mite allergen concentrations exceeding 2 micrograms per gram of dust, a level associated with allergy development. The study also revealed that 17% of household occupants reported cockroach infestations in the year prior to the study.
A National Jewish Medical and Research Center study, funded by the EPA, investigates the effectiveness of HEPA filters and electrostatic air filtration systems in removing allergens and irritants from homes of children with asthma. The study aims to determine if these interventions can help lower asthma severity in some children.
A recent study found that cockroach allergen exposure is a significant contributor to asthma morbidity among inner-city children. Children who were both allergic and heavily exposed to cockroach allergen were more likely to experience severe asthma symptoms, including hospitalizations and lost sleep.
The new report updates asthma clinical practice guidelines with a focus on early use of anti-inflammatory medication, personalized treatment approaches, and reduced exposure to environmental allergens. The guidelines also include practical tools for physicians and expanded information about identifying specific allergens for each patient.
A new study of 121 children aged 5-14 found that allergy shots had no significant benefits for patients whose asthma symptoms are controlled with medication. However, shots may be useful in certain groups, such as those with irregular medication use or difficulty avoiding allergens.
Research from Johns Hopkins Children's Center reveals that African-American children are 16.4 times more likely than Caucasian children to be sensitive to cockroach allergens, highlighting the link between race and asthma. The study also found that poor children and those from urban areas are more susceptible to roach infestation.