PORTLAND, OR - Researchers from SWOG, a cancer clinical trials group funded by the National Cancer Institute, will participate in 30 presentations to be made at the 54th Annual Meeting of the American Society of Clinical Oncology (ASCO), the world's largest clinical cancer research meeting, which runs June 1-5 in Chicago.
At ASCO 2018, SWOG investigators will report on trials involving treatment and prevention strategies for breast, lung, prostate, colorectal, and pancreatic cancers, as well as melanoma and myeloma. SWOG investigators will also report on cancer prevention, symptom control, and survivorship topics, including a symptom control and quality of life study that was selected as a "Best of ASCO" submission and the subject of an oral presentation by Dr. Sherry Shen, a SWOG investigator and an internal medicine resident at NewYork-Presbyterian/Columbia University Irving Medical Center.
Shen analyzed data from S0927, a SWOG breast cancer trial led by SWOG investigator and NewYork-Presbyterian/Columbia University Irving Medical Center physician Dr. Dawn Hershman which closed in 2013. Shen's analysis uncovered an important result: omega-3 fatty acid supplements can significantly reduce the joint pain that is a common side effect of aromatase inhibitors (AIs), a common treatment for hormone-sensitive breast cancers. But only obese women - those with a body mass index over 30 - saw a reduction in their joint pain. Women of healthy weight, or those who were overweight, did not benefit from taking omega-3 fatty acid supplements. These results are significant because tens of thousands of women each year are treated with AIs, pills that stop the production of estrogen and essentially starve hormone-positive breast cancer cells. Obese patients have higher rates of AI-related pain, and their treatment options are limited.
"If our results are confirmed, omega-3 fatty acids can be considered for treatment of AI-related pain among obese breast cancer patients," Shen said. "And if that pain is reduced, more women may continue to take their medication. Ultimately, this would lead to better health, and better quality of life, for many women."
Here are other SWOG highlights at ASCO 2018:
A member of the National Cancer Institute's National Clinical Trials Network (NCTN), SWOG collaborates on treatment trials with its network partners. One of those multi-group studies, Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx, will be featured at the ASCO 2018 plenary session. TAILORx was designed and managed by the ECOG-ACRIN Cancer Research Group and is the largest adjuvant breast cancer treatment trial ever conducted, enrolling 10,273 women. The ASCO presentation will focus on the trial's evaluation of the efficacy of endocrine therapy (ET) alone versus ET plus chemotherapy in early stage breast cancer patients with a 21-gene recurrence score result of 11 to 25. SWOG investigators Daniel Hayes, MD, a former ASCO president from the University of Michigan Comprehensive Cancer Center, and Kathy Albain, MD, the Huizenga Family Endowed Chair in Oncology Research at Loyola University Chicago Stritch School of Medicine, are on the TAILORx team.
"SWOG always proves its value at ASCO," said SWOG Chair Charles D. Blanke, MD. "We have a deep bench of experts who work on the full spectrum of challenges in cancer treatment, prevention, and survivorship. Because of our size, and our independence, we can lead trials other organizations can't or won't. I'm really proud of the work we're presenting in Chicago."
###
SWOG was founded in 1956, and is a member of the National Cancer Institute's National Clinical Trials Network and the NCI Community Oncology Research Program, making it part of the oldest and largest publicly-funded cancer research network in the United States. SWOG has over 12,000 members in 47 states and six countries who design and conduct cancer prevention and treatment trials. SWOG trials have led to the approval of 14 cancer drugs, changed more than 100 standards of cancer care, and saved more than 3 million years of human life. Learn more at swog.org .