Withdrawal of tirzepatide after 36-week treatment led to 25% or greater weight regain in most participants within a year, reversing initial cardiometabolic parameter improvements. Continued obesity treatment is crucial for sustained benefits.
A new monolithic synaptic device mimics human CT afferents for robot emotional interaction, achieving ultralow threshold sensitivity and high energy efficiency. The device enables real-time processing of gentle touch into emotional signals.
The study demonstrates that fexofenadine reduces cartilage degradation, inflammation, and senescence in mice models for OA and IVDD. Pharmacological inhibition of cPLA2 preserves cartilage structure and improves behavioral outcomes.
A new electronic application highlights discrepancies between parents and children's views on the child's well-being, providing powerful insight into how children truly cope. This approach has broad implications beyond transplant medicine and may reshape patient-reported outcomes for pediatric chronic illnesses.
A team of scientists has identified key mechanisms behind the triggering of the ribotoxic stress response, a protective program initiated in cells to remove damage or initiate cell death. The researchers found that protein ZAK plays a crucial role in mediating this stress response by recognizing collided ribosomes.
The National Center for Supercomputing Applications (NCSA) has received the 2025 HPCwire Readers' and Editors' Choice Awards for its outstanding research in artificial intelligence and energy systems. NCSA's premier supercomputing systems Delta and DeltaAI were utilized in two different domains, including a novel AI-based approach to m...
A new €4.4 million EU-funded doctoral network, HiPOVor, aims to establish optical vortex beams as a key technology for advanced light-matter interaction. The project will train 15 doctoral researchers in generating and applying high-power optical vortex beams.
JMIR Publications has joined the International Association of Scientific, Technical and Medical Publishers (STM) to enhance research quality and trust. The publisher is integrating STM's Integrity Hub to prevent paper mills from operating with fake credentials.
A new analysis by the Physicians Committee for Responsible Medicine found that a vegan diet, including
Cancer researchers at Cold Spring Harbor Laboratory have identified key proteins that determine the behavior of two hard-to-treat carcinomas, pancreatic cancer and tuft cell lung cancer. These findings could lead to new therapies targeting specific vulnerabilities in these cancers.
Researchers at Pusan National University have developed a new framework for predicting vessel turnaround time by leveraging queuing-based operation indicators. This dynamic approach captures time-varying fluctuations in port operations, offering a more accurate and actionable forecast.
Researchers created AI model popEVE that can identify disease-causing mutations in human proteins, even for unique cases. It ranks mutation severity across the body, helps doctors focus on most damaging variants first.
A novel liver cancer vaccine has achieved responses in a rare disease affecting children and young adults, with 75% of patients experiencing disease control. Three patients are now believed to be cancer-free after receiving the therapy, including a 13-year-old patient who achieved a nearly complete response.
New research reveals that Antarctic mountain peaks can significantly increase the supply of vital nutrients to the Southern Ocean, enhancing its ability to absorb atmospheric carbon dioxide. Sediments from exposed rock surfaces contain higher concentrations of bioavailable iron, which fuels phytoplankton growth and absorbs CO2 through ...
A new study reveals that wild orangutans' dietary knowledge forms a culturally-dependent repertoire, which can only be acquired through years of social learning. The team's simulation model showed that young orangutans need to learn from others to develop their full diet repertoire by adulthood.
Researchers identify a rare gene mutation that appears to protect the brain's immune cells from damage caused by Alzheimer's disease. The study reveals how this mutation can confer resilience on the brain, potentially leading to new therapeutic approaches.
Researchers have successfully grown platinum crystals in liquid metal using a powerful X-ray technique. The study reveals the formation and growth of crystals within liquid metals like Gallium, which could be used to create new materials for hydrogen extraction and quantum computing applications.
Researchers found that early brain firings occur in structured patterns without external experiences, suggesting a genetically encoded blueprint. This discovery can help better understand neurodevelopmental disorders and the impact of toxins on the developing brain.
Sixty-million-year-old rock samples have revealed how massive amounts of carbon dioxide are stored in piles of lava rubble on the seafloor. This discovery sheds light on the importance of breccia, a geological sponge for carbon in the long-term carbon cycle.
Researchers develop ex vivo treatment of blood stem cells with Rhosin, a RhoA inhibitor, to rejuvenate them and improve the production of healthy blood cells. This strategy targets the core of the ageing process, making blood stem cells more capable of regenerating and producing new healthy blood cells.
The Einstein Foundation Berlin has awarded €350,000 prizes to recognize researchers advancing research quality and promoting methodological rigor. The Individual Award honors Simine Vazire for pioneering rigorous research methods in psychology.
By 2100, coral reefs will be slow to recover, less complex, and dominated by fleshy algae as a result of high carbon dioxide changes in ocean chemistry. The study uses unique coral reefs in Papua New Guinea to determine the impact of ocean acidification on coral reefs.
A Garvan-led clinical trial has found that using metformin, a common type 2 diabetes medication, reduces the amount of insulin needed to maintain blood sugar levels in type 1 diabetes. The study suggests that metformin may serve as an affordable treatment option for people with type 1 diabetes.
Researchers found that higher muscle mass combined with a lower visceral fat to muscle ratio tracks with a younger brain age. Building muscle and reducing visceral fat are actionable goals for improving brain health. The study used whole-body MRI and AI algorithms to quantify muscle volume, fat tissue, and brain age.
A new study published in Trends in Biotechnology suggests that mRNA technology could protect against muscle damage caused by snake venom. The treatment, which teaches cells to produce protective antibodies, has shown promising results in laboratory tests and preclinical models.
Researchers have found a gene linked to the risk of delirium, a common medical condition characterized by sudden mental confusion. The study suggests targeted treatments and new ways to prevent progression from delirium to dementia.
Researchers capture astrocytes' behavior and morphology using a novel nanowire platform, enabling precise quantification of shape shifts and growth patterns. This breakthrough paves the way for studying neurodegenerative diseases and advancing 'brain on a chip' technologies.
Researchers discovered that synthetic stress hormone dexamethasone can combat therapy-resistant breast cancer metastases in mice trials. The drug activates the glucocorticoid receptor, suppressing estrogen receptor production and slowing tumor growth. Further studies are needed to confirm these findings in patients with breast cancer.
A new study reveals that social determinants of health have a significant impact on rural–urban differences in colorectal cancer mortality rates. The research found that low socioeconomic status, household characteristics, and racial/ethnic minority status were key drivers of these disparities.
A US study of over a million Medicaid enrollees reveals major gaps in access to medication-based addiction treatments, particularly for Black patients. Methadone and buprenorphine show significant overdose risk reductions, highlighting the need for policy reforms to ensure timely access.
A recent clinical study by the World Institute of Kimchi reveals kimchi's immunomodulatory effects through single-cell transcriptomics analysis. The study found that kimchi consumption strengthened antigen-presenting cells and balanced CD4+ T cell differentiation, suggesting a 'precision regulator' effect on the immune system.
A new study reveals that four wild cat species in Guatemala's Maya Biosphere Reserve coexist without competitive exclusion by hunting in different vertical zones. Pumas primarily consume tree-dwelling prey, while jaguars and ocelots focus on ground-dwelling prey.
The Atacama Cosmology Telescope's sixth and final data release confirms the 'Hubble tension' and rules out extended cosmological models, providing new insights into the Universe's evolution and current state. ACT's observations offer a cleaner starting point for future research.
Researchers at Technion Faculty of Biology discovered that marine viruses deploy a sophisticated Trojan horse maneuver to dismantle ocean bacteria's energy systems, using the breakdown products for self-replication. This process reduces global photosynthetic energy production by about 5% and could impact global carbon and oxygen cycles.
Researchers developed a monolithic 3D-integrated, flexible tactile sensing array inspired by human skin, achieving ultra-high integration and low power consumption. The device uses holey MXene paste for intelligent user identification.
Research reveals that pleural cavity macrophages support lung tumor growth by suppressing anti-tumor immunity. Macrophage depletion leads to increased cytotoxic CD8 T cells, establishing their role as key drivers of tumor progression.
A new study by Mass General Brigham researchers found that combining generative AI with ambient documentation technologies significantly reduced after-hours work and note delays. The hybrid program, which included a virtual scribe, showed a 41% decrease in after-hours work and a 66% decline in documentation delays.
Researchers have developed a breakthrough strategy for ultraflat, electronically homogeneous perovskite films through supramolecule-confined growth. This innovative approach enhances reproducibility and performance of perovskite solar cells.
Researchers elucidated the structure of GPR1 bound to chemerin and β-arrestin, revealing a dynamic transition from a pre-coupled state to a fully engaged state. The study sheds light on the molecular mechanism underlying arrestin-mediated modulation of non-canonical GPCRs.
Two new Cochrane reviews show that HPV vaccines are effective in preventing cervical cancer and pre-cancerous changes, especially when given to young people before they are exposed to the virus. Girls vaccinated before the age of 16 were found to be 80% less likely to develop cervical cancer.
A multi-algorithm machine learning approach enhances AECOPD prediction by identifying key clinical features, including biochemical indicators, demographic characteristics, and pulmonary function parameters. The integrated model demonstrates superior predictive performance compared to traditional methods.
Recent advances reveal circadian rhythms modulate gut microbiota diversity and metabolic functions, affecting the tumor microenvironment and immune cell function. Gut microbial dysbiosis induced by circadian misalignment promotes an immunosuppressive TME and accelerates tumor growth.
A team of international scientists reconstructed size evolution in ancient sharks using interdisciplinary analysis. The study revealed that modern sharks experimented with enormous body sizes much earlier in their evolutionary history than previously suspected.
Researchers from Tokyo Metropolitan University reveal how copper particles create in mid-reaction, converting nitrite ions to ammonia. This insight promises leaps forward in developing new industrial chemistry for greener ammonia production.
New research published in Atmospheric Chemistry and Physics reveals that cleaner fuels have reduced ship emissions' influence on cloud formation, helping refine global climate models. The study found a 67% decrease in cloud-altering abilities after the IMO regulations went into effect.
A new study using magnetoelectric nanoparticles successfully shrinks pancreatic tumors in preclinical models, extending survival. The Sylvester Cancer Institute has also launched its Survivorship and Supportive Care Institute to provide evidence-based care for cancer patients.
Researchers at Columbia University have introduced metasurfaces to 2D materials, allowing for the enhancement of nonlinear optical properties and the creation of entangled photons. The technique, developed by Jim Schuck's team, shrinks nonlinear platforms to just 160 nanometers while maintaining high efficiency.
Researchers at Rice University have developed lab-grown diamond coatings that can naturally resist scale formation without constant intervention. The nitrogen-terminated diamond surface accumulated significantly less scale than other surfaces, making it a promising anti-scaling material for water desalination and energy systems.
Researchers developed a wearable sensor to track thoroughbred horse movements and identify risk factors for catastrophic injury. The study found that horses with high risk scores were 44 times more likely to suffer fatal injuries, and implementing the technology could reduce fatal injury rates by nearly 20%.
Researchers found that exposure to hotter weather during pregnancy disrupts key amino acids and vitamins, increasing the risk of preterm delivery. The study provides new insights into the biological mechanisms behind preterm birth and may lead to the development of early biomarkers for identification and prevention strategies.
The American Heart Association honors nine students, schools, and educators for their efforts to create healthier classrooms and communities. Participants in the Kids Heart Challenge and American Heart Challenge programs are recognized for building a culture of wellness, stress management, and lifesaving skills.
Researchers developed a noninvasive approach using nasal drops to deliver potent tumor-fighting medicine to the brain, boosting the immune response and eradicating glioblastoma tumors in mice. The nano-sized medicine successfully activated the STING pathway and armed the immune system to fight the cancer.
A new online platform has been launched at Newcastle University to enable public participation in bowel cancer research and patient care. The platform aims to speed up research, improve clinical practice and save lives by transforming the way studies are delivered.
An emerging AI-powered system, coordn8, has tripled the speed of fax processing and cut a full week off the new patient intake process. The system automates the intake and filing of faxed documents into electronic health records and allows patients to digitally give their consent.
Scientists at the Salk Institute have discovered a new mode of epigenetic targeting in plant cells, where specific DNA sequences guide DNA methylation patterns. This finding has major implications for understanding epigenetic regulation and could inform future strategies for epigenetic engineering.
A new analysis challenges traditional conservation strategies by highlighting the importance of sustainable pastoralism in protecting global biodiversity. Rangelands harbor vast biodiversity and support millions of people, yet only a small percentage receive formal protection.
A new study by the University of Florida finds that most US home buyers are overpaying mortgage fees, with average costs ranging from 1-3% of the loan. Shopping around can help consumers save an average of $32 in fees and more than $1,000 in interest per loan.
Okamama University of Science has been ranked 52nd globally in the THE World University Rankings 2026, improving its position from a tie for 63rd last year. The university's emphasis on collaboration with companies and local communities is seen as a key factor behind its success.
Researchers found that male green hermit hummingbirds' bills are straighter (3%) and sharper (69%) than females', allowing for more efficient energy expenditure and stress resistance during fights. These differences were driven by the birds' tendency to fight for mates, rather than solely by ecological factors.
Researchers found that tropical forests may be less sensitive to climate change than thought. They discovered that dead leaves cool nearby leaves by reflecting more sun energy, reducing heat buildup.