About the Study: In a randomized trial conducted within Kaiser Permanente Northern California, digital outreach produced a modest improvement in short-term statin refill rates among patients with cardiovascular disease or high cardiovascular risk who had fallen behind on their prescriptions. A second reminder further improved refill rates among initial nonresponders, while switching to a different type of message offered no additional benefit. These findings support adaptive, sequential health system outreach strategies to improve cardiovascular prevention when integrated into population health programs; however, the majority of patients continued to not refill their medications.
Meeting Information: ESC 2026
This paper will be presented during European Society of Cardiology Congress in Munich, Germany.
Local Embargo Time: 18:00 (6 P.M.) CEST.
ESC Presentation: Ankeet Bhatt will simultaneously present the findings during the Hot Line 5 session in the Main Auditorium.
Related Content: This paper has an accompanying editorial .
Corresponding Author: Ankeet S. Bhatt, MD, MBA, ScM, Kaiser Permanente San Francisco Medical Center and Division of Research, Kaiser Permanente Northern California, 2238 Geary Blvd, 8th Floor, San Francisco, CA 94115 ( ankeet.s.bhatt@kp.org ).
10.1001/jama.2026.16372
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JAMA
Digital Outreach to Improve Statin Refills in Patients with Low Statin Adherence (ADHERE-ASCVD)