Researchers at Sanford Burnham Prebys discovered that blocking an energy transfer enzyme shifts mammalian hearts into a regenerative state, promoting regeneration and improving recovery after a heart attack. By modulating heart cell metabolism, scientists can potentially awaken the heart's dormant regenerative abilities.
A UCLA research team engineered immune cells that target atherosclerotic plaques, clearing out rogue smooth muscle cells and inflamed macrophages and foam cells. The 'triple-threat' cells outperformed single-target versions in mouse models and artery tissue, showing promise in treating cardiovascular disease.
The EVAOLD trial suggests that routine invasive treatment is more effective than a selective approach in older patients with NSTEMI, a common type of heart attack. The trial found that the selective approach did not demonstrate noninferiority to routine invasive treatment for major cardiovascular events.
A new study confirms the safety of rapid heart attack testing but finds no reduction in emergency department stay length. The 0/1-hour pathway was compared to the standard 0/3-hour pathway and was found to be noninferior in terms of safety.
Remote exercise-based cardiac rehabilitation shows promise as an additional option for patients, but does not replace centre-based rehabilitation. The study found that remotely delivered exercise improved physical capacity and was used by a substantial proportion of patients, despite not increasing overall participation.
A universal definition of myocardial infarction has been developed to improve diagnosis and treatment. The new definition considers the underlying cause of the MI and aligns with established approaches to clinical evaluation.
Dr. Sebastian Spethmann joins JMIR Cardio as Editor-in-Chief, bringing expertise in heart failure, cardiomyopathies, and digital health. He aims to integrate digital advancements into routine clinical care, enhancing cardiovascular health systems and patient outcomes.
Researchers used an AI tool to analyze health records of 12,701 UK Biobank participants who had experienced a heart attack. The study found three distinct health paths, with 63% developing cardiometabolic conditions and 23% suffering a decline in lung function. The AI tool predicted the health trajectory and identified high-risk groups...
Dysregulated neutrophils may play a key role in persistent low-grade inflammation seen in chronic coronary syndrome. Researchers found that neutrophils from patients with stable coronary artery disease do not die as they should, persisting and remaining highly active.
Researchers have developed a new stretchable catheter that can reveal features of arterial plaque not visible with conventional imaging. The device uses electrical measurements to identify metabolically active plaques, allowing doctors to spot potentially deadly buildup before it causes a heart attack.
The Marcus Foundation has awarded $28.7 million to advance a clinical trial testing a stem cell-based therapy designed to regenerate damaged heart tissue after a heart attack. Researchers aim to develop approaches that could reduce or eliminate the need for immunosuppressive drugs.
Tirzepatide has been shown to reduce the risk of heart attacks and hospitalizations due to infections in people with type 2 diabetes and obesity. The study found a relative risk reduction of about one-third, corresponding to a 36% reduced risk of infection-related hospitalization.
Katherine Wilemon, Family Heart Foundation CEO, receives Honorary Fellow Award from ASPC for her advocacy and research efforts in inherited lipid disorders. The award reflects the organization's impact on advancing care and awareness for conditions like familial hypercholesterolemia.
Researchers have developed a new biological treatment that targets inflammation-driven scarring after a heart attack, aiming to reduce the risk of heart failure. The treatment uses donated human bone marrow-produced exosomes to dampen inflammation and promote healing.
Scientists have uncovered a new mechanism used by heart cells to resist reprogramming and found that carbohydrate sulfotransferase 7 (CHST7) is the most potent preventer of reprogramming in mouse and human cells. By targeting CHST7, researchers may develop treatments to help the heart fix itself after injury.
Researchers found that a single parameter in the differential blood count can identify at-risk patients on hospital admission following a heart attack. Immature immune cells, specifically preneutrophils, significantly increase short-term risk of death.
The new calculator predicts that over 98% of people eligible for statin treatment are at low risk of serious muscle disorders. The tool aims to support informed treatment decisions by providing personalized risk estimates, helping patients and clinicians weigh benefits and risks.
Igor F. Palacios, MD, is honored for his groundbreaking work in structural heart disease interventions, including mitral balloon valvuloplasty and the percutaneous pericardial window technique. He has mentored hundreds of physician leaders worldwide through his kindness, generosity, and passion for patient-centered care.
A new study published in JACC found that women who consistently strength train showed substantially lower risk of major cardiovascular disease, particularly alongside aerobic activity and reduced sedentary time. Higher levels of resistance training were associated with lower risk of major CVD, especially myocardial infarction, with no ...
A new study by Uppsala University researchers shows that internet-based CBT can significantly reduce symptoms of stress and anxiety in women with broken-heart syndrome, a condition often triggered by extreme stress. The treatment also helps patients better cope with emotions related to their illness.
