A related commentary in this issue by D. Grahame Hardy from the University of Dundee places these data in the context of what is currently understood about the molecular mechanisms for altering energy use under conditions of stress and how these finding might provide new directions for therapy in heart disease.
TITLE: AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
AUTHOR CONTACT:
Lawrence H. Young Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA Phone: (203) 785-4102; Fax: (203) 785-7567; E-mail: lawrence.young@yale.edu
View the PDF of this article at: http://www.jci.org/cgi/content/full/114/4/495
ACCOMPANYING COMMENTARY: AMP-activated protein kinase: the guardian of cardiac energy status
AUTHOR CONTACT:
D. Grahame Hardie University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK Phone: 44-1382-344253; Fax: 44-1382-345783; E-mail: d.g.hardie@dundee.ac.uk
Journal of Clinical Investigation