Articles tagged with Allergens
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A new study published in Clinical & Experimental Allergy reveals a 4-fold increase in allergy clinics for children in the UK, but most are small and vary in services offered. The research highlights the need for standardized care through national networks and simulation training to ensure safe service provision.
Dermatitis will be published bimonthly in print and online formats with open access options. The Journal focuses on contact, atopic, occupational, drug-induced dermatitis and environmental dermatitis.
Researchers at NIST developed a new, faster, and more accessible method for screening skin allergens without animal testing. The electrophilic allergen screening assay (EASA) achieved similar results to existing methods with 77% agreement rate, paving the way for potential standardization and increased international trade.
Researchers have identified formononetin as a potential therapeutic for treating food allergies, which affect nearly 10% of the world population. The plant compound has been shown to decrease IgE production and influence gene and protein targets regulated in food allergy and mast cell diseases.
Researchers have identified a unique population of memory CD4 T-cells that produce IL-9, which plays a key role in allergic memory responses. Blocking this cytokine may lead to reduced lung inflammation and improved treatment options for seasonal asthma.
Researchers developed a novel, in vitro cell culture-based allergy test that simplifies diagnosis and predicts therapy success. The test can generate mature mast cells with IgE receptors, allowing for easy activation and quantification using flow cytometry.
Researchers found an association between a specific HLA-DPB1 gene variant and poor response to sublingual immunotherapy (SLIT) for Japanese cedar pollinosis. The study suggests that genotyping the HLA-DPB1 gene could help predict patient responsiveness to SLIT.
Researchers developed a microneedle treatment that increased desensitization rates to peanut allergy in mice, outperforming existing immunotherapy methods. The novel approach achieved significant results using lower doses of allergen, offering new hope for millions suffering from peanut allergy.
Two new treatments have been found to induce peanut allergy remission in children, with about half achieving remission and experiencing significant improvements in quality of life. The combination treatment and oral immunotherapy alone were both highly effective, providing substantial benefits for children's health and well-being.
Researchers found sublingual immunotherapy with house dust mite extract to be effective in reducing signs and symptoms of atopic dermatitis. The treatment, administered over 18 months, resulted in significant improvements in pruritus and lesions, with rare side effects.
A study by researchers at NYU School of Global Public Health and Tufts University found that only a third of online grocery items display required nutrition information. This omission poses significant health risks for consumers, particularly those with allergies or dietary restrictions. The authors advocate for federal regulation to e...
A study published in Cell Reports reveals that LPS protects against developing asthma when combined with allergens containing cysteine protease enzymatic activity, but promotes development when paired with allergens lacking this enzyme. This protective effect relies on the production of GM-CSF by non-classical monocytes.
A recent study found that over 50% of products containing sesame did not declare it on the label, leading to accidental ingestion and allergic reactions. Clear and specific product labeling is essential for preventing adverse reactions, especially anaphylaxis, in food-allergic individuals.
Researchers at Lancaster University examine the use of AI in the food sector, highlighting the need for trusted data collaboration to reduce waste and increase sustainability. They also warn about potential ethical issues and unexpected consequences of new technology.
A new study followed 5,000 kids with asthma in Los Angeles for 15 years and found no significant increase in allergic sensitizations to environmental allergens. Despite rising temperatures and pollen loads, children with asthma were not more likely to become sensitized to specific pollens.
Breast milk from Mennonite moms on farms contains higher concentrations of IgA antibodies against food allergens and bacteria associated with farm animals. Babies born to these mothers show reduced rates of atopic diseases, suggesting a protective factor passed on through breast milk.
A new study found that 31% of children with food allergies experience victimization behaviors, including verbal teasing and criticism, compared to 17% when asked a simple yes/no question. Only 12% of parents reported being aware of the issue.
Researchers at Uppsala University found that allergic stimulation activates mast cell precursor cells, which can produce cytokine IL-13 contributing to asthma development. This challenges the idea that only mature immune cells are involved in immune reactions.
A new Rutgers study suggests that food companies use the terms "cell-based" or "cell-cultured" when labeling seafood products made from fish cells. The study found that both terms meet FDA regulations and help consumers understand the production process, while also recognizing potential allergens.
Researchers found that cells in specific skin areas develop local memory to contact allergens, leading to faster reactions and a more complex picture of the disease. This discovery may lead to new treatment options for patients with contact allergy.
The guidelines recommend training staff on food allergies, having epinephrine available, and promoting handwashing to reduce the risk of reactions. Research has found little evidence that food bans work in reducing allergy-related bullying and anxiety.
Researchers developed a novel immunotherapy approach using CpG adjuvant to boost immune tolerance to the major cat allergen Fel d 1. The treatment reversed allergy hallmarks and reduced inflammation in allergic mice, offering new hope for treating cat allergy.
Researchers have identified 20 proteins found in cricket food products that could cause serious allergic reactions in individuals with shellfish allergies. The study aims to provide a framework for detecting and labelling insect-derived allergens in food products, ensuring safe consumption by those with allergies.
A study from WashU Medicine reveals that allergens in the environment trigger episodes of acute itch in eczema patients, which often don't respond to antihistamines. Researchers found a previously unrecognized pathway carrying itch signals to the brain, opening new avenues for treatment.
A University of Cincinnati immunologist recommends individuals with contact dermatitis choose facial masks made without elastic to avoid allergic reactions and safely use masks during COVID-19. Cotton-based, knot-tie masks can be a suitable alternative, helping patients manage symptoms and prevent delayed reactions.
A breakthrough discovery has revealed a new pathway for the development of allergy treatments by identifying the release of neuropeptide Substance P by sensory neurons upon detection of allergens. This finding suggests that interrupting this pathway could potentially stop allergic immune responses.
Researchers found that even cooked carrots can cause allergic reactions in sensitive individuals, as the allergen Dau c 1 retains its structure when heated. This study highlights the importance of acidity and temperature in triggering immune reactions.
A new study published in CMAJ found a spike in peanut and tree-nut anaphylaxis cases among Canadian children during Halloween and Easter, with previously unknown allergies identified.
Researchers at Johns Hopkins Bloomberg School of Public Health identified a new allergy pathway triggered by house dust mites, which can lead to asthma and allergic rhinitis. The study found that blocking this pathway may be a potential preventive or treatment strategy against these disorders.
Researchers at La Jolla Institute for Immunology have uncovered a previously unknown subset of T cells that may control allergic immune reactions and asthma. These cells, which express an 'interferon response signature,' may dampen the activation of helper T cells and reduce inflammation.
Researchers from the University of Tsukuba developed a novel high-yield method for producing the major birch pollen allergen Bet v 1 in plant leaves. The new system enables rapid and massive production of allergens, which can be used in clinical settings to desensitize patients to environmental allergies.
A study of 25 people found that Pavlovian conditioning to an allergen can lead to a placebo allergic reaction in the environment where the allergen was encountered. Sleep consolidation is thought to play a role in this response, according to the authors.
A new diagnostic method for allergic rhinitis has been developed using nasal smears, providing a gentle alternative to blood tests. The method detected identical allergic sensitization patterns in both blood and nasal secretions for a wide range of airborne allergens.
Researchers have described the overall structure of IgE antibodies, a key molecule in allergic diseases. The study provides insights into basic mechanisms of allergic reactions and may lead to more effective treatments.
A new study suggests that lowering exposure to mouse allergens can lead to improved lung growth in asthmatic children living in low-income neighborhoods. The research found a strong association between mouse allergen exposure and lung function growth, with potential implications for long-term lung health and even longevity.
Research suggests previously unrecognized latex allergies could play a role in equine asthma. Studies applied microarray platforms to determine precise allergens within stable dust that elicit the condition. Latex proteins were found among the most significant allergens associated with equine asthma, alongside Aspergillus fumigatus.
The OUtMATCH study will test the ability of omalizumab to increase tolerance to peanut and other food allergens in children and adults. The trial aims to enroll 225 participants with a history of multiple food allergies, assessing whether biweekly or monthly injections of omalizumab can prevent allergic reactions.
A new study uses Genomic Allergen Rapid Detection (GARD) assays to differentiate and classify vape e-liquids, detecting allergens in ingredients. This innovative approach represents an exciting step towards assessing and classifying future e-liquids.
A new Canadian study found that pre-hospital treatment with epinephrine autoinjectors has the highest protective effect against uncontrolled allergic reactions in children. The study also revealed that steroids can have a negative impact on patient outcomes, suggesting that current guidelines should be reassessed.
A study of restaurant staff in Germany found low levels of food allergy knowledge and negative attitudes toward serving customers with food allergies. Factors such as education level, management status, and restaurant size influenced staff attitudes towards food allergies.
A study found that filtering tiny particles from diesel exhaust increased nitrogen dioxide levels, impairing lung function and exacerbating allergy symptoms. The effects were most pronounced in genetically susceptible individuals.
Researchers identified two epitopes capable of eliciting strong allergic reactions in serum samples from all or nearly all patients, and engineered molecules to selectively bind to IgEs recognizing these epitopes. Treatment with the inhibitors inhibited over 80% of the allergic response to peanut extract in patients.
Researchers at the University of Notre Dame have developed a novel inhibitor that selectively targets IgE and prevents allergic reactions to peanuts. The breakthrough finding has significant implications for treating severe peanut allergies, with up to 90% success rate in inhibiting an allergic response.
A recent study found that patients with lung disease bronchiectasis often display sensitivity to airborne allergens, with a particular role for fungi. The discovery highlights the importance of examining bronchiectasis patients for allergies, as existing treatments can prevent worsening of the disease.
A new research suggests that a single allergic reaction during pregnancy can prompt significant changes in the brains of offspring, leading to more male-like behavior and brain development. Female rats born to mothers exposed to an allergen during pregnancy exhibited higher levels of male-like behavior and brain changes.
A study published in PLOS Pathogens found that cytomegalovirus (CMV) infection can convert harmless protein antigens into allergens, sensitizing immune cells to cause allergic airway disease. This effect is mediated by activated airway dendritic cells and may contribute to the development of asthma.
Researchers at the University of Helsinki found that allergen immunotherapy reduces symptom scores and alters nasal epithelial transcriptome in patients with allergic rhinitis. The study also showed improved diversity of the nasal microbiome in response to treatment.
A new Canadian study found that nearly 7.5% of anaphylaxis cases were due to an unknown trigger (AUT), with suboptimal treatment and follow-up management common both inside and outside hospitals. The study highlights the need for clear guidelines and educational programs to ensure prompt and appropriate management of anaphylaxis.
A study found that pregnant women who have a family history of food allergies are more likely to avoid certain foods, such as nuts and eggs. However, this avoidance does not necessarily prevent food allergies in their infants, but rather increases the risk of problems with food at 4 months old.
Researchers used mouse models to track the immune cell triggering during anaphylactic shock, revealing a previously unknown mechanism in which dendritic cells mine blood vessels for allergens and rapidly deliver them to mast cells. This finding opens innovative lines of attack against deadly allergic reactions.
A recent study predicts ragweed will expand its range northward due to climate change, reaching areas including New York and Vermont. The plant's distribution is expected to surge in the eastern US by the 2050s before declining slightly in the following decades.
Research found that strawberry and tomato allergy potential depends on the specific variety, with some varieties exhibiting lower allergenic proteins due to heat sensitivity. The study's results could lead to the development of hypoallergenic tomato and strawberry varieties.
Researchers at the University of Virginia Health System have discovered a link between sensitivity to an allergen in red meat and increased plaque buildup in heart arteries. This allergy, spread by tick bites, may increase the risk of heart attacks and stroke, highlighting the need for further clinical studies.
Researchers are working to identify biomarkers for food allergies, aiming to improve understanding of how children's immune systems react to certain foods. Current blood tests are only 30-55% specific, leaving room for further innovation in diagnostics and treatments.
A Northwestern University study links infant skin exposure and genetics to food allergy development, providing potential ways to intervene early. Limiting use of infant wipes with soap and washing hands before handling babies may help avoid developing food allergy.
A team of scientists has identified a human protein called interleukin-33 (IL-33) that reacts to various environmental allergens, including mold, pollen, and cockroaches. This discovery establishes a direct link between genetics and the environment, and offers new potential targets for treatment of allergic diseases.
Researchers developed a cream combining antioxidants, moisturizers and free radical scavengers to treat ACD. The treatment relieved itch, reduced swelling and protected peripheral nerves without corticosteroid side effects.
Researchers at the University of Liverpool are developing a device that harnesses cold plasma technology to destroy airborne allergens on contact. The project aims to create a low-cost, efficient, and effective solution to tackle the problem of airborne allergens in the home, which affects over 12 million people in the UK alone.
A new study published in Pediatric Allergy and Immunology reveals that food-induced anaphylaxis reactions occur frequently under adult supervision, with adults other than parents often present. The research highlights the importance of increasing education and awareness among all caregivers of food-allergic children.
The study found that 90% of US homes have at least one elevated allergen level, with pets and pests playing a major role. Housing characteristics and geographic locations also impact allergen exposure levels. Preventive actions can help reduce exposure to indoor allergens.