A study by IR Sant Pau finds that intravenous administration of atorvastatin during myocardial infarction reduces myocardial damage compared to pre-infarction oral loading dose. This results in less necrosis, inflammation and improved cardiac recovery over time.
Researchers at UT MD Anderson Cancer Center have made significant advances in understanding cancer biology, developing AI-powered atlas of tertiary lymphoid structures as prognostic biomarkers, and uncovering drivers of resistance to KRAS inhibitors. Additionally, they have discovered a molecular pathway that drives stressed cells to b...
Senescent cells that stop dividing but don't die can become abnormally active, causing inflammation and instability in blood vessel plaques. The study found that losing key regulatory proteins activates the CD38 enzyme, leading to a higher risk of blood clots and cardiovascular events.
New York Valves 2026 will unveil groundbreaking clinical science and innovation in transcatheter aortic valve replacement and mitral/tricuspid valve therapies. The conference features 22 late-breaking clinical science presentations that aim to transform the treatment of structural heart disease.
A University of Cincinnati research team will examine how microplastics and nanoplastics accumulate in the body and affect cardiovascular health, with a focus on potential toxicity and worsening outcomes after a heart attack. The five-year study aims to advance understanding of microplastic impact on heart diseases.
Researchers from The University of Osaka found that treatment with five mRNAs effectively promoted cardiac repair and extended survival in mice with heart failure. The study showed that simultaneous administration of five therapeutic mRNAs reduced heart tissue damage and improved heart function.
Adults should aim for 560-610 minutes of moderate to vigorous exercise a week to achieve significant cardiovascular risk reduction. Current guidelines are too low, and individuals with lower fitness levels need more exercise to achieve equivalent benefits.
Dr. Rebecca T. Hahn, MD, is the first imager to receive the TCT Geoffrey O. Hartzler Master Operator Award for her groundbreaking work in imaging structural heart procedures. Her unparalleled expertise has redefined the role of imaging in cardiovascular care.
Researchers discovered that stress hormones trigger neutrophils to detach from blood vessel walls and travel to the heart, causing inflammation. Blocking these stress signals with beta blockers may prevent excessive inflammation and improve heart healing.
A study from Tulane University found that long-term, untreated syphilis increases the risk of serious cardiovascular issues, including stroke, heart attack, and aortic aneurysm. Adults with syphilis were more likely to develop these problems than similar patients without the infection.
A new study by Lund University researchers found that genetic risk scores can predict coronary artery disease even before diabetes onset. The study identifies a group at high risk of developing both conditions, offering potential for early detection and prevention.
Researchers found that influenza vaccination reduced the risk of heart attack and stroke by half for those who got infected, even if they didn't get vaccinated beforehand. The study's findings suggest prioritizing influenza vaccination among high-risk populations could have significant public health impact.
A new trial found that using a microaxial flow pump before and during cardiac stenting procedures for high-risk heart attack patients with severe heart attacks did not reduce heart damage. The study, published in the Journal of the American College of Cardiology, also showed increased bleeding complications.
Registration is now open for TCT 2026, the annual scientific symposium of CRF, taking place October 31 - November 3 in San Diego. The event will feature a dynamic program with groundbreaking research and expert-led tutorials.
A study of over 14 million cardiovascular deaths found that colder temperatures are responsible for significantly more heart-related deaths than milder months. The optimal temperature for heart health is 74°F, with temperatures under this point accounting for approximately 40,000 deaths each year.
A groundbreaking study found that frail men have a significantly higher risk of dying within one year after a heart attack, challenging the prevailing narrative that high clinical risk is predominantly a female issue. The research highlights the need for sex-informed care pathways to address this disparity.
A nationwide Japanese study of 270,000 patients found that widespread mask-wearing during the pandemic significantly lowered PM2.5-associated risk of MINOCA, a non-obstructive type of heart attack. The study suggests that simple protective measures like mask use can mitigate cardiovascular risks associated with air pollution.
A study found that childhood obesity can lead to premature vascular damage in children as young as six, increasing the risk of diseases such as atherosclerosis and heart attack. The research identified early signs of inflammation and dysfunction in the endothelium, highlighting the need for public policies to prevent childhood obesity.
Researchers found that patients seen by cardiologists had lower mortality rates and fewer serious heart problems, including heart attack, sudden failure, or irregular heartbeat. The study suggests close teamwork between surgical and heart teams can improve outcomes after major surgery.
Researchers have shown that human hearts can regrow muscle cells after a heart attack, paving the way for new treatments to reverse heart failure. The discovery was made possible by pioneering techniques that use living tissue samples taken from patients during bypass surgery.
A new study from Cedars-Sinai found a 118% increase in visits for general illness and significant spikes in heart attack and lung complication cases following the January 2025 LA fires. Fine particles released by wildfires can cause injury, particularly to the heart and lungs.
A systematic review of 17 randomized trials found that reducing saturated fat intake lowered all-cause mortality and cardiovascular deaths among high-cardiovascular risk individuals. For people at low to intermediate risk, cutting or replacing saturated fat intake offered little benefit over 5 years. The study suggests that saturated f...
Researchers identified a way to suppress daily fluctuations in immune cells' activity, which may prevent tissue damage during daylight hours. A drug that targets neutrophils was found to alleviate inflammation and protect against infections.
A new study found that calcium accumulation in breast arteries and its progression on mammograms can predict future cardiovascular disease. Women with more severe calcification and those whose calcification worsened over time had a higher risk of heart-related events, such as heart attack, stroke, and death.
Researchers at SwRI and Trinity University are working on a new prodrug to mitigate ischemia/reperfusion injury (IRI), which causes permanent cellular and tissue damage. The team aims to protect against IRI by targeting protein misfolding during cellular stress.
A large analysis found that even low-intensity smokers have a significantly higher risk of heart disease and death compared to non-smokers. Quitting smoking at a younger age is the best way to decrease this risk.
Researchers found that waiting to treat narrowed coronary arteries after a heart attack is safe and can reduce the number of stent procedures. An MRI scan at a later stage can provide reassurance for patients.
In a clinical trial of 12,257 patients at high risk, investigators found that adding the drug evolocumab to a patient’s treatment reduced the risk of a first heart attack, first stroke, or coronary heart disease death by 25%. The study also showed a 36% reduction in heart attacks and a nominally lower rate of death in the evolocumab arm.
A recent study found that fewer than half of young adults with severely high cholesterol levels start taking a statin within five years of first high LDL-C measurement. The study highlights significant care gaps in lipid management among adults aged 18-39, particularly those at high risk for premature atherosclerotic cardiovascular dis...
MIT engineers have developed a programmable drug-delivery patch that can reduce damaged heart tissue by 50 percent and improve cardiac function. The patch is designed to release different drugs at specific times, promoting healing and regeneration of cardiac tissue.
Cardiac rehabilitation significantly improves short and long-term recovery for heart surgery patients, but women participate less than men due to barriers such as lower referral rates, clinician bias, and caregiving responsibilities. The American Heart Association scientific statement calls for targeted interventions to improve enrollm...
A study published in JACC: Cardiovascular Interventions found that AI-based ECG interpretation detected more ST-segment elevation myocardial infarctions (STEMIs) and had fewer false positives than standard triage. The technology improved accuracy, reduced unnecessary activations, and has the potential to shorten time to treatment.
The merger strengthens CRF's leadership in medtech, integrating Fogarty's expertise in early-stage innovation. The unified platform will accelerate breakthroughs into patient care, driving global progress in cardiovascular medicine.
The Cardiovascular Research Foundation (CRF) has announced the 2025 SET-10 Rankings, honoring institutions whose groundbreaking research is shaping the future of cardiovascular care. The rankings recognize academic and medical institutions that are advancing the science and improving patient outcomes.
A new study published in The Lancet found that semaglutide, a 'weight loss' drug, can help prevent heart attacks and other major cardiac events, regardless of the amount of weight people lose. The study suggests there are multiple ways the drug benefits the heart, beyond its protective effect on cardiovascular health.
A new AI-based risk assessment tool, GRACE 3.0, has shown better predictability of future risk for heart attack patients compared to traditional methods.
A large-scale study analyzing health records for over 9 million adults in South Korea and nearly 7,000 people in the U.S. found that more than 99% had at least one risk factor before their first cardiac event. High blood pressure was the most common culprit, affecting over 95% of patients.
Researchers found a correlation between solar storms and an increase in heart attacks, especially among women. Data from São Paulo's public health network showed that women are more susceptible to geomagnetic disturbances, which may be related to changes in blood pressure, heart rate, and circadian rhythm.
A multidisciplinary panel published in the Journal of Pediatrics advocates for accelerated diagnosis of familial hypercholesterolemia, a life-threatening genetic condition. Universal lipid screening is recommended to identify affected children at high risk of heart disease decades earlier than those without the condition.
A new American Heart Association scientific statement highlights the importance of recognizing and treating depression, anxiety and post-traumatic stress disorder among heart attack survivors. Psychological distress after a heart attack is common and can affect physical recovery and long-term heart health